ライフサイエンスコーパス: variable region

1 -specific responses (targeting V1, V2, or V3 variable regions).

2 nce changes accumulated throughout the MG192 variable region.

3 ngineering new functions into the antibody's variable region.

4 c antibodies with specificity for the unique variable region.

5 the length and amino acid composition of the variable region.

6 ous phosphorylation sites within the PACSIN2-variable region.

7 cells expresses a unique set of IgH and IgL variable regions.

8 m molecular dynamics simulations of antibody variable regions.

9 ogically active forms of cagA with longer 3' variable regions.

10 luenza infection but generally target highly variable regions.

11 permutation, both in their CDR and framework-variable regions.

12 and also immunodominant epitopes located in variable regions.

13 f sequence coverage of both the constant and variable regions.

14 tated by a relatively few amino acids within variable regions.

15 despite ongoing somatic hypermutation of Ig variable regions.

16 n the AAV2 capsid are mainly in AAV-featured variable regions.

17 ymphoma immunoglobulin heavy- or light-chain variable regions.

18 ghout the protein and not just in the highly variable regions.

19 into the Env trimer fold as well as more the variable regions.

20 of conserved regions interweaved with highly variable regions.

21 he composition of residues within the capsid variable region 1 (VR1) of AAV1 and AAVrh.10 profoundly

22 plasma IgG against the HIV-1 envelope (Env) variable region 1 and 2 inversely correlated with risk,

23 oduces reads spanning 16S ribosomal RNA gene variable regions 1 and 2 ( approximately 360 bp) with a

24 d directly with antibodies to HIV-1 envelope variable regions 1 and 2 (V1-V2).

25 ction risk: the binding of IgG antibodies to variable regions 1 and 2 (V1V2) of HIV-1 envelope protei

26 s capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, b

27 tralization by monoclonal antibodies against variable regions 1 and 2 (V1V2), suggesting that SIV and

28 449 interfered with the ability of the gp120 variable regions 1 and 2 (V1V2)-targeted broadly neutral

29 the T cell antigen receptor (TCR) beta-chain variable region 11 (TRBV11-2) were 'preferentially' acti

30 17, as well as with mucosal IgG to the gp120 variable region 2 (V2) and the expression of 12 genes, t

31 immune pressure in the HIV-1 envelope (Env) variable region 2 (V2) focused on residue 169, which is

32 -chain variable region 9 and the delta-chain variable region 2 (Vgamma9Vdelta2 T cells) are the predo

33 Arabidopsis CESA7 reveals four cysteines in variable region 2 (VR2) and two cysteines at the carboxy

34 onstrate that vaccine-induced HIV-1 envelope variable region 2 and constant region 1 antibodies syner

35 om the sequence of the vaccine insert in Env variable region 2 positions 169 and 181, which were impl

36 d protection identified HIV-1 envelope (Env) variable region 2-binding antibodies as inversely correl

37 evidence, the antiviral mechanisms by which variable region 2-specific antibodies may have contribut

38 receptor (TCR) incorporating TCRdelta-chain variable-region-2 [Vdelta2((+))], which are activated by

39 and found that immunoglobulin G heavy-chain variable region 3-53 (IGHV3-53) is the most frequently u

40 the microbial flora were analyzed using 16S variable region 4 rRNA gene DNA sequencing and Quantitat

41 lative microscopy, we found that gamma-chain variable region 5 (V(gamma)5) TCRs expressed by epiderma

42 ragine-linked glycosylation sites (PNGSs) in variable region 5 (V5) than did paired ibalizumab-suscep

43 oop D and two glycosylation sites located in variable region 5 of Env allows Env-binding to, and acti

44 reared Amblyomma americanum using PCR of the variable region 5 of the 16S rRNA gene followed by semic

45 aracterized by high-throughput sequencing of variable regions 7-9 of prokaryotic 16S ribosomal DNA.

