ライフサイエンスコーパス: vascularize

1 ients, is decidedly heterogeneous and highly vascularized.

2 They are well vascularized.

3 the TMJ in higher order species are in fact vascularized.

4 stringent orchestration by the tissue being vascularized.

5 s fibrotic, less immunosuppressive, and more vascularized.

6 e biomedical applications.The fabrication of vascularized 3D tissues requires an understanding of how

7 ved stromal vascular fraction (SVF) cells to vascularize a human liver cell (HepG2) implant.

8 ipocytes in mice produces well-organized and vascularized adipose tissue, capable of beta-adrenergic-

9 ower A20 expression or function in donors of vascularized allografts may inform risk and severity of

10 relation of the IOH to the junction between vascularized and avascular retina.

11 -like cellular microarchitectures resembling vascularized and bone marrow tissue architectures.

12 ining microtissue spheroids resulted in well-vascularized and cellular pulp-like tissues, compared wi

13 t, we showed that fully allogeneic primarily vascularized and conventional skin transplants were reje

14 lesions from IL-33 treated mice were highly vascularized and exhibited increased proliferation.

15 a vascular structure for over 200 days as a vascularized and functional brain organoid model.

16 reserved in vivo in the context of the fully vascularized and innervated islet.

17 ll) immunodeficient host mice regenerate new vascularized and innervated myofibers from human myogeni

18 exibility of these scaffolds by regenerating vascularized and innervated neo-muscle, vascularized neo

19 During this progression, tumors become vascularized and mitotically active.

20 e skin reservoir or the presence of a poorly vascularized and mobile wound bed.

21 d very severe leakage at the junction of the vascularized and non-vascularized retina and optic nerve

22 Follicle-seeded scaffolds become highly vascularized and ovarian function is fully restored when

23 n building human-scale constructs, which are vascularized and readily implantable.

24 anted pancreatic and renal buds were rapidly vascularized and self-organized into functional, tissue-

25 Pancreatic tumors are poorly vascularized and severely hypoxic.

26 lastic cells, whereas central marrow remains vascularized and splenic vascular niches expand.

27 generating hearts of nrp1a mutants were less vascularized, and epicardial-derived cell migration and

28 he mitoNEET-enriched fat pads feature a more vascularized, anti-inflammatory and less fibrotic enviro

29 phery of the tumors, corresponding with well-vascularized areas of the tumor.

30 showed significantly increased limbal lymph vascularized areas, a higher number of lymphatic vessel

31 fabrication of scalable constructs that are vascularized, autologous, functional, implantable, cost-

32 kin (IL)-10 (CD19-Cre::IL-10) mice, received vascularized BALB/c cardiac allografts.

33 odular tissue engineering results in an s.c. vascularized bed that enables the transplantation of pan

34 l sources, graft sites, and ultimately fully vascularized bioengineered insulin-secreting microtissue

35 Transplantable vascularized bioengineered intestine could restore nutri

36 novel strategies focus on the development of vascularized biomaterial scaffolds.

37 ilage template that completely remodels into vascularized bone and involves a dynamic interplay among

38 CSC and endothelial cell interactions during vascularized bone formation.

39 thelial cells are essential for FCSC-derived vascularized bone formation.

40 tor cells (EPCs) could significantly enhance vascularized bone regeneration.

41 veloped to overcome the challenge of forming vascularized bone tissue.

42 nlagen, which is subsequently remodeled into vascularized bone using an ectopic transplantation model

43 ated bone reveals osteogenesis of organized, vascularized bone with histologic and mechanical charact

44 eplace the avascular cartilage template with vascularized bone.

45 ral integrity and characteristics as seen in vascularized bones and osteochondral tissues.

46 cilitates the generation of large autologous vascularized bony tissue of customized geometry without

47 Protocol I aimed to develop the vascularized brachial plexus allotransplantation (VBP-al

48 Vascularized brachial plexus allotransplantation could o

49 A free vascularized brachial plexus with a chimeric compound sk

50 Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy imp

51 ated by pulse-chase experiments, EECs in the vascularized, but not in the avascular, region efficient

52 ssociated with C3 glomerulonephritis are not vascularized, but rather of serous type.

