ライフサイエンスコーパス: vacuolization

1 rstitial inflammation, fibrosis, and tubular vacuolization.

2 previously identified cause of endolysosomal vacuolization.

3 fy small molecules that rescue endolysosomal vacuolization.

4 targeted cardiomyocytes and wavy fibers with vacuolization.

5 matin, nuclear segmentation, and cytoplasmic vacuolization.

6 ed with inflammation, cellular diversity and vacuolization.

7 ct lysosomal swelling and extensive cellular vacuolization.

8 -/-) fibroblasts was effective in preventing vacuolization.

9 cells and induces cell death by catastrophic vacuolization.

10 d age-dependent neurodegeneration visible as vacuolization.

11 cell cycle arrest, and increased cytoplasmic vacuolization.

12 months, which is accompanied by gliosis and vacuolization.

13 ervation preceded mitochondrial swelling and vacuolization.

14 ns rich in neuronal cell bodies also display vacuolization.

15 ization, and blebbing as well as cytoplasmic vacuolization.

16 correlated with notochord extension through vacuolization.

17 was a higher frequency of isometric tubular vacuolization (71 % vs. 31%) and more widespread involve

18 ndings in MDS do not include myeloid lineage vacuolization, abnormal nuclear lobulation of both eryth

19 ng cytotoxin gene vacA, resulting in loss of vacuolization activity.

20 zation and rejection and 14 biopsies showing vacuolization alone.

21 n SR/ER membrane destabilization and luminal vacuolization along with decreased myocyte contractility

22 e are degenerative features characterized by vacuolization and accumulation of stressor and amyloid-r

23 ia/ischemia but also may induce brain tissue vacuolization and alter glucose metabolism.

24 icity (gck, gsr and nqo1) and caused hepatic vacuolization and apoptosis as well as increase of the l

25 CH is characterized by widespread hepatocyte vacuolization and apoptosis, which, in contrast to more

26 , ventriculomegaly, cytomegaly and extensive vacuolization and astrocytosis of white matter.

27 uctural abnormalities in astrocytes, such as vacuolization and astrogliosis.

28 reas K8/K18 pancreata displayed age-enhanced vacuolization and atrophy of the exocrine pancreas and e

29 like membrane structures in association with vacuolization and cell death.

30 its synthesis in skeletal myofibers induces vacuolization and contraction impairment.

31 used spontaneous and progressive acinar cell vacuolization and death, interstitial fibrosis, inflamma

32 Cellular defects, including vacuolization and disrupted mitochondria, were observed

33 lls arrest in G1/G0 phase and suffer massive vacuolization and eventual cell death by autophagy.

34 ycle arrest that was associated with massive vacuolization and expansion of the ER.

35 alterations in chromatin condensation, cell vacuolization and extracellular matrix swelling in both

36 34-deficient podocytes exhibited substantial vacuolization and foot process effacement.

37 Vacuolization and gliosis were evident before clinical o

38 lterations, including flattened cell bodies, vacuolization and granularity in the cytoplasm and abnor

39 e hepatocytes, which resulted in cytoplasmic vacuolization and increased cell damage closely resembli

40 pearing, squamous epithelium with occasional vacuolization and keratinization.

41 rovesicular tubular epithelial cytoplasmatic vacuolization and luminal dilatation with flattening of

42 expression causes age-dependent hippocampal vacuolization and many other intermediate phenotypes of

43 renal tubular cell desquamation, with toxic vacuolization and mitochondrial swelling as hallmarks of

44 ated cells revealed cytoplasmic changes with vacuolization and mitochondrial swelling, nuclear conden

45 ak expression demonstrated massive cytosolic vacuolization and multifocal nuclear chromatin condensat

46 and ultrastructural analyses revealed severe vacuolization and myelination defects in all white matte

47 reas MK-801 produced characteristic neuronal vacuolization and necrosis in the posterior cingulate/re

48 5)NMDA receptor antagonists produce neuronal vacuolization and necrosis in the rat posterior cingulat

49 g astrocytes and neurons, showed cytoplasmic vacuolization and other degenerative changes.

50 Morphological alterations included cytoplasm vacuolization and partial loss of epidermal stratificati

51 cludes Z-disc streaming, excess myofibrillar vacuolization and plaque-like myofibrillar aggregation.

