ライフサイエンスコーパス: vault

1 e of Jagged1 in the development of the skull vault.

2 ted with development of the face and cranial vault.

3 revealed 48-fold rotational symmetry for the vault.

4 ction and 48 copies of MVP forming each half vault.

5 ensity bands lining the inner surface of the vault.

6 persistent unossified areas within the skull vault.

7 ral ascension if introduced into the vaginal vault.

8 ed to form the central barrel portion of the vault.

9 than previously observed for the intact rat vault.

10 e fusion of 1 or more sutures of the cranial vault.

11 e in morphogenesis and growth of the cranial vault.

12 ttack, especially in those with greater lens vault.

13 lity, chondrodysplasia and loss of the skull vault.

14 nce tomography was performed to measure lens vault.

15 tial prion seeding activity lining the nasal vault.

16 ranslated vault RNA are also associated with vaults.

17 of vault-interacting proteins into preformed vaults.

18 s well as wild-type and TEP1-deficient mouse vaults.

19 s in their co-assembly into regularly shaped vaults.

20 reported as a protein that co-purifies with vaults.

21 The AUC for lens vault (0.816) and ACD (0.822) for detecting narrow angle

22 Synthesis of concave and vaulted 2H-pyran-fused BINOLs has been achieved.

23 serve a structural or organizing role in the vault, a particle with eight-fold symmetry.

24 Purified vaults also contain the poly(ADP-ribosyl)ation activity,

25 RNA and affected its stable association with vaults, although there were no telomerase-related change

26 ority of the bones of the vertebrate cranial vault and craniofacial complex develop via intramembrano

27 the frontal and parietal bones of the skull vault and deployment of the coronal (fronto-parietal) an

28 suture is a major growth center of the skull vault and develops at a boundary between cells derived f

29 systemic circulation, as well as the vaginal vault and intestinal lumen, with CCL20 playing a central

30 Lens vault and PCAL explained 76.8% of the variability in ACD

31 al characteristics similar to endogenous rat vaults and display the distinct vault-like morphology wh

32 gation into the link between upregulation of vaults and malignancy, the mechanism behind non-P-gp-med

33 pression system to form MVP-only recombinant vaults and performed a series of protein-mixing experime

34 we examine the local stiffness of individual vaults and probe their structural stability with atomic

35 Vaults and telomerase are ribonucleoprotein (RNP) partic

36 The sharing of the TEP1 protein between vaults and telomerase suggests that TEP1 may play a comm

37 omponent of two ribonucleoprotein complexes: vaults and telomerase.

38 nent of a ribonucleoprotein organelle called vault, and has been implicated in multiple drug resistan

39 halization and in supraorbital, neurocranial vault, and nuchal gracilization.

40 a, iris curvature, lens vault (LV), anterior vault, angle opening distance (AOD500, AOD750), and trab

41 area (TISA), iris area, iris curvature, lens vault, anterior chamber depth, and anterior chamber area

42 ith curvature (such as waisted nanotubes and vaulted architecture) and to develop novel methods for s

43 Vaults are 13 million Da ribonucleoprotein particles wit

44 Vaults are 13-MDa ribonucleoprotein particles composed l

45 Vaults are 13-MDa ribonucleoprotein particles with an in

46 The modified vaults are compatible with living cells.

47 ough their function has not been determined, vaults are found in nearly all eukaryotic cells.

48 Vaults are highly conserved ubiquitous ribonucleoprotein

49 Vaults are large cytoplasmic ribonucleoprotein complexes

50 Vaults are naturally occurring ovoid nanoparticles const

51 Mammalian vaults are ribonucleoprotein (RNP) complexes, composed o

52 Vaults are self-assembled ribonucleoprotein nanocapsules

53 Vaults are the largest (13 megadalton) cytoplasmic ribon

54 Vaults are the largest ribonucleoprotein particles found

55 The membranous bones of the mammalian skull vault arise from discrete condensations of neural crest-

56 y in a near-native state, and 3) reveal that vaults arrive early in macroautophagy.

