ライフサイエンスコーパス: vacuolate

1 ich time the tapetum also appears abnormally vacuolated.

2 duced the neurons to become hypertrophic and vacuolated.

3 er, the cortical cataracts were punctate and vacuolated.

4 ain irregular in shape, and the lens becomes vacuolated.

5 both mono-ADP ribosyltransferase (mART) and vacuolating activities known as Community-Acquired Respi

6 m1 and m2/m1 forms of VacA had similar cell-vacuolating activities.

7 (C-CARDS) contains the receptor binding and vacuolating activities.

8 ctor with ADP-ribosyltransferase (ADPRT) and vacuolating activities.

9 cid substitutions (P9A and G14A) that ablate vacuolating activity and membrane channel-forming activi

10 N-terminal extension found on s2 VacA blocks vacuolating activity as its removal (to make the strain

11 of mutant VacA proteins that have defects in vacuolating activity despite exhibiting channel activiti

12 rnatant (CS) from H. pylori 60190, which has vacuolating activity for HeLa cells (Tox+), and isogenic

13 s, and VacA Delta346-347 inhibited wild-type vacuolating activity in a dominant-negative manner.

14 t negative effect, completely inhibiting the vacuolating activity of wild-type VacA.

15 th vacA from a toxigenic strain confers full vacuolating activity proving that this activity is entir

16 and m1b-m2 alleles produced higher levels of vacuolating activity than did isolates with m2 alleles (

17 The gene for V. cholerae vacuolating activity was cloned and was found to corresp

18 med by a VacA s2m1 chimera (which lacks cell-vacuolating activity) and VacADelta301-328 (which retain

19 ctivity) and VacADelta301-328 (which retains vacuolating activity) each contain p33 central cores sim

20 g truncated VacA fragments for intracellular vacuolating activity, we reduced the minimal functional

21 organelle, and are independent of the toxin vacuolating activity.

22 nts, p37 and p58, that are both required for vacuolating activity.

23 acellular site are important for the toxin's vacuolating activity.

24 protein and a marked enhancement of its cell-vacuolating activity.

25 t remain noncovalently associated and retain vacuolating activity.

26 cked toxin required to mediate intracellular vacuolating activity.

27 lls and were internalized but had defects in vacuolating activity.

28 uds, which contained microspores at the late-vacuolate and bicellular stages of development.

29 These cells become vacuolated and expand, and lead to failure in pollen mot

30 Instead, these cells are highly vacuolated and express large amounts of vesicular ATPase

31 ument of Ov-tsp-2-KO flukes was increasingly vacuolated and fewer EVs were secreted.

32 Protegrin-treated N. gonorrhoeae became vacuolated and had striking membrane changes when viewed

33 ng bovine papillomavirus (BPV) E5 are highly vacuolated and have a much enlarged, distorted and fragm

34 eurone occurs only after cells become highly vacuolated and is manifested in an abrupt loss of plasma

35 late bodies, examples of binary fission, and vacuolated and nonvacuolated intermediate bodies, wherea

36 to transient degenerative changes; RPE were vacuolated and separated from photoreceptor outer segmen

37 These cells then differentiate into vacuolated and sheath cells.

38 Cell bodies of affected neurons are vacuolated, and apparently empty spaces are present in a

39 normal antipodal cells that are larger, more vacuolated, and fewer in number than wild type.

40 We find that CSMN display vacuolated apical dendrites with increased autophagy, sh

41 als) that divide asymmetrically to produce a vacuolate basal cell, a stalk cell, and a cytoplasmicall

42 ree to four epithelial cell layers; swollen, vacuolated basal epithelial and endothelial cells; and e

43 al myocardial fibrosis and the appearance of vacuolated cardiomyocytes.

44 es, clasmatodendrocytes were swollen and had vacuolated cell bodies.

45 We demonstrate that inppl1a-dependent vacuolated cell expansion is essential to establish norm

46 lls the cytoplasmic space and contributes to vacuolated cell expansion.

