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1 nst orthopoxviruses, including monkeypox and variola.
2 ects, supporting the efficacy of MVA against variola.
3 ), a genus that includes the human pathogens variola and monkeypox and the vaccine species vaccinia v
4 terotypic immunity which can protect against Variola and Monkeypox disease.
5 ncompetent vaccinia strains being tested for variola and monkeypox prevention and for the delivery of
6                                     Although variola and vaccinia share remarkable DNA homology, the
7                                              Variola and vaccinia viruses, the two most important mem
8 ool containing selected sequences from MPXV, variola, and VAC-V in MPXV-infected individuals than MVA
9                                              Variola causes the contagious disease smallpox, which ha
10 we demonstrate the functional advantage of a variola complement regulatory protein over that of its v
11  two sets of clade I primers and probes with variola, cowpox, camelpox, and vaccinia viruses was noti
12 identified, including an interaction between variola G1R, an ankryin/F-box containing protein, and hu
13 verwhelming systemic infection suggests that variola gene products may ablate this response.
14 ur understanding of variola pathogenesis and variola-host interactions, we examined the molecular and
15                                              Variola infection elicited striking and temporally coord
16 rently being developed as an animal model of variola infection in humans.
17 erged from an ancestral African rodent-borne variola-like virus either approximately 16,000 or approx
18 h showed a CTX1B recovery of 42% and 32% for Variola louti and Seriola dumerili, respectively, and al
19                                              Variola major (smallpox) infection claimed hundreds of m
20 served among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting t
21 indicate that the divergence of alastrim and variola major occurred earlier than previously believed.
22 ses include many important pathogens such as variola major virus, camelpox, buffalopox, monkeypox, co
23                                              Variola major virus, the etiological agent of smallpox,
24 rmer being closely related to a protein from variola major virus, the smallpox etiological agent.
25 alization titers to vaccinia, monkeypox, and variola major were assessed and cell-mediated immune res
26 xviruses, including vaccinia, monkeypox, and variola major, and broad T-cell responses, indicating th
27 ) that is conserved in J8R of smallpox virus variola major.
28 camelpox, buffalopox, monkeypox, cowpox, and variola minor viruses.
29 ved because other orthopoxviruses, including variola, monkeypox and cowpox viruses, encode orthologue
30 ved because other orthopoxviruses, including variola, monkeypox and cowpox viruses, encode orthologue
31 ed the identification and differentiation of variola, monkeypox, camelpox, vaccinia, and cowpox virus
32 raccoonpox viruses, as well as those such as variola, monkeypox, vaccinia, and camelpox viruses, whic
33 ybridize these GeneChips with some known non-Variola orthopoxvirus isolates, including monkeypox, cow
34  have arisen about the possible existence of variola outside these sites and the potential for using
35              To improve our understanding of variola pathogenesis and variola-host interactions, we e
36                              Smallpox virus (variola) poses a significant threat as an agent of biote
37 uire development of an animal model in which variola produces a disease course with features consiste
38                            Because authentic variola proteins are not available for study, we molecul
39       SPICE provides the first evidence that variola proteins are particularly adept at overcoming hu
40 in the more potent complement inhibitor from Variola (small pox) virus.
41 dimeric N1L protein is a potent vaccinia and variola (smallpox) virulence factor.
42 ted orthopoxvirus proteins, the vaccinia and variola (smallpox) virus complement control proteins, wh
43                      For DNA viruses such as variola (smallpox), three target genomes provide suffici
44 f antiviral agents, including agents against variola (smallpox), which has an almost identical E3L.
45 ox virus is an Orthopoxvirus (genus includes variola [smallpox] and vaccinia [smallpox vaccine]).
46 homologous complement regulatory proteins of variola (SPICE) and vaccinia (VCP).
47 x persists because clandestine stockpiles of variola still exist.
48  kidney BSC-40 and VERO-E6 cells in vitro by variola strain Solaimen is blocked by CI-1033, primarily
49  cynomolgus macaques were exposed to several variola strains through aerosol and/or i.v. routes.
50 le DNA homology, the strict human tropism of variola suggests that its proteins are better suited tha
51 e orthopoxviruses infect mammals and include variola, the causative agent of smallpox, and monkeypox,
52                                              Variola, the causative agent of smallpox, and the relate
53                   Most poxviruses, including variola, the causative agent of smallpox, express a secr
54                                              Variola, the causative agent of smallpox, is a highly in
55 MPXV) is an orthopoxvirus closely related to variola, the etiological agent of smallpox.
56 s, an Orthopoxvirus in the same genus as the variola, vaccinia, and cowpox viruses.
