ライフサイエンスコーパス: vacuolation

1 is not a downstream consequence of cellular vacuolation.

2 dramatic PIKfyveK1831E-induced endomembrane vacuolation.

3 tin or compactin had no detectable effect on vacuolation.

4 rol levels strongly potentiated VacA-induced vacuolation.

5 th nystatin also inhibited VacA-induced cell vacuolation.

6 ular mechanism of VacA-induced intracellular vacuolation.

7 nd enters mammalian cells to induce cellular vacuolation.

8 key molecular event in VacA-induced cellular vacuolation.

9 ted the capacity of the toxin to induce cell vacuolation.

10 ect in the form of endomembrane swelling and vacuolation.

11 reflected in a marked reduction in lysosomal vacuolation.

12 but this mutant toxin failed to induce cell vacuolation.

13 pa nonsense mutation Nur7 also develop brain vacuolation.

14 tion, glial activation and, in later stages, vacuolation.

15 d blocked its capacity to induce cytoplasmic vacuolation.

16 (LYVAC), is a general mediator of lysosomal vacuolation.

17 ed extensive myocardial fibrosis and myocyte vacuolation.

18 f chloride depletion can act as a signal for vacuolation.

19 mitochondrial cristae, lipid inclusions and vacuolation.

20 le was found to have mislocalized nuclei and vacuolation.

21 patterns of PrP(Sc) deposition and neuronal vacuolation.

22 protein synthesis for death with cytoplasmic vacuolation.

23 torage vacuoles and abscisic acid inhibiting vacuolation.

24 eported to regulate endosomal morphology and vacuolation.

25 racterized by excessive autophagic-lysosomal vacuolation.

26 tic step in the process of VacA-induced cell vacuolation.

27 d to CS from Tox+ H. pylori exhibited marked vacuolation (52% +/- 5% of cells) compared with epitheli

28 of the outer wall, enlarged endothecium, and vacuolation affected pollen grains and resulted in the i

29 (3,5)P2 reduction result in massive membrane vacuolation along the endosomal system, but the cell-spe

30 also resulted in increases in ploidy level, vacuolation and altered accumulation of several differen

31 d the morphological and biochemical signs of vacuolation and apoptosis.

32 Like most cattle with BSE, vacuolation and astrocytic gliosis were confined in the

33 In addition to neuronal vacuolation and astrocytic hypertrophy, dendritic atroph

34 IKfyve product PI(3,5)P2 triggered cytosolic vacuolation and blocked lysosomal fusion reactions essen

35 tection against 15d-PGJ2-induced cytoplasmic vacuolation and cell death, suggesting a novel role of L

36 usceptibility of these cells to VacA-induced vacuolation and cell death.

37 important event in nonautophagic cytoplasmic vacuolation and cell death.

38 gest that enhanced membrane cycling precedes vacuolation and cell swelling.

39 several abnormalities, including hepatocyte vacuolation and changes in nonparenchymal tissue.

40 CvpB association to early endosome triggers vacuolation and clustering, leading to the channeling of

41 In line with extensive vacuolation and cytoarchitectural disintegration, the nu

42 activation of the toxin is required for both vacuolation and cytochrome c release, which suggests tha

43 nt lacking the ligand-binding domain induced vacuolation and death of Purkinje neurons.

44 which included coarse internal architecture, vacuolation and disorganized membrane morphology with re

45 g plasma membrane blebbing and invagination, vacuolation and fragmentation of organelles, and alterat

46 f the central nervous system gray matter and vacuolation and hypomyelination of some white matter tra

47 us enhancer/beta-actin promoter, resulted in vacuolation and increasing accumulation of the 4-kd amyl

48 ring ring-enhancing myelitis revealed tissue vacuolation and loss of AQP4 immunoreactivity with prese

49 a(v)beta(3) and alpha(5)beta(1) integrins in vacuolation and lumen formation in a fibrin matrix, impl

50 a(5)beta(1), regulate human endothelial cell vacuolation and lumen formation in three-dimensional fib

51 s-type PCD, including nuclear fragmentation, vacuolation and lysis.

52 had developed widespread neuronal and glial vacuolation and lysosomal accumulation of sphingomyelin

53 These data indicate that cellular vacuolation and mitochondrial cytochrome c release are t

54 n the brain was associated with severe brain vacuolation and neurodegeneration, leading to death.

55 neurodegenerative diseases characterized by vacuolation and neuronal loss.

56 ogy (transmissible spongiform encephalopathy vacuolation and prion protein deposition) were analysed

57 Neuropathology includes mild scattered vacuolation and prominent, mainly cerebellar localized,

58 taxia and diminishes cerebellar and thalamic vacuolation and Purkinje cell dendritic atrophy.