47 Each vacuolated cell possesses a single fluid-filled vacuole,

48 e(K1831E Delta fyve) protein, incompetent to vacuolate cells, implying that an active PIKfyve enzyme

49 that the high density of caveolae present in vacuolated cells [5, 6] could buffer mechanical tension.

50 Upon loss of caveola function, vacuolated cells collapse at discrete positions under th

51 Similarly, notochord vacuolated cells expand to one of the largest cell types

52 During morphogenesis, vacuolated cells maintain their structural integrity des

53 indicate that nucleotides released by dying vacuolated cells promote sheath cell vacuolization and t

54 ion and spine development, consists of giant vacuolated cells surrounded by an epithelial sheath [1-3

55 ress a spore coat protein gene (cotB) within vacuolated cells that form part of the stalk and they ex

56 In zebrafish, the notochord vacuolated cells undergo vacuole fusion to form a single

57 d, causing a significantly reduced number of vacuolated cells, and compromising the mechanical proper

58 d that VacA-CFP and VacA-YFP interact within vacuolated cells, supporting the belief that monomer ass

59 e the inner notochord and differentiate into vacuolated cells, thereby restoring notochord function a

60 hord rod which contains a core made of large vacuolated cells.

61 e VacA with mutant forms of the toxin within vacuolated cells.

62 mids expressing both p33 and p70 resulted in vacuolated cells.

63 nique adenosine diphosphate-ribosylating and vacuolating Community Acquired Respiratory Distress Synd

64 cells in the THLs had abundant eosinophilic vacuolated cytoplasm and pleomorphic nuclei, and express

65 ed by cell shrinkage, substratum detachment, vacuolated cytoplasm, and DNA degradation.

66 entified 10 mutant VacA proteins that lacked vacuolating cytotoxic activity when added to HeLa cells.

67 VacA and that both domains are required for vacuolating cytotoxic activity.

68 alidate a simple PCR-based system for typing vacuolating cytotoxin (vacA) alleles of H. pylori and sh

69 enetic diversity is particularly striking in vacuolating cytotoxin (vacA) alleles.

70 The Helicobacter pylori vacuolating cytotoxin (VacA) binds and enters mammalian

71 er pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic typ

72 At early time points, vacuolating cytotoxin (VacA) constituted a major extrace

73 gy that occur following cell exposure to the vacuolating cytotoxin (VacA) from Helicobacter pylori.

74 hogenicity island and contained a degenerate vacuolating cytotoxin (vacA) gene.

75 The Helicobacter pylori vacuolating cytotoxin (VacA) induces degenerative vacuol

76 The Helicobacter pylori vacuolating cytotoxin (VacA) induces the degenerative va

77 Previous studies have shown that H. pylori vacuolating cytotoxin (VacA) inhibits proliferation of g

78 Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted protein that

79 The Helicobacter pylori toxin vacuolating cytotoxin (VacA) promotes gastric colonizati

80 The H. pylori vacuolating cytotoxin (VacA) recently has been shown to

81 Helicobacter pylori secretes an 88-kDa vacuolating cytotoxin (VacA) that may contribute to the

82 he amino terminus of the Helicobacter pylori vacuolating cytotoxin (VacA) was investigated by analyzi

83 with acid activation of Helicobacter pylori vacuolating cytotoxin (VacA).