57 The use of vaults as functional transporters requires a profound un

58 Understanding vault assembly will enable us to design agents that disr

59 To gain insight into the mechanisms for vault assembly, we have expressed rat MVP in the Sf9 ins

60 hermore, we show that one substrate for this vault-associated PARP activity is the MVP.

61 The vault-associated small RNA, termed vault RNA (VR), is de

62 The central vault at 3 months was measured using optical coherence t

63 ctron microscopy (TEM) of negatively stained vaults at pH 6.5 and 3.4 confirmed the fluorescence spec

64 F candidate backfill cement, Nirex Reference Vault Backfill (NRVB), in a model system.

65 n of one or more of the sutures of the skull vault before the brain completes its growth, is a common

66 diazoacetate, B(OPh)(3), and a molecule of a vaulted biaryl ligand (VAPOL or VANOL).

67 solid-state structure and properties of the vaulted biaryl ligand VAPOL were investigated.

68 is method involves the reaction of a racemic vaulted biaryl ligand with one equivalent of BH(3).SMe(2

69 -mediated deracemization of the C2-symmetric vaulted biaryl ligands VANOL and VAPOL has been investig

70 the dynamic thermodynamic resolution of the vaulted biaryl ligands with this method in combination w

71 This method has been applied to 16 different vaulted biaryl ligands, including 10 whose preparation i

72 an alternative method for the resolution of vaulted biaryls has been developed.

73 s prepared from triphenylborate and both the vaulted binaphthol (VANOL) and vaulted biphenanthrol (VA

74 and both the vaulted binaphthol (VANOL) and vaulted biphenanthrol (VAPOL) ligands.

75 nd fluorescent properties on the recombinant vaults, both of which can be detected by their emission

76 ce normalized many dimensions of the cranial vault, but did not correct all craniofacial anatomy.

77 e central stem and the lateral struts of the vault cartilages.

78 TNFalpha injected over the calvarial vault caused a greater increase in osteoclast number, os

79 , resulted in their sequestration within the vault cavity.

80 ter biologically active materials within the vault cavity.

81 posterior-frontal suture (PF) of the cranial vault closes through endochondral ossification, while ot

82 Eyes with narrow angles had greater lens vault compared to eyes with open angles (775.6 microm vs

83 (MVP) is the primary component of the 13 MDa vault complex.

84 lysis and its association with the canonical vault component TEP1.

85 ing of the specimen's well preserved cranial vault confirms that Aegyptopithecus had relatively unexp

86 (QCM) as tools in investigating recombinant vault conformational change in response to a varied solu

87 The mammalian skull vault consists of several intricately patterned bones th

88 nes from the mandible and the expanded brain vault could be correlated.

89 accompanied by structural adjustments to the vault, cranial base, and face.

90 Glenoid morphology (version, vault depth, erosion), injury or disease (osteoarthritis

91 The flat bones of the vertebrate skull vault develop from two migratory mesenchymal cell popula

92 Anomalies in skull vault development are relatively common in humans.

93 At the onset of skull vault development, these mesenchymal cells emigrate from

94 M findings by providing visual evidence that vaults disassemble into halves as the solution pH is low

95 Identification of conditions for reversible vault disassembly and reassembly could enable applicatio

96 This result prompted the hypothesis that vaults dissociate at least partially at low pH.

97 self-assembled monolayers, data that suggest vault dissociation at low pH, even when the vault is in

98 have suggested pH as a parameter to control vault dynamics.

99 removed, inconsistent with suggestions that vaults either act to prevent the drug from entering the

100 VPARP and TEP1 are able to incorporate into vaults even after the formation of the MVP vault particl

101 The face and cranial vault evolve faster than other regions, showing several

102 , the temporomandibular joint, and the brain vault evolved incrementally through mammaliaform evoluti

103 H 3.4 compared to that at pH 6.5, suggesting vaults exhibit a more open conformation at low pH.

104 features on neuroimaging and during cranial vault expansion were included.