59 ogic disease resulting from extensive myelin vacuolation and subsequent demyelination.

60 Pathological evaluation demonstrated vacuolation and swelling of the myelin sheaths in the sp

61 Channel blockers known to inhibit cellular vacuolation and VacA membrane channel activity also inhi

62 e relationship between VacA-induced cellular vacuolation and VacA-induced cytochrome c release from m

63 several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations i

64 their cytoplasmic characteristics, timing of vacuolation, and extent of cell elongation.

65 morphological signs of neurodegeneration and vacuolation, and features of apoptosis.

66 ssociated with exacerbated tubular injuries, vacuolation, and lipid accumulation.

67 tion of reactive oxygen species, cytoplasmic vacuolation, and plasma membrane permeability that are d

68 d overall animal body weights, reduced liver vacuolation, and reduced inguinal adipose tissue (iWAT)

69 otoxic effect on ASK cells, Vah1 causes cell vacuolation, and RtxA causes cell rounding.

70 tosolic Ca2+, it did inhibit secretion, cell vacuolation, and vacuolar acidification, all responses l

71 Motor impairment and striatal vacuolation are apparent in PGC-1alpha (-/-) mice by fou

72 Neuronal death and vacuolation are characteristics of the CNS degeneration

73 blocked, it confers cell line specificity of vacuolation as in natural s1/m2 strains.

74 This manifested as increased cytoplasmic vacuolation as observed in cultured fibroblasts.

75 to remarkably less neuronal death and myelin vacuolation, as well as reduced spinal cord swelling and

76 by increased G-CSF signaling and testicular vacuolation associated with decreased fertility.

77 of abnormal prion protein and/or associated vacuolation at this time, temporally close to disease on

78 pinal cord, accompanied by severe spongiform vacuolation, axonal swellings, and degeneration.

79 ed in male infertility, atrophic testes with vacuolation, azoospermia, and spermatogenesis arrest.

80 nversely, bafilomycin A1 blocks VacA-induced vacuolation but not VacA-induced cytochrome c release, w

81 f damage, such as fusion/fission defects and vacuolation, but axons do not show increased levels of H

82 ells with etoposide for 2d induced cytosolic vacuolation, but not nuclear condensation or DNA fragmen

83 Vacuolation by endothelial cells and lumen formation, th

84 ally nicked VacA are able to induce cellular vacuolation by themselves.

85 ed a dramatic decrease in neuronal and glial vacuolation (by standard histological staining) and in c

86 In contrast to vacuolation caused by Helicobacter pylori VacA protein,

87 dictate the pattern of PrPSc deposition and vacuolation, characteristic for different prion strains.

88 This vacuolation did not happen when spermatozoa were freed f

89 The BAT in the HD mice showed vacuolation due to accumulation of neutral lipids, and a

90 racterized by thin or absent myelin sheaths, vacuolation, enlarged periaxonal collars, oligodendrocyt

91 vous system), where common hallmarks include vacuolation, gliosis, accumulation of a protease-resista

92 al mechanism by which VacA mediates cellular vacuolation has not been established.

93 digestion and elutriation were evaluated for vacuolation in a blinded protocol by light and electron

94 ctivation recruits CaM to promote fusion and vacuolation in a Ca(2+)-dependent fashion.

95 ith persistent foci of surface AQP4 and (ii) vacuolation in adjacent myelin consistent with edema.

96 ) synthesis, previously shown to block brain vacuolation in aspartoacylase-deficient mice, also preve

97 ains produce a cytotoxin (VacA) that induces vacuolation in epithelial cells.

98 ue cytotoxin (VacA) that induces cytoplasmic vacuolation in eukaryotic cells.

99 licobacter pylori, vacA, induces cytoplasmic vacuolation in gastric epithelial cells.

100 /m1 VacA from H. pylori strain 60190 induced vacuolation in HeLa and Vero cells, whereas the chimeric

101 on in the central nervous system and minimal vacuolation in most visceral organs.

102 hether Helicobacter pylori cytotoxin induces vacuolation in primary epithelial cells from normal huma

103 +) T cells showed unique pathological bulbar vacuolation in the brain parenchyma of infected mice wit

104 The 22A strain caused more extensive vacuolation in the brains of SAMP8 and SAMR1 mice than i

105 e mutant animals have consistent cytoplasmic vacuolation in the central nervous system and minimal va

106 ty and also develop abnormal myelination and vacuolation in the central nervous system.

107 opathology of jam2 KO mouse showed prominent vacuolation in the cerebral cortex, thalamus, and cerebe

108 ted rats was limited to extensive enterocyte vacuolation in the ileum.

