ライフサイエンスコーパス: vacuole

1 carboxylase and stored as malic acid in the vacuole.

2 CO(2) into malate (Mal) and store it in the vacuole.

3 (PM) protein, whereas Rcr2 is sorted to the vacuole.

4 ry of itaconate to the Salmonella-containing vacuole.

5 ide and establishing itself in the resulting vacuole.

6 ates within a membrane-bound parasitophorous vacuole.

7 s delaying fusion of autophagosomes with the vacuole.

8 ites and for delivery of mitochondria to the vacuole.

9 al ER architecture and an enlarged digestive vacuole.

10 evacuolar endosome (PVE) compartments to the vacuole.

11 ted surface of the L. pneumophila-containing vacuole.

12 zed with the parasite in the parasitophorous vacuole.

13 rieval to the ER or delivery to the lysosome/vacuole.

14 afficking of host cytoplasm to the digestive vacuole.

15 nd are primarily stored in the large central vacuole.

16 ckpoint in the control of traffic toward the vacuole.

17 0 and interact with AGO1 on the ER up to the vacuole.

18 y, but parasites remain connected within the vacuole.

19 nfection, a process largely regulated by the vacuole.

20 rmation and endocytic trafficking toward the vacuole.

21 so present on small vesicles adjacent to the vacuole.

22 nesis driven by endocytic trafficking to the vacuole.

23 nert hemozoin within the parasitic digestive vacuole.

24 lla is phagocytosed, it resides in an acidic vacuole.

25 unity-related GTPases and destruction of the vacuole.

26 Dstyk regulates fusion of membranes with the vacuole.

27 synthesis and retrograde transport from the vacuole.

28 est at polarized stage with a single central vacuole.

29 f polyP and of endopolyphosphatases from the vacuole.

30 mately leads to lysosomal degradation of the vacuole.

31 mobilization of sugars from taproot storage vacuoles.

32 t Ser-331 increased the number of fragmented vacuoles.

33 oduction and/or transport into intracellular vacuoles.

34 alizations including the cytoplasm, SDVs and vacuoles.

35 t its involvement in the formation of apical vacuoles.

36 ing to the plasma membrane or degradation in vacuoles.

37 autophagic marker and the presence of LDs in vacuoles.

38 abnormal storage, and enlarged intracellular vacuoles.

39 fusion was equally affected using yvc1Delta vacuoles.

40 for translocation to the shoot or stored in vacuoles.

41 ated host targets with Legionella-containing vacuoles.

42 cycle phases except induction of cytoplasmic vacuoles.

43 Wtf4(poison) and promote its trafficking to vacuoles.

44 omponent of this trait is Na(+) retention in vacuoles.

45 rgoes delivered from PVE compartments to the vacuole?

46 xylation limit daytime mobilisation from the vacuole?

47 s triggered by functional alterations in the vacuole, a known early event in aging.

48 ms, including herbicide sequestration in the vacuole, a rapid cell death response, nucleotide polymor

49 However, yeast vacuoles accumulate large amounts of polyP, and upon cel

50 brain reveal that blood vessels, cells, and vacuoles affect axonal diameter and trajectory.

51 lator that promotes protein targeting to the vacuole, altered PI4P abundance at both the plasma membr

52 questosomes within multivesicular autophagic vacuoles (amphisomes or autolysosomes).

53 of bromoquine distribution in the digestive vacuole and at its membrane surface, we deduce that the

54 y and PIN1 localisation, thereby controlling vacuole and auxin-related developmental processes in Ara

55 targeting the exopolyphosphatase Ppx1 to the vacuole and concomitantly depleting the two endopolyphos

56 structure alterations and loss of water from vacuole and cytoplasm/extracellular space, more pronounc

57 localized to cortical actin patches and the vacuole and Golgi membranes; they utilize several lipid

58 ino acids resulted in mislocalization to the vacuole and impaired n-glycan processing in vivo.

59 overview of the current knowledge about the vacuole and its internal structures, as well as their ro

60 Dstyk knockdown inhibits notochord vacuole and lysosome biogenesis through mTORC1-dependent

61 des host cells, ruptures its internalization vacuole and reaches the cytosol for replication.