105 environment highest in lactate, the cranial vault, expressed high levels of lactate importers, harbo

106 here is a pronounced rounding of the cranial vault, extension of the mandible beyond the maxilla, and

107 olumetric loss of ~0.11% of the intracranial vault for each daily drink (0.25 g/kg), and selective vu

108 The bones of the mammalian skull vault form through intramembranous ossification.

109 will enable us to design agents that disrupt vault formation and hence aid in elucidating vault funct

110 shift of associated vRNA, demonstrating that vault formation is limited by expression of MVP or the m

111 exquisitely balanced to ensure proper skull vault formation.

112 estimates of the long-term effect of cranial vault fractures on the risk of dying have been generated

113 FP) from the jellyfish Aequorea victoria has vaulted from obscurity to become one of the most widely

114 vault formation and hence aid in elucidating vault function in vivo.

115 how that the barrel, the central part of the vault, governs both the stiffness and mechanical strengt

116 xc1 results in a dramatic reduction in skull vault growth and causes an expansion of Msx2 expression

117 On multivariate analysis, subjects with lens vault >667.6 microm were more likely to have narrow angl

118 Recently, assembly of recombinant vaults has been established in insect cells expressing o

119 In humans, vaults have been implicated in multidrug resistance duri

120 Vaults have been implicated in multidrug resistance of h

121 e TEP1 is a component of the vault particle, vaults have no detectable telomerase activity.

122 Mammalian vaults have two high molecular mass proteins of 193 and

123 The vault height (distance between the posterior ICL surface

124 Additionally, a shallow palatal vault height (PVH) was associated with a higher leakage

125 A smaller vault height was associated with the development of lens

126 ve an absence of flat bones within the skull vault, hypertelorism, open-bite malocclusion, cleft pala

127 e affected by factors outside of the cranial vault in addition to the local effects of the TBI.

128 e craniofacial phenotypes, including cranial vault in adult Ts65Dn mice.

129 tidrug resistance supports a direct role for vaults in drug resistance.

130 gp-mediated drug resistance, and the role of vaults in human cells.

131 microm vs 438.56 microm, P < .001), and lens vault increased significantly with age (P for trend <.00

132 s in defects in the development of the skull vault indicating Tgfbr2 has a critical role in intramemb

133 of selective mortality on males with cranial vault injuries who survived long enough for bones to hea

134 The vault-interacting domain of vault poly(ADP-ribose)-polym

135 a possible mechanism for in vivo assembly of vault-interacting proteins into preformed vaults.

136 bility analysis and spectroscopic studies of vault-interacting proteins were used to confirm this res

137 Finally, this study suggests that the vault interior may functionally interact with the cellul

138 exogenous proteins from interacting with the vault interior.

139 The vault is a highly conserved ribonucleoprotein particle f

140 vault dissociation at low pH, even when the vault is in an adsorbed state, were also obtained.

141 However, mouse models in which the vaginal vault is inoculated with C. trachomatis do not recapitul

142 important cellular role, the function of the vault is unknown.

143 Although the precise function of vaults is unknown, their wide distribution and highly co

144 ar body length (r = 0.68; p < 0.01), cranial vault length (r = -0.57; p < 0.05), and the mandibular s

145 ifferences (p < 0.05) were noted for cranial vault length, maxillary length, mandibular body length,

146 500, TISA-500), anterior chamber angle, lens vault, lens thickness, anterior chamber depth (ACD), and

147 n the absence or after resolution of cranial vault lesions, and once the primary tumor is resected, P

148 of FDG blocked PET visualization of cranial vault lesions.

149 dogenous rat vaults and display the distinct vault-like morphology when negatively stained and examin

150 CI: 1.070-4.526) compared to those with lens vault </=462.7 microm.

151 release rate of biomolecular cargo from the vault lumen is related to the interaction between MVP an

152 a shuttle to pack biomolecular cargo in the vault lumen.

153 ea (ACA) (P < .001), as well as greater lens vault (LV) (P = .007), compared with fellow eyes.

