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4 igated embryonic asymmetry along both animal-vegetal and dorsal-ventral axes during early stages of d
5 doderm- and mesoderm-inducing signals to the vegetal and marginal zones of the pre-gastrula Xenopus l
6 during oogenesis ensures its inheritance by vegetal and not animal cells, and directs the differenti
10 ost alkyl substituted pyrazines include mild vegetal aromas, not necessarily undesirable for the cork
12 osed pronuclei align obliquely to the animal-vegetal axis after ICSI, with asymmetric furrows assembl
13 is now evident that patterning in the animal/vegetal axis also needs to be taken into consideration.
14 patterning the mesendoderm along the animal-vegetal axis and indicate that dorsal and ventrolateral
15 mbryo, including establishment of the animal-vegetal axis as it relates to formation of the dorsovent
16 l cell divisions that occur along the animal/vegetal axis beginning early in embryogenesis, but not a
17 avage planes do not coincide with the animal-vegetal axis but rather form approximately 45 degrees of
18 the embryo and away from the initial animal-vegetal axis defined by the starting location of the bla
20 asymmetries are established along the animal-vegetal axis during oogenesis, but the underlying molecu
24 patterning because they subdivide the animal-vegetal axis into tiers of cells with different developm
27 e animal kingdom establish a primary, animal-vegetal axis maternally, and specify the remaining two a
28 s must be tightly regulated along the animal-vegetal axis of the early sea urchin embryo to allow bet
32 ectoderm-endoderm boundary along the animal-vegetal axis of the sea urchin embryo remain largely unk
38 of polar body formation sets up a new animal-vegetal axis that organizes cleavage and the segregation
39 pendent processes operating along the animal-vegetal axis, as evidenced by an expansion of SpNK2.1 ex
40 n of 2- to 4-cell divisions along the animal-vegetal axis, can affect the second step, the establishm
41 is established at right angles to the animal-vegetal axis, in contrast to hemichordates and indirect-
42 derm boundary more animally along the animal-vegetal axis, whereas expression of a dominant negative
43 PK) activation is polarized along the animal/vegetal axis, with the Xnr2-expressing cells in the vege
51 rtant, both in terms of comprehension of the vegetal biochemistry and as basis for sterolomic studies
52 s made evident by the expression of Sox17 in vegetal blastomeres and Brachyury (Xbra) in marginal bla
53 n, beta-catenin accumulates in the nuclei of vegetal blastomeres and controls endomesoderm specificat
55 ipped orthologue expressed very early in all vegetal blastomeres and then gradually shifting to veg(1
56 ion of endogenous VegT and/or Vg1 in ventral vegetal blastomeres can induce a neural fate, but only a
57 t to contribute cells to the retina; ventral vegetal blastomeres do not form retina even when provide
58 The mesendoderm (ME) cells are the two most vegetal blastomeres in the early developing embryo of th
59 lium that undergoes epiboly and in the large vegetal blastomeres that gradually become internalized.
60 ntal defects of chimaeras made from the most vegetal blastomeres that result from later second cleava
69 s increased bioavailability generated by the vegetal cell disruption and the release of the bioactive
71 his factor suppresses differentiation of all vegetal cell types, a phenotype that is very similar to
72 the region of xCR1 mRNA sufficient to confer vegetal cell-specific repression contained both Pumilio
75 red for the stabilization of beta-catenin in vegetal cells and provide evidence that Dsh undergoes a
76 the endogenous mesoderm inducing activity of vegetal cells before gastrulation; and third, it has sub
77 cient to impair sorting of animal cells from vegetal cells but is not sufficient (at similar doses) t
83 be the mesoderm-inducing signal released by vegetal cells, but its function in vivo has never been r
84 herited as a maternal mRNA localized only in vegetal cells, VegT activates the transcription of a lar
85 s, Vg1 and Bicaudal-C, are also inherited by vegetal cells, while germ plasm-associated mRNAs, such a
90 o obvious polarization yet, then the meiotic-vegetal center forms at zygotene bouquet stages, when sy
91 n the available plant species and associated vegetal components, members of the Kasekela community se
93 mRNA caused the release of Vg1 mRNA from the vegetal cortex and a reduction of Vg1 protein, without a
94 ther is not clear, but RNAs localized to the vegetal cortex during oogenesis are known to be essentia
96 required for localization of Vg1 mRNA to the vegetal cortex during the late RNA localization pathway.