53 Lymphoid tissue in diseased rats was vascularized by aquaporin-1(+) high endothelial venules

54 In patients who were re-vascularized by CABG, mortality and major adverse cardia

55 (A and B), immune-high (D and E), and highly vascularized (C) groups.

56 The efficacy of donor ECDI-SPs in protecting vascularized cardiac allografts and mechanism(s) of prot

57 As proof of the concept, vascularized cardiac constructs are bioprinted and their

58 To achieve vascularized cardiac tissues, we tested various tri-cult

59 - 16.4 kPa) to engineer biomimetic models of vascularized cardiac tissues.

60 ges upon transplantation in a BALB/c into B6 vascularized cardiac transplant model.

61 s spontaneously formed a BM cavity through a vascularized cartilage intermediate in vivo that was pro

62 demonstrate a novel strategy to engineer pre-vascularized, cell-laden hydrogel pulp-like tissue const

63 neering is producing three-dimensional (3D), vascularized cellular constructs of clinically relevant

64 This study demonstrated a useful vascularized complete brachial plexus allotransplantatio

65 harnessing mechanical properties to generate vascularized, complex organ buds with broad applications

66 The definition of vascularized composite allograft (VCA) and the nomenclat

67 previously demonstrated that tolerance to a vascularized composite allograft (VCA) can be achieved a

68 Monitoring vascularized composite allograft (VCA) hand recipients f

69 an Sharing was charged with the oversight of vascularized composite allograft (VCA) procurement and t

70 Current knowledge of the impact of facial vascularized composite allograft (VCA) procurement on th

71 Vascularized composite allograft (VCA) transplantation c

72 Vascularized composite allograft (VCA) transplants inclu

73 ent of acute rejection of the abdominal wall vascularized composite allograft (VCA).

74 o SCS and holds promise to be beneficial for vascularized composite allograft recipients and victims

75 ascular lesions and prospects for defining a vascularized composite allograft rejection classificatio

76 Chronic rejection of vascularized composite allografts (VCA) is an emerging p

77 d with animal modeling of transplantation of vascularized composite allografts (VCA).

78 Vascularized composite allografts (VCAs) are unique amon

79 Vascularized composite allografts (VCAs) can restore ful

80 ng functional vessels during preservation of vascularized composite allografts (VCAs) remains a major

81 Achieving tolerance of vascularized composite allografts (VCAs) would improve t

82 erved for the primarily vascularized skin of vascularized composite allografts (VCAs).

83 To date, there are more than 80 reports of vascularized composite allografts (VCAs; a.k.a. composit

84 or-host hematopoietic chimerism and accepted vascularized composite allografts for periods ranging be

85 nd 90 weeks; in turn, marrow donors rejected vascularized composite allografts from their respective

86 er, the literature on the use of MP in human vascularized composite allografts is scarce.

87 Vascularized composite allografts, particularly hand and

88 Facial vascularized composite allotransplantation (fVCA) presen

89 Vascularized composite allotransplantation (VCA) allows

90 Over the last 2 decades, vascularized composite allotransplantation (VCA) has app

91 Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has dem

92 Cellular therapies for immunomodulation in vascularized composite allotransplantation (VCA) have ga

93 : Vascularized composite allotransplantation (VCA) is a re

94 ominal wall have confirmed the potential for vascularized composite allotransplantation (VCA) to rest

95 We used our nonhuman primate model of facial vascularized composite allotransplantation (VCA) to stud

96 Approaches to safely induce tolerance in vascularized composite allotransplantation (VCA) with ch

97 ey immediate goals for clinical expansion of vascularized composite allotransplantation (VCA).

98 istological rejection in graft skin in human vascularized composite allotransplantation (VCA).

99 istological rejection in graft skin in human Vascularized Composite Allotransplantation (VCA).

