ライフサイエンスコーパス: valency

1 er, and strength of N-protein binding sites (valency).

2 ty, and receptor clustering, which modulates valency.

3 gree of Cu-O hybridization and, thus, the Cu valency.

4 or a particular set of rate coefficients and valency.

5 at they are examples of proton-coupled mixed valency.

6 of the putative sugar ligand with identical valency.

7 bs involved in these two different states of valency.

8 election through the manipulation of display valency.

9 eved with excellent control over the desired valency.

10 cy being better detected than those of lower valency.

11 observed at a frequency dependent on display valency.

12 ter size with high surface area and thiolate valency.

13 termediates are resolved is sensitive to ion valency.

14 pe on engagement of surface integrins at low valency.

15 mannooligosaccharides and thereby the total valency.

16 rpolarizing shift and decreased the apparent valency.

17 reated with MHC-peptide oligomers of varying valency.

18 rs including temperature, concentration, and valency.

19 cell death-inducing potency that scaled with valency.

20 Dimer was the minimum functional valency.

21 e antigens and thereby spatially control IgG valency.

22 accination programmes and increasing vaccine valency.

23 clustering and higher-order antigen-binding valency.

24 e show here that Fe doping influences the Ni valency.

25 nvolving specific biointeractions at tunable valency.

26 of the nanoassemblies is related to the dye valency.

27 through changes in scaffold concentration or valency.

28 noids" for silicon clusters with unsaturated valencies.

29 at high concentrations and large interaction valencies.

30 accommodate cations with different sizes and valencies.

31 The sum of the effective valencies, 1.14 +/- 0.12, demonstrates that the electrog

32 We report a strategy for making COFs with valency 8 (cubes) and "infinity" (rods).

33 ted, dual-ligand liposomes with equal ligand valencies achieved enhanced binding and selectivity for

34 How antigen valency affects B cells in vivo during immune responses

35 ibrary of rigid architectures to explore how valency, affinity, and nano-spacing control the presence

36 that the Y sequence preferences are tuned by valency, allowing multivalent PAs to sample greater sequ

37 ynamics of the clusters are modulated by the valencies and affinities of the interacting species.

38 An examination of the valencies and charges of the hydrogen-bonding groups sug

39 13 modularly assembled ligands with defined valencies and distances between ligand modules was synth

40 ally designed protein complexes with precise valencies and geometries to generate soluble cytokine-li

41 s, when designed to have well-defined ligand valencies and spacings, can effectively inhibit IAV infe

42 owed quantification of the effects of ligand valency and affinity.

43 A linear relationship between valency and average core size for the corresponding vale

44 e were evaluated to understand the effect of valency and avidity on delivery.

45 We investigate the nature of valency and bonding in the highly unusual O(2)PR(3) "pho

46 cess into secondary lymphoid organs, antigen valency and cellular environment of antigen acquisition

47 that nucleosome turnover models predict both valency and chromosomal propagation of methylation marks

48 cross length scales as a function of protein valency and compactness.

49 a-electrolyte interface as a function of ion valency and concentration using subnanometer oscillation

50 functional ligand presentations in terms of valency and density, most of the reported multivalent ca

51 osis: NC binding-uptake depended directly on valency and exocytosis-detachment was inversely related

52 ry receptor CD27 by increasing both antibody valency and FcgammaRIIB engagement.

53 were constructed to facilitate both display valency and formats, based on various phage coat protein

54 skeleton, whereas ICAM-1 clustering enhances valency and further promotes ligand-dependent LFA-1 acti

55 peptide-DNA crosslinkers varying in length, valency and geometry.

56 ent stabilized versions of HIV-1 Env at high valency and in the context of varied conformational stab

57 ificantly affecting diffusion, including the valency and ionic radius, are discussed.

58 role of the H4 tail varied depending on the valency and ionic strength, suggesting that electrostati

59 By tuning the valency and linker length, we designed polyvalent inhibi

60 ted bell-shape relationship was found for NC valency and lysosomal trafficking rates.

