ライフサイエンスコーパス: vicinal

1 high-quality PMN-PT epitaxial thin films on vicinal (001) Si wafers with the use of an epitaxial (00

2 A formal intramolecular vicinal 1,2-diamination of alkynes is achieved for the s

3 egy for the direct and selective assembly of vicinal 1,2-diamines using readily available olefin and

4 oxidation of primary and secondary alcohols; vicinal 1,2-diols are oxidized selectively to hydroxy ke

5 g only four general types of SSCCs: geminal, vicinal, 1,3-, and long-range constants.

6 is an artificial genetic polymer composed of vicinal 2',3'-phosphodiester bonds linking adjacent thre

7 rise from branch-point nucleotides harboring vicinal 2',5'- and 3',5'-phosphodiester linkages.

8 proximity between 4'-OMe substituent and the vicinal 5'- and 3'-phosphate group, as seen in the X-ray

9 usters containing bistranded AP sites with a vicinal 8-oxoG form DSBs with nuclear extract, as confir

10 reoselective process for the construction of vicinal acyclic ternary/ternary stereogenic centers, in

11 eavage of the N-CN bonds in conjunction with vicinal addition of sulfonamide and nitrile groups acros

12 roviding a methodology for the generation of vicinal alkane stereogenic centers.

13 Vicinal alkene carboamination is a highly efficient and

14 blems at once and allows the installation of vicinal all-carbon quaternary and tertiary stereocentres

15 in unprecedented Michael adducts containing vicinal all-carbon quaternary centers is also demonstrat

16 iastereomeric series possessing the critical vicinal all-carbon quaternary centers needed for each sy

17 The vicinal all-carbon quaternary stereocenters having trans

18 ped for the synthesis of 2-oxindoles sharing vicinal all-carbon quaternary stereocenters.

19 ith an intriguing polycyclic core containing vicinal all-carbon quaternary stereocenters.

20 ticularly challenging cases-for example, the vicinal all-carbon(8), oxa- and aza-quaternary centres(9

21 cyclization that led to cyclopentenones with vicinal all-carbon-atom quaternary centers (see example;

22 e diastereoselective asymmetric synthesis of vicinal all-carbon-atom quaternary stereocenters is a ch

23 city of SP-C, and to include no, one, or two vicinal amide-linked, N-terminal octadecyl chains (provi

24 ly proved that Zr(CH2tBu)4 reacts with these vicinal amine-modified surfaces to give mainly bipodal b

25 binatorial active site saturation focused on vicinal amino acids were used to alter the acceptor spec

26 tion to establish the stereochemistry of the vicinal amino alcohol motif embedded within the targets.

27 d for the highly selective synthesis of anti-vicinal amino alcohol natural products.

28 ha-amino)allyliridium-aldehyde pairs to form vicinal amino alcohols 3a-3z, 3a'-3c' with high levels o

29 defined enamides toward the synthesis of cis vicinal amino alcohols and tetrasubstituted alpha-boryla

30 action, a range of cyclic allylic amines and vicinal amino alcohols have been prepared stereoselectiv

31 d straightforward approach to prepare chiral vicinal amino alcohols.

32 ic 5- or 6-membered ring, with an additional vicinal amino stereocenter in each.

33 esaturation via I(2) complexation, and (iii) vicinal amino-iodination of an in situ generated allyl i

34 e structure on SAMs adsorbed onto low index, vicinal and chiral surfaces.

35 ted two different functional groups that are vicinal and lack chromophores entirely.

36 tations into three distinct classes-special, vicinal, and general-with respect to their Peierls stres

37 via a 6pai electrocyclization involving the vicinal aryl or hetaryl substituent and the N=C bond of

38 Vicinal aziridine-containing diamines have been obtained

39 rms an intramolecular disulphide bond with a vicinal "backdoor" cysteine, a process thought to revers

40 s that contain otherwise difficult-to-access vicinal beta-tertiary and gamma-quaternary carbon stereo

41 syntheses of oxygen- and nitrogen-containing vicinal bis-heterocyclic compounds.