46 xpressing the TCR containing the gamma-chain variable region 9 and the delta-chain variable region 2

47 strated that amino acid substitutions within variable region A altered the specificity of the Env-rec

48 ptor binding domain (RBD) extends beyond the variable regions A and B (VRA and VRB, respectively), to

49 ric between GALV and KoRV-B established that variable regions A and B of the surface unit of the enve

50 results suggest that outside of structurally variable regions, admixture does not substantially disru

51 g these loci, and highlight that copy number variable regions allow for the creation of novel genes t

52 st a homology model of the antibody fragment variable region and a protein-protein docking model of t

53 In contrast, Met oxidation in the variable region and CH3 domain had no detectable impact

54 reaction amplification of the 16S rRNA V4-V5 variable region and deep sequencing using the Illumina M

55 ulated by PACSIN1 phosphorylation within the variable region and is required for AMPAR endocytosis.

56 itopes on spikes, including the proximity of variable regions and a high density of glycans.

57 he need for primers conventionally targeting variable regions and allow single cell level Ig and TCR

58 rimer pairs in conserved regions that border variable regions and could differentiate between serotyp

59 e produced with mouse-derived immunoglobulin variable regions and huIgG(1) or huIgG(4) C regions and

60 comparing monoclonal IgA1 that had different variable regions and mesangial deposition patterns indic

61 Eight highly variable regions and potential sources of molecular mark

62 Env also contains variable regions and protein surfaces occluded within th

63 binding epitopes on the therapeutic antibody variable region, and featured inhibitory and neutralizin

64 ptide sequences are attributable to antibody variable regions, and are potentially indicative of dise

65 tein that undergoes antigenic variation at 7 variable regions, and variants are selected by immune pr

66 nal status of the immunoglobulin heavy-chain variable region are important in clinical management of

67 ncoded elements in the T cell receptor (TCR) variable regions are evolutionarily conserved to only re

68 fidence peptide spectral matches of antibody variable regions are obtained by searching a reference d

69 The atp1 gene is flanked by very variable regions, as deduced from four completely sequen

70 Furthermore, our data show that some variable regions associated with either chain can remain

71 ir major viral protein 3 contains loops with variable regions at their apexes conferring capsid surfa

72 8 weeks of infection, sequences within mgpB variable region B were replaced by novel sequences gener

73 ressing an SEA-nonresponsive T-cell receptor variable region beta chain are nonresponsive to SEA in m

74 ress this, sequencing of the T-cell receptor variable-region beta-chain was performed on peripheral b

75 n within the well-known activation T-loop, a variable region between protein kinase catalytic subdoma

76 variants have been identified, 3 in the EYA4 variable region (c.160G > T; p.Glu54*, c.781del; p.Thr26

77 , antibodies that were bioengineered to have variable regions capable of binding to neurons or oligod

78 w often gene segments are chosen to complete variable region coding exons remain elusive.

79 s using targeted amplification of rearranged variable regions comprised of V(D)J gene segments miss a

80 The MG192 variable region consisted of 11 discrete subvariable reg

81 Identical variable regions consistently neutralized virus more pot

82 Protochordate variable region-containing chitin-binding proteins (VCBP

83 Each variable region contains three antigen-contacting comple

84 cificity, challenging the paradigm that only variable regions contribute to antigen binding.

85 selection and/or mutability of the antibody variable region contributed significantly to observed de

86 N-linked glycosylation and sequence-variable regions cover the pre-fusion closed spike; we u

87 rminus of Bacillus subtilis FtsZ (C-terminal variable region (CTV)) are both necessary and sufficient

88 omologous inoculation of the PF2-containing, variable region-deleted YU2 gp120 trimers (DeltaV123/PF2

89 the E2 receptor-binding domain lacking three variable regions, Delta123-HMW, elicits broad neutralizi

90 Analysis of previously reported genomic variable regions demonstrated that these regions were li

91 ce exposure of amino-acid side-chains in the variable region directly from the antibody sequence.

92 activate the mutational machinery at Ig gene variable regions during SHM.

93 N-glycosylation sites in the immunoglobulin variable regions during somatic hypermutation.

94 e nucleotide substitutions in immunoglobulin variable regions during somatic hypermutation.

95 ly, we describe three distinct, structurally-variable regions emanating from the core scaffold often

96 mposition undergo stepwise rearrangements of variable region-encoding gene segments.