61 lls become activated by ligands with varying valency and mode of presentation to the B-cell receptor

62 quantitative information about the residual valency and orientation of surface-bound molecules is mi

63 proach, we are able to precisely control the valency and position of ligands on a polymer scaffold in

64 ate in a directional manner, with controlled valency and recognition motifs.

65 ivalent approach to determine optimal ligand valency and spacing that can be subsequently optimized f

66 mimetics with systematically varied mannose valency and spacing.

67 e DNA scaffold allows for exact control over valency and spatial ligand distribution, and the discoti

68 ctionalization allow a strict control of the valency and spatial orientation of the recognition motif

69 ent surface densities to evaluate how glycan valency and spatial separation affect the preferential b

70 4,5-trisphosphate receptor suggests that the valency and specificity of ankyrin binding is achieved b

71 relationship was found between NC targeting valency and the rate of transcytosis, where high and low

72 Both the change in valency and the release rate of the molecules are strong

73 The ability to control independently the valency and the spacing between ligands would be valuabl

74 fashion to satisfy the complexation [2 + 2] valency and thereby give stable two-dimensional supramol

75 e familiar chemical concepts of "bonds" and "valency" and review two distinct but related strategies

76 sfully while evaluating FN3 affinities, CSAN valencies, and antigen expression levels.

77 nalyses provided the associated bond orders, valencies, and natural population analysis charges.

78 its molecular characteristics such as size, valency, and affinity.

79 ther impacted by factors such as Ab epitope, valency, and affinity.

80 formation and links configurational entropy, valency, and compactness of proteins inside the condensa

81 at were varied include scaffold shape, size, valency, and density of binding elements.

82 s a function of ligand interaction strength, valency, and density.

83 cells enhanced ligand binding affinity, not valency, and did not alter cell-surface clustering as de

84 4E10 combining sites that differed in size, valency, and flexibility.

85 ltimeric complexes with defined composition, valency, and geometry.

86 the influence of polymeric backbone length, valency, and hapten presentation on binding to anti-DNP

87 polydispersity, zeta-potential and antibody valency, and its lung accumulation increased with the nu

88 of the dissociation rate coefficient, strand valency, and seed species.

89 is strongly dependent on ion concentration, valency, and size.

90 nked to allergen affinity, oligomeric state, valency, and spacing of IgE-binding epitopes on the alle

91 res the power law dependence on the strand's valency, and the inverse relationship to the rung-openin

92 ng the number of defects, that is, the shell valency, and their positions, is a key success factor fo

93 gnition elements to introduce the concept of valency, and through anisotropic interactions resulting

94 thetic signaling ligands that exhibit potent valency- and geometry-dependent Ca(2+) release and mitog

95 s into the role of water in stabilizing high-valency anions and how these ions can pattern the struct

96 Low-valency antigens induced smaller effector B cell respons

97 he natural water oxidation system; the mixed valencies (AOS = 3.7); and the lowest charge transfer re

98 lipid bilayers (SSLB) to study the effect of valency, aptamer affinity, and epidermal growth factor r

99 Multimeric antigen display and high overall valency are increasingly regarded as strategic goals for

100 The mixed valency arises in SmB(6) from thermal population of thes

101 with high affinity but likely with different valencies based on their binding orientation.

102 We differentiated between affinity- and valency-based modes of activation by TM domain mutations

103 sensitivity than NPs with targets of higher valency being better detected than those of lower valenc

104 primary determinant of TLR9 signaling is not valency but endosomal location and demonstrates a strict

105 We revisited the issue of TCR valency by examining complexes isolated from primary alp

106 finity conformation of LFA-1, for increasing valency by recruiting LFA-1 to the immunological synapse

107 s) can be replicated in the absence of mixed-valency by the introduction of electronic asymmetry.