42 yldimethylsilyloxy)furans are established as vicinal bisketene equivalents for application as dienes

43 reover, this method effectively promotes the vicinal bisperoxidation of sterically hindered various s

44 easurably active, despite missing one of the vicinal bisphosphate groups normally thought to be cruci

45 ing toward the potency of adenophostins, the vicinal bisphosphate motif is not essential for activity

46 e solvolysis of an enantiomerically enriched vicinal bromochloride.

47 Over 160 chiral vicinal bromochlorinated natural products have been iden

48 indicate a preferred geometry with eclipsed vicinal C-H bonds in the alkane donor.

49 formation of benzothiophenes by the twofold vicinal C-H functionalization of arenes that does not re

50 oimidazoles has been accomplished via alkene vicinal C-N bonds formation of 2-bromo-2-alkenones with

51 Mutation of cysteine 106 (C106), but not the vicinal C23 and C45, of HMGB1 promotes cytosolic localiz

52 ) with a guanidinium unit connected by a 1,2-vicinal calix[4]arene spacer was investigated in the tra

53 substrate for the Cu(II) complex of the 1,2-vicinal catalyst and a bad substrate for the correspondi

54 ic efficiency, with a superiority of the 1,2-vicinal catalyst in both cases.

55 3,3-disubstituted fluorooxindoles exhibiting vicinal chirality centers were obtained in high yields a

56 An oxygen adatom and a vicinal Co-atom form a metal-oxygen site-pair that cleav

57 ation density and species composition of the vicinal community.

58 sess the total bacterial cell density of the vicinal community.

59 These data suggest that vicinal constraint of the GPCR PAC1 and AC6 determines t

60 and (3)J(obs) represents the proton-fluorine vicinal coupling constant observed at the midpoint of an

61 (3)J(AH) and (3)J(A) are the proton-fluorine vicinal coupling constants of the standard acid and its

62 triazole, which was found to have unexpected vicinal coupling constants.

63 discrepancies in observed and predicted NMR vicinal couplings implied that the simulation overestima

64 Products of the vicinal cyanotriflation can be stereospecifically readil

65 ghted the role of a disulfide bond formed by vicinal Cys residues in maintaining calcium-bound TG2 in

66 cts together with the Ca(2+)binding site and vicinal cysteine disulfide bond to control unfolding and

67 tion depends upon a Ca(2+)binding site and a vicinal cysteine disulfide bond.

68 The MAs(III) binding site is a vicinal cysteine pair in a flexible loop.

69 This cysteine-rich region contains two vicinal cysteine pairs in CXXC and CCXXC configurations

70 steine-rich region are two highly conserved, vicinal cysteine sulfhydryl motifs (cysteine-X-X-cystein

71 oxidants by a unique mechanism involving two vicinal cysteines and one distant cysteine (Cys(3), Cys(

72 ng agents of disulfide bonds and contain two vicinal cysteines in a CXXC motif at the active site.

73 confirming the important role of the paired vicinal cysteines in VWF A2 domain stabilization.

74 A pair of vicinal cysteines, Cys-216 and Cys-217, was found to be

75 Oxidation of 7 afforded a dearomatized vicinal di-tert-butyl substituted BIAN ligand (8).

76 on reduction pathway that was accompanied by vicinal di-tert-butylation of the BIAN ligand backbone.

77 the construction of stereotriads containing vicinal diaminated motifs.

78 -opening reaction at both C1 and C3 to yield vicinal diaminated products corresponding to formal ring

79 The enantioselective, vicinal diamination of alkenes represents one of the ste

80 e of hypervalent iodine(III) reagents in the vicinal diamination of styrene has been investigated.