62 Degradation occurs in the vacuole and requires the E2 ubiquitin ligase Ubc4, the E

63 ent cell-autonomous immunity can destroy the vacuole and the parasite inside.

64 was retained onto the Legionella-containing vacuole and was also present on small vesicles adjacent

65 dstyk that causes fragmentation of notochord vacuoles and a severe congenital scoliosis-like phenotyp

66 regions of necrosis, the presence of larger vacuoles and cysts, changes in the architectural organiz

67 egions of necrosis and the presence of large vacuoles and cysts.

68 of the conserved regulator of H(+)-ATPase of vacuoles and endosomes (RAVE) complex, which binds to cy

69 ression in volume and shape of the bacterial vacuoles and found that the T2SS mutant grows at a decre

70 PAMAM-CNTs were visualised in cellular vacuoles and in the cell nucleus.

71 ded in shape, with hypertrophied contractile vacuoles and intense cytoplasmic vacuolization, possibly

72 tant defects as they rounded up, accumulated vacuoles and lipid bodies and displayed subtle but consi

73 haracterized neuropathologically by neuronal vacuoles and neurofibrillary tangles.

74 due to dysregulated biogenesis of notochord vacuoles and notochord function.

75 At high magnification, intracytoplasmic vacuoles and occasional intermixed signet ring cells wer

76 Ms, as evidenced by cell death with numerous vacuoles and perinuclear spaces, and depleted intracellu

77 ana tabacum) leaves, MtNPD1 colocalized with vacuoles and the endoplasmic reticulum.

78 arval internal body cavity into a network of vacuoles and vesicles, where calcium ions are concentrat

79 Lysosome (vacuole) and mitochondria decline interdependently durin

80 tob1 mutants, TOB1 transport of IBA into the vacuole, and cytokinin-regulated TOB1 expression provide

81 vasion, replication within a parasitophorous vacuole, and egress from the cell.

82 ession, rupture of the Salmonella-containing vacuole, and host cell death.

83 uolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in

84 keratocytes, presence of small intracellular vacuoles, and hyperreflective epithelial intercellular s

85 ic components, such as clathrin-coated pits, vacuoles, and micropinocytic vesicles.

86 Vacuoles are acidic organelles that store Fe(III) polyph

87 Vacuoles are essential organelles in plants, playing cru

88 gens, but recent research has identified the vacuole as a possible target of microbial interference.

89 Autophagic vacuoles, as well as frequent and extensive deposits of

90 hanism that steers the Legionella-containing vacuole away from endolysosomal maturation pathways.

91 within a membrane-bound bacterium-containing vacuole (BCV).

92 ells through uptake into bacteria-containing vacuoles (BCVs) and subsequent rupture of the vacuolar m

93 ambers, was first interpreted as fossilized vacuole-bearing microorganisms, but later regarded as ar

94 nteracts with the host protein TBC1D5 during vacuole biogenesis and intracellular replication.

95 activity can rescue the defect in notochord vacuole biogenesis and scoliosis in dstyk mutants.

96 ings reveal a key role of DSTYK in notochord vacuole biogenesis, notochord morphogenesis and spine de

97 relationship between TORC1 inactivation and vacuole biogenesis.

98 uture research directions in parasitophorous vacuole biology.

99 ar pathogens reside in host-membrane-encased vacuoles, but the mechanism initiating xenophagic target

100 partments repeatedly deliver material to the vacuole by a kiss-and-run mechanism.

101 into the lumen of the Salmonella-containing vacuole by a secretion mechanism strictly dependent on T

102 sion events to establish a large replication vacuole called the Coxiella-containing vacuole (CCV).

103 find that localized disruption of notochord vacuoles causes vertebral malformation and curving of th

104 ation vacuole called the Coxiella-containing vacuole (CCV).

105 ide the lysosome-derived Coxiella-containing vacuole (CCV).

106 ections and localizes to Coxiella-containing vacuoles (CCVs).

107 redistribute adjacent to forced mitochondria-vacuole contact sites.

108 demonstrate that NVJ1- and MDM1-enriched NE-vacuole contacts increase when NPC assembly is compromis

109 Vacuoles contained double-membrane vesicles suggestive o

110 as targeted by the host xenophagy system but vacuoles containing L. pneumophila avoided targeting.