108 We demonstrate how the residual valency can be adjusted to one or two biotin binding sit

109 Valency can be critical for function, such as determinin

110 Valency can be defined as the number of discrete interac

111 emonstrates that binding affinity and ligand valency can be optimized to afford discrimination betwee

112 Currently, nanoparticles with a defined DNA valency can only be obtained in a narrow range of sizes,

113 Our findings indicate that glycan valency can set thresholds for cross-linking by lectins.

114 Clusters with satisfied valencies cannot coalesce readily, resulting in metastab

115 nd other mean-field theories fail for higher valency cations where ion-ion correlation effects may be

116 roach as a novel tool to elucidate the probe valency, clearly distinguishing between monovalent and m

117 phase-separated liquids that concentrate low valency client proteins.

118 Whereas low-valency clients that compete for scaffold-scaffold bindi

119 ions of gold surface of the QCM owing to ion valency/concentration changes using state of the art ESE

120 how structural parameters such as the size, valency, conformation, self-assembling behaviour of the

121 may reduce racial disparities in IPD, higher valency conjugate vaccines and strategies to directly ad

122 The valency (connectivity) of building units in covalent org

123 18% with a transition from single to double valency, consistent with a doubling of the molecular bri

124 The pseudopolyrotaxane exhibited a valency-corrected 10-fold enhancement over native lactos

125 copolymers displayed 10-20-fold increases in valency-corrected affinities compared to the correspondi

126 e the effects of target concentration, phage valency, degree of background binding and other laborato

127 rying effective site pair affinities and RNA valency demonstrate that interactions between multivalen

128 Thus, the valency dependence of the response of CD8 T cells to sol

129 n live cells decreased GFP fluorescence in a valency-dependent manner, indicating that the RNA aptame

130 ein interaction network: ligand and receptor valencies determine the number of interacting species in

131 We find that mannose spacing and valency dictate whether glycopeptides engage GRFT in a f

132 Different valencies did not significantly affect antitumor efficac

133 small molecule-DNA hybrids with controllable valency, different sequences, and directionalities (5'-3

134 ortrait painted by these results is that ion valency differentially affects steps in the folding proc

135 s the effect of varying the surface density, valency, dimensions, and affinity of the ligand to be in

136 channel that can conduct cations of multiple valencies down the electrochemical gradient.

137 mum in gene delivery as a function of ligand valency, due to saturation of receptor binding and inter

138 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in v

139 The increased valency enhances the apparent affinity of 2G12 for Man(4

140 e consider up to four DNA loci and different valencies for diffusing molecular factors.

141 or as superagonists when presented at higher valency for OX40 and 4-1BB.

142 This explains the opposite behavior of NC valency for transcytosis vs. lysosomal transport.

143 d for LLPS or that have higher-than-scaffold valencies form additional scaffold-client-scaffold bridg

144 Cr(VI) is the most toxic valency form of Cr, but its toxicity targets and the cel

145 work is consistent with a two-electron mixed valency formulation for the [L(Delta)Zn] species.

146 ient transcytosis rates than an intermediate valency formulation.

147 the alpha-GalNAc epitope and cross-link low valency glycoconjugates, only SBA showed a tendency to f

148 pectra and electrochemical data support a Co valency greater than 3 for both Co-Pi samples when catal

149 and is exhibited broadly by homo-multimeric (valency >= 2) proteins across several cell types.

150 Thus, antigen valency has multifaceted effects on B cell responses and

151 Models of different stoichiometry and valency have been proposed based on cellular experiments

152 ging from 1:10 to 1:1 to hemoglobin, are the valency hybrid intermediates alpha3+beta2+ and alpha2+be

153 tained with a hemoxometer indicated that the valency hybrids were measured as MetHb and the values of

154 itrosothiols, methaemoglobin and its related valency hybrids.

155 ic affinity for ligand, but not the receptor valency, i.e., clustering.