100 o sustain devastating composite tissue loss, vascularized composite allotransplantation (VCA; e.g., h

101 Mechanical skin irritation in vascularized composite allotransplantation can trigger l

102 Vascularized composite allotransplantation has become es

103 Skin chronic rejection (CR) in vascularized composite allotransplantation has not been

104 The effect of cold ischemia (CI) in vascularized composite allotransplantation is unknown.

105 Ischemia times in vascularized composite allotransplantation should be kep

106 proceeding ethically with research on penile vascularized composite allotransplantation will require

107 y reported for the treatment of rejection in vascularized composite allotransplantation.

108 nsplantation Network (OPTN) began overseeing vascularized composite allotransplantation/allografts (V

109 duces donor-specific tolerance to kidney and vascularized composite allotransplants (VCA).

110 c criteria for diagnosing acute rejection in vascularized composite tissue allograft (VCA) have been

111 Vascularized composite tissue allografts (VCA) can under

112 Vascularized composite tissue allografts (VCA) have beco

113 Well-vascularized composite tissue offers improved outcomes f

114 After transplantation of vascularized condensed progenitors into immunodeficient

115 g eyes, crusty eyelids, eyelid edema, highly vascularized cornea and tarsal plates (TPs), slit eye, a

116 rogressive keratopathy, resulting in a dense vascularized corneal pannus, and eventually leading to v

117 For these vascularized corneas at high risk for immunologic reject

118 stem cells (MDSCs) to develop bioengineered vascularized corpora.

119 e insulin-secreting human pancreatic islets, vascularize decellularized rat intestines and arborize h

120 nd effective strategy for engineering of pre-vascularized dental pulp constructs offering potentially

121 ventually can reach the blood vessels in the vascularized dermis.

122 The pancreatic islet is a highly vascularized endocrine micro-organ.

123 Kaposi's sarcoma is a highly vascularized, endothelial cell-based tumor supporting la

124 ropylene fumarate) scaffolds is proposed for vascularized engineered tissues.

125 crocapsules (Micro) in the confined and well-vascularized epididymal fat pad (EFP) site, a model of t

126 Brown adipose tissue is highly vascularized, facilitating delivery of nutrients to brow

127 The patients presented with vascularized, focally cystic, nonulcerated eyelid margin

128 were differentiated into nonvascularized and vascularized forms with 3 main underlying etiologies: AM

129 med in 31 eyes of 31 patients with a central vascularized full-thickness leukoma, resulting from infe

130 We then fabricated pre-vascularized, full-length, dental pulp-like tissue const

131 inal astrocytic hamartomas (RAH) is a benign vascularized glial tumor of the retina.

132 er maturation of kidney tissue, formation of vascularized glomeruli with fully differentiated capilla

133 ompartment model to simulate heterogeneously vascularized growing tumors and the corresponding protei

134 ingle-center study, 52 consecutive eyes with vascularized (>=2 quadrants) herpetic corneal scars unde

135 inflammatory response due to it being highly vascularized, having constant exposure to environmental

136 We found that vascularized hCOs (vhCOs) acquired several blood-brain b

137 ed direct evidence that chronic rejection of vascularized heart allografts occurs in the complete abs

138 t tumors, as well as human JGCTs, are highly vascularized, hemorrhagic and mitotically active.

139 and steroid prophylaxis for MK in high-risk, vascularized herpetic corneal scars achieves clinical ou

140 Murine hearts were transplanted as fully vascularized heterotopic grafts from BALB/c donors into

141 lethally irradiated before receiving skin or vascularized heterotopic heart grafts from C57Bl/6 mice.

142 was performed in hemevascularized and lymph-vascularized high-risk host beds, and graft recipients r

143 Here, we show that a vascularized human BM-on-a-chip (BM chip) supports the d

144 It is enriched in highly vascularized human tissues, and upregulated in the heart

145 ntation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma

146 systemic intravascular injection only in SVF-vascularized implants demonstrating that SVF cell-derive

147 the most common primary brain tumors, highly vascularized, infiltrating, and resistant to current the

148 We report on an unusual case of a vascularized iris lesion in a three year old Caucasian p

149 uli were capable of engrafting on the highly vascularized iris.

150 in immunodeficient mice, grafted cells form vascularized islet-like structures containing MAFA/C-pep

151 , not only does the brain need to be densely vascularized, it also requires a tightly controlled envi

152 ere found to be crucial for obtaining a well-vascularized kidney graft.

