ライフサイエンスコーパス: very long chain

1 and severity of neuropathy and the levels of very-long-chain 1-deoxyceramides such as C24 (P < 0.05),

2 romoter between the two human genes encoding very long chain acyl-CoA dehydrogenase (VLCAD) and posts

3 ferase, very long chain acyl-CoA synthetase, very long chain acyl-CoA dehydrogenase) in livers of the

4 re we provide evidence that in this organism very long chain acyl-CoA esters are hydrolyzed by the Px

5 raphy and demonstrated a 10-fold increase in very long chain acyl-CoA specific activity (C24:0/C16:0)

6 hibited markedly decreased expression of the very long chain acyl-CoA synthase-related gene (VLACSR),

7 cell extracts suggested that FATP1 exhibits very long chain acyl-CoA synthetase (ACS) activity and t

8 Members of the fatty acid transport protein/very long chain acyl-CoA synthetase (FATP/Acsvl) family

9 The very long chain acyl-CoA synthetase activity of the two

10 These results indicate that FATP1 is a very long chain acyl-CoA synthetase and suggest that a p

11 , liver carnitine palmitoyl-CoA transferase, very long chain acyl-CoA synthetase, very long chain acy

12 nthetase activity (C16:0), characteristic of very long chain acyl-CoA synthetases, whereas both mutan

13 The 11 long-chain (ACSL) and very long chain acyl-coenzyme A (acyl-CoA) synthetases [

14 in skin homeostasis, which may be due to its very long chain acyl-coenzyme A synthetase activity.

15 t exogenous long-chain fatty acids, and have very long-chain acyl CoA synthetase activities that were

16 The depression in very long-chain acyl CoA synthetase activities were not

17 Very long-chain acyl-CoA dehydrogenase (VLCAD) deficienc

18 though many patients have been found to have very long-chain acyl-CoA dehydrogenase (VLCAD) deficienc

19 Very long-chain acyl-CoA dehydrogenase (VLCAD) deficienc

20 long-chain acyl-CoA dehydrogenase (LCAD) and very long-chain acyl-CoA dehydrogenase revealed that 5-t

21 unsaturated acyl-CoAs are poor substrates of very long-chain acyl-CoA dehydrogenase when compared wit

22 , and deficiency of mitochondrial medium- or very long-chain acyl-CoA dehydrogenase.

23 ls suggest that, in contrast to yeast cells, very long-chain acyl-CoA esters are transported into per

24 s been associated with decreased peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity and

25 creased VLCFA beta-oxidation and peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity.

26 We reported previously that homolog 2 of very long-chain acyl-CoA synthetase (VLCS) can activate

27 LACS1 thus appears to function as a very long-chain acyl-CoA synthetase in wax metabolism.

28 A human homolog of very long-chain acyl-CoA synthetase, hVLCS-H2, has two r

29 002 is a prodrug that requires activation by very long-chain acyl-CoA synthetase-1 (ACSVL1) to modula

30 The family of proteins that includes very long-chain acyl-CoA synthetases (ACSVL) consists of

31 fatty acid transport proteins (FATP) and the very long-chain acyl-CoA synthetases (VLACS).

32 The most recently identified family is the very long-chain acyl-CoA synthetases (VLCS).

33 Other long- and very long-chain acyl-CoA synthetases were incapable of a

34 Very-long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes

35 specifically exhibit down-regulation of the very-long-chain acyl-CoA dehydrogenase (VLCAD) enzyme, w

36 Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a majo

37 Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a memb

38 trate specificity, it appears that ACAD9 and very-long-chain acyl-CoA dehydrogenase are unable to com

39 In three patients with very-long-chain acyl-CoA dehydrogenase deficiency, this

40 istribution and gene regulation of ACAD9 and very-long-chain acyl-CoA dehydrogenase identify the pres

41 Moreover, the FAO enzyme very-long-chain acyl-CoA dehydrogenase physically intera

42 function that is highly homologous to human very-long-chain acyl-CoA dehydrogenase was identified by

43 Gel filtration analysis indicated that, like very-long-chain acyl-CoA dehydrogenase, ACAD-9 is a dime

44 ACBP binds very-long-chain acyl-CoA esters, which is required for i

45 We generated very-long-chain acyl-coenzyme A dehydrogenase (VLCAD)-de

46 decreased ability of cells to activate (via very-long-chain acyl-coenzyme A synthetase [VLCS]) and s

47 ly hydrophobic compounds including saturated very-long-chain alkanes, ketones, and alcohols.

