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1 rine less frequently than did cases with non-VIA.
3 (2) CH(2) NSiPr(i) (3) )](3-) ), with RbC(8) via [2+2+1] cycloaddition, produces an unprecedented hex
4 even a separation pin, unwinding is achieved via a "dam-and-diversion tunnel" mechanism that does not
5 Bronsted bases, facilitating TBA dehydration via a carbocation intermediate in an E1 mechanism; the c
7 ve-free synthesis of dihydro-4H-1,2-oxazines via a Cloke-Wilson-type ring expansion of the aryl-subst
8 sulting fragmentation spectra were processed via a commercial software for sequence identification.
10 ze the nonlinear equations, which are solved via a computational method called the step-by-step linea
12 -CoV-2 RNA could be detected from NP samples via a direct RT-qPCR assay that omits the RNA extraction
14 k shows that TAT-RasGAP(317-326) kills cells via a form of necrosis that relies on the physical disru
16 erially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and
18 d of the violation of time-reversal symmetry via a magnetic field; thus establishing CPA beyond its i
20 report that vIRF-2 also interacts with USP7, via a means distinguishable from USP7 interactions with
21 induced DNA damage enhanced P-TEFb occupancy via a mechanism that involved activation of ATR and ATM
22 ocesses for the production of bulk chemicals via a metabolic engineering approach it is necessary to
23 ve when ORC5 protein expression is abolished via a mutation in the initiator ATG of the ORC5 gene.
24 studies indicate that the reaction proceeds via a nonclassical carbocation followed by anti-1,2-migr
26 aditional moulding and granulation, and also via a novel spray-drying powdering process without addit
28 ch to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with
29 ck copolymers, with the two blocks connected via a pH sensitive imine bond, we generate nanoscopic po
30 etabolite-responsive T-cell clones activated via a pharmacological interactions pathway in patients w
33 asks and format conversions are accomplished via a set of automated scripts that enable the user to g
34 t as resonant (5) unit cells that are linked via a shared wing membrane to form this metamaterial, an
35 and human cytomegalovirus (HCMV), generated via a similar mechanism exploiting the TENT4-ZCCHC14 com
37 +)](o) modulates cardiomyocyte contractility via a sodium-calcium exchanger (NCX) mediated pathway.
38 ns, restoring synchronization for correction via a standard Reed-Solomon outer code that is interleav
39 autophagy(4,5), is phosphorylated by mTORC1 via a substrate-specific mechanism that is mediated by R
40 hich have their hydrophobic linker connected via a thiourea group to the amphiphilic part of Janus gl
41 This cost-effective strategy is achieved via a two-component regulatory system (BceRS) working in
42 ucan reprograms HSCs in the bone marrow (BM) via a type II interferon (IFN-II) or interleukin-1 (IL1)
43 he environment and can reach polar latitudes via a wide range of routes, such as some persistent orga
46 incorporation of magnetic ions occurs solely via addition of Mn-Se units without uncontrolled deposit
54 nts were randomly assigned (1:1:1) centrally via an interactive voice or web response system to recei
56 ra, O-Pair Search identifies O-glycopeptides via an ion-indexed open modification search and localize
58 r the enzymatic activity of p97 in real time via an NMR-based approach that allows us to follow the s
59 othesise that LAI variation can be predicted via an optimality-based approach, using net canopy C exp
60 oonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infect
62 lyzed by supported Au nanoparticles proceeds via an unsymmetrical concerted transition state in which
63 al growth factor-mediated immune suppression via angiogenesis inhibition may augment the activity of
67 sultant tetrasubstituted cyclobutane product via atomistic modeling of the CdSe surface and substrate
72 formate serves as a source of methyl radical via beta-scission from a tertiary radical generated upon
73 romophores are ligated to specific cysteines via bilin lyases, and some of these enzymes, called lyas
74 have spilled over into wild birds and spread via bird migration to countries in Europe, Africa, and N
76 nt mechanism conferring tamoxifen resistance via both ERalpha dependent and independent pathways.