81 An enantioselective catalytic vicinal diamination of styrenes is reported, which proce

82 An enantioselective Pd-catalyzed vicinal diamination of unactivated alkenes using N-fluor

83 )-H bonds using chelation-assisted removable vicinal diamine directing groups was developed.

84 A chiral vicinal diamine forms an enamine-iminium adduct with alp

85 Four vicinal diamine-catalyzed aldol reactions were examined.

86 migration provided differentially protected vicinal diamines 7 in good yield (80-91%).

87 acetamides 5 (five examples) were reduced to vicinal diamines 7 with zinc hydrochloride; concomitant

88 Vicinal diamines are a common structural motif in bioact

89 ition states of aldol reactions catalyzed by vicinal diamines are characterized with density function

90 Vicinal diamines are ubiquitous materials in organic and

91 le intermediates for the synthesis of chiral vicinal diamines as has been verified for a representati

92 ould be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.

93 ort a highly diastereoselective synthesis of vicinal diamines by the treatment of nitroepoxides with

94 This strategy streamlines the preparation of vicinal diamines from multistep sequences to a single ch

95 tant 1,2-diazides can be smoothly reduced to vicinal diamines in a single step, with high chemoselect

96 cinchona alkaloid-derived amines, and chiral vicinal diamines in general, have been determined by den

97 ox ligands afforded differentially protected vicinal diamines in good yields with high enantioselecti

98 ry 2-azidoamines are versatile precursors to vicinal diamines, which are among the most common motifs

99 nd pyridine affords differentially protected vicinal diamines.

100 amino acids, proline homologues, and cyclic vicinal diamines.

101 reaction with an aryl iodide to constitute a vicinal diarylation of an alkene.

102 3 + 2] cycloaddition reaction of unsaturated vicinal dicarboxylic acid derivatives and in situ genera

103 nd amines, were transformed into the desired vicinal dichlorides with high chemoselectivity.

104 n technologies, the direct generation of the vicinal difluoride moiety from simple olefins without a

105 In general, the vicinal difluoride products are produced with high diast

106 y, contemporaneous strategies to achieve the vicinal difluorination of alkenes via an I(I)/I(III) cat

107 Herein we report a catalytic, vicinal difluorination of olefins displaying broad funct

108 ng the geminal difluoro group in PT2385 to a vicinal difluoro group resulted in enhanced potency, dec

109 harness MMPs 2, 8, 9, and 13 to validate the vicinal difluoro motif as a hybrid bioisostere of CF(3)

110 ative structures reveal conformations of the vicinal difluoro motif that manifest stabilizing hyperco

111 ning of new methods for the enantioselective vicinal difunctionalization of alkenes initiated by elec

112 We disclose a Ni-catalyzed vicinal difunctionalization of alkenes with benzyl halid

113 Key synthetic transformations include vicinal difunctionalization of an advanced alpha,beta-un

114 se two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way t

115 An iron-mediated vicinal difunctionalization of enamides and enecarbamate

116 Herein we report a direct vicinal difunctionalization of thiophenes via the pallad

117 he target through a sequence of enone tandem vicinal difunctionalization, Friedel-Crafts cyclodehydra

118 dditive were crucial for promoting efficient vicinal difunctionalization.

119 taining a bridgehead alkene, is forged via a vicinal difunctionalization/Diels-Alder strategy.

120 enation of olefins to afford enantioenriched vicinal dihalide products remains comparatively underdev

121 ereospecific reactions, typically delivering vicinal dihalides resulting from anti-addition.

122 ghly regio-, diastereo- and enantioselective vicinal dihalogenation of allyl amides.

123 These vicinal dihalonium or the corresponding protosolvated sp

124 talyze the cleavage of phenolic rings with a vicinal dihydroxyl group to muconoid products accepting

125 synuclein fibrillation were determined to be vicinal dihydroxyphenyl moieties, irrespective of the ri

126 the second methods were used for esters and vicinal diketones analysis, respectively.