97 or genes for the heavy chain and light chain variable region-encoding genes were determined by using

98 T cell antigen receptor delta (Tcrd) variable region exons are assembled by RAG-initiated V(D

99 Ig heavy-chain variable region exons are assembled developmentally from

100 Ig heavy chain (IgH) variable region exons are assembled from V, D, and J gen

101 noglobulin heavy (IgH) and light (IgL) chain variable region exons from germline gene segments to gen

102 V, D, J segments (that can be assembled into variable region exons that encode bnAb precursors), have

103 n sites: one present on the heavy chain (HC) variable region (Fab) and the other present on the conse

104 une-challenged chicken single-chain antibody variable-region fragment (scFv) libraries targeting the

105 The effect requires binding of both anti-RAS variable region fragments and is RAS-specific, producing

106 ire sequencing of PB and CSF IgG heavy chain variable regions from MS patients.

107 showed previously that deletion of the three variable regions from the E2 receptor-binding domain (De

108 t immunotoxins containing mouse single-chain variable regions fused with a Pseudomonas toxin.

109 A variable region fusion strategy was used to generate an

110 An empirical model relating variable region (Fv) charge and hydrophobicity to cyno n

111 identified by their coexpression of the TCR variable regions gamma4 and delta4.

112 mined the role of immunoglobulin heavy-chain variable region gene (IGHV) mutation status and genetic

113 Use of immunoglobulin heavy-chain variable region gene families 1 (IGHV1) and 5 (IGHV5) wa

114 ed lymphomas use a restricted immunoglobulin variable region gene repertoire.

115 tools for determining the complete set of Ig variable region gene segment alleles carried by an indiv

116 is required for assembly of antigen receptor variable region gene segments by V(D)J recombination.

117 We reasoned the introduced human variable region gene segments would function indistingui

118 minal center (GC) disruption experiments and variable region gene sequencing.

119 respective of the immunoglobulin heavy-chain variable-region gene (IGHV) mutational status.

120 eep repertoire sequencing of IgG heavy chain variable region genes (IgG-VH) in paired cerebrospinal f

121 o present mutated immunoglobulin heavy chain variable region genes (IGHVs), being the most frequently

122 olated used different heavy- and light-chain variable region genes and carried high levels of somatic

123 ibodies do not differ in their repertoire of variable region genes and in most of the molecular featu

124 We also found immunoglobulin variable region genes that were disproportionally used t

125 body discovery process, and the selected IgG variable region genes were successfully humanised and re

126 hypermutation (SHM) of their immunoglobulin variable region genes, generating a heterogeneous tumor

127 lower numbers of somatic mutations in their variable region genes.

128 that have a full set of human immunoglobulin variable region genes.

129 ed to anticipate its maneuvers, the antibody variable-region genes pursue the virus in futility.

130 acing 6 Mb of mouse Ig heavy and kappa light variable region germ-line gene segments with their human

131 this aim, we characterized the repertoire of variable region germline genes of lambda LC preferential

132 Here, we investigated the effect of N-linked variable-region glycosylation for BCR interaction with c

133 ions shared with closely related species and variable regions harboring genes that are unique to F. g

134 imultaneously determine the natively paired, variable region heavy and light chain amplicons and the

135 p13.1), complex karyotype, or immunoglobulin variable region heavy chain mutation status).

136 The variable regions (HVR-1, HVR-2 and VR-3) exhibit particu

137 present a new method that identifies highly variable regions (HVRs), and then maps each HVR to a com

138 s revealed that the mcr-1 was located on the Variable Region I of IncX4 plasmids in 11 E. coli isolat

139 ated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) displays different states of aner

140 clonality, use of immunoglobulin heavy-chain variable region (IGHV) genes and-in particular-isotype u

141 patients without immunoglobulin heavy-chain variable region (IGHV) mutation, ibrutinib-rituximab res

142 -70 expression or immunoglobulin heavy chain variable region (IGHV) status is uncertain.

143 e from a specific antibody gene, heavy-chain variable region IGHV1-69, after limited affinity maturat

144 lood and spleen revealed that immunoglobulin variable region (IgV) gene unmutated CLL derives from un

145 yses indicated that PD-1H has a very long Ig variable region (IgV)-like domain and extraordinarily hi

146 estigate the frequency of use of light-chain variable region (IGVL) genes among patients with systemi

147 N type III repeat (FNIII13), and one from FN variable region (IIICS), which when tethered to a surfac

148 avoid the vague alignments rooted in highly variable regions, improving remote homologue identificat

149 ir strategy, to replace the heavy chain (HC) variable region in B cell lines with that from an HIV br

150 ff, although the ST and antigenic flaA short variable region in combination were stable over a number

151 n a transcription terminator into an Ig gene variable region in DT40 chicken B cell line.