48 In summary, the CoA thioesters of very-long-chain and branched-chain fatty acids are much

49 ) is very similar to the multigene family of very long chain (C20-C26) acyl-CoA synthetases.

50 Very long chain (C22-C24) ceramides are synthesized by c

51 (N-palmitoyl sphingosine) and nonsaturated, very long chain C24:1 ceramide (N-nervonoyl sphingosine)

52 le of activating both long-chain (C16:0) and very long-chain (C24:0) fatty acids.

53 hat confluence caused selective increases in very long chain ceramide C(24:1) (370 +/- 54%) and C(24:

54 bases in blood, accompanied by increases in very long chain ceramide species, and have defective lym

55 d cellular levels of specific long-chain and very long-chain ceramide species relative to vector cont

56 nt with a significant reduction in long- and very-long-chain ceramide levels.

57 ivering a single dose of radiation, long and very-long-chain ceramide species, and the expression lev

58 f growth arrest on the increase in levels of very long chain ceramides.

59 Stress increased the amounts of long- and very long-chain ceramides in HEK293 cells, and this was

60 haCER1 catalyzed the hydrolysis of very long-chain ceramides to generate sphingosine (SPH).

61 terestingly, elevated levels of only certain very long-chain ceramides were evident in V5-aSMase(S508

62 Ablation of very-long-chain ceramides (Cers) with consecutive elevat

63 ication of several endogenous long-chain and very-long-chain ceramides using two nonphysiological odd

64 cluding C(24/25)-which are predominant among very-long-chain components.

65 s in the retina with special emphasis on the very-long-chain-containing saturated (VLC-FA) and polyun

66 the Gly-containing desaturase was capable of very-long-chain desaturation.

67 Typically very long chain diacetylene lipids formed gels in ethano

68 d seed coats with a severalfold reduction in very long chain dicarboxylic acid and omega-hydroxy fatt

69 carboxylase, inhibited only elongation into very long chain FAs (>or=20 carbons) but not synthesis o

70 ptor CD36 is required both for the uptake of very long chain FAs (VLCFAs) in cultured cells and the a

71 The elongases of very long chain fatty acid (ELOVL or ELO) are essential

72 ed to provide insight into the regulation of very long chain fatty acid (VLCFA) biosynthesis in Brass

73 letion of ALD gene (ABCD1) and the resultant very long chain fatty acid (VLCFA) derangement has drama

74 roxisomal transmembrane protein required for very long chain fatty acid (VLCFA) metabolism.

75 Utilizing the plasma very long chain fatty acid assay, supplemented by mutati

76 ese studies reveal roles for Rvs161p and the very long chain fatty acid elongase, Sur4p, in the local

77 sequence identity with previously identified very long chain fatty acid elongases.

78 ,3-enoyl-CoA reduction reactions in long and very long chain fatty acid elongation, respectively.

79 tly linked to the (omega-1)-hydroxy group of very long chain fatty acid in bradyrhizobial lipid A.

80 Although FATP4 deficiency primarily affected very long chain fatty acid metabolism, mutant fibroblast

81 etabolic pathways, ether lipid synthesis and very long chain fatty acid oxidation.

82 CoA synthetase that preferentially activates very long chain fatty acid substrates, such as C24:0, to

83 3-ketoacyl-CoA synthase which is involved in very long chain fatty acid synthesis in vegetative tissu

84 r C18:1, suggesting that in vivo, defects in very long chain fatty acid uptake may underlie the skin

85 oblasts, FATP4 is the major enzyme producing very long chain fatty acid-CoA for lipid metabolic pathw

86 the condensation of a long chain base with a very long chain fatty acid.