127 d to the workplace (eg, indium compounds and vicinal diketones).

128 For vicinal-diketones group, a complete validation study for

129 PA (RvD5n-3DPA) and maresin (MaR)-1, the DHA vicinal diol 19,20-dihydroxy-DPA and n-6 PUFA derived 15

130 rolyze a cyclic phosphodiester directly to a vicinal diol and inorganic phosphate.

131 ay for C-1027 biosynthesis, unveiling an (R)-vicinal diol as a key intermediate.

132 ized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.

133 ecific glycans, indicated that the exocyclic vicinal diol coordinates to a protein-bound calcium ion.

134 -1 binds microbial glycans bearing exocyclic vicinal diol groups.

135 s), and the protocol was then applied to the vicinal diol hydrobenzoin.

136 ox-neutral acid-catalyzed rearrangement of a vicinal diol to give the requisite carbonyl, followed by

137 xide to afford preferentially the (R)-phenyl vicinal diol via attack at the beta-position, albeit wit

138 functional groups (primary alcohol, phenol, vicinal diol, and carboxylic acid), ranging in complexit

139 ition to exclusively generate the (R)-phenyl vicinal diol, consistent with the stereochemistry of the

140 of primary alcohols and acetalation of a cis-vicinal diol, followed by a controlled per-O-benzylation

141 hich an unactivated alkene is converted to a vicinal diol.

142 re, they share a common feature-an exocyclic vicinal diol.

143 ated fatty acid like species that includes a vicinal diol.

144 e core epoxide intermediate mimic, to form a vicinal diol.

145 isition of a ribose sugar with an intact 2-3 vicinal diol.

146 A colorimetric assay containing a vicinal-diol recognition moiety, additives, and a photoi

147 thenium(0)-catalyzed hydrohydroxyalkylation, vicinal diols 1a-1l and methyl acrylate 2a are converted

148 oducts could be efficiently transformed into vicinal diols and alpha-hydroxy propargylic esters witho

149 a reducing agent, both terminal and internal vicinal diols are deoxygenated to olefins in good yield.

150 strategy toward the asymmetric synthesis of vicinal diols bearing a tertiary center is presented.

151 es from the reaction of diarylhydrazones and vicinal diols has been developed.

152 ombination with different type of amines and vicinal diols into various substituted pyrroles in reaso

153 The oxidation of vicinal diols is both faster and more selective than the

154 ethod for the catalytic didehydroxylation of vicinal diols is described.

155 substituent of thiophene 3 covalently bound vicinal diols of the ribofuranose moiety, and amide subs

156 The first use of vicinal diols, ketols, or diones as 22pi components in m

157 entration, and enantiomeric excess of chiral vicinal diols, specifically threo diols, has been develo

158 The present work describes vicinal diols, tethered to a rigid 1,3-diethynylbenzene

159 is product-determining for the oxidation of vicinal diols, whereas for primary and secondary alcohol

160 rates and various other compounds containing vicinal diols.

161 op (R1597W), the hydrophobic core around the vicinal disulfide (M1528V), and hydrogen bonds to the al

162 ly of nicotinic acetylcholine receptors is a vicinal disulfide between Cys-192 and Cys-193.

163 2-VicCC, residues 1473-1670) and without the vicinal disulfide bond (A2-DeltaCC, residues 1473-1668).

164 TRs) have the unusual feature of utilizing a vicinal disulfide bond (Cys(1)-Cys(2)) which forms an ei

165 tructure has revealed the presence of a rare vicinal disulfide bond between C1669 and C1670, predicte

166 2 Cys residues that are linked by an unusual vicinal disulfide bond that is buried in a hydrophobic p

167 mmals) in the reactive center loop to form a vicinal disulfide bond.

168 regiospecific reaction between a thiol and a vicinal disulfide bond.

169 We propose that the role of the vicinal disulfide is to distort the beta turn and thereb

170 ed by a hydrophobic residue and a C-terminal vicinal disulfide moiety.