111 Ubiquitin-labeled vacuoles containing L. pneumophila failed to recruit aut

112 ed by increased LC3-II levels and autophagic vacuoles content.

113 driver; however, AgNPs internalized in food vacuoles contributed to the perturbation of amino acid m

114 t a parallel pathway, which initiates on the vacuole, converges with ubiquitylation to release the va

115 tion with ATG1 to remodel the NE and promote vacuole-dependent degradation of specific nucleoporins i

116 ed over via both the 26S proteasome- and the vacuole-dependent pathways.

117 secretion system whose effectors modify the vacuole, driving endosomal tubulation.

118 evealed that PI(3)P stabilizes the digestive vacuole (DV) under heat stress.

119 ic glycoside saponin and engenders digestive vacuoles (DVs) that are small and malformed.

120 We named this disorder the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic

121 lular locations, including cytosol, nucleus, vacuole, endoplasmic reticulum, plasma membrane and cell

122 S33A is a core component of the class C core vacuole/endosome tethering (CORVET) and the homotypic fu

123 We found that the components of class C core vacuole/endosome tethering (CORVET) complex are essentia

124 VI Secretion System (T6SS) was required for vacuole escape.

125 and has been characterized as a regulator of vacuole fission during hyperosmotic shock, where it inte

126 he formation of ER-derived large cytoplasmic vacuoles followed by "implosive" cell death.

127 ral lipids, are delivered to the lysosome or vacuole for degradation.

128 ading to the biogenesis of a parasitophorous vacuole for intracellular replication.

129 , degenerative changes such as intracellular vacuole formation, and reduced Ki67 expression.

130 Ag-MNP, leading to membrane degeneration and vacuole formation.

131 borated by the observation of enzyme-induced vacuole-formation ("bubbling") events, which can only oc

132 somes in that they are single-membrane bound vacuoles formed by projection, ruffling, and contraction

133 arallel pathways are required to release the vacuole from Myo2 suggests that multiple signals are int

134 converges with ubiquitylation to release the vacuole from Myo2.

135 Here, we show that mesophyll vacuoles from Arabidopsis sense and control the membrane

136 In comparison to wild type, vacuoles from the fou2 mutant, harboring TPC1 channels i

137 These currents were strongly reduced in vacuoles from two independent H(+)-PPase mutant lines (v

138 ly inside host cells within a characteristic vacuole, from where it manipulates host cells by injecti

139 Defects in vacuole function result in a breakdown in intracellular

140 a Rab family GTPase involved in contractile vacuole function, is likely a direct target.

141 Together, our data show that notochord vacuoles function as a hydrostatic scaffold that guides

142 testing showed that C8-PI(3,5)P(2) inhibited vacuole fusion after trans-SNARE pairing.

143 ylinositol 3,5-bisphosphate (PI(3,5)P(2)) on vacuole fusion remains unknown.

144 Yeast vacuole fusion requires R-SNARE, Q-SNAREs, and HOPS.

145 r/endoplasmic reticulum membrane morphology, vacuole fusion, and growth on glycerol medium).

146 ct is likely due to a more general defect in vacuole fusion, as assessed by changes in vacuole morpho

147 ctanoyl (C8) PI(3,5)P(2) abolishes homotypic vacuole fusion.

148 We also establish that Env7 vacuole fusion/fission regulation and vacuolar localizat

149 Bafilomycin treatment abrogated vacuole generation, indicating that H(+)-driven Cl(-) ac

150 of an acyltransferase via trafficking to the vacuole, heterologous transporters to facilitate intrace

151 these lipids throughout the stages of yeast vacuole homotypic fusion.

152 ound the abnormal accumulation of autophagic vacuoles, impaired autophagic flux, altered intracellula

153 lementation restores mitochondrial health in vacuole-impaired cells and prevents mitochondrial declin

154 tivated by metabolic stress that arises from vacuole impairment, and loss of Fzo1 degradation severel

155 fructose-1,6-bisphosphatase (FBPase) and the vacuole import and degradation protein Vid24p.

156 ssociated vesicles that are mobilized to the vacuole in an ATG5- and ATG7-dependent manner.

157 an parasite Toxoplasma gondii lives inside a vacuole in the host cytosol where it is protected from h

158 he host xenophagy pathway from targeting the vacuole in which it resides were examined.