153 We found that vascularized kidney organoids cultured under flow had mo

154 ted access of the drug to tumor loci in hypo-vascularized lesions has hampered clinical application.

155 nsport in 3D cell cultures representing hypo-vascularized lesions, enhancing drug uptake and effect.

156 eatic ductal adenocarcinoma (PDAC), a poorly vascularized lethal KRAS-driven malignancy.

157 outcome is that liver metastases are poorly vascularized, limiting the ability to deliver therapeuti

158 The highly vascularized lung holds up to 40% of blood, and thus, th

159 ice) resulted in the development of a highly vascularized lung implant.

160 t of physiologic surgical options, including vascularized lymph node transplant (VLNT) and lymphoveno

161 c lymphatics, developed a surgical model for vascularized lymph node transplantation, and confirmed P

162 Search terms were focused on vascularized, lymph node transfer (also autologous, lymp

163 The dura mater is a vascularized membrane surrounding the brain and is heavi

164 We show that human B-ALL blasts alter a vascularized microenvironment promoting monocytic differ

165 al M1-induced cytotoxicity, even in a highly vascularized microenvironment.

166 Here we describe in vitro vascularized microtumors (VMTs).

167 Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growt

168 anized luminal/glandular epithelium, stroma, vascularized mucosa and two-layered myometrium.

169 or tumor angiogenesis and survival in highly vascularized murine lung tumor xenografts.

170 o underwent a tracheal reconstruction with a vascularized myofascial flap and 2-year follow-up was in

171 As an alternative, we used a vascularized myofascial flap for tracheal reconstruction

172 LSCI can be used to distinguish between well vascularized (n = 32) and compromised (n = 27) parathyro

173 Bioengineering intestine on vascularized native scaffolds could bridge the gap betwe

174 in the slight RPE detachment, confirming its vascularized nature.

175 ting vascularized and innervated neo-muscle, vascularized neo-nerve and pulsatile neo-artery with fun

176 The ability to generate vascularized nephrons from single-cell suspensions marks

177 pear more suitable for engineering of mature vascularized networks than DPSCs or SCAPs.

178 r volume reduction at 3 months than did less-vascularized nodules (10.9% +/- 14.5 vs 41.5% +/- 20.3,

179 4), or used to close the abdomen while still vascularized on the forearm (n = 2).

180 None of the preoperative corneas were vascularized or had pronounced subepithelial fibrosis on

181 C sponge group had significantly more tense, vascularized, or encapsulated blebs as a late complicati

182 The lung is a highly vascularized organ and replete with a large population o

183 nt depends on the placenta, a highly complex vascularized organ comprised of both maternal and foetal

184 In vascularized organ transplants, gender mismatches have h

185 s also observed after placement of different vascularized organ transplants, including hearts and kid

186 Brown adipose tissue (BAT) is a highly vascularized organ with abundant mitochondria that produ

187 rated a novel paradigm for the generation of vascularized organoids (vOrganoids) consisting of typica

188 enesis is vital for tumor growth but in well-vascularized organs such as the lung its importance is u

189 approach toward regenerating functional and vascularized organs.

190 n a fully MHC mismatched mouse VCA such as a vascularized osteomyocutaneous as compared to a non-VCA

191 ng that the BioCer was transformed into well-vascularized osteonal bone, with a morphology, ultrastru

192 epithem is composed of a lacunar and highly vascularized parenchyma offering a direct connection bet

193 PCV patients had large, vascularized, peaked PEDs associated with polyps and a v

194 vascularized PEDs (drusenoid and serous) and vascularized PEDs (type 1 and type 3 neovascularization)

195 Eyes with vascularized PEDs secondary to AMD may show specific OCT

196 n, especially when assessing the response of vascularized PEDs to antiangiogenic therapy.

197 precise underlying etiology and manage both vascularized PEDs, where evidence-based treatment exists

198 ost fatal cancers, characterized by a strong vascularized phenotype.

199 to overcome thrombocytopenia associated with vascularized pig-to-primate xenotransplantation.