156 Surprisingly, anti-NP antibodies of lower valency, IgA (n = 4) and IgG (n = 2), were also found to

157 Z0) was highest in Kir2.2 channels while the valencies in Kir2.1 and Kir2.3 channels were not signifi

158 observation of Robin-Day Class II/III mixed valency in a MOF.

159 We explored the role of antigen valency in B cell receptor (BCR) activation and rearrang

160 To determine the role of ligand valency in M6P/IGF-II receptor-mediated endocytosis, we

161 , we highlight the importance of the role of valency in regulating immune responses, with a focus on

162 rameters in the biradical complexes to mixed valency in the corresponding quinone-semiquinone radical

163 s were observed for compounds with identical valencies, indicating that the spatial distribution of t

164 Thus, Ag valency influences B cell responses by modulating the st

165 Although carrier targeting valency influences this process, the mechanism is unknow

166 mply explained by the interception of a high-valency iron-oxo species.

167 A prototypical complex with formally high valency is [Cu(CF(3) )(4) ](-) (1), which has a formal C

168 , but still find that the resulting moderate valency is insufficient to support phase separation with

169 found that expanding infant-administered PCV valency is likely to result in diminishing returns, and

170 We discuss some of the ways in which valency itself is regulated through transcriptional, pos

171 onstrate that an increase of the interaction valency leads to a precipitous decline in the dissociati

172 iffuse double layer as an ion with effective valency < 6.

173 nition domain specificity, presentation, and valency make distinct contributions to the specific effe

174 This work shows that high-valency metal-oxo species can be used to create reductio

175 functional theory suggested that non-3d high-valency metals such as tungsten can modulate 3d metal ox

176 s tetramer behaved as an ideal model for the valency mode of regulation, because it exhibited signifi

177 Finally, we propose that the valency model can be applied at the whole cell level to

178 Cu(2+)/Cu(+) mixed valency modulates the energy level and carrier density o

179 and was selected here for engineering higher-valency molecules because of its compact size, simple st

180 se-designed SAv constructs having controlled valencies (mono-, di-, trivalent in terms of biotin-bind

181 In mice and nonhuman primates, the full-valency nanoparticle immunogen displaying 20 DS-Cav1 tri

182 ar and in vivo data showed that intermediate valency NCs resulted in higher delivery of a therapeutic

183 rom the basolateral side in the case of high valency NCs which are slower at detaching from the recep

184 Since Abeta aggregates possess the multiple valencies of an FAED motif (20th to 23rd amino acid resi

185 rogenase has been proposed to have metal-ion valencies of either Mo(4+)6Fe(2+)Fe(3+) (derived from me

186 tent with decreasing affinity and functional valencies of the multivalent analogues upon sequential b

187 IgE and challenged with Pen a 1 (IgE epitope valency of >/=8), although measurable responses were ach

188 Importantly, differences in the functional valency of a triantennary analog for concanavalin A and

189 tage (g(V)) curve and increased the apparent valency of activation.

190 analysis, thus, are unable to determine the valency of an individual nanoparticle.

191 olyelectrolytes such as Caprin1 and the high valency of ATP-magnesium is a significant factor for its

192 number of points of attachment (that is, the valency of attachment).

193 target affinity, cellular localization, and valency of bioPROTACs impact efficacy of targeted degrad

194 t TAM depletion constructs by increasing the valency of both the M2pep targeting and KLA drug domains

195 on, both in vitro and in vivo, driven by the valency of constituent proteins.

196 In all these NCs the valency of Cu in the lattice stays always close to +1, w

197 design to specify the size, flexibility, and valency of de novo protein building blocks, as well as t

198 el was built to explore how the affinity and valency of dual-ligand liposomes affect the binding and

199 he multidomain interacting partners, and the valency of each partner.

200 By altering length and valency of epitope-bearing synthetic peptides, we examin

201 al-induced proximity (CIP), we find that the valency of H3K79 methylation (mono-, di-, and tri-) is d

202 h dissipation monitoring, while the residual valency of immobilized SAv is quantified using spectrosc

203 quid condensate hardening via changes in the valency of its components is more efficient than alterin

204 physical studies to determine the oligomeric valency of membrane-associated env.