159 hila can disrupt xenophagic targeting of the vacuole in which it resides.

160 esulting from abnormal storage, and enlarged vacuoles in cultured fibroblasts.

161 ruits is due to the extreme acidification of vacuoles in juice vesicle cells via a mechanism that rem

162 ood, with fevers, cytopenias, characteristic vacuoles in myeloid and erythroid precursor cells, dyspl

163 Rickettsia-containing double-membrane-bound vacuoles in the BMMs of B6 mice.

164 ramatic accumulation of large, multigranular vacuoles in the cytoplasm, with reduction of insulin con

165 l lipodystrophy with histological finding of vacuoles in the macrophages of the intestinal mucous.

166 vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine kinking.

167 tuted fusion with pure components from yeast vacuoles including SNAREs, the HOPS (homotypic fusion an

168 fractions indicated that freezing disrupted vacuole integrity, enhancing oxidation in the seed coat.

169 These results therefore define how NE-vacuole interorganelle contacts coordinate responses to

170 ites involves formation of a parasitophorous vacuole into which the parasite moves.

171 In plant cells, the vacuole is a vital organelle that plays a central role i

172 Once the vacuole is brought to the bud cortex via the Myo2-Vac17-

173 ac17-Vac8 complex, Vac17 is degraded and the vacuole is released from Myo2.

174 for the sorting of proteins to the lysosomal vacuole is Rsp5, a member of the Nedd4 family of ligases

175 e, early in the cell cycle, a portion of the vacuole is transported into the emerging bud.

176 These interorganelle nucleus-vacuole junctions (NVJs) cooperate with lipid droplets t

177 Malate accumulation in the vacuole largely determines apple (Malus domestica) fruit

178 ic reticulum (ER)-like Legionella-containing vacuole (LCV) that supports bacterial replication.

179 hin macrophages in the Legionella-containing vacuole (LCV).

180 embrane recruitment to Legionella-containing vacuoles (LCV) emerged as major SidE targets.

181 The Rab Ypt7 and vacuole lipids together allosterically activate the boun

182 egates, lipid droplets or organelles) to the vacuole (lysosome in mammals) for degradation and recycl

183 cytoplasmic components are delivered to the vacuole/lysosome for degradation and recycling.

184 mbrane vesicular system with numerous apical vacuoles/lysosomes.

185 ing in yeast, we show that the lysosome-like vacuole maintains mitochondrial respiration by spatially

186 ll, Hughes et al. (2020) show that defective vacuole-mediated cysteine compartmentalization in aging

187 he vacuolar structures and the mechanisms of vacuole-mediated defense responses is of great importanc

188 membranes, presumably at the parasitophorous vacuole membrane (PVM).

189 ents (PVCs) and autophagosomes fuse with the vacuole membrane (tonoplast) to deliver cargoes.

190 overcome the barrier of the parasitophorous vacuole membrane and thereby allow the delivery of prote

191 s embraced by a double-layer parasitophorous vacuole membrane derived from host cell.

192 In contrast to the plasma membrane, the vacuole membrane has not yet been associated with electr

193 related to the established autophagy factor vacuole membrane protein 1 (VMP1), and our data show tha

194 After ubiquitination, vacuole membrane proteins are sorted into the lumen for

195 Down-regulation of vacuole membrane proteins is initiated by ubiquitination

196 t also result in the down-regulation of many vacuole membrane proteins to supply amino acids as part

197 The vacuole membrane seals and pinches off behind the parasi

198 imuli elicit transient depolarization of the vacuole membrane that can last for seconds.

199 RT), a transporter resident on the digestive vacuole membrane that in its variant forms can transport

200 n ligases, including TRAF2 and TRAF6, to the vacuole membrane, which enhances recruitment of ubiquiti

201 overexpression or mutations in the digestive vacuole membrane-bound ABC transporter PfMDR1 (P. falcip

202 infection by disrupting the parasitophorous vacuole membrane.

203 ed that FolVam7 is localized to vesicles and vacuole membranes in the hyphae stage.

204 ar1 and Ssh4, which localize to endosome and vacuole membranes.

205 lular parasite infection by disrupting their vacuole membranes.