154 curvature (I-Curv), iris area (I-Area), lens vault (LV), and angle opening distance (AOD750), trabecu

155 ckness (IT), iris area, iris curvature, lens vault (LV), anterior vault, angle opening distance (AOD5

156 including anterior chamber depth (ACD), lens vault (LV), iris curvature (IC), anterior chamber width,

157 me (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and

158 el ocular biometric parameters, such as lens vault (LV), posterior corneal arc length (PCAL), and iri

159 width, and area (ACD, ACW, and ACA) and lens vault (LV).

160 ACD), anterior chamber width (ACW), and lens vault (LV).

161 erior chamber area (ACA, R(2)=0.49) and lens vault (LV, R(2)=0.47); for AOD750, these were LV (R(2)=0

162 rea, volume, and width [ACA, ACV, ACW], lens vault [LV], iris thickness at 750 mum from the scleral s

163 al features present in the face and anterior vault, many of which are related to the masticatory appa

164 Higher lens vault may play a role in the development of an acute att

165 purification and intracellular distribution, vaults may be involved in the nucleocytoplasmic transpor

166 One month after surgery, vault measurements correlated with TIA (R = -.309; P = .

167 N termini interacting non-covalently at the vault midsection and 48 copies of MVP forming each half

168 une the release of molecular cargos from the vault nanoparticles, we determined the interactions betw

169 es, is a developmental disorder of the skull vault, occurring in approximately 1 in 2250 births.

170 was evaluated by applying it to the vaginal vault of macaques (n = 4) 15 min before each weekly expo

171 determine the structure of nine recombinant vaults of various composition, as well as wild-type and

172 Using the QCM to study adsorption of the vault onto self-assembled monolayers, data that suggest

173 leaping towards a vertical surface by first vaulting onto an obstacle with variable traction to indu

174 rior chamber depth, iris curvature, and lens vault (P </= 0.002 for all).

175 = 0.77), lens thickness (P = 0.44), or lens vault (P = 0.053).

176 sociation of the vault RNA with the purified vault particle and also resulted in a decrease in the le

177 te that the protein shell of the recombinant vault particle is a dynamic structure and suggest a poss

178 stable association of the vault RNA with the vault particle is dependent on its interaction with the

179 o vaults even after the formation of the MVP vault particle shell is complete.

180 protein is not entirely associated with the vault particle, suggesting that it may interact with oth

181 e show that while TEP1 is a component of the vault particle, vaults have no detectable telomerase act

182 d entire exterior shell of the barrel-shaped vault particle.

183 also sufficient to target the protein to the vault particle.

184 100/MVP) and a small RNA comprise the 13-MDa vault particle.

185 tion and recruitment of the vault RNA to the vault particle.

186 As both the function of vault particles and the mechanism of drug resistance in

187 Vault particles are naturally occurring proteinaceous ca

188 ultidrug-resistant cell lines, the levels of vault particles have not been investigated.

189 Sedimentation measurements of vault particles in multidrug resistance cells have indee

190 nitor the structural evolution of individual vault particles while changing the pH in real time.

191 The ability to engineer vault particles with designed properties and functionali

192 ilize the barrel region, the central part of vault particles, and leads to the aggregation of the cag

193 ange of pHs on the stability and dynamics of vault particles.

194 These data suggest that vaults play no direct role in the MDR phenotype in non-s

195 Vault poly(ADP-ribose) polymerase (VPARP) and telomerase

196 s composed of the major vault protein (MVP); vault poly(ADP-ribose) polymerase (VPARP); telomerase-as

197 The vault-interacting domain of vault poly(ADP-ribose)-polymerase (INT) has been used as

198 separately, abdominal mesh repair of vaginal vault prolapse compared with vaginal non-mesh repair.

199 approach for treatment of uterine or vaginal vault prolapse following hysterectomy.

200 al and abdominal mesh procedures for vaginal vault prolapse repair are associated with similar effect

201 een considered the gold standard for vaginal vault prolapse repair for several decades.