78 formation about the seen category is encoded via broadband and sub-gamma (<30 Hz) power variations, w
81 otential functional contributions of B cells via bulk and single-cell RNA sequencing, which demonstra
82 ce host mucosal immune cells and enterocytes via butyrate production, or contribute to synergism with
83 g theories suggest that gas migration occurs via capillary invasion and/or initiation and propagation
85 wn to directly target tau pre-mRNA in cells, via chemical cross-linking and isolation by pull-down ta
86 in therapeutics, including biotransformation via clipping, deamidation, isomerization, oxidation, etc
87 and in situ activation of electrode surfaces via cold-air plasma, we show that soft biocompatible mat
89 ubmicromolar [Ca(2+) ] activates the channel via constitutively-bound calmodulin, whereas higher [Ca(
93 emains unclear how such ecologic competition via cross-immunity and antigenic mutations that allow im
94 RCCs accelerate functional variant discovery via decreasing the number of segregating variants by ord
96 inase in mediating depression-like behaviors via dendritic remodeling of NAc D1-MSNs and may prove a
99 most pervasive global change drivers operate via different pathways when decreasing soil animal bioma
100 s and their central role in redox signalling via different post-translational modifications, denoted
102 ous virus against the exogenous form, either via direct interference or indirectly via gene regulatio
103 hiazolo[3,2-c][1,3,5,2]oxadiazaborinine dyes via direct lithiation of the 1,3-thiazole ring was devel
104 convenient method seems to be derivatization via direct metalation, but synthesis of polysubstituted
105 is interaction modulates antiviral signaling via disruption of USP7 interactions with innate immune s
106 nitive control is enacted by the FPN and CON via distinct but complementary roles reflected in networ
108 off of social benefits and transmission risk via dominance across 13 dimensions of risk and importanc
109 Graft assessment was performed using NMP via double perfusion of the hepatic artery and portal ve
111 w shifts in the magnitude of anorexia (e.g., via drugs) affect disease dynamics and virulence evoluti
112 warming gases of carbon dioxide and methane via dry reforming is environmentally crucial and for the
113 fication of mRNA and protein of a given gene via dual fluorescent reporters in single, live cells of
114 dehydrogenase (i.e. lactate dehydrogenase), via EDC/S-NHS chemistry, for the fabrication of a Bio-Na
115 e cell which appears to promote inflammation via elaboration of complement-dependent anaphylatoxins.
119 rse PS nanoparticles (MPNPs) are synthesized via emulsion polymerization in five sizes (50, 150, 300,
120 ts requiring invasive mechanical ventilation via endotracheal tube for acute respiratory failure.
125 cellular process of neurotransmitter release via exocytosis and provide a better physical framework t
126 e, predicting potential endocrine disruption via exogenous chemicals requires that aromatase inhibiti
127 he study was to evaluate the activity of FAP via FAPI-positron emission tomography-computed tomograph
129 of plants relies on maternal photosynthesis, via food reserves in the seed, to supply the necessary e
131 assembly to enable directional ion transport via forming vertically aligned nanosheets is reported.
133 O(2) may be used to generate electric power via fuel cells or combustors, O(2) may be used as a comp
134 either via direct interference or indirectly via gene regulation, and may suggest evolutionary outcom
136 that tunes transcription factor availability via genome-wide redistribution and couples BRAF to tumor
137 CblC to a common cob(II)alamin intermediate via glutathione-dependent alkyltransferase or reductive
139 vascular systems, develops at least in part via hemovasculogenesis, a process in which vasculogenesi
142 actions that regulate epigenetic inheritance via histone post-translational modifications and DNA met
146 biting restricted replication in these cells via incorporation of target sequences for skeletal muscl
148 Nina events are also performed and assessed via information-theoretic metrics, showing an improvemen
150 nduced MSDB-specific knockout of CB1 or MAGL via injection of virally-delivered Cre recombinase into
152 autophagy by modulating ATG16L1 translation via interaction with circPABPN1 in the intestinal epithe
153 f the condensate into higher momentum states via interaction-induced fluctuations-the phenomenon of q
155 y links DNA methylation to disease endpoints via intermediate proteomics phenotypes and identifies co
156 regate clusters form, grow, fuse, and evolve via internal rearrangement, leading to overall hydrogela
157 l5 knockout male mice treated with isoform 1 via intrajugular injection at age 28-30 days exhibited s
158 -substituted B,N,B-benzo[4]helicenes 2 a/2 b via intramolecular borylation and sequential B-Mes bond
162 uces R-Ras upregulation in endothelial cells via JNK and p38 mitogen-activated protein kinase but not
166 can be mapped from the same SECCM experiment via local voltammetry, which demonstrates the variation
167 Specifically, large proteins often fold via long-lived partially folded intermediates, whose str
169 ium and carbon-11 into the desired compounds via methylation of pharmaceutical precursors bearing ary
170 otes the degradation of damaged mitochondria via mitophagy and mutations in Parkin are a major cause
171 effects of pharmacologically activating PKM2 via ML-265, a small molecule activator of PKM2, during a
172 A specifically inhibits Salmonella infection via modulation of endolysosomal trafficking and the vacu
173 IKV NS1 contributes to placental dysfunction via modulation of glycosaminoglycans on trophoblasts and
174 the replenishment of youthful gut microbiome via modulation of immunologic, microbial, and metabolomi
175 f MMC9s is in part BATF-dependent and occurs via modulation of metabolic transcriptional programs.