57 rains belonging to the orthopoxvirus species variola, vaccinia, camelpox, mousepox, cowpox, and monke
58 rld, African-Eurasian orthopoxviruses (OPV): variola, vaccinia, cowpox, monkeypox, camelpox, ectromel
59 ratures (T(m)s) determined for 46 strains of variola virus (T(m)s, 55.9 to 57.8 degrees C) differed s
60 duce the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro
61 ited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro
62 monkeypox virus, and the potential biothreat variola virus (the causative agent of smallpox).
63 rus genus, which includes Vaccinia virus and Variola virus (the causative agent of smallpox).
64 man infections on an intermittent basis, and variola virus (VARV) has potential for use as an agent o
65 dae family members monkeypox virus (MPX) and variola virus (VarV) use conserved mechanisms for actin
66 mescale of emergence of the causative agent, variola virus (VARV), and how it evolved in the context
67 ith hepatitis B virus (HBV), parvovirus B19, variola virus (VARV), and Mycobacterium leprae.
68         Human disease likely attributable to variola virus (VARV), the etiologic agent of smallpox, h
69                                              Variola virus (VARV), the etiological agent of smallpox,
70             Within the family of poxviruses, variola virus (which causes smallpox) is the most pathog
71                            Whereas the human variola virus and mouse ectromelia virus encode one vTNF
72 eutic intervention against infections by the variola virus and other poxviruses.
73  as a global illness more than 30 years ago, variola virus and other related pathogenic poxviruses, s
74 hage host range protein, myxoma virus M011L, variola virus B22R, four ankyrin repeat proteins, three
75 rotein, D7L BTB/POZ domain protein, and B22R variola virus B22R-like protein.
76               With genomic DNA purified from variola virus Bangladesh 1975, the limit of detection wa
77  naturally occurring systemic infection with variola virus both lead to the characteristic skin "pox"
78    Of the 43 samples that contained purified variola virus DNA ranging in concentration from 1 fg/ mi
79            Of the 206 samples that contained variola virus DNA ranging in concentrations from 100 fg/
80      Contained within those 322 samples were variola virus DNA, obtained from purified viral preparat
81   The Poxviridae family members vaccinia and variola virus enter mammalian cells, replicate outside t
82 hat confer cross-protective immunity against variola virus for decades after immunization.
83 lpox) in a scenario involving the release of variola virus from a laboratory, 19 deaths in a human-ve
84  Viking Age, and reconstructed near-complete variola virus genomes for four of them.
85                 Thus, proteomic screening of variola virus has the potential to uncover modulators of
86                             The vaccinia and variola virus homolog sequences predict 94% identical am
87  amino acid differences compared with its B6 variola virus homologue, B6 might be a better choice for
88 ata suggest that a subunit vaccine using the variola virus homologues might exhibit improved protecti
89  interaction, in contrast to results for the Variola virus IL-18BP, which has been shown to primarily
90 surrogate mouse model for smallpox caused by variola virus in humans.
91                                 Survivors of variola virus infection demonstrated VV-specific CD4 mem
92           Of 8 individuals with a history of variola virus infection, 1 had a VV-specific IFN- gamma
93 n magnitude to that achieved through natural variola virus infection, and this may explain the notabl
94 ection in nonhuman primates, a surrogate for variola virus infection, were characterized.
95 fection, and 8 individuals with a history of variola virus infection.
96 tive genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the sma
97 the 14-kDa fusion protein gene of each of 14 variola virus isolates of the Russian World Health Organ
98 ting inhaled onset of smallpox caused by the variola virus of Orthopoxvirus genus.
99  a majority of the population susceptible to variola virus or other emerging poxviruses.
100 otection of macaques from monkeypox virus, a variola virus ortholog.
101 time polymerase-chain-reaction assay for non-variola virus orthopoxviruses were positive, and DNA seq
102 eins encoded by the ectromelia virus and the variola virus possess E3 ubiquitin ligase activity in bi
103 te that despite the enhanced activity of the variola virus protein, its cofactor activity in the fact
104  protein interaction screening of the unique variola virus proteome by using yeast 2-hybrid screening
105                     In this study, we used a variola virus proteome microarray to characterize and di
106 d alone or in combination with inhibitors of variola virus replication.
107 hed sequencing is required using Marburg and variola virus sequences.
108 encing GeneChips for the rapid sequencing of Variola virus strains in the WHO Repository of the Cente
109 etected among the 116 samples not containing variola virus tested; i.e., the overall specificity of t
110 s the model because it is closely related to variola virus that causes smallpox.