84 acteria produce two main cytotoxic proteins: Vacuolating cytotoxin A (VacA) and Cytotoxin-Associated

85 Cytotoxin-associated gene A (CagA), and vacuolating cytotoxin A (VacA) genes predominantly drive

86 The vacuolating cytotoxin A (VacA) is both essential and suf

87 Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe dise

88 pylori secretes a pore-forming toxin called vacuolating cytotoxin A (VacA), which contains two domai

89 r example, in-vitro experiments showing that vacuolating cytotoxin A affect the regulation of T or B

90 ation upon H. pylori infection, and identify vacuolating cytotoxin A and cag pathogenicity island as

91 omplished through many mechanisms, including vacuolating cytotoxin A and CagA activities, and may be

92 H. pylori vacuolating cytotoxin A and cytotoxin-associated gene A

93 studies have investigated the interaction of vacuolating cytotoxin A or cytotoxin-associated gene A w

94 for urease subunit alpha), VacA (coding for Vacuolating cytotoxin A) and CagA genes (coding for cyto

95 tension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA

96 ssociation between neutrophil activation and vacuolating cytotoxin activity was also investigated.

97 and function), neutral red uptake (to detect vacuolating cytotoxin activity), and adhesion assays.

98 ed within oligomeric structures and retained vacuolating cytotoxin activity.

99 uently identified in H. pylori isolates with vacuolating cytotoxin activity.

100 s and i regions are the key determinants of vacuolating cytotoxin activity.

101 lori from the West have linked production of vacuolating cytotoxin and a particular signal sequence (

102 elated to H. pylori infection, including the vacuolating cytotoxin and the cag pathogenicity island.

103 Lipopolysaccharide, urease, and vacuolating cytotoxin are among the factors that allow H

104 tructural organization and processing of the vacuolating cytotoxin are characteristic of a family of

105 e to H pylori extract or its immunomodulator vacuolating cytotoxin confers robust protective effects

106 These results indicate that Sat, a vacuolating cytotoxin expressed by uropathogenic E. coli

107 omenon, we analyzed the transcription of the vacuolating cytotoxin gene (vacA) in eight Tox+ strains

108 Alleles of the vacuolating cytotoxin gene (vacA) of Helicobacter pylori

109 cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native

110 n associated gene (cagA), the cagA-EPIYA and vacuolating cytotoxin gene (vacA) were typed by PCR and

111 potentially toxigenic vacAs1 alleles of the vacuolating cytotoxin gene (vacA), independent of diseas

112 The vacuolating cytotoxin gene of Helicobacter pylori, vacA,

113 the vaccine group acquired mutations in the vacuolating cytotoxin gene vacA, resulting in loss of va

114 irulence gene, cagA, and active forms of the vacuolating cytotoxin gene, vacA, are major determinants

115 The Helicobacter pylori vacuolating cytotoxin gene, vacA, is naturally polymorph

116 Strains lacking a TPM were typically vacuolating cytotoxin genotype vacA m2.

117 These results suggest that the H. pylori vacuolating cytotoxin interferes with EGF-activated sign

118 H. pylori strains that express the vacuolating cytotoxin or the outer membrane protein OipA

119 he gamma-glutamyl-transpeptidase GGT and the vacuolating cytotoxin VacA, are required and sufficient

120 he gamma-glutamyl transpeptidase GGT and the vacuolating cytotoxin VacA, contribute critically and no

121 nd exclusively through its pro-apoptotic and vacuolating cytotoxin VacA.

122 nickel(3), and two additional copies of the vacuolating cytotoxin VacA.

123 ase in humans, secretes a toxin called VacA (vacuolating cytotoxin) into culture supernatants.

124 he cag PAI had no effect on synthesis of the vacuolating cytotoxin, but this deletion and several cag

125 identified from H. pylori strains, known as vacuolating cytotoxin, induces vacuole formation in euka

126 polysaccharide); and (3) damage host tissue (vacuolating cytotoxin, protease, CagA-related factors, i

127 The vacuolating cytotoxin, VacA, is an important virulence f

128 effects of H. pylori MV with and without the vacuolating cytotoxin, VacA, which inhibits human T cell

129 eceptor type Z were not damaged by H. pylori vacuolating cytotoxin.