178 exadiene intermediate, which can be accessed via multicomponent coupling of Ti imidos with nitriles a
181 f luciferase inhibition and autofluorescence via multiple wavelengths (red, blue, and green) and unde
183 uent double-ring cyclization of the E-enone (via Nazarov, electrophilic aromatic substitution, and el
185 ocarbenium system decrease glycal reactivity via negative hyperconjugation as protecting group electr
186 application of basaltic rock dust, including via newly formed soil carbonate minerals whose long-term
191 light-sensing mechanism in brown adipocytes via Opn3-GPCR signaling that can regulate fuel metabolis
192 y innervated by GRP fibers, whose activation via optogeneics and chemogenetics in the skin evokes itc
193 However, the need to address the nuclei via oscillating magnetic fields complicates their integr
194 actory information to higher-order neuropils via parallel pathways, and local interneurons (LNs), whi
195 icrobe-associated molecular patterns (MAMPs) via pattern recognition receptors, internal cellular sig
197 protein charge in solution to be controlled via pH adjustment without changing the protein conformat
199 l2 triggered the integrated stress response, via phosphorylation of eIF2alpha, thus linking these pat
200 ats regulate global gene expression in trans via piRNA-mediated gene silencing that is essential for
201 in-plane optical anisotropy is demonstrated via polarized Raman spectroscopy and second-harmonic gen
202 contrast, the silica scale layer was formed via polymerization of silicic acid and gelation of silic
204 stroke recovery in aged mice can be reversed via poststroke bacteriotherapy following the replenishme
205 ng that E4BP4 may suppress the AMPK activity via promoting the AMPKbeta1 ubiquitination and degradati
207 t significant sensitivity gains are achieved via proton detection under the conditions of our experim
209 r(2) C(6) H(3) )NC(Me)}(2) CH), was isolated via reaction of [(Me) LZnSCPh(3) ] (1) with 2.3 equivale
211 ile total contractile work was held constant via reciprocal changes in contraction frequency: (1) low
212 se the concentration of analytes in solution via reduction of the sample volume under well-defined co
214 in HSCs during chronic liver injury in vivo via regulation of HSC survival and migration and affect
215 teomimetic that activates cell proliferation via regulation of the Hippo pathway, highlighting the po
216 ability of this molecule to induce signaling via rhesus macaque CD200R, as well as the potential func
217 f-assembles into phase-separated condensates via RNA-RNA interactions that reorganize to form filamen
218 es incentivize larger mitigation proportions via rotation and forest management activities in tempera
220 yping of CYP2C19 major alleles (*2, *3, *17) via salivary swab (genotyped group) or no genotyping (us
221 ed therapeutic effect of eHNP-A1-CD15-LDE225 via scavenger receptor class B type 1 (SR-B1) and CD15 o
223 c acids to the corresponding organic halides via selective cleavage of a carbon-carbon bond between t
224 sors targeted to various subcellular regions via sequence specific motifs to measure spatiotemporal c
225 st cholesterol metabolism and energy balance via several nuclear receptors and/or G-protein-coupled r
226 tion associated with storms can affect lakes via short-term runoff events from watersheds and physica
228 with CYCA2;3, a binding partner of CDKB1;1, via SIM motif A, which we previously identified as a CDK
229 ry concentrations (MIC) were then determined via simple colorimetric reactions in only 4.5-6 h using
230 w complex molecular structures and functions via simple genetic mechanisms that recruit existing biop
231 -translationally modified protein substrates via simultaneous sensing of both chemo- and stereoselect
232 labeled K562 human cell line protein digests via single-shot nanoLC-MS/MS analysis on a Q Exactive HF
233 of brain structure, but might be achievable via small adjustments of neural circuitry in key brain a
234 cerebral blood flow (CBF; +10-20%) mediated via small elevations in arterial PCO2 and metabolism.