171 kbone mutagenesis of the peptide bond of the vicinal disulfide, we have established the presence of a

172 th reliably genuine examples of cis or trans vicinal disulfides and discuss their conformations, cons

173 Some vicinal disulfides are essential to large, functionally

174 Vicinal disulfides between sequence-adjacent cysteine re

175 l features that provide it with stability: a vicinal disulphide bond and a Ca(2+)-binding site (CBS).

176 ility provided by its 2 structural elements (vicinal disulphide bond and CBS) is a key protective det

177 mutagenesis of residues involved in both the vicinal disulphide bond and the CBS to demonstrate that

178 ning of cyclopropane-1,1-dicarboxylates with vicinal donor aryl groups by boronic acids and potassium

179 cular endothelium and chemotaxis through the vicinal extracellular matrix until contact is made with

180 ( approximately 2.77 A) are longer than the vicinal Fax...Feq- distances ( approximately 2.73 A) sug

181 The vicinal FLP 4 was shown by X-ray diffraction and by spec

182 , or vinyl alkyl fluorides embedded within a vicinal fluoro amine functional group.

183 nverts readily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N

184 ins carrying two, three, four, five, and six vicinal fluoromethylene motifs is described, with an emp

185 The vicinal frustrated Lewis pair (FLP) mes2P-CH2CH2-B(C6F5)

186 iate, obtained by regio- and stereoselective vicinal functionalization of a diene utilizing an intram

187 We present a new generation of "true vicinal" functions well-distributed on the inner surface

188 (AKTIP) expression, but expression of other vicinal genes, including IRX3, IRX5, and RBL2, which hav

189 atom-economical synthesis of enantioenriched vicinal haloamines.

190 Vicinal haloethers show substrate-dependent reactivities

191 The stereocontrolled introduction of vicinal heteroatomic substituents into organic molecules

192 es of organometallic complexes stabilized by vicinal heteroatoms.

193 his method gives access to an adduct bearing vicinal, highly substituted sp(3) stereocenters.

194 cid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-spec

195 are capable of the concerted removal of two vicinal hydrogen atoms from a hydrocarbon.

196 The removal of two vicinal hydrogen atoms from an alkane to produce an alke

197 fluorine-decoupled (13)CF3 resonance and the vicinal hydrogens.

198 ative cleavage of the aromatic bond with two vicinal hydroxy groups to yield substituted cis,cis-muco

199 vent oxidation reactions and the presence of vicinal hydroxyl groups correlated with flavonoid reacti

200 Flavonoids with three vicinal hydroxyl groups exhibited enhanced inhibitory ef

201 on of weak reversible covalent bonds between vicinal hydroxyl groups of arabitol and boronic acid sub

202 d glucose residues by Ca(2+) coordination of vicinal hydroxyl groups with similar stereochemistry.

203 nal interactions) or sigma hyperconjugation (vicinal interactions, through-bond coupling).

204 ultures of human lymphocytes to classify the vicinal interactomes of the viral Env and Vif proteins a

205 In summary, we show that Vicinal is a useful tool for determination of the precis

206 t match the variations typically observed in vicinal J(H-H) coupling constants as a function of dihed

207 Two vicinal J-couplings sensitive to amide bond conformation

208 Six vicinal J-couplings sensitive to the C2-N2 torsion angle

209 The vicinal M(+)/P complexes 4 also show some typical FLP re

210 The vicinal M(+)/P complexes 4 can be also used as efficient

211 The vicinal M(+)/P systems 4 behave as reactive frustrated L

212 carried out on 2b supported the existence of vicinal Nb centers on the silica surface for this specie

213 site pairs consisting of exposed Pd(2+) and vicinal O(2-), Pd(ox)-O(ox), cleave C-H bonds heterolyti

214 te to form RNA(3')pp(5')A; and attack of the vicinal O2' on the 3'-phosphorus to form a 2',3' cyclic

215 therification toward the equatorial-oriented vicinal OH is kinetically favored.