52 There was striking podocyte vacuolization and proteinaceous casts, with marked glome

53 Vacuolization and PrP deposition were observed in some b

54 enal allograft biopsies showing both tubular vacuolization and rejection and 14 biopsies showing vacu

55 eatment with doxorubicin induced cytoplasmic vacuolization and severe damages in myofilaments and nuc

56 electron microscopy, extensive sarcoplasmic vacuolization and severe disruption of mitochondrial fin

57 y showed significantly increased cytoplasmic vacuolization and significantly decreased mitotic activi

58 We propose that these cells, via vacuolization and stiffening, gave rise to the chordate

59 All these steps are required for cytoplasmic vacuolization and subsequent cytolysis to occur.

60 virus induced marked cytopathologic changes (vacuolization and syncytium formation) in infected micro

61 y dying vacuolated cells promote sheath cell vacuolization and trans-differentiation.

62 Remarkably, MPN372 elicits extensive vacuolization and ultimate cell death of mammalian cells

63 a distinct morphology exhibiting cytoplasmic vacuolization and, finally, cytolysis.

64 nimals included proximal tubule collapse and vacuolization and, less frequently, interstitial edema a

65 oint pertinent adverse outcomes (i.e., liver vacuolization) and groups of chemicals that preselected

66 vascular cell interactions, endothelial cell vacuolization, and an overall failure of vascular organi

67 Moreover, MLKL phosphorylation, cytoplasmic vacuolization, and cytolysis were observed in eosinophil

68 iopsies showed epidermal atrophy, basal cell vacuolization, and diffuse dermal sclerosis in the absen

69 as shown by nuclear morphology, cytoplasmic vacuolization, and host cell DNA fragmentation.

70 Podocyte pathology included effacement, vacuolization, and hypertrophy with crescent formation.

71 plasm of affected cells displayed subnuclear vacuolization, and in some cases, nuclei of affected cel

72 imple cold stored tissue displayed increased vacuolization, and machine perfused tissue showed region

73 n microscopy showed cytoplasmic swelling and vacuolization, and marked decrease or absence of dense-c

74 ltrate, hypercellular appearance, pronounced vacuolization, and mucoid degeneration, appearing as Wal

75 cell morphological changes such as swelling, vacuolization, and nuclear fragmentation following treat

76 erulein reduced hyperamylasemia, acinar cell vacuolization, and pancreatic inflammation but did not a

77 , and replicate within, the RGC resulting in vacuolization, and ultimately lysis, of the RGC.

78 On light microscopy cytoplasmic swelling, vacuolization, apoptosis, and abnormal immunostaining fo

79 ative stress, and mitochondrial swelling and vacuolization are among the earliest pathologic features

80 Mitochondrial swelling and vacuolization are early signs of incipient motor neuron

81 degeneration with fiber size variability and vacuolization, as well as reduced motor performance, fea

82 injury stimulus resulted in focal epithelial vacuolization at birth, but otherwise normal tubule hist

83 GlcNAc-Asn was detected along with lysosomal vacuolization, axonal swelling in the gracile nucleus an

84 s characterized in part by early cytoplasmic vacuolization before nuclear changes occur.

85 to show variable degrees of degeneration and vacuolization by postnatal day 21.

86 gy studies revealed an extensive cytoplasmic vacuolization coherently with a paraptosis-like cell dea

87 ncluding cell membrane blebbing, cytoplasmic vacuolization, condensation of nuclear chromatin, and nu

88 In developing organs, vacuolization contributes to cell size heterogeneity and

89 proximal tubules showed geographic isometric vacuolization, corresponding to a focus of tubules with

90 vere proximal tubule injury characterized by vacuolization, decreased uncoupling of protein-2 express

91 ressive loss of electroretinograph response, vacuolization, degeneration of the RPE, thickening of Br

92 eterioration and resolved intracardiomyocyte vacuolization, demonstrating that early T(2) prolongatio

93 tic edge IOLs included iris changes, such as vacuolization, disruption and loss of the pigmented epit

94 illumination defects, iris changes including vacuolization/disruption/loss of the pigmented layer, ir

95 ypical features of PCD including cytoplasmic vacuolization, DNA condensation, and apoptotic body form

96 lacking c-Jun displayed massive cytoplasmic vacuolization due to ER distension.