202 que for the treatment of symptomatic vaginal vault prolapse that is rapidly gaining popularity among

203 rectocele, uterine prolapse, enterocele and vault prolapse.

204 The 100-kD major vault protein (MVP) accounts for >70% of the particle ma

205 ound that B7-H3 is associated with the major vault protein (MVP) and activates MEK through MVP-enhanc

206 rotein particles primarily composed of major vault protein (MVP) are highly expressed in cells that e

207 urification method, we have identified major vault protein (MVP) as a novel interacting partner for C

208 trate-trapping mutants to identify the major vault protein (MVP) as a putative SHP-2 substrate.

209 The 100-kDa major vault protein (MVP) constitutes approximately 75% of the

210 The human major vault protein (MVP) is the primary component of the 13 M

211 NLS mutant PTEN did not interact with major vault protein (MVP), a previously hypothesized nuclear-c

212 copies of a single protein, termed the major vault protein (MVP), is sufficient to form the minimal s

213 ion signal-like sequences required for major vault protein (MVP)-mediated nuclear translocation.

214 miR-193a interacts with major vault protein (MVP).

215 that is composed of multiple copies of major vault protein (MVP).

216 haped structure and is composed of the major vault protein (MVP); vault poly(ADP-ribose) polymerase (

217 entified a partial cDNA encoding the 240-kDa vault protein and determined it is identical to the mamm

218 We have identified the 193-kD vault protein by its interaction with the MVP in a yeast

219 a novel role for TEP1 in vivo as an integral vault protein important for the stabilization and recrui

220 crotubule preparations, the sea urchin major vault protein is not predominantly microtubule-associate

221 The expression of the unique 100-kDa major vault protein is sufficient to form the basic vault stru

222 In addition, the vault protein localizes to short linear strings juxtapos

223 d largely of a 104-kDa protein, termed major vault protein or MVP, and a small vault RNA, vRNA.

224 omain-containing protein (TbArmtor), a major vault protein, and LST8 to form a unique TOR complex, Tb

225 of multiple copies of three proteins (major vault protein, VPARP, and TEP1) and an untranslated RNA.

226 )-like sequences that are required for major vault protein-mediated nuclear import.

227 s occur along the contacts between two major vault proteins and disappear over time.

228 ion of MVP with one or both of the other two vault proteins results in their co-assembly into regular

229 is limited by expression of MVP or the minor vault proteins.

230 Although vaults purified from the livers of mTep1(-/-) mice appea

231 of craniosynostosis require complex cranial vault reconstruction that is associated with a high risk

232 ere viable, fertile, and did not display any vault-related or telomerase-related phenotype, whereas d

233 erefore do not clearly favour any particular vault repair procedure.

234 which serve as growth centers for the skull vault, result in craniosynostosis.

235 dimensional reconstruction of the mTep1(-/-) vault revealed less density in the cap than previously o

236 The vault ribonucleoprotein (RNP), comprising vault RNA (vtR

237 iated protein 1 (TEP1) are components of the vault ribonucleoprotein complex.

238 Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one o

239 La interacts with the vault RNA (both in vivo and in vitro) presumably through

240 The vault-associated small RNA, termed vault RNA (VR), is dependent upon TEP1 for its stable as

241 Vault RNA (vRNA) genes have been cloned from several ver

242 he vault ribonucleoprotein (RNP), comprising vault RNA (vtRNA) and telomerase-associated protein 1 (T

243 s a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its ass

244 in 1 in mice led to reduced stability of the vault RNA and affected its stable association with vault

245 ns, VPARP and TEP1, and a small untranslated vault RNA are also associated with vaults.

246 equences from the 7SL RNA gene, U6 RNA gene, vault RNA gene, and BC1 gene increase transcription of A

247 We find that a portion of the vault RNA is complexed with the La autoantigen in a sepa

248 for the stabilization and recruitment of the vault RNA to the vault particle.

249 (5)C deposition into the abundant non-coding vault RNA VTRNA1.1.