206 e, in 10-15% of the Deltapofut2 or Deltanst2 vacuoles, MIC2 accumulated earlier in the secretory path

207 of PtdIns(4,5)P(2) on aberrant endomembrane vacuoles, mislocalization of the cytokinetic machinery,

208 were accompanied by dramatic differences in vacuole morphology and distribution, as well as disturbe

209 two tonoplast proton pumps are required for vacuole morphology and PIN1 localisation, thereby contro

210 This, in turn, regulates (1) vacuole morphology, (2) recruitment of TORC1 and the TOR

211 in vacuole fusion, as assessed by changes in vacuole morphology.

212 ave dysfunctional V-ATPases, rendering their vacuoles nonacidic.

213 fered by genotype, including the presence of vacuoles, nuclear count, and proximal tubule brush borde

214 tes with double-membrane vesicles containing vacuoles observed with electronic microscopy, may be a u

215 The lysosomal vacuole of budding yeast (Saccharomyces cerevisiae) has

216 an essential role in forming the replication vacuole of Legionella pneumophila bacteria, which requir

217 osition and functions of the parasitophorous vacuole of Plasmodium blood stages.

218 averses the membrane of the acidic digestive vacuole of the parasite(3-9).

219 d conditions where this strain is trapped in vacuoles of cells infected through bacterial transfer.

220 arsenite, the form of arsenic stored in the vacuoles of this fern.

221 ajor site for sorting of cargo to either the vacuole or apoplast.

222 ane vesicles that subsequently fuse with the vacuole or lysosome, thereby delivering cargo for degrad

223 ane bound vacuole, the Salmonella-containing vacuole or SCV, a significant proportion of them promptl

224 nd localization of Pg within single-membrane vacuoles or cytosol, with some nuclear localization appa

225 t the cargo to the degradative compartments (vacuoles or lysosomes).

226 ed amounts of synapses containing autophagic vacuoles/phagosomes.

227 house hundreds of cilia in an intra-cellular vacuole (phaosome).

228 tissues, specifically targeting the cytosol, vacuole, plasma membrane, and wall of plant cells.

229 Some, particularly the digestive vacuole plasmepsins, have been extensively characterized

230 e removal of Na(+) from the cytosol into the vacuole plays a critical role in salinity tissue toleran

231 out the interfering effects of cell lysis on vacuole polyP and of endopolyphosphatases.

232 Moreover, yeast vacuoles possess two very active endopolyphosphatases, P

233 endolysosomal tethering homotypic fusion and vacuole protein sorting (HOPS) complex, was recently ide

234 ncodes a subunit of the homotypic fusion and vacuole protein sorting (HOPS) complex, which plays a ke

235 ze membrane fusion, and homotypic fusion and vacuole protein sorting (HOPS), that serve as adaptors w

236 hering/SM complex HOPS (homotypic fusion and vacuole protein sorting) increases the fusion of membran

237 uding SNAREs, the HOPS (homotypic fusion and vacuole protein sorting) tethering and SNARE-assembly co

238 y lead to the up-regulation of autophagy and vacuole proteins involved in recycling but also result i

239 thin an acidic lysosome-like parasitophorous vacuole (PV) in human macrophages.

240 ic pH of lysosomes to form a parasitophorous vacuole (PV) in which to replicate.

241 modium parasites reside in a parasitophorous vacuole (PV) that associates with lysosomes.

242 sing a unique organelle, the parasitophorous vacuole (PV).

243 lar network (IVN) within the parasitophorous vacuole (PV).

244 ective organelle, called the parasitophorous vacuole (PV).

245 that bromoquine accumulates in the digestive vacuole, reaching submillimolar concentration, 1,000-fol

246 Vacuoles receive material via the endocytic, secretory,

247 gs suggest that endocytic trafficking to the vacuole regulated by the enzymatic activities of PI4KIII

248 s lacking PI(3,5)P2 activation have enlarged vacuoles relative to those in WT cells.

249 he bud cortex provides spatial regulation of vacuole release.

250 proteins to supply amino acids as part of a vacuole remodeling process.

251 more, we showed that Taok2 recruitment to Lm vacuoles requires the presence of pore-forming toxin lis

252 n of VPS4A mutants caused enlarged endosomal vacuoles resembling those induced by expression of known

253 uring the formation of Salmonella-containing vacuole (SCV).