111 jority of the orthopoxviruses, including the variola virus that causes the dreaded smallpox disease,
112 poxviruses such as vaccinia virus (VACV) and variola virus that fail to form inclusions.
113   We date the most recent common ancestor of variola virus to ~1700 years ago.
114 O) vaccination campaign in the 1970s and the variola virus was restricted to repositories in the Unit
115                                           If variola virus were used as a biological weapon, however,
116  bubonic plague (Yersinia pestis), smallpox (Variola virus) and cholera (Vibrio cholerae) - and for t
117       Outbreaks of smallpox (i.e., caused by variola virus) resulted in up to 30% mortality, but thos
118               Immunization against smallpox (variola virus) with Dryvax, a live vaccinia virus (VV),
119 e sequences of 24 strains of smallpox virus (variola virus), for rapid characterization of this human
120 (OPVs), which include the agent of smallpox (variola virus), the zoonotic monkeypox virus, the vaccin
121 concern over the use of pathogens, including variola virus, as biological weapons.
122 d mouth disease virus (n=2 each, 12.5%); and variola virus, Burkholderia pseudomallei, and influenza
123                Similar to the human pathogen variola virus, ectromelia virus has a limited host range
124  the disease is essential because its cause, variola virus, is considered a potential biological weap
125         Many pathogenic orthopoxviruses like variola virus, monkeypox virus, and cowpox virus (CPXV),
126 ACV) affords long-lasting protection against variola virus, the agent of smallpox.
127 irus affords long-lasting protection against variola virus, the agent of smallpox.
128 by modified vaccinia virus Ankara as well as variola virus, the agent of smallpox.
129 stablished as the result of the concern that variola virus, the causative agent of smallpox, as well
130                                              Variola virus, the causative agent of smallpox, enters a
131                                              Variola virus, the causative agent of smallpox, is a pot
132                                              Variola virus, the causative agent of smallpox, is the m
133                     Interestingly, CrmB from variola virus, the causative agent of smallpox, is the m
134  T-lymphocyte (CTL) epitopes are defined for variola virus, the causative agent of smallpox, or for v
135 MPXV) is an orthopoxvirus closely related to variola virus, the causative agent of smallpox.
136 ved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox.
137 re encoded by all orthopoxviruses, including variola virus, the causative agent of smallpox.
138  use as a vaccine enabled the eradication of variola virus, the etiologic agent of smallpox.
139                         The potential use of variola virus, the etiological agent of smallpox, as a b
140                                              Variola virus, the most virulent member of the genus Ort
141                  Prior to the eradication of variola virus, the orthopoxvirus that causes smallpox, o
142 e Poxviridae family, which also includes the variola virus, vaccinia virus, and cowpox virus.
143  contains other pathogenic viruses including variola virus, vaccinia virus, camelpox virus, and cowpo
144 is nearly identical in vaccinia virus and in variola virus, which causes smallpox.
145 erived from virus-infected cell cultures and variola virus-infected tissues; thus, the DNA material c
146            Assuming that B6 contains similar variola virus-specific epitopes, our data suggest that a
147                                    By use of variola virus-specific primers and long-range PCR, 22 ov
148 , we detail the design and validation of two variola virus-specific real-time PCR assays, since previ
149 dvantage that it can simultaneously identify variola virus.
150 irus (ECTV), the murine counterpart to human variola virus.
151  in pathogenicity between vaccinia virus and variola virus.
152 virulence mechanisms of the causative agent, variola virus.
153 ed genomic DNA from 48 different isolates of variola virus; 25 different strains and isolates of came
154 ths of genotypic host adaptation resulted in variola viruses that circulated widely among humans.
155 eal a now-extinct sister clade of the modern variola viruses that were in circulation before the erad
156  epitopes are completely conserved among VV, variola viruses, and most mammalian poxviruses, includin
157 , rabbitpox, cowpox, monkeypox, camelpox and variola viruses, deploy countermeasures.
158 74-82), which is shared between vaccinia and variola viruses, may be a CD8(+) T-cell epitope of vacci
159 ilarity between the proteins of vaccinia and variola viruses, these new inhibitors are anticipated to
160 pitopes are highly conserved in vaccinia and variola viruses.
161 eacted with OPG153 orthologs from cowpox and variola viruses.
162 camelpox, cowpox, ectromelia (mousepox), and variola viruses.
163                           After inoculation, variola was disseminated by means of a monocytic cell-as
164 ion of protective efficacy against authentic variola will require development of an animal model in w

 
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