87 tachyzoites synthesized a range of long and very long chain fatty acids (C14:0-26:1).

88 cid elongases that catalyze the synthesis of very long chain fatty acids (C24 to C26) required for ce

89 n of VLCFA synthesizing enzymes, elongase of very long chain fatty acids (ELOVLs) (1 and 3) in both c

90 Abnormalities in the transport of saturated very long chain fatty acids (VLCFA; >C18:0) contribute t

91 adrenoleukodystrophy is the accumulation of very long chain fatty acids (VLCFAs) due to impaired per

92 lting in the inability to transport acylated very long chain fatty acids (VLCFAs) into the peroxisome

93 he bubblegum mutant shows elevated levels of very long chain fatty acids (VLCFAs), as seen in the hum

94 The assay of plasma very long chain fatty acids (VLCFAs), developed in our l

95 id elongase required for the biosynthesis of very long chain fatty acids (VLCFAs).

96 Elongation of very long chain fatty acids 4 (ELOVL4) is a novel member

97 ed in exon six of a gene named Elongation of very long chain fatty acids 4 (ELOVL4).

98 ed by mutations in the ELOVL4 (Elongation of very long chain fatty acids 4) gene.

99 receptor drives adults to convert lipids to very long chain fatty acids and hydrocarbons for an anti

100 Rather, dHNF4 directs their conversion to very long chain fatty acids and hydrocarbons, which wate

101 The very long chain fatty acids are crucial building blocks

102 Degradation of very long chain fatty acids decreased by 47% and resulte

103 S), the enzyme responsible for production of very long chain fatty acids of plant seed oils.

104 miR-219 and its target ELOVL7 (elongation of very long chain fatty acids protein 7) were identified a

105 In contrast, synthesis of very long chain fatty acids was primarily dependent on a

106 oil and fatty acid composition, accumulating Very Long Chain Fatty Acids with industrial applications

107 dehydratases are required for elongation of very long chain fatty acids, and HACD1 has a role in ear

108 lar endothelial cells causes accumulation of very long chain fatty acids, but much later than the imm

109 We found very long chain fatty acids, medium chain acylcarnitines

110 Elongation of very long chain fatty acids-4 (ELOVL4) has been identifi

111 in the expression of the gene elongation of very long chain fatty acids-like 2, an enzyme needed for

112 ulin-induced gene 2a, Insig2a, elongation of very long chain fatty acids-like 3, Elovl3 and sterol 12

113 A Met299Val variant in the elongation of very long chain fatty acids-like 4 (ELOVL4) gene was sig

114 haracterized by the abnormal accumulation of very long chain fatty acids.

115 activity, with an apparent preference toward very long chain fatty acids.

116 ormalities in these cells are not limited to very long chain fatty acids.

117 gation of a second stearate molecule to form very long chain fatty acids.

118 active on long chain fatty acids relative to very long chain fatty acids.

119 nounsaturated fatty acids and a reduction in very long chain fatty acids.

120 saturases, enzymes involved in elongation of very long chain fatty acids.

121 roteins that function in the biosynthesis of very long chain fatty acids.

122 kodystrophy protein, with an accumulation of very long chain fatty acids.

123 TmELO2 function to synthesize long chain and very long chain fatty acids.

124 in the ABCD1 gene leading to accumulation of very long chain fatty acids.

125 PpORS condenses a very long chain fatty acyl-CoA with four molecules of ma

126 ption mutant (DeltafoxA) was eliminated on a very long-chain fatty acid (C(22:1)), growth was only pa

127 classes on the stem and leaf, except in the very long-chain fatty acid (VLCFA) class wherein acids l

128 In this study, we investigated the roles of very long-chain fatty acid (VLCFA) synthesis by fatty ac

129 the elongase system of enzymes required for very long-chain fatty acid (VLCFA) synthesis.