205 ions; and product topology determined by the valency of monomeric units.

206 concentration would be expected to alter the valency of NuMA toward MTs; the "density" of NuMA-MT cro

207 lergen-specific IgE, as well as the dose and valency of Pen a 1.

208 tics demonstrate that augmenting the binding valency of proximity-induced modalities can be an enabli

209 to four bioO variants designed to reduce the valency of repressor binding from 2 to 1 have been perfo

210 ays always close to +1, while the average -1 valency of S in covellite gradually evolves to -2 with i

211 expected trends due to net charge on Fe and valency of S, and both exhibit a splayed configuration w

212 fluence the average orientation and residual valency of SAv on a biotinylated surface.

213 ils were employed to mimic the physiological valency of selectins and selectin ligands.

214 The effective valency of spermine block (Z0) was highest in Kir2.2 cha

215 mmunofluorescent approaches to determine the valency of TCRgammadelta heterodimers and CD3gammaepsilo

216 ost can be qualitatively correlated with the valency of the adsorbate, and this is the key to underst

217 Rather, it appears that the valency of the antibody is the critical factor determini

218 d reversibly about tenfold by decreasing the valency of the bathing external cation (La3+ < Ca2+ < Na

219 orresponding F(AB) fragments showed that the valency of the binding protein had no influence on the v

220 Epitope valency of the e-antigen was also studied, using a sandw

221 We show here that the valency of the entering Sn ions dictates the structure a

222 l alterations influence the receptor-binding valency of the FimH adhesin via distal effects on the co

223 phase transition are directly related to the valency of the interacting species.

224 mostly independent of the ionic strength and valency of the ions.

225 ype A erythrocytes increases with increasing valency of the isolectin.

226 resent study indicates that the location and valency of the M6P moieties and the right oligosaccharid

227 ns from rehybridization of the oxygen, mixed valency of the metals, magnetic exchange between the met

228 ulting structure-activity relationships, the valency of the polyanion seems to be an important chemic

229 erent maxima and midpoints, depending on the valency of the soluble oligomer used.

230 olume transition, whose sign depended on the valency of the solvent.

231 The valency of the system (i.e., the number of molecules bou

232 physical techniques to assess the oligomeric valency of virion-associated Env prior to fusion activat

233 portional to the number of binding epitopes (valency) of each carbohydrate.

234 r to fully characterize the effect of GalNAc valency, oligonucleotide length, flexibility and chemica

235 lymphocytes and increasing targeting peptide valency on particle surfaces results in an increase in n

236 igand cross-linker spacer length, and ligand valency on polyplex cell surface binding, internalizatio

237 luate the impact of fatty acid structure and valency on siRNA clearance, distribution, and efficacy.

238 opportunity to examine the effect of lectin valency on the association constants of these GS-I isole

239 In this study, we analyzed the effects of Ag valency on the signaling and Ag-targeting functions of t

240 These bsAbs varied in valency or in the presence or absence of an Fc domain.

241 different sialic acid compounds of different valency or number of sialic acid moieties per molecule t

242 Higher valency PCVs among adults could address an important pro

243 come countries, introduce PCVs and as higher valency PCVs are used.

244 As higher-valency PCVs may trigger a weaker immune response, it is

245 We measured the effects of introducing high-valency PCVs on the incidence of invasive pneumococcal d

246 Higher valency PCVs would have the added benefit of preventing

247 or the effects after introduction of higher valency PCVs.

248 Data suggested a model where NC valency plays an opposing role in the two sub-processes

249 at establish more connections (via increased valencies, promiscuous binding, and topologies that enab

250 omagnetic coupling promoted by organic mixed-valency provides keen insight into the ability of single

251 Single-particle tracking with defined-valency quantum dots confirmed that HA has significant m

252 Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role

253 presentation, setting the limits of the low-valency regime.