254 lerated polarized growth but constant width, vacuoles segregated to the nongrowing half of the cell,

255 Q3: Does malate efflux from the vacuole set the pace of decarboxylation?

256 . faecalis was identified in single-membrane vacuoles, some of which were in the process of binary fi

257 which attaches to the vacuole via Vac17, the vacuole-specific adaptor protein.

258 macrophages, but bacteria did not return to vacuoles such as lysosomes or autophagosomes and macroph

259 ses with yeast cells expressing a truncated, vacuole-targeted version of pSuT indicate that both gluc

260 -induced macroautophagy and the cytoplasm-to-vacuole targeting pathway are inhibited, and the recruit

261 pathogen Legionella pneumophila resides in a vacuole that is ubiquitinated; however, this pathogen av

262 ehind diurnal malate remobilisation from the vacuole that liberates CO(2) to be fixed by RuBisCo behi

263 an parasite Toxoplasma gondii, live inside a vacuole that resides in the host cytosol.

264 We first demonstrated that the enlarged vacuoles that accumulate in fibroblasts lacking FIG4, a

265 f RavD significantly increased the number of vacuoles that accumulate the late endosome/lysosome mark

266 tamylation of SidE enzymes on the surface of vacuoles that contain Legionella.

267 diate vicinity of the inner wall using giant vacuoles that form in Schlemm's canal cells as micropres

268 ot ClC-6(WT), generated giant LAMP1-positive vacuoles that were poorly acidified.

269 y asymmetric: one daughter cell inherits the vacuole, the other the growing tip.

270 are initially taken up into a membrane bound vacuole, the Salmonella-containing vacuole or SCV, a sig

271 The vacuoles then merge and rupture, killing the cells.

272 so exhibited markedly enlarged intracellular vacuoles; this finding was recapitulated by the overexpr

273 pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB secreti

274 strates to the proteasome or to the lysosome/vacuole through ER-associated degradation (ERAD) or ER-p

275 ogy, likely because of K redistribution from vacuole to chloroplast.

276 chloroplasts that have been displaced by the vacuole to the cell periphery.

277 s from the lumen of the parasite's digestive vacuole to the cytosol, thereby providing a source of am

278 ic trafficking of the C. burnetii-containing vacuole to the lysosome.

279 a re-localization of this protease from the vacuole to the nucleus and cytoplasm, which is likely to

280 es from the trans-Golgi network within small vacuoles to the plasma membrane.

281 , there appears to be no direct or dedicated vacuole-to-mitochondria iron trafficking pathway.

282 gulated, suggesting disruption of a putative vacuole-to-mitochondria iron trafficking pathway.

283 Rcr2 is delivered to the vacuole using ubiquitin as a sorting signal.

284 myosin V motor, Myo2, which attaches to the vacuole via Vac17, the vacuole-specific adaptor protein.

285 onic osmolyte internalized, exited endocytic vacuoles via two-pore channels, accompanied by parallel

286 Enhanced adaptor recruitment to the vacuole was observed by using a strain of L. pneumophila

287 ism initiating xenophagic targeting of these vacuoles was unknown.

288 Besides observing LD translocation into vacuoles, we also provide evidence for direct interactio

289 latelet alpha-granules were decreased, while vacuoles were increased.

290 ls; only individual viral particles in small vacuoles were seen.

291 cape the endoplasmic reticulum and reach the vacuole, where peptide exchange with the cross-presented

292 e fusion, increasing the number of prominent vacuoles, whereas a phosphomimetic substitution at Ser-3

293 However, the limiting membrane of the vacuole, which constitutes the host-pathogen interface,

294 smic reticulum-derived Legionella-containing vacuole, which facilitates bacterial replication.

295 e, leading to malic acid accumulation in the vacuole, which peaks at dawn.

296 membrane fusion, as exemplified by the yeast vacuole, which uses various PIs at different stages of f

297 g, whereas they were significantly larger in vacuoles with engineered heightened expression of the H(

298 Vacuoles with functional V-ATPases appear unnecessary in

299 ma was associated with accumulation of lipid vacuoles within knockout cardiomyocytes; (3) Hypoxia-ind

300 ates are transported via large M6PR-positive vacuoles without degradative xenophagy to the plasma mem