130 nted the defects in fatty acid transport and very long-chain fatty acid activation associated with a

131 mBG1 appears to play a minor role in very long-chain fatty acid activation in these cells, in

132 transport protein 4 (FATP4), which each have very long-chain fatty acid acyl-CoA synthetase (VLCFA-AC

133 phingolipid pathway, such as deletion of the very long-chain fatty acid elongase, Sur4, suppress the

134 Very long-chain fatty acid levels were partially restore

135 other acyl-CoA synthetases are necessary for very long-chain fatty acid metabolism in Neuro2a cells.

136 and is capable of activating both long- and very long-chain fatty acid substrates.

137 f the ACC and elevation of the ceramides and very long-chain fatty acid syntheses with normal cell-cy

138 synthase that catalyzes the initial step of very long-chain fatty acid synthesis.

139 smembrane proteins that facilitate long- and very long-chain fatty acid uptake.

140 amily of six FATPs that facilitate long- and very long-chain fatty acid uptake.

141 Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated wit

142 , which is responsible for the elongation of very long-chain fatty acids (at least 26 carbons).

143 ese cells are devoid of ABCD1 and accumulate very long-chain fatty acids (C26:0 and C26:1).

144 defect in synthesis of unsaturated long and very long-chain fatty acids (LCFAs and VLCFAs) and deple

145 Sphingolipids are synthesized de novo from very long-chain fatty acids (VLCFA) and sphingoid long-c

146 bers of this group are capable of activating very long-chain fatty acids (VLCFA), one is a bile acid-

147 ve disorder characterized by accumulation of very long-chain fatty acids (VLCFA).

148 re of X-ALD is increased levels of saturated very long-chain fatty acids (VLCFA; carbon chains of 22

149 Very long-chain fatty acids (VLCFAs) are essential lipid

150 present study, we found that the contents of very long-chain fatty acids (VLCFAs) in akr2a mutants we

151 (del/del) mice revealed a global decrease in very long-chain fatty acids (VLFAs) (i.e., carbon chain

152 X-ALD is characterized by an accumulation of very long-chain fatty acids and partially impaired perox

153 possibility that intermediate metabolites of very long-chain fatty acids and peroxisomal beta-oxidati

154 p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular f

155 tol-ceramides [IPC, MIPC, and M(IP)(2)C] and very long-chain fatty acids C(24) and C(26) declined sha

156 ssion pattern and ability of BG1 to activate very long-chain fatty acids implicates this enzyme in th

157 icantly inhibited the omega-hydroxylation of very long-chain fatty acids in cultured human keratinocy

158 rely impaired as degradation of unesterified very long-chain fatty acids in X-ALD and is abolished in

159 ferentiation: ELOVL1, encoding elongation of very long-chain fatty acids protein 1, and SLC27A1, enco

160 Mycolic acids are very long-chain fatty acids representing essential compo

161 Major cuticular wax compounds, such as very long-chain fatty acids, alcohols, alkanes, and keto

162 and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both El

163 of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower i

164 l membrane proteins involved in transport of very long-chain fatty acids, which are a unique componen

165 NA library, we have identified elongation of very long-chain fatty acids-like 1 (ELOVL1) and fatty ac

166 nd C24:0 as substrates), and accumulation of very long-chain fatty acids.

167 xogenous fatty acids or in the activation of very long-chain fatty acids.

168 t-chain and severely restricted on long- and very long-chain fatty acids.

169 long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic

170 ble exceptions, the fatty acid transport and very long-chain fatty acyl-CoA synthetase activities wer

171 ates, the levels of fatty acid accumulation, very long-chain fatty acyl-CoA synthetase activities, an

172 coenzyme A derivatives using long-chain and very-long chain fatty acids, bile acids and bile acid pr

173 ts, led us to discover that BacA affects the very-long-chain fatty acid (27-OHC28:0 and 29-OHC30:0) c

174 We showed that NLMs lost saturated very-long-chain fatty acid (FA; C24:0) SM in cancer cell

175 es the first and rate-limiting enzyme of the very-long-chain fatty acid (VLCFA) beta-oxidation pathwa

176 and Schefflera elegantissima) contained only very-long-chain fatty acid (VLCFA) derivatives such as a