109 , and cerebellum and particularly widespread vacuolation in the midbrain with reactive astrogliosis a

110 ment revealed loss of brush border and lipid vacuolation in the renal cortex of Slc7a7Lbu/Lbu mice, w

111 ith rapamycin hastened weakness, atrophy and vacuolation in VCP-IBM mice.

112 ecreted pore-forming toxin that induces cell vacuolation in vitro and contributes to the pathogenesis

113 We propose that this vacuolation, in itself, contributes to the virulence of

114 ormation, whereas SKD1(WT) did not alter the vacuolation induced by PIKfyve(K1831E).

115 IKfyve(WT) in COS and HEK293 cells inhibited vacuolation induced by subsequent intoxication with VacA

116 s was further substantiated by examining the vacuolation-induced potency of several pharmacological s

117 cell lines, we found that diverse lysosomal vacuolation inducers converged on lysosomal osmotic stre

118 iagnostic feature of the response to GA, and vacuolation is also inhibited by cPrG.

119 Lysosomal vacuolation is commonly found in many pathophysiological

120 acA concentrations, indicating that cellular vacuolation is not a downstream consequence of cytochrom

121 Additionally, toxin-mediated cell vacuolation is strictly dependent on the function of vac

122 roidal abnormalities including degeneration, vacuolation, loss or disruption of the RPE basal infoldi

123 enhanced in vitro inhibition of endothelial vacuolation, lumen and cord formation, and VEGF- and HGF

124 that TNF-alpha may mediate the myelin sheath vacuolation observed in experimental CJD.

125 Severe brain vacuolation observed in the histology of the PA control

126 nsistent with a role for OsCBL2 in promoting vacuolation of barley aleurone cells following treatment

127 fluoromethylornithine) or both apoptosis and vacuolation of basal epithelial cells (perillyl alcohol)

128 ation pathways was found to be essential for vacuolation of cells by VacA.

129 cortical, and epidermal cells, and increased vacuolation of cells in the calyptrogen of the root cap,

130 addition, beta-cyclodextrin reagents blocked vacuolation of cells that were either preloaded with Vac

131 idemic V. cholerae strains from Mexico cause vacuolation of cultured Vero cells.

132 in (VacA) is a secreted protein that induces vacuolation of epithelial cells.

133 n be added to purified p55 in trans to cause vacuolation of HeLa cells and inhibition of IL-2 product

134 from Tox+ Helicobacter pylori strains induce vacuolation of HeLa cells in vitro and contain VacA in c

135 stigated by analyzing the relative levels of vacuolation of HeLa cells transfected with plasmids enco

136 n of the m region was less potent in causing vacuolation of HeLa cells, AGS gastric cells, and AZ-521

137 VacA-G13A, VacA-G22A, and VacA-G26A induced vacuolation of HeLa cells, whereas VacA-P9A, VacA-G14A,

138 x mutants that lacked the capacity to induce vacuolation of HeLa cells.

139 y transverse organization and an increase in vacuolation of its longitudinal tubules across adjacent

140 aser treatment at 532 nm elicited noticeable vacuolation of keratinocytes and melanocytes within all

141 ons and microglia display the characteristic vacuolation of lysosomal storage of undegraded substrate

142 ng cytotoxin (VacA) induces the degenerative vacuolation of mammalian cells both in vitro and in vivo

143 plasma membrane cholesterol is essential for vacuolation of mammalian cells by VacA.

144 ed by nuclear and cytoplasmic inclusions and vacuolation of muscle fibers.

145 in disruption of the endoplasmic reticulum, vacuolation of nerve cell bodies, and abnormal reticular

146 f Purkinje cells, intensive astrogliosis and vacuolation of neurons in the deep cerebellar nuclei, an

147 on of the gastric mucus layer, and increased vacuolation of parietal cells.

148 data to show that H. pylori cytotoxin causes vacuolation of primary human mucosal epithelial cells.

149 m of GA in a signaling pathway that leads to vacuolation of protein storage vacuoles and abscisic aci

150 g dissolution of the glomerular membrane and vacuolation of proximal tubule cells.

151 capacity of i1 and i2 forms of VacA to cause vacuolation of RK13 cells.

152 lating cytotoxin (VacA) induces degenerative vacuolation of sensitive mammalian cell lines.

153 , elevates brain NAA and causes "spongiform" vacuolation of superficial brain white matter and neighb

154 Vacuolation of the aleurone cell is a diagnostic feature

155 n the deep cerebellar nuclei, and the severe vacuolation of the cells in vestibular and cochlear nucl

156 Homozygotes exhibit intense vacuolation of the central nervous system gray matter an

157 uptured outer membranes, autophagosomes, and vacuolation of the internal compartment, which were sign

158 Vacuolation of the Sertoli's cells is the earliest obser

159 Other findings were vacuolation of the temporal cortex, unusual neuronal los

160 progressive hindlimb paralysis and extensive vacuolation of the ventral region of the spinal cord.