200 In all eyes, pretear images revealed a vascularized pigment epithelial detachment (PED) contain

201 A recent innovation is the use of vascularized posterior rectus sheath to enable closure o

202 fies both these criteria, the site is poorly vascularized, precluding its utility.

203 Here, we have created 3D vascularized proximal tubule models composed of adjacent

204 atically decreases in hosts with inflamed or vascularized recipient beds.

205 osed algorithm accurately identified densely vascularized regions from the rest of the tumor.

206 an infection that primarily affects the most vascularized regions of the growing skeleton.

207 at the junction of the vascularized and non-vascularized retina and optic nerve head.

208 ofile from the microbeads resulted in highly vascularized s.c. tissue containing up to 16-fold more c

209 e latter require invasive surgery to implant vascularized scaffolds.

210 that islet transplantation in confined well-vascularized sites like the epididymal fat pad (EFP) imp

211 nses (IL-2 and IFN-gamma), whereas primarily vascularized skin allografts failed to trigger a signifi

212 Finally, we show that long-term survival of vascularized skin allografts induced by anti-CD40L Abs w

213 nti-CD40L Abs achieved long-term survival of vascularized skin and cardiac transplants but not conven

214 ce" would also be observed for the primarily vascularized skin of vascularized composite allografts (

215 latform provides a unique model for studying vascularized solid tumors in vitro.

216 y be a valuable target for therapy of poorly vascularized solid tumors.

217 ry hypertrophic vitreous, an optically dense vascularized structure located in the vitreous humor bet

218 terials due to the challenges in fabricating vascularized structures.

219 s high as ~220 vessels mm(-2), in the poorly vascularized subcutaneous space of SCID-Beige mice.

220 These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signa

221 io of the activity in middle cerebral artery-vascularized territories in each hemisphere.

222 eometries and local vessels are recruited to vascularize the developing construct.

223 the zebrafish embryo comprises vessels that vascularize the gut, liver and pancreas and, as such, re

224 tif chemokine receptor Cxcr4a and migrate to vascularize the ventricle under the guidance of the myoc

225 The blood vessels vascularizing the central nervous system exhibit a serie

226 d were more efficient in migrating to and re-vascularizing the deep neural layers of the ischemic ret

227 stablish a versatile protocol for generating vascularized three-dimensional (3D) kidney organoids.

228 Two hundred and eleven (99.5%) became vascularized through zone III without needing treatment.

229 Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly i

230 loped significantly larger and markedly more vascularized thymic tumors than those observed in Rpl22(

231 The mammary gland is a highly vascularized tissue capable of expansion and regression

232 tissue engineering applications where both a vascularized tissue environment and control of tissue re

233 ity with no immunological rejection, support vascularized tissue ingrowth, and promote neovascularisa

234 dynamic crosstalk in a highly innervated and vascularized tissue matrix.

235 ignificant factor to reduce tissue damage in vascularized tissue transplantation.

236 ne defects naturally regenerate via a highly vascularized tissue which progressively remodels into ca

237 characterized by progressive growth of white vascularized tissue with associated traction on the reti

238 earby vasculature, about 30% invaded the non-vascularized tissue, reminiscent of their metastatic phe

239 iscale mathematical model of tumor growth in vascularized tissue, we investigated the selection press

240 lity of the AVL in the de novo production of vascularized tissue.

241 ltured adult endothelial cells, which do not vascularize tissues in an organotypic manner.

242 These thick vascularized tissues are actively perfused with growth f

243 Spatial models of vascularized tissues are widely used in computational ph

244 detailed three-dimensional (3D) datasets of vascularized tissues at the scale of individual cells.

245 Cell-based therapies and pre-vascularized tissues have shown promise, but the former

246 m cells are widely employed to create mature vascularized tissues in vitro.

247 port a method for bioprinting 3D cell-laden, vascularized tissues that exceed 1 cm in thickness and c

248 Signal in blood and highly vascularized tissues was evident over the first 24 h aft

249 endly composition of efficient, 3D models of vascularized tissues, and comparison of predictions with

250 of these structures poses a threat to highly vascularized tissues, such as the lungs.