152 previously characterised, common copy number variable regions in 6 independent cohorts (n = 24,237) u

153 ation allowed an analysis of the role of TCR variable regions in determining T cell lineage choice an

154 even though the unstructured, thus generally variable regions in proteins are often flanked by very c

155 olving targeted amplification of one or more variable regions in the 16S rRNA gene.

156 frequency in nsp2, which is one of the most variable regions in the PRRSV genome, than MLV.

157 ntibody sequences for the entire heavy chain variable region, including framework, CDR1, and CDR2 mut

158 D-J gene combinations of the B-cell receptor variable region; increased frequency of variable regions

159 frequencies and spectra of mutations in the variable region, indicating that loss of Pol iota did no

160 K regulation and raises the possibility that variable region inhibition may be released by cellular s

161 ovides count data for both 16S ribosomal RNA variable regions, integrated with phylogeny, taxonomy, p

162 Partitioning the human immunoglobulin variable region into variable (V), diversity (D), and jo

163 CD) in mutant RAS expressing cells when each variable region is fused to procaspase-3.

164 ccumulation of somatic mutations in antibody variable regions is critical for antibody affinity matur

165 chimeric antigen receptors with the antibody variable regions kill MUC1(+) target cells, express acti

166 The highly variable regions lead to vague alignments in threading a

167 Envelope second variable region length, glycosylation sites and V3 amino

168 he PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig cons

169 that a weakly conserved sequence region (the variable region), located between the Cdc42-binding CRIB

170 basic segment, but not the N- and C-terminal variable regions, masks the effect of this determinant.

171 tment to cell-cell contacts, but only if the variable region-mediated inhibition is released.

172 independently of immunoglobulin heavy chain variable region mutational status, CD38, and ZAP-70 expr

173 High-variable region of 16S rRNA of bacteria was used as biom

174 A strand that is complementary to the target variable region of 16S rRNA of M. aeruginosa.

175 t the strategic placement of a glycan in the variable region of a monoclonal antibody can substantial

176 ug composed of a single-chain version of the variable region of an anti-alphaIIbbeta3 mAb fused to a

177 The remaining variable region of each molecule likely targets the rece

178 s into exons that encode the antigen-binding variable region of Ig heavy (H) and light (L) chains.

179 1 interacts with the cytoplasmically exposed variable region of IRT1, and we demonstrate that this in

180 The highly variable region of MG192 was amplified by PCR from M. ge

181 ghly conserved binding site found within the variable region of nearly all antibody Fab arms.

182 the O antigen polysaccharide represents the variable region of outer membrane lipopolysaccharides.

183 ere designed for the nested run to amplify a variable region of the 23S-5S intergenic spacer (IGS) of

184 ctive site was identified in the light chain variable region of the antibody.

185 uly tumor-specific cell-surface product, the variable region of the B-cell receptor (BCR), otherwise

186 We used 454-based sequencing of a variable region of the bacterial 16S ribosomal RNA gene

187 fied using barcoded primers targeting the V6 variable region of the bacterial 16S rRNA gene and the I

188 X encodes a glycosyltransferase located in a variable region of the enterococcal polysaccharide antig

189 attachment to the conserved portions of the variable region of the kappa and lambda light chains.

190 ER were determined to be located only on the variable region of the light chain.

191 The variable region of the MG192 gene was PCR amplified, sub

192 ce of these extra glycosylation sites in the variable region of the molecule causes significant charg

193 Deep sequencing at a highly variable region of the P. vivax merozoite surface protei

194 luded high-throughput sequencing of the CDR3 variable region of the T cell receptor beta-chain and an

195 ition activity in planta, and the C-terminal variable region of VgrG2 governs this specificity for Td

196 irst time, that every Leu/Ile residue in the variable regions of a monoclonal antibody that could not

197 The major variable regions of all the IncX4 plasmids were fully ch

198 re single-domain antibodies derived from the variable regions of Camelidae atypical immunoglobulins.