237 could increase future catch by at least 20% via spillover, generating 9 to 12 million metric tons mo
239 brain) that underlies the gut-brain axis, is via spinal afferent neurons, with cell bodies in dorsal
241 Effect measure modification was explored via stratification on individual- and area-level vulnera
242 xt-generation fouling-resistant RO membranes via structural optimization: first, a smooth selective l
243 tly communicate occupancy to the active site via subtle changes in dynamics, enabling exquisite fine-
246 agent from a bench-stable Bi(III) precursor via telescoped B-to-Bi transmetallation and oxidation.
247 neutralizing/effector function-positive bNAb via the airway and systemic routes showed increased effe
249 nthesis of alpha,alpha-disubstituted ketones via the alkylation of secondary alcohols with primary al
251 PD-L1(+) T cells restrained effector T cells via the canonical PD-L1-PD-1 axis and were sufficient to
252 also utilize lactose and galactosyl-glycerol via the cellobiose-PTS system together with a bifunction
253 the unimolecular consumption of which occurs via the cis form when the terminal oxygen atom of the NO
254 e in determining seed size and yield, likely via the control of nitrogen delivery to the reproductive
256 and nucleus, targeting them for degradation via the endosomal/vacuolar RSL1-dependent pathway or 26S
258 quantitative sensing of miR-141 was achieved via the first example of an electrochemical oligonucleot
261 We uncovered a role for Xinbeta in signaling via the Hippo-YAP pathway by recruiting NF2 to the ICD t
263 emale human islets convert T into DHT and E2 via the intracrine activities of SRD5A1 and aromatase.
264 A), whereas MoBA compounds decomposed faster via the isomer (C(6)H(4), O)(C, N, Ph) formed by P-stere
266 PKA-dependent mitochondrial Ca(2+) extrusion via the mitochondrial Na(+)/Ca(2+) exchanger, NCLX.
268 tion of IBMX or of the second messenger cAMP via the patch pipette had no effect on THIK-1 currents.
270 omponent secreted onto mucosal surfaces and, via the process of immune exclusion, shapes the architec
271 (TMB) for Bayesian and frequentist analysis via the R packages R-INLA and glmmTMB, we hope to make e
272 ibody and a tetrazine (Tz)-based radioligand via the rapid and bioorthogonal inverse electron-demand
273 that C-C bond coupling in Y-DeAlBEA proceeds via the reaction of coadsorbed acetaldehyde and ethanol
274 P-2-dependent internalization of PM proteins via the recognition of functional Tyr motifs also operat
277 nderstand if sex determination is controlled via the same physiological pathway and if dioecy evolved
278 h to access solid-state CNT mimic structures via the self-assembly of fluorinated nanohoops, which ca
281 tion of the components of nucleotides-either via the synthesis of ribose and the canonical nucleobase
283 active approach to reduce gene expression is via the use of antisense oligonucleotides (ASOs) that ha
284 distinct sEV pools to mediate communication via their apical and basolateral domains and suggest tha
290 bound receptors transition to the open state via two conformations, an "unconstrained pre-active" sta
291 sters proceeding are reported, which proceed via two distinct mechanistic pathways: enantioselective
292 interacts with a closed pore domain directly via two interfaces and indirectly via an intercalated ph
294 ects of starch nanoparticles (SNPs) produced via ultra-sonication for rutin encapsulation was explore
295 ely excited to form a charge-separated state via ultrafast photoinduced electron transfer from the PE
296 lm electrodes with isolated Pd nanoparticles via underpotential deposition of copper on a gold substr
297 is transported to the surface of the system via varying dominant discontinuous conduits for flow dic
299 c consequences of delaying Abeta aggregation via weak metal-ion binding, quantitatively linking the c
300 ignaling and heat-induced auxin biosynthesis via YUCCA family genes are synergistically required to m