216 an array of stereocenters, particularly two vicinal ones, remains a synthetic challenge, and no meth

217 e on whether the substitution pattern is 1,2-vicinal or 1,3-distal.

218 wever, experiments suggest binding to a site vicinal or allosteric to Colchicine.

219 sylation reactions by esters from either the vicinal or more remote positions.

220 e reactivity of mono- and disulfide-derived (vicinal or neighbors-through-space) dithiols.

221 tually proceed via initial substitution at a vicinal or remote CH position, followed by protodeboryla

222 aalphabetabetabeta motifs, a hallmark of the vicinal oxygen chelate superfamily.

223 atomic distance between interacting atoms on vicinal peptide chains thereby increasing the electrosta

224 ing of the last remaining proton between the vicinal phosphomonoester groups.

225 rotation about the sulfonamide S-N bond, and vicinal phosphorus-hydrogen coupling constants over 40 H

226 -Karplus effect of lone-pair conformation on vicinal phosphorus-hydrogen coupling constants.

227 h Peierls stress-stress spikes-surrounded by vicinal plateau regions.

228 and chemoselective oxidation of unprotected vicinal polyols with [(neocuproine)Pd(OAc)]2(OTf)2 (1) (

229 It also provides a convenient approach to vicinal primary diamines as well as other synthetically

230 rsine oxide (PAO), which covalently binds to vicinal protein cysteine thiol groups, induces Mt1 with

231 stablished in DMSO solution by comparing the vicinal proton-proton coupling constants (3J(HH)) obtain

232 and dimethyl sulfoxide (DMSO) solutions from vicinal proton-proton NMR J couplings ((3)J(HH)).

233 the dihedral angle between different sets of vicinal protons, the molecules were energy-minimized by

234 hedral angle (varphi) between the respective vicinal protons.

235 ted 2-rings, formed by condensation within a vicinal Q(2)-Q(3) pair.

236 are formed by reaction of Ga(CH(3))(3) with vicinal Q(3)-Q(3) pairs which have not condensed, even a

237 a-branched aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters.

238 tends to the stereodivergent construction of vicinal quaternary and tertiary stereocenters in similar

239 nd an electron-deficient double bond to form vicinal quaternary and tertiary stereocenters with high

240 s of cyclic ketoesters and enones to install vicinal quaternary and tertiary stereocenters.

241 esulting in the stereoselective formation of vicinal quaternary and tertiary stereocenters.

242 x tertiary homoallylic alcohols containing a vicinal quaternary carbon stereogenic center and a versa

243 rically enriched [3.1.0] bicycles containing vicinal quaternary centers were synthesized from [1,6]-e

244 tings to generate hindered bicyclic systems, vicinal quaternary centers, and even cyclopropanes in go

245 tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacycl

246 hat provides cyclopentenone derivatives with vicinal quaternary stereocenters in high optical purity

247 yne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product

248 l addition-aldol reaction sequence to access vicinal quaternary stereocenters.

249 ecarbonylation reaction to introduce the key vicinal quaternary stereocenters.

250 ation to install the seven-membered ring and vicinal quaternary stereocentres of the natural product.

251 nones containing two new sigma-bonds and two vicinal quaternary stereogenic centers were formed under

252 By using a proper design of vicinal single-crystal substrate, the interface strain i

253 A double functionalization of vicinal sp(3) C-H bonds has been developed, wherein a be

254 CO coverage, where {100} facets roughen into vicinal stepped high Miller index facets, while {111} fa

255 Vicinal stereocenters are found in many natural and unna

256 Highly congested vicinal stereocenters comprised of tertiary and all-carb

257 pared, including crotylated products bearing vicinal stereocenters that are inaccessible through enol

258 everal anti beta-acyloxy amides that possess vicinal stereocenters with a high degree of stereocontro

259 es (as mixtures of stereoisomers) to produce vicinal stereocenters with very good stereoselectivity.