99 Xenopus depends on rearrangements of the egg vegetal cortex following fertilization, concomitant with
104 otrimeric kinesin II becomes enriched at the vegetal cortex of stage III/IV Xenopus oocytes concomita
105 Prrp and Vg1 mRNAs are co-localized to the vegetal cortex of stage IV oocytes, substantiating an in
108 es mRNA and protein are both detected at the vegetal cortex of the oocyte; however, the protein is de
116 us laevis, several RNAs that localize to the vegetal cortex via one of three temporally defined pathw
117 Vg1 mRNA, VgRBP71 does not accumulate at the vegetal cortex with the mRNA; rather, it is present in t
118 rtical recruitment and binding of AGS to the vegetal cortex, contributing to formation of micromeres
119 dependent on VegT mRNA for anchoring to the vegetal cortex, indicating a novel function for maternal
120 lation of microtubules with plus ends at the vegetal cortex, supporting roles for these kinesin motor
127 ecular mechanisms governing the formation of vegetal cortical microtubule arrays are not fully unders
130 regions of the protein that are required for vegetal cortical targeting, including a phospholipid-bin
131 certified sulphur concentrations of various vegetal CRM samples applying linear calibration techniqu
132 enopus oocyte, Vg1 RNA is transported to the vegetal cytoplasm, where localized expression of the enc
135 unique opportunity to study mid-Pleistocene vegetal diet and is crucial for understanding subsistenc
136 est that RNA movement in both the animal and vegetal directions may influence the timescale of RNA lo
138 iptors of Malbec wines were aromas of cooked vegetal, earthy, soy and volatile acidity, as well as ac
139 ng of cell fates along the sea urchin animal-vegetal embryonic axis requires the opposing functions o
143 we provide three lines of evidence that two vegetal-enriched maternal factors (VegT, Vg1), which are
145 ryos, pigmented immunocytes are specified in vegetal epithelium, transition to mesenchyme, migrate, a
146 or screening of thiols in plants, using four vegetal examples and beginning with HPLC-MS/MS in precur
147 that the formation of mesoderm cells by the vegetal explants accounts for the apparent autonomous de
156 uphorbia resin, and possibly egg, wrapped in vegetal fibers, dated to approximately 40,000 BP, may ha
158 Smad1/5 linker region localizes to a ventral vegetal gastrula region that could coordinate DV pattern
159 gene is expressed maternally in an animal to vegetal gradient, and its expression levels decline rapi
162 mesoderm tissue specification process in the vegetal half of the early sea urchin embryo using Boolea
163 plasm, initially distributed throughout the vegetal half of the egg cortex, move to the vegetal pole
165 activity is uniformly distributed across the vegetal half of the Xenopus blastula and that this activ
166 al differentiation, while the ability of the vegetal half to regulate by forming apical lobe structur
169 organization started with the contraction of vegetal hemisphere approximately 20 s after the fertiliz
170 cence in Xenopus oocytes was stronger in the vegetal hemisphere because of localization of internal s
171 inductive interaction in which cells of the vegetal hemisphere of the embryo act on overlying equato
172 RNA localized to the mitochondrial cloud and vegetal hemisphere of the oocyte; second, it is required
173 meobox-containing genes are expressed in the vegetal hemisphere of the Xenopus embryo at the early ga
175 vity of a network of regulatory genes in the vegetal hemisphere, called the endomesoderm gene regulat
176 laterally aligned cortical actomyosin in the vegetal hemisphere, which in turn generates the directio
177 ed actin filaments at the cell cortex of the vegetal hemisphere, which ran perpendicular to the anima
179 va (JRE) showed higher percentage of 'grassy-vegetal' impact odorants, while 'spicy' compounds highli
181 case of the equal-cleaving molluscs, animal-vegetal inductive interactions between the derivatives o
182 aying a role in the development of posterior/vegetal larval fates (i.e., endoderm) in C. lacteus.
183 rates the oral from aboral ectoderm; (3) the vegetal lateral CB, which bilaterally serves as signalin
185 t block this remodeling event also eliminate vegetal localization of the RNA, suggesting that RNP rem
186 mitted to endoderm through the action of the vegetal localized maternal transcription factor VegT.