97 nasal mucosa out to 23 days with associated vacuolization, edema and immune cell infiltration.

98 ulted in significantly attenuated pancreatic vacuolization, edema, necrosis, inflammation, and enzyme

99 Podoptosis was associated with cytoplasmic vacuolization, endoplasmic reticulum stress, and dysregu

100 he nervous system, with widespread lysosomal vacuolization evident in most cell types.

101 dual ion transport model involving seawater vacuolization, followed by the active release of Ca(2+)

102 L-e-sphingosine, caused massive perinuclear vacuolization, Golgi fragmentation, and cell rounding.

103 showing both rejection and isometric tubular vacuolization has not been well defined in the literatur

104 the heart; importantly, this occurs without vacuolization, hypertrophy or fibrosis.

105 xamination showed chromatin condensation and vacuolization in a fraction of cells infected with d120

106 ddition, the C-terminal region alone induces vacuolization in a manner similar to full-length toxin.

107 ophages (which are characterized by abundant vacuolization in Arsg KO mice) and oligodendrocytes.

108 nsation of nuclear chromatin and perinuclear vacuolization in focal areas.

109 protein aggregates and for reducing cellular vacuolization in HCT116 colon cancer cells and DU145 pro

110 This resulted in diminished/absent lysosomal vacuolization in multiple cell types and reversal of sia

111 he surrounding myocardium showed cytoplasmic vacuolization in myocytes and in another patchy intersti

112 We observed similar vacuolization in outer segments of transgenic mice expre

113 cularly in neurons, elevated plasma gastrin, vacuolization in parietal cells, and retinal degeneratio

114 frequency and severity of isometric tubular vacuolization in renal allograft biopsy specimens obtain

115 Focal vacuolization in some of the seminiferous tubules was ob

116 st evidence of myocardial injury was myocyte vacuolization in the absence of microvascular thrombosis

117 used loss of motility, cell enlargement, and vacuolization in the algal cells.

118 ed fractionated zones of laser-induced micro-vacuolization in the epidermis and dermis.

119 e in Sp4 hypomorphic mice resulted in subtle vacuolization in the hippocampus as well as deficits in

120 erfusion, the core ischemic region exhibited vacuolization in the neuropil by 36 h after ischemia, an

121 oxygenation exposure for 8 weeks resulted in vacuolization in the perikarya and dendrites and markedl

122 hology in HeLa cells by inducing cytoplasmic vacuolization in the presence of ammonium chloride.

123 The pathogenesis of the vacuolization in this clinical setting is not clear, but

124 bit behavioral abnormalities and progressive vacuolization in various brain regions.

125 ation in the peripheral nervous system, with vacuolization indicative of endosome/lysosome traffickin

126 res including pancreatic oedema, acinar cell vacuolization, intrapancreatic trypsin activity, cell de

127 Isometric tubular vacuolization is a common finding in renal transplant bi

128 rown adipose tissue of Ppt1-KO mice had less vacuolization (lipid droplets) compared to wild-type ani

129 by 42%, and there was extensive Sertoli cell vacuolization, loss of germ cells, reduced sperm counts,

130 d no change in the size or extent of tubular vacuolization (mean score 2.88+/-0.19 vs. 2.83+/-0.21).

131 mmed cell death characterized by cytoplasmic vacuolization, mitochondrial swelling, and endoplasmic r

132 neuromuscular denervation and mitochondrial vacuolization, MNs were completely rescued from mutant S

133 mammalian cells-did not prevent swelling and vacuolization, nor did it counteract the toxic effects o

134 Tubular isometric vacuolization observed with light microscopy, which corr

135 t mitochondrial vacuolation, we suggest that vacuolization occurs independently of axonal damage.

136 characterized by neutrophilic infiltration, vacuolization of acinar cells, and foci of necrosis.

137 dema, pancreatic trypsinogen activation, and vacuolization of acinar cells.