177 Notably, an unusual very-long-chain fatty acid (VLCFA) is found in the lipid

178 chological, electrophysiological, and plasma very-long-chain fatty acid (VLCFA) measurements were use

179 se complex are required for the synthesis of very-long-chain fatty acid (VLCFA) precursors of cuticul

180 reviously undescribed desaturase activity on very-long-chain fatty acid (VLCFA) substrates and exhibi

181 slation initiation factor 2B (eIF2B) and the very-long-chain fatty acid (VLCFA) synthesis keto-reduct

182 ase type 12 (HSD17B12) as a human hub of the very-long-chain fatty acid (VLCFA) synthesis pathway and

183 CS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.

184 and B. abortus are unusually modified with a very-long-chain fatty acid (VLCFA; C > or = 28) and we d

185 ectrometry (LC/MS) method for long-chain and very-long-chain fatty acid analysis and its application

186 not ZS, fibroblasts there was an increase in very-long-chain fatty acid beta-oxidation and plasmaloge

187 X-ALD fibroblasts synergistically increased very-long-chain fatty acid beta-oxidation, indicating th

188 lasmalogen concentrations, and a decrease in very-long-chain fatty acid concentrations.

189 drenoleukodystrophy (X-ALD) is a disorder of very-long-chain fatty acid metabolism, adrenal insuffici

190 Reduction of very-long-chain fatty acid sphingolipid levels leads in

191 results in an increase in phospholipids with very-long-chain fatty acid tails (PL-VLCFAs) that contai

192 distribution of LPS fatty acids, including a very-long-chain fatty acid thought to be unique to the a

193 amily of six FATPs that facilitate long- and very-long-chain fatty acid uptake.

194 he PM showed an enrichment of 2-hydroxylated very-long-chain fatty acid-containing GIPCs and polyglyc

195 ision, suggesting that enhanced synthesis of very-long-chain fatty acid/trihydroxy LCB ceramides prom

196 Individuals with ABCD1 mutations accumulate very-long-chain fatty acids (VLCFA) (carbon length >22).

197 Very-long-chain fatty acids (VLCFA) and branched-chain f

198 X-ALD) is associated with elevated levels of very-long-chain fatty acids (VLCFA; C(>22:0)) that have

199 Long-chain and very-long-chain fatty acids (VLCFAs) are also metabolize

200 Among lipid species, the very-long-chain fatty acids (VLCFAs) are relatively rare

201 The extension of very-long-chain fatty acids (VLCFAs) for the synthesis o

202 TSC13 is required for the biosynthesis of very-long-chain fatty acids (VLCFAs) in yeast.

203 which exacerbates accumulation of LCFAs and very-long-chain fatty acids (VLCFAs) that mediate lipoto

204 ce blast fungus Magnaporthe oryzae, requires very-long-chain fatty acids (VLCFAs), which act as media

205 , including fatty acid elongation to produce very-long-chain fatty acids (VLCFAs).

206 des accumulation of peroxisomal educts (like very-long-chain fatty acids [VLCFAs] or branched-chain f

207 flammatory demyelination in the brain, where very-long-chain fatty acids accumulate within phospholip

208 1/lpcat2 mutant showed increased contents of very-long-chain fatty acids and decreased PUFA in TAG an

209 lopmental and environmental requirements for very-long-chain fatty acids and flavonoids, whose synthe

210 ACC (ScACC) is crucial for the production of very-long-chain fatty acids and the maintenance of the n

211 This led to a significant increase in the very-long-chain fatty acids C24 and C26 in the cuticular

212 synthetase [VLCS]) and subsequently degrade very-long-chain fatty acids in peroxisomes.

213 n GIPCs and sterols and suggested a role for very-long-chain fatty acids in the interdigitation betwe

214 mutations in ABCD1 lead to incorporation of very-long-chain fatty acids into phospholipids, we separ

215 litate the transfer of long-chain as well as very-long-chain fatty acids into the apoplast, depending

216 Our findings implicate very-long-chain fatty acids or their derivative complex

217 ein, required for the efficient transport of very-long-chain fatty acids out of the cytoplasm.