189 between the progeny of animal micromeres and vegetal macromeres are established during the interval b
190 ives of the first quartet micromeres and the vegetal macromeres specify which macromere becomes the 3
191 ters and BRS Violeta wines were described as vegetal mainly due to the higher concentration of terpen
192 axis, with the Xnr2-expressing cells in the vegetal marginal zone having no detectable activated MAP
193 in totipotent while surrounding cells in the vegetal mass become committed to endoderm through the ac
195 s signaling ligands that induce cells in the vegetal mass to form endoderm, and the marginal zone to
198 In the current study, we determined that the vegetal maternal dorsal determinant in fish is not the W
199 ur-cell stage blastomeres that inherits some vegetal membrane marked in the previous cleavage cycle t
200 , Mkif5Ba promotes formation of the parallel vegetal microtubule array required to asymmetrically pos
202 d became localized to the nuclei of the four vegetal-most cells at the 64-cell stage, which give rise
203 rms that Notch functions sequentially in the vegetal-most secondary mesenchyme cells and later in the
208 whereas 1-octen-3-one and one unknown spicy-vegetal odorant were highly correlated to the maturation
209 rmulation are powdered milk, peanuts butter, vegetal oil, sugar, and a mix of vitamins, salts, and mi
210 uable extra-virgin olive oils from the other vegetal oils (canola, corn, grape seed, linseed, olive p
212 ssociated with mRNAs localized to either the vegetal or animal hemispheres, but was not found with co
213 lly serves as signaling centers; and (4) the vegetal oral CB, which delineates the boundary with the
214 lastomeres with the ability to function as a vegetal organizing center and to coordinate the developm
217 ation during gastrulation and overall animal-vegetal patterning at earlier stages of anthozoan develo
218 OX3c-injected Xenopus embryos, normal animal-vegetal patterning of mesodermal and endodermal markers
219 xamined the possible dorsoventral and animal-vegetal patterning roles for Nodal signals by using muta
220 en a transplanted micromere is placed at the vegetal plate after removing all 4 host micromeres, the
221 elopment for the activation of endo16 in the vegetal plate and for the activation of spec2a in the ab
225 vo transcripts, however, are enriched in the vegetal plate of the mesenchyme blastula stage and Sp-va
228 tion of the central mesodermal domain of the vegetal plate; and they exclusively give rise to the ske
229 roperties of 1d all depend on inheritance of vegetal polar lobe cytoplasm by its mother cell D at sec
231 minants (mRNAs) are first transported to the vegetal pole a few minutes after fertilization and then
232 thway, recruits endogenous kinesin II to the vegetal pole and colocalizes with it at the cortex.
233 nal blastomeres failed to migrate toward the vegetal pole and epiboly did not occur, a phenotype simi
234 were novel mRNAs over 4-fold enriched at the vegetal pole and six were over 10-fold enriched at the a
239 subset of the GRN connections in the central vegetal pole mesoderm of the late sea star blastula and
240 pe is rescued by axin mRNA injected into the vegetal pole of axin-depleted oocytes before fertilizati
245 vegetal half of the egg cortex, move to the vegetal pole of the egg, fusing with each other as they
247 enesis a maternal factor is localized to the vegetal pole of the oocyte that is a determinant of dors
249 Vg1 LE (VgLE) direct this transcript to the vegetal pole of Xenopus oocytes via the binding of a pro
251 is to comprehensively interrogate animal and vegetal pole RNAs in the fully grown Xenopus laevis oocy
252 propose potential pathways operating at the vegetal pole that highlight where future investigations
253 eterminants, which are translocated from the vegetal pole to the future dorsal side of the embryo sho
254 ent of maternal dorsal determinants from the vegetal pole to the future dorsal side of the embryo, pr
255 ic mesoderm are co-expressed in the sea star vegetal pole, although this territory does not form a la
256 s are selectively localized to the animal or vegetal pole, including determinants of somatic and germ
262 validating the approach by recovering animal-vegetal-pole proteomic asymmetry in the frog zygote, the
263 a-catenin levels, to adopt the fate of their vegetal-pole sisters, which normally have high nuclear b
264 in beta-catenin half-life at the animal and vegetal poles of the early embryo is sufficient to produ
265 doderm formation more animally, while in the vegetal portion, LvNotch signaling also promotes the ect
267 ow that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity
268 find that Fgf activity is required to induce vegetal prospective neural markers and can do so without
269 Because meat is more resource intensive than vegetal protein sources, replacing it with efficient pla
270 etal region is the site of gastrulation; the vegetal region forms the ectoderm of the ventral and pos
271 lity to form apical lobe ectoderm, while the vegetal region has the ability to form a normal larva.
273 todermal covering of the apical lobe and the vegetal region is the site of gastrulation; the vegetal
275 evidence that LvDsh is active locally in the vegetal region of the embryo but is inactive in animal b
277 l blood islands and primitive blood from the vegetal region of the marginal zone in regularly cleavin
278 gest that endogenous maternal factors in the vegetal region repress the ability of blastomeres to for
279 o, and (2) a cell non-autonomous role in the vegetal region that regulates a signal(s) mediating ecto
280 e localized oocyte markers are expanded into vegetal regions in bucky ball mutants, but patterning wi
281 analyzed participation of kinesin motors in vegetal RNA transport and identified a direct role for X
287 sumptive endoderm is internalised as part of vegetal rotation, a large-scale movement that encompasse
289 certified reference materials and three real vegetal samples were employed for the quantitative deter
291 l embryo this protein suppresses the primary vegetal signaling mechanism that is required for specifi
292 onversely, SpKrl mRNA injection rescues some vegetal structures in beta-catenin-deficient embryos.
293 e zygote, is concentrated in both animal and vegetal teloplasm during stage 1 and is at higher levels
294 is known to be required for specification of vegetal tissues, because transcripts are undetectable in
295 rly cleavage stages, eomes is expressed in a vegetal to animal gradient in the embryo, whereas Eomeso
296 ractile ring of actin and myosin immediately vegetal to the blastoderm margin via Ca(2+) reduction or