161 egeneration of cerebellar granule cells, and vacuolation of white matter in the brain and spinal cord

162 14, 21 and 28, and lamellar body swelling or vacuolation on days 21 and 28.

163 In some mice, more prominent vacuolation or a noncerebellar distribution of PrP plaqu

164 owever, VacA Delta346-347 did not cause cell vacuolation or membrane depolarization, and it was impai

165 erence in bacterial colonization, epithelial vacuolation, or gastritis between the two groups of pigl

166 ormation of the mouse strain, whereas PP and vacuolation patterns depended on the scrapie strain-mous

167 We recently showed that the vacuolation phenotype in cultured Vps34-deficient podocy

168 pression in cells of kidney origin induces a vacuolation phenotype.

169 Within intoxicated cells, vacuolation precedes cytochrome c release and occurs at

170 Thus, a distinct form of cell vacuolation precedes cytolysis at low doses of hemolysin

171 As cytoplasmic vacuolation progressed, however, signs of viral protein

172 lecular mechanisms by which VacA causes this vacuolation remain largely unknown.

173 echanism by which these two fragments induce vacuolation requires direct association.

174 sted by 'dystrophic' morphology, cytoplasmic vacuolation, Rosenthal fibres and associated stress prot

175 ient cells, suggesting that flocculation and vacuolation serve homeostatic functions in zinc-deficien

176 amylin showed increased interstitial space, vacuolation, spongiform change, and capillaries bent at

177 Vacuolation starts after osmotic cell swelling has subsi

178 y of these cells exhibited focal cytoplasmic vacuolation, suggesting that infection by spongiogenic r

179 CJD) virus is characterized by myelin sheath vacuolation that closely resembles that induced in murin

180 et macrocephaly and progressive white matter vacuolation that lead to ataxia, spasticity, and cogniti

181 er Rab7 or Rab9 proteins induces severe cell vacuolation that resembles the phenotype seen in fibrobl

182 This detergent caused a rapid vacuolation; these vacuoles were shown by electron micro

183 utophagy inhibition, and unusual cytoplasmic vacuolation, thus granting PBC a unique anticancer activ

184 stalk, and the continuous process with cell vacuolation, together with stalk sheath extension.

185 with increased tegument thickness, increased vacuolation (tsp-2) and reduced electron density (tsp-3)

186 In contrast to VacA-induced cell vacuolation, VacA-induced clustering and redistribution

187 Vacuolation was associated with cellular toxicity.

188 dges of EAE and MS lesions, a zone of myelin vacuolation was common, whereas in the lesion proper, my

189 degrees C and then shifted to 37 degrees C, vacuolation was completely inhibited.

190 Vacuolation was found in the brains of all scrapie-infec

191 arly in those regions, where the most severe vacuolation was found.

192 In FVB mice, vacuolation was less intense but more widely distributed

193 VT2-induced vacuolation was maintained in adaGb(3)-treated Vero cell

194 ssociates with wild-type VacA in cells where vacuolation was not detectable, suggesting that the form

195 This neuronal vacuolation was particularly severe in the lateral thala

196 Detailed analyses indicated that this vacuolation was related to that caused by aerolysin, a p

197 Vacuolation was seen in many cells, including macrophage

198 Moreover, vacuolation was suppressed in WNK1/WNK3 double knockouts

199 eneration but does not prevent mitochondrial vacuolation, we suggest that vacuolization occurs indepe

200 agosome and endosome maturation resulting in vacuolation, weakness and muscle atrophy.

201 rocytes in areas with striking myelin sheath vacuolation were intensely stained with an antibody agai

202 reover, P2X4 activation-triggered fusion and vacuolation were suppressed by inhibiting CaM.

203 rganoid monolayers and caused increased cell vacuolation when interacting with the basolateral surfac

204 33 resulted in VacA internalization and cell vacuolation, whereas sequential addition in the reverse

205 ls with the p33/p55 mixture resulted in cell vacuolation, whereas the individual domains lacked detec

206 l in the absence of CI-MPR, as was lysosomal vacuolation, which correlated with increased AKT signali

207 uncover an essential mechanism for lysosomal vacuolation with broad implications in pathophysiology.

208 ines, characterized by extensive cytoplasmic vacuolation with dilatation of endoplasmic reticulum (ER

209 th this disorder have morphological changes: vacuolation with disordered endosomal/lysosomal compartm

210 loped microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis

211 y, incubation with Sat triggered significant vacuolation within the cytoplasm of both human bladder (

212 ochrome c release, and extensive cytoplasmic vacuolation, yielding a morphotype that is typical of ne