218 have shown that larval oenocytes synthesize very-long-chain fatty acids required for tracheal waterp

219 an acyl CoA synthetase activity specific for very-long-chain fatty acids suggesting this protein play

220 (CER6) is necessary for the biosynthesis of very-long-chain fatty acids with chain lengths beyond C(

221 mutations in the ELOVL4 gene (elongation of very-long-chain fatty acids).

222 of Elovl proteins that mediate elongation of very-long-chain fatty acids, block or dramatically slow

223 In a yeast strain engineered to produce very-long-chain fatty acids, CER1-LIKE1 interacted with

224 ngation of not only linear but also branched very-long-chain fatty acids, leading to production of th

225 n cause accumulation of unbranched saturated very-long-chain fatty acids, particularly in brain and a

226 pecies with C16 fatty acids rather than with very-long-chain fatty acids, which are more commonly enr

227 ndensing enzyme involved in the synthesis of very-long-chain fatty acids, which are precursors of epi

228 ng patterns of saturated and monounsaturated very-long-chain fatty acids, with the observed pattern c

229 ingle allelic mutations in the elongation of very-long-chain fatty acids-like 4 (ELOVL4), whereas rec

230 long-chain fatty acids and the activation of very-long-chain fatty acids.

231 ber of genes involved in the biosynthesis of very-long-chain fatty acids.

232 hase--an enzyme involved in the synthesis of very-long-chain fatty acids.

233 showed that AtLtpI-4 protein can bind these very-long-chain fatty acids.

234 tent, with some molecular species containing very-long-chain fatty acids.

235 We also investigated two distantly related very-long-chain fatty acyl (VLCFA) desaturases from Arab

236 3 (At1g19260)-encoded ceramide synthases use very-long-chain fatty acyl-CoA and trihydroxy LCB substr

237 oxidation chain shortening of long-chain and very-long-chain fatty acyl-coenzyme (CoAs), long-chain d

238 vity of class II ceramide synthases that use very-long-chain fatty acyl-coenzyme A and trihydroxy LCB

239 t jojoba FAO and FADH proteins are active on very-long-chain fatty alcohol and fatty aldehyde substra

240 gest that jojoba FAO and FADH constitute the very-long-chain fatty alcohol oxidation pathway that is

241 Upon germination, WE hydrolysis releases very-long-chain fatty alcohols, which must be oxidized t

242 ax profile (especially on leaves) toward the very-long-chain free fatty acids tetracosanoic acid (C(2

243 pressed in photoreceptor cells and generates very long chain (>/=C28) polyunsaturated fatty acids inc

244 ancer suggest that 1-deoxysphingolipids, the very-long-chain in particular, play a role as molecular

245 istics suggest that it may interact with the very long chain intermediates in mycolic acid biosynthes

246 he other hand, was missing O-antigens of the very long chain length, indicating the Wzz2 protein is r

247 ed with other fatty acids and because of its very long chain length, the effect of dietary behenic ac

248 responsible for the expression of different very long chain lengths despite high sequence homology.

249 out for long chain palmitic acid (C16:0) and very long chain lignoceric acid (C24:0) as well as for A

250 ut for long chain (palmitic acid, C16:0) and very long chain (lignoceric acid, C24:0) fatty acids as

251 suppressor demonstrates that low amounts of very long chain lipids are sufficient for pollen hydrati

252 Very long chain lipids contribute to the hydrophobic cut

253 Mutations in Arabidopsis CER genes eliminate very long chain lipids from the cuticle surface and, in

254 e display massive increases in a rare set of very long chain LPS lipids that have been previously rep

255 he N-acyl chains showed a high occurrence of very-long-chain moieties; phytosphingosine and 4-hydroxy

256 Cuticular wax is a mixture of aliphatic very-long-chain molecules, ranging from 22 to 48 carbons

257 NA bases influences the global properties of very-long-chain molecules.

258 and a dramatic increase in the percentage of very-long-chain monounsaturated fatty acids in the acyl-

259 whether red blood cell (RBC) long-chain and very-long-chain MUFAs are associated with risk of CAD in

260 c and lipotoxicity effects of long-chain and very-long-chain MUFAs on cardiomyocytes.