251 enesis is essential for fluid homeostasis in vascularized tissues.

252 vivo, may aid in the regenerative repair of vascularized tissues.

253 s remarkable given the cornea's proximity to vascularized tissues.

254 imit the ability to print elastic and highly vascularized tissues.

255 "Accommodation" refers to a vascularized transplant that has acquired resistance to

256 d nutrients is restricted, such as in poorly vascularized tumor areas.

257 Vascularized tumor growth is characterized by both abnor

258 erating and necrotic cell populations during vascularized tumor growth, and the associated extra- and

259 mor and progressing through angiogenesis and vascularized tumor growth.

260 tor deprivation characteristic of the poorly vascularized tumor microenvironment and has aided in the

261 L (von Hippel-Lindau) that leads to a highly vascularized tumor microenvironment.

262 Vascularized tumor models are created to mimic key steps

263 tumor burden (VTB), a measure of the area of vascularized tumor on computed tomographic (CT) images,

264 , colonization was most pronounced in poorly vascularized tumor regions.

265 These 3D vascularized tumor tissues provide a proof-of-concept pl

266 amics to simulate chemotherapy with the same vascularized tumor under different vascular pathologies.

267 Metastatic melanoma, a highly vascularized tumor with strong expression of vascular en

268 KS is a highly disseminated and vascularized tumor.

269 tive tumors and vascular defects, as well as vascularized tumors and juvenile nasopharyngeal angiofib

270 In clinical specimens of cancer, less vascularized tumors exhibited lower microvascular expres

271 expression in a manner with smaller and less vascularized tumors in vivo.

272 xpression with the net consequence of poorly vascularized tumors in vivo.

273 l fluid pressurization and ECM remodeling in vascularized tumors is well characterized, while earlier

274 surgery, the control rats had large, highly vascularized tumors that contained proliferating cells.

275 at form rapidly growing, invasive and highly vascularized tumors, as compared with non-stem cancer ce

276 Importantly, loss of TAp73 results in highly vascularized tumors, as well as an increase in vessel pe

277 ced their tumorigenicity and produced highly vascularized tumors, suggesting the importance of this c

278 on type of kidney cancer and it forms highly vascularized tumors.

279 formation of aggressive, invasive and highly vascularized tumors.

280 multiforme (GBM) cells, known to form highly vascularized tumors.

281 Given that MSCs are recruited within vascularizing tumors and are believed to contribute to t

282 abolism to promote cell survival in a poorly vascularized tumour microenvironment.

283 ofound survival advantage to cells in poorly vascularized tumour regions.

284 and an IFNgamma-GFP fusion protein in large, vascularized tumours growing in mice that express the IF

285 bility and organ-specific functions of eight vascularized, two-channel organ chips (intestine, liver,

286 ses the proportions of oxidative and densely vascularized type IIA and IIX myofibers and decreases gl

287 myofibers and decreases glycolytic and less vascularized type IIB myofibers.

288 resulted in larger, more fibrotic and higher vascularized venous thrombi.

289 Given that liver is highly vascularized, we reasoned that fluctuations in oxygenati

290 fer, the engineered muscle flaps were highly vascularized, were well-integrated within the surroundin

291 cing antiangiogenic genes and RCC are highly vascularized, which suggests that p53 is inactive in the

292 )CD44(+)) and were less invasive than tumors vascularized with control endothelial cells.

293 In vivo, tumor xenografts vascularized with EGF-silenced endothelial cells exhibit

294 rs formed by CD14-high cells are more highly vascularized with higher myeloid cell infiltration.

295 Epithelial tumors were highly vascularized with tight cell-cell junctions, compared wi

296 R26R-EYFP mice generated a plug that became vascularized within 5 days.

297 An initial rejection of transplanted vascularized xenograft is attributed to Galalpha1,3Galbe

298 iforme (GBM) tumors are highly metabolic and vascularized, yet little has been reported regarding the

299 Ultimately, these cells form the vascularized YS that functions in nutrient transfer to t

300 ct the boundary between the ischemic and the vascularized zones in this experimental model.

301 corresponding to the ischemic, marginal, and vascularized zones, respectively).