138 seizures cause an immediate, but transient, vacuolization of astrocytes, followed over several days

139 Cellular destruction and vacuolization of basal epithelial cells associated with

140 inguish these entities including cytoplasmic vacuolization of both erythroid and myeloid precursors,

141 rate rescued lipid accumulation and apparent vacuolization of brown adipose tissue in the HD mice.

142 Despite significant vacuolization of endosomal compartments similar to SPPL2

143 Vacuolization of fibroblasts was rescued by transfection

144 livers 24 hr after transplantation, moderate vacuolization of hepatocytes by histology with the immun

145 and, less frequently, interstitial edema and vacuolization of interstitial cells.

146 idge, a loss of OHCs from cochlear apex, and vacuolization of OHCs.

147 y specimens of these allografts is isometric vacuolization of proximal tubular epithelium.

148 trix, rounding, a mottled cell membrane, and vacuolization of the cytoplasm, all of which are indicat

149 used an increase in cell size, and triggered vacuolization of the cytoplasm.

150 croscopy of the retinas revealed progressive vacuolization of the photoreceptor outer segments.

151 o a thinning of the nonpigmented epithelium, vacuolization of the pigmented epithelium, loss of capil

152 Vacuolization of the T9-C2 cell's mitochondria and endop

153 d spastic paralysis of adult worms and rapid vacuolization of the worm surface.

154 gnal on acid hydrolases, exhibited extensive vacuolization of their exocrine gland cells, while the l

155 Nonspecific changes (vacuolization of tubular cells, loss of brush border, an

156 re degeneration of the BLB, there was severe vacuolization or frank apparent necrosis of VECs and los

157 appears to play some role in the process of vacuolization or vacuole fusion leading to intercellular

158 res accompanying loss of cell viability were vacuolization, other changes in cell morphology, and inc

159 contractile vacuoles and intense cytoplasmic vacuolization, possibly resulting in osmotic stress; no

160 hibit numerous defects including aneuploidy, vacuolization, protruding spikes, and precocious fusion

161 there was a significant association between vacuolization score and blood tacrolimus level on the da

162 Myocyte vacuolization seems to be an early feature of delayed xe

163 ei associated with gliosis and intramyelinic vacuolization similar to that observed in cytotoxic edem

164 glomerular cell count with focal cytoplasmic vacuolization, suggesting increased degranulation, was a

165 Mitochondrial vacuolization, swelling, and dissolution of cristae occu

166 membrane permeability, blebbing, cytoplasmic vacuolization, swollen mitochondria, low adenosine triph

167 tudies indicated that 13 induces cytoplasmic vacuolization that is lysosomal in nature.

168 gy is characterized by extensive cytoplasmic vacuolization that is rarely observed in degenerating co

169 vesicles, and induces extensive cytoplasmic vacuolization that is reminiscent of autophagy.

170 cumulation and massive endoplasmic reticulum vacuolization that precede a nonapoptotic (paraptotic) c

171 ological changes including tubular swelling, vacuolization, thrombotic microangiopathy, and increased

172 tarting at approximately 20 weeks of age and vacuolization throughout the renal cortex in older mice.

173 gions of coagulative necrosis and hepatocyte vacuolization unapparent in mice carrying either infecti

174 with concurrent acute rejection and tubular vacuolization usually benefit from increased immunosuppr

175 Vacuolization was also seen in the brain.

176 Isometric vacuolization was graded on a 0 to 4 scale based on the

177 c cardiomyocytes, but almost no sarcoplasmic vacuolization was observed, and the mitochondrial struct

178 riking necrotic features such as cytoplasmic vacuolization, watery cytoplasm, and dissolution of orga

179 o identify novel genetic causes of lysosomal vacuolization, we developed an assay for enlargement of

180 the presence of great number of cytoplasmic vacuolization were healed by SP2.

181 necrosis and hepatic glycogen depletion with vacuolization were more severe after infection with the

182 miniferous tubules, germ cell depletion, and vacuolization), whereas testicular structure was remarka

183 c; swelling, dendritic retraction, blebbing, vacuolization, which are all characteristics of necrosis

184 From 3 months, widespread white matter vacuolization with intramyelinic edema developed.

185 e exhibited loss of the basal infoldings and vacuolization, with accumulation of amorphous deposits b

186 d with intracardiomyocyte edema secondary to vacuolization without extracellular space expansion.