260 he alkene, the potential for high dr between vicinal stereocenters, and the ability to further elabor

261 bonation reaction provides products with two vicinal stereocenters, with one being quaternary, in exc

262 processes that generate, much less control, vicinal stereocenters.

263 tion reaction was developed to introduce the vicinal stereodiad.

264 titution reactions and the generation of new vicinal stereogenic centers if regio- and stereocontrol

265 , a beta,gamma-unsaturated diester unit, and vicinal stereogenic centers in up to 67 % yield, 87:13 Z

266 ramolecular Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of c

267 This methodology allows the creation of vicinal stereogenic centers, including adjacent quaterna

268 achieve such a stereodivergent synthesis of vicinal stereogenic centers, one containing a fluorine a

269 ligand, allows for full control over the two vicinal stereogenic centers.

270 -C bond forming process, which generates two vicinal stereogenic centers.

271 g of carbon monoxide adsorbed on a 'tunable' vicinal surface, allowing a straightforward visualizatio

272 stress-release effects on clean and covered vicinal surfaces.

273 An analogous dearomatized vicinal tert-butyl-hydroxy substituted BIAN ligand (9) w

274 lkylation of acyclic beta-ketoesters to form vicinal tertiary and all-carbon quaternary stereocenters

275 s furnishing products bearing a newly formed vicinal tertiary and all-carbon quaternary stereodyad.

276 ning a quaternary carbon stereocenter with a vicinal tertiary stereocenter are obtained.

277 ated into new azetidine scaffolds containing vicinal tertiary-quaternary and even quaternary-quaterna

278 ns with high levels of cysteine residues and vicinal thiol groups, such as promyelocytic leukemia pro

279 metal site 2 is coordinated by a C-terminal vicinal thiolate pair, Cys110 and Cys111.

280 e goal of directing these As(III) species to vicinal thiols in susceptible targets within cells and t

281 uggesting that these two Cys residues act as vicinal thiols, consistent with C119S/C162S being incapa

282 f alpha-hydroxydivinylketones catalyzed by a vicinal thiourea-primary amine first reported by Tius ha

283 ductive cleavage, an NH(2) is formally added vicinal to an alcohol.

284 f alkenes that construct carbon-sulfur bonds vicinal to carbon-oxygen, carbon-nitrogen or carbon-carb

285 avage occurs in oxygenates only at locations vicinal to the C horizontal lineO group in RCCO* interme

286 the absolute requirement of N-sulfate groups vicinal to the epimerization site for substrate binding.

287 er-resolution microscopy show that Nup188 is vicinal to the inner core of the interphase centrosome.

288 ducts underwent isomerization of the carbons vicinal to the nitrogen atom to afford pyrrolidines with

289 for orientations within the plateau regions vicinal to the Peierls stress spikes.

290 rom steric interactions between substituents vicinal to the pivot bond.

291 tropisomers having a biaryl stereogenic axis vicinal to the reactive triple bond are demonstrated to

292 We developed a bioinformatic method, called Vicinal, to precisely map the ends of numerous fruitfly,

293 e C-O coupling products may be hydrolyzed to vicinal tricarbonyl compounds, which are otherwise cumbe

294 egioselectivity is due to the hydration of a vicinal triketone intermediate in the presence of both a

295 trolled cleanrooms (ISO 5 and ISO 8) and two vicinal uncontrolled areas (office, changing room) by cu

296 omputationally the translational dynamics of vicinal water molecules within the volume of a supramole

297 binding mode is proposed involving a single vicinal water monolayer between the surface and the sorb

298 suggest that enhanced structural ordering of vicinal water near the hydrophilic amino acids shifts th

299 on has a profound effect on the structure of vicinal water.

300 ecause of the fact the functional groups are vicinal, we found that the ee determination at the two s