130 tion, aging lynx1 null mutant mice exhibit a vacuolating degeneration that is exacerbated by nicotine

131 deeply into the gradient developed bulbous, vacuolated endings that looked remarkably similar to dys

132 striatum and motor cortex areas included 1) vacuolated endothelial cells containing large autophagos

133 stration resulted in neutrophil margination, vacuolated endothelium, intra-alveolar hemorrhage and ma

134 e show that spe-5 mutants contain defective, vacuolated FB-MOs and usually arrest spermatogenesis at

135 IBM vacuolated fibers also contain accumulations of several

136 s been shown to accumulate abnormally in the vacuolated fibers and to localize to amyloid-like fibril

137 ls invade non-vacuolated fibers, whereas the vacuolated fibers are not invaded by T cells, implying t

138 ereditary inclusion body myopathy, only rare vacuolated fibers had immunoreactive inclusions, whereas

139 Vacuolated fibers in LOPD patient muscle biopsies were s

140 y myositis the inflammatory cells invade non-vacuolated fibers, whereas the vacuolated fibers are not

141 wed a focal increase of TIA1 in atrophic and vacuolated fibers.

142 lipids and amino acids was increased in non-vacuolated fibres, indicating early metabolic abnormalit

143 and muscle regeneration was observed only in vacuolated fibres.

144 We found that the vacuolated giant cells had multiple signs of organelle d

145 We found similar vacuolated giant cells in human tuber specimens.

146 rt early in sexual development, resulting in vacuolated, highly disarranged, and disintegrating paras

147 n-vacuolated (histologically unaffected) and vacuolated (histologically affected) myofibres of LODP p

148 myofibres from healthy individuals with non-vacuolated (histologically unaffected) and vacuolated (h

149 et cells, and the anterior cortical lens was vacuolated in Klf4CN mice.

150 atives including Abeta, and phospho-tau into vacuolated inclusions is an early pathogenic event.

151 2.8 J/cm(2) generated increasing degrees of vacuolated keratinocytes and melanocytes.

152 half of the stroma displayed thin and finely vacuolated lamellae, and keratocytes throughout the stro

153 The vacuolated lens (vl) mouse mutant causes congenital cata

154 disturbance, blood film microscopy to detect vacuolated lymphocytes is a rapid, readily accessible, a

155 Blood film microscopy revealed vacuolated lymphocytes, and electron microscopy showed l

156 nsgene-the cultures were dominated by highly vacuolated macrophages.

157 signs include gliosis, dystrophic neurites, vacuolated mitochondria, and accumulation of soluble hyp

158 ibire(ts1) contain terminals with widespread vacuolated mitochondria, reduced numbers of vesicles and

159 lta(346-347) also co-immunoprecipitated from vacuolated monolayers, supporting the hypothesis that th

160 Between 80% and 90% of IBM vacuolated muscle fibers contained well-defined ERK-immu

161 inclusion body myositis muscle biopsies are vacuolated muscle fibers containing intracellular amyloi

162 monstrates mononuclear cell inflammation and vacuolated muscle fibers containing paired helical filam

163 le diseases, characterized pathologically by vacuolated muscle fibers containing paired helical filam

164 Seventy to eighty percent of the vacuolated muscle fibers of both s-IBM and autosomal-rec

165 Vacuolated muscle fibers of both s-IBM and the h-IBMs co

166 As in Alzheimer-disease (AD) brain, vacuolated muscle fibers of inclusion-body myositis (IBM

167 Approximately 80 to 90% of the vacuolated muscle fibers of sporadic inclusion body myos

168 loid and congophilic amyloid deposits within vacuolated muscle fibers.

169 le diseases, characterized pathologically by vacuolated muscle fibres containing paired helical filam

170 Approximately 75% of the vacuolated muscle fibres in all recessive and dominant i

171 ion and 15-18-nm tubulo-filaments within the vacuolated muscle fibres.

172 a lysosomal storage disease (ie, clusters of vacuolated myocytes) but also typical of HCM due to sarc

173 sies, but not in non-myopathic muscle or non-vacuolated myopathic controls.