261 Therefore, the very long chain n-3 PUFAs in eggs were protected from un

262 Proportions of n-3 PUFAs (very long-chain n-3 [VLC n-3; sum of eicosapentaenoic ac

263 f refrigerated stored hen eggs enriched with very long-chain n-3 fatty acids, was investigated.

264 Higher proportions of certain VLC n-3 and very long-chain n-6 PUFAs in plasma phospholipids at age

265 he effect and the mechanism of action of the very-long-chain n-3 (omega-3) polyunsaturated fatty acid

266 Serum linoleic acid and very-long-chain n-3 PUFAs, partly reflecting vegetable o

267 feasibility for CEC-ESI-MS analysis of these very long chain nonionic surfactants for the first time.

268 in place of the proximal glucosamine, and a very long chain omega-1 hydroxy fatty acid, 27-hydroxyoc

269 ELONGASE1 is required for the production of very long chain omega-7s in the aleurone.

270 function.We tested the effects of high-dose, very-long-chain omega-3 fatty acids on adipose tissue in

271 Very long chain polyunsaturated fatty acid (VLC-PUFA)-co

272 e activity and approximately 40% decrease in very long chain polyunsaturated fatty acid chain shorten

273 is therefore a key step in the production of very long chain polyunsaturated fatty acid in oil-seed s

274 aturated fatty acids (VLC-FA) and of C28-C38 very long chain polyunsaturated fatty acids (VLC-PUFA),

275 nsiderable beneficial effects of n-3 and n-6 very long chain polyunsaturated fatty acids (VLC-PUFAs),

276 We report the production of two very long chain polyunsaturated fatty acids, arachidonic

277 duction of phospholipids containing 22:6 and very long-chain polyunsaturated fatty acids (VLC-PUFAs)

278 an elongase required for the biosynthesis of very long-chain polyunsaturated fatty acids (VLC-PUFAs).

279 ptor-specific phosphatidylcholine containing very long-chain polyunsaturated fatty acids and severely

280 nthesized in the stroma, then converted into very-long-chain polyunsaturated fatty acids (FAs) at the

281 acid, as well as decreased incorporation of very-long-chain polyunsaturated fatty acids (PUFAs), par

282 mal models clearly indicates that a group of very-long-chain polyunsaturated fatty acids, the n-3 fat

283 of peroxisomes in the oxidation of complex, very long chain, polyunsaturated fatty acids.

284 etion may prevent the conversion of ALA into very-long-chain PUFAs.

285 enrichment in sterols and sphingolipids with very long chain saturated fatty acids when compared with

286 an oxidase required for the biosynthesis of very-long-chain saturated alpha,omega-bifunctional aliph

287 (DNL) FAs and low n-6 (omega-6) FAs, 2) high very-long-chain saturated FAs, 3) high n-3 (omega-3) FAs

288 Circulating very-long-chain saturated fatty acids (VLCSFAs) may play

289 id, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrat

290 lly expressed in Arabidopsis, GPAT5 produced very-long-chain saturated monoacylglycerols and free fat

291 6-ceramide, which occurred at the expense of very long chain, saturated ceramides.

292 tions that enable a switch between long- and very-long-chain selectivity.

293 hat higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), beh

294 Very-long-chain SFAs (VLSFAs) have recently gained consi

295 16:0) are associated with diabetes; however, very-long-chain SFAs (VLSFAs), with 20 or more carbons,

296 llowed by the more challenging separation of very long chain TX-series with a large number (n = 30-70

297 nsation reaction catalyzing the formation of very-long-chain (VLC) (C-28 to C-40) fatty acids, satura

298 In land plants, very-long-chain (VLC) alkanes are major components of cu

299 id bilayer, facilitating the desaturation of very-long-chain (VLC) substrates.

300 cates that AD1 functions in the formation of very-long-chain wax components.