199 These amino acids are present in the variable regions of distantly related species such as sh

200 r and immunity proteins are contained in two variable regions of GA3 loci, GA3 T6SSs of the species B

201 detergent does not involve the V1, V2, or V3 variable regions of gp120.

202 Variable regions of Ig chains provide the antigen recogn

203 Possibly the variable regions of Ig genes have evolved for low nucleo

204 y selected from a naive library derived from variable regions of llama heavy chain-only antibodies, a

205 all level of selective constraint within the variable regions of mammalian proteins allows the metabo

206 polymerase chain reaction (RT-PCR) amplified variable regions of mouse immunoglobulin genes using a s

207 sequence diversity exists across the entire variable regions of rhesus Ig and TCR transcripts.

208 reflect accurate genetic distances in highly variable regions of rRNA genes than do traditional multi

209 ddition, we have cloned and expressed the Ig variable regions of several L chain-included B cells in

210 or and the library insert comprises only the variable regions of the antibodies and a central bi-dire

211 A/HBV peptide complexes through the TCR-like variable regions of the antibodies.

212 The antigen-binding variable regions of the B cell receptor (BCR) and of ant

213 engineered IgA2m(1) antibody containing the variable regions of the EGFR antibody cetuximab.

214 within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and m

215 eliciting immunodominant responses targeting variable regions of the HIV proteome are hurdles in the

216 rse antibody repertoire against constant and variable regions of the therapeutic antibody immunogen.

217 The variable regions of two anti-murine CD8-depleting antibo

218 ion process, and by the introduction, in BCR variable regions, of N-glycosylation acceptor sites harb

219 Hemizygous deletion of a variable region on chromosome 11q containing FLI1 causes

220 Grafting the mAb variable regions onto the IgG2 constant region dramatica

221 -cell boundary-targeting motifs but that the variable region prevents type I PAK accumulation at junc

222 sequencing of an immunoglobulin heavy chain variable region repertoire before vaccination revealed a

223 , we analyzed the immunoglobulin heavy chain variable region repertoire in both graft and blood.

224 t heavy chain variable and kappa light chain variable regions repertoire for the generation of an unb

225 ognition, and seemingly minor changes to its variable region reprogram recognition outcomes.

226 The use of complex disulfide bonds within variable regions required for receptor binding is found

227 nserved bocaparvovirus-specific features and variable regions resulting in unique surface topologies

228 olymorphisms (SNPs) immediately flanking its variable region (rs25531 and rs25532), the intron 2 VNTR

229 ation fluorescent probe using a single-chain variable region (scFv) fragment of a specific antibody w

230 ion of a high-affinity single-chain fragment variable region (scFv).

231 to make mice that more efficiently use human variable region segments in their humoral responses by p

232 em for analyzing vast amounts of heavy chain variable region sequences and exploring the resulting da

233 significantly higher antibody titers to tprK variable region sequences found in the inoculum compared

234 Analysis of variable region sequences of 16 clones suggests that the

235 tions as a result of nucleotide mutations at variable region sequences rarely targeted by activation-

236 showed that these antibodies have different variable region sequences, suggesting that the individua

237 Matched heavy- and light-chain variable-region sequences were amplified from single IgG

238 pathogens and toxins through the coupling of variable region specificity to Fc-triggered cellular act

239 se two vaccine-elicited mAbs and the topside variable region spike cap, whereas the bNAbs duck under

240 attributed to the unusual properties of bnAb variable regions, such as poly-reactivity and long antig

241 Highly variable regions, such as the density assigned to the la

242 observed in the previously described surface variable regions, suggesting that specific residues S269

243 t of the outer membrane, with its C-terminal variable region surface exposed.

244 A T-cell receptor (TCR)-variable region, TCR-Vbeta13, is required for susceptibi

245 ounder virus with shorter, less glycosylated variable regions than matched chronic viruses.

246 veral evolutionary conserved residues in TCR variable regions that contact MHC.

247 re, but achieve functional diversity through variable regions that determine how the catalytic core i

248 provide protection exclusively through their variable region; the contributions of mechanisms conferr

249 ell receptors (TCRs) can use the same set of variable regions to bind both proteins, we have presente

250 bilized gp120 core (0G) deleted of its major variable regions to preferentially expose the conformati

251 actions between targeted switch (S) regions, variable region transcription before somatic hypermutati

252 es of recipient T-cell receptor beta-subunit variable region (TRbetaV) were analyzed.