250 tely disrupted the stable association of the vault RNA with the purified vault particle and also resu

251 we have shown that stable association of the vault RNA with the vault particle is dependent on its in

252 rmed major vault protein or MVP, and a small vault RNA, vRNA.

253 entify other proteins that interact with the vault RNA, we used a UV-cross-linking assay.

254 decrease in the levels and stability of the vault RNA.

255 ces the steady-state and p62-bound levels of vault RNA1-1 and induces autophagy.

256 we show that a 106-nucleotide noncoding RNA vault RNA2-1 (vtRNA2-1), previously misannotated as miR8

257 rmines the processing of VTRNA1.1 into small-vault RNAs (svRNAs).

258 Vault RNAs (vtRNA) are small non-coding RNAs transcribed

259 Here, we found that vault RNAs (vtRNAs) were greatly induced in A549 cells a

260 several host RNAP III transcripts, including vault RNAs and Alu transcripts.

261 Here, we show that vault RNAs directly bind the autophagy receptor sequesto

262 telomerase RNA and with several of the human vault RNAs in a yeast three-hybrid assay.

263 -15b~16-2 and highly structured RNAs such as vault RNAs is RanGTP-independent.

264 Vault RNAs, found in vault ribonucleoprotein complexes,

265 ncRNA species, including tRNAs, Y RNAs, and Vault RNAs.

266 to certain geometric constraints, might help vaults safely pass through the nuclear pore complex and

267 s in the intrinsic fluorescence intensity of vaults showed a 60% increase at pH 3.4 compared to that

268 Twist function causes a foramen in the skull vault similar to that caused by loss of Msx2 function.

269 ns reflect the breadth of the skull, cranial vault size and shape, and aspects of nasal morphology.

270 ching studies provided further evidence of a vault structural change at low pH.

271 ault protein is sufficient to form the basic vault structure.

272 as LV greater than one-third of the anterior vault (sum of LV and ACD), was present in 61.5% of the c

273 he transvaginal uterosacral ligament vaginal vault suspension is increasingly our procedure of choice

274 The uterosacral ligament vault suspension is the most anatomic of the repairs and

275 here are proponents for uterosacral ligament vault suspension, iliococcygeus and sacrospinous ligamen

276 sis cases, but most studies focus on cranial vault sutures.

277 The observation that vault synthesis is linked directly to multidrug resistan

278 are unknown, we decided to determine whether vault synthesis was coupled to MDR.

279 indeed revealed up to a 15-fold increase in vault synthesis, coupled with a comparable shift of asso

280 Attachment of a vault-targeting peptide to two proteins, luciferase and

281 Women had significantly greater lens vault than men (497.28 microm vs 438.56 microm, P < .001

282 MVP is the predominant component of vaults that are cytoplasmic ribonucleoprotein complexes

283 unction plays in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.

284 improvement in SFC that has the potential to vault their performance to levels of similar reproducibi

285 es as the sphenoid bone connects the cranium vault to the facial bones.

286 er protein or non-protein coding genes, have vaulted to prominence.

287 Lens vault was defined as the perpendicular distance between

288 The vaginal vault was exteriorized as a stoma in the lower right abd

289 Lens vault was highest in AACG eyes, followed by fellow eyes,

290 Lens vault was independently associated with narrow angles an

291 and endochondral ossification of the cranial vault were delayed in the mutant embryos, and cranial bo

292 lations with ocular variables including lens vault were examined.

293 sition were less and lens thickness and lens vault were greater in angle-closure than open-angle eyes

294 , significant associations with greater lens vault were shorter axial length, shallower anterior cham

295 Vaults were also seen in these structures, consistent wi

296 occurring cellular nanoparticle known as the vault, which is named for its morphology with multiple a

297 nt upon TEP1 for its stable association with vaults, while the association of telomerase RNA with the

298 Reconstruction of a recombinant vault with a cysteine-rich tag revealed 48-fold rotation

299 posed for the organization of MVP within the vault with all of the MVP N termini interacting non-cova

300 Recombinant vaults with MVP N-terminal peptide tags showed internal