174 complement has been demonstrated is X-linked vacuolated myopathy.

175 ially uniform cells and encase the inflating vacuolated notochord cells.

176 Vacuolating notochord cells undergo a constrained expans

177 pathology of white matter tracts comprising vacuolated oligodendrocytes and intramyelinic edema.

178 e only phakic individual exhibited white and vacuolated opacities in the cortical region.

179 Highly vacuolated or foamy macrophages are a distinct character

180 Larger, vacuolated organisms (such as diatoms), having a bigger

181 In electron micrographs, the AC is a highly vacuolated part of the cytoplasm.

182 e capacity while maintaining the cytoplasmic vacuolated phenotype.

183 region of s2/m2 vacA does not cause the non-vacuolating phenotype, but if VacA is unblocked, it conf

184 rely loosened intercellular junctions in the vacuolated region.

185 Vacuolated remnant cells were seen throughout the monola

186 ytokinesis was observed in a wide variety of vacuolate shoot cells and in some small root cells, impl

187 While pslA- cells produce mature, vacuolated stalk cells during multicellular development,

188 from amoebae to either refractile spores or vacuolated stalk cells.

189 tiation of hyphal growth, to produce highly "vacuolated" subapical compartments.

190 ggs and embryos, can be interpreted as giant vacuolate sulphur bacteria.

191 ion have recently been discovered within the vacuolate sulphur-oxidizing bacteria.

192 ll wall degeneration, resulting in enlarged, vacuolated tapetum surrounding collapsing microspores.

193 This protein, VCaB45, is enriched in highly vacuolate tissues and is located within the lumen of vac

194 large oligomeric structures and that lacked vacuolating toxic activity for HeLa cells.

195 that bacterial virulence factors such as the vacuolating toxin (VacA) and the cytotoxin-associated ge

196 icates that the secreted Helicobacter pylori vacuolating toxin (VacA) inhibits the activation of T ce

197 in the process by which Helicobacter pylori vacuolating toxin (VacA) intoxicates cells.

198 Helicobacter pylori vacuolating toxin (VacA) is a secreted toxin that is rep

199 Vacuolating toxin (VacA) is crucial in facilitating the

200 was to investigate the capacity of H. pylori vacuolating toxin (VacA) to induce gastric epithelial ce

201 ri secretes a pore-forming exotoxin known as vacuolating toxin (VacA).

202 les in pathogenesis have been recognized for vacuolating toxin A (VacA) and urease, H. pylori membran

203 ydrophobic region that are known to abrogate vacuolating toxin activity.

204 n M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory

205 ently, we identified an ADP-ribosylating and vacuolating toxin of M. pneumoniae, designated Community

206 ), hra (heat-resistant agglutinin), and vat (vacuolating toxin) were significantly associated with ba

207 ence genes, including pap (P fimbriae), vat (vacuolating toxin), kpsM II (group 2 capsule), ibeA (inv

208 on of the genes involved in acidic survival, vacuolating toxin, cag-pathogenicity island, motility, a

209 first direct evidence that alpha-toxin is a vacuolating toxin.

210 related variants of the polyomavirus simian vacuolating virus 40 (SV40) have differing host target r

211 more effective inhibitor of in vitro simian vacuolating virus 40 DNA replication system than that of

212 s a key difference between MCV LT and simian vacuolating virus 40 LT, which activates a DDR but inhib

213 Uro-AR(-/y) mice with the transgene, simian vacuolating virus 40 T (SV40T), in the urothelium (Uro-S

214 in primate polyomaviruses, including simian vacuolating virus 40, BKV, and JCV.

215 s: JC virus (JCV), BK virus (BKV) and Simian Vacuolating virus-40.

216 th, which occurred after cells became highly vacuolated, was manifest by an abrupt loss of plasma mem

217 acidic LE/LYs, and some cells become highly vacuolated, with enlarged Rab7-positive endosomes.