253 igen-specific chimeric human IgE (with mouse variable regions) upon the immunization with ovalbumin a

254 ere, we review known interactions at the Igh variable region (V(H)) promoters and present our perspec

255 tify large numbers of heavy- and light-chain variable regions (V(H) and V(L)) in a given B-cell reper

256 ers and bind antigens by their single domain variable regions (V-NARs).

257 Furthermore, our results indicate that Env variable regions V1, V2, V3, and V5 do not represent a m

258 olated, and PCR amplicons from 16S rRNA gene variable regions V1-V3 and V3-V5 from these fractions we

259 n tolerate a high degree of mutation in five variable regions (V1-V5), and also at N-linked glycosyla

260 he region consisting of the first and second variable regions (V1V2) of gp120 plays vital roles in th

261 esence of antibodies to the first and second variable regions (V1V2) of gp120 was associated with the

262 hat the presence of antibodies to the second variable region (V2) of HIV-1 gp120 was responsible for

263 alizing antibodies (bnAbs) but not for third variable region (V3) antibodies.

264 rabbit MAbs, R56 and R20, against the third variable region (V3) of HIV-1 gp120.

265 The levels of antibodies to the third variable region (V3) of the HIV envelope protein correla

266 idging sheet and the base of the third major variable region (V3), which are elements of the CoRbs.

267 pping predominantly to the gp120 third major variable region (V3).

268 Analysis of the two most variable regions (V4 and V6) in five sequential specimen

269 he T cell antigen receptor (TCR) alpha-chain variable region (Valpha) and beta-chain variable region

270 n 3 (CDR3) regions containing the beta-chain variable region (Vbeta) demonstrated a more diverse repe

271 irrespective of the member of the beta-chain variable region (Vbeta) family present in the TCR or the

272 hain variable region (Valpha) and beta-chain variable region (Vbeta).

273 ell clone expansion involved the heavy chain variable region (Vh) 5 and Vh7 B-cell receptor families

274 single rearranged immunoglobulin heavy chain variable region (VH) sequence for each clone.

275 sequenced the paired heavy- and light-chain variable regions (VH and VL, respectively) from large po

276 equencing of immunoglobulin (Ig) heavy chain variable regions (VH) from CSF and subsorted peripheral

277 osition 41, a non-CDR residue in heavy chain variable regions (VH), is important for humanization of

278 Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonst

279 The variable regions (VHH) in these heavy chain-only Abs dem

280 The variable regions (VHHs) of two heavy chain-only antibodi

281 the present study, we developed GPI-anchored variable regions (VHHs) of two heavy chain-only antibodi

282 Using a bioinformatics approach, six variable regions (VRI-VRVI) were identified.

283 tional differences in two of the AAV surface variable regions (VRs), VR-IV and VR-VII.

284 t the major ADK8 epitope is formed by an AAV variable region, VRVIII (amino acids 586 to 591 [AAV8 VP

285 The tumor immunoglobulin heavy chain variable region was more frequently unmutated in CLL cel

286 Somatic mutations within the immunoglobulin variable region were almost exclusively presented by MHC

287 the PCR results, 20 amplicons of the cagA 3' variable region were sequenced, and analyzed in silico,

288 Variable regions were cloned and expressed as recombinan

289 Two novel variable regions were identified.

290 ibodies directed against the gp120 V2 and V3 variable regions were isolated from the immunized monkey

291 The cloned IgG-specific AHA-variable regions were mutated from germ line-derived seq

292 Interestingly, the variable region, which binds to PICK1, is not essential

293 away from the membrane surface and exposes a variable region, which is identified by hydrogen-deuteri

294 Accordingly, substitution of the PAK1 variable region with that from PAK6 or removal of this r

295 ptor variable region; increased frequency of variable regions with higher content of positively charg

296 We demonstrate that targeting of 16S variable regions with short-read sequencing platforms ca

297 mAbs, comprising fully human variable regions with subnanomolar Ag affinity and carry

298 and one guanylate kinase domain, flanked by variable regions with unknown structures.

299 amplicon sequencing of two 16S ribosomal RNA variable regions, with extensive controlled-access parti

300 by segmental recombination between discrete variable regions within mgpB and mgpC and multiple archi