254 gy, thus propelling COF chemistry into a new valency regime.

255 rate of transcytosis, where high and low NC valencies rendered less efficient transcytosis rates tha

256 resented to other T cells, clouding the true valency requirement for activation.

257 Valency requirements for B cell activation upon antigen

258 ring of the identified molecules to increase valency resulted in enhanced neutralizing activity.

259 Tuning the QD surface mannose valency reveals that DC-SIGN binds more efficiently to d

260 Deviations from the commonly assumed atom valency rule of small adsorbates are also manifested.

261 Furthermore, studies with ligands of varying valency show that kindlins primarily increase cellular a

262 Fatty acid valency significantly altered the physicochemical proper

263 ity of antibody agonists by optimizing their valency, specificity for different receptors (e.g., bisp

264 ss with rich information on Li distribution, valency, spin states, and crystal field.

265 ctroscopically that NO reacts with all three valency states of cobalamin and that NO's inhibition of

266 -selective binding to be observed within low-valency systems, and the transition point for stable int

267 t chemical feature such that anions with low valency tend to be weaker aggregation inducers, even at

268 om temperature and for ca. 1:1 mol:mol mixed valencies, the bimolecular ET rate constants (assuming a

269 is not absolute, and factors that include Ag valency, the availability of T help, and polyclonal B ce

270 Beyond valency, the physical features of folded domains that pr

271 nges in integrin ligand-binding affinity and valency through inside-out signaling.

272 , and overall it is unlikely that Mo changes valency throughout the catalytic cycle; and (ii) two dis

273 a1-integrin-Arg-Gly-Asp-peptide affinity and valency, thus implicating Ld domains in modulation of in

274 Using bispecific antibodies of different valencies to cell surface antigens including MET and EGF

275 f a semiclassical three-state model of mixed valency to complexes of the type [Ru(3)(mu(3)-O)(OAc)(6)

276 Increasing M2pep valency to four, however, resulted in a reduction in bot

277 which is perfectly matched in both size and valency to the target toxin, provides a convenient route

278 perties, from structurally homogeneous mixed valency, to superconductivity, spectral anomalies, and u

279 how that larger DNP(16)-dendrimers of higher valency trigger degranulation by cross-linking IgE-recep

280 lustering and the stop signal, whereas LFA-1 valency up-regulation occurs normally.

281 en evaluating the potential impact of higher valency vaccines on overall disease burden and associate

282 stimated for the serotypes covered by higher valency vaccines.

283 assessing the potential benefit of different valency vaccines.

284 ing surveillance and development of expanded valency vaccines.

285 fibers, we determined that increased antigen valency was associated with increased antibody magnitude

286 Thus electrostatic selection by valency was computed self-consistently, and selection by

287 The apparent valency was decreased for all mutations.

288 The extent of valency was determined directly by measuring the visible

289 o sufficient quantity of input antigens, and valency was not a major factor for potency or breadth of

290 and average core size for the corresponding valency was observed.

291 To obtain targets of different size and valency, we attached the Tag peptide to BSA (M(w)= 65000

292 reate synthetic Gal3 constructs with defined valency, we demonstrate that oligomerization can physica

293 onductivity is determined to be ligand mixed-valency, which is characterized using a suite of spectro

294 P3 secondary structure is independent of ion valency while the rate at which the respective intermedi

295 eats shows incremental gains with increasing valency, while the background binding to genomic DNA is

296 en proteins, and the exhaustion of available valencies within smaller clusters.

297 The method allows for high valency within many different kinds of interacting molec

298 T, magnetic phase transitions, and no mixed valency), YbB(6) (mixed valent topological insulator), a

299 e values of V(c) and E(m) to the mean charge valency (z(x)) of intracellular membrane-impermeant anio

300 ant solute content (X-i) and its mean charge valency (zX), while in contrast, the set point of Em was