ライフサイエンスコーパス: visceral endoderm

1 entiated to an epithelium that resembled the visceral endoderm.

2 lopment of the cardiovascular system and the visceral endoderm.

3 on early in embryonic development across the visceral endoderm.

4 ives rise to the extraembryonic parietal and visceral endoderm.

5 ed to be the homologue of the mouse anterior visceral endoderm.

6 symmetric patterns of gene expression in its visceral endoderm.

7 l positioning and structure formation of the visceral endoderm.

8 embryonic mesodermal cells that underlie the visceral endoderm.

9 buting to the epithelial organization of the visceral endoderm.

10 y and its regulation in the formation of the visceral endoderm.

11 tion to the extra-embryonic ectoderm and the visceral endoderm.

12 rm and anterior neuroectoderm but not in the visceral endoderm.

13 cascade that controls differentiation of the visceral endoderm.

14 d the epithelial defects observed in the cKO visceral endoderm.

15 plete gastrulation due to dysfunction of the visceral endoderm.

16 Dab2 is a downstream target of GATA-6 in the visceral endoderm.

17 and that the process depends on signals from visceral endoderm.

18 mesoderm, whereas it is nonessential in the visceral endoderm.

19 er cell mass cells into the postimplantation visceral endoderm.

20 opological equivalent of the murine anterior visceral endoderm.

21 I/HDL allows maternal nutrient uptake by the visceral endoderm.

22 ependent on amnionless gene functions in the visceral endoderm.

23 ascade that regulates differentiation of the visceral endoderm.

24 the initial anterior movement of the distal visceral endoderm.

25 nd altered epithelial characteristics in the visceral endoderm.

26 etic manipulation and can be induced to form visceral endoderm.

27 he dynamics of the embryonic lineage, except visceral endoderm.

28 ing establish the anterior-posterior axis in visceral endoderm.

29 ignaling center that is specified within the visceral endoderm.

30 proliferates at a much higher rate than the visceral endoderm.

31 NM II-B or chimeric NM IIs restores a normal visceral endoderm.

32 ryo proper but rather in the extra-embryonic visceral endoderm.

33 thality at E5.5-E6.5, showing defects in the visceral endoderm.

34 This includes an epCam+Dpp4+ subtype of visceral endoderm.

35 opment of the first columnar epithelium, the visceral endoderm.

36 microarray analysis on E8.25 definitive and visceral endoderm.

37 ities and differences between definitive and visceral endoderm.

38 flow cytometric isolation of definitive and visceral endoderm.

39 as GATA6 is essential for development of the visceral endoderm.

40 in homeobox transcription factor Lhx1 in the visceral endoderm.

41 hat is expressed asymmetrically in the mouse visceral endoderm [2].

42 of lacZ, the imprinted X inactivation in the visceral endoderm, a derivative of the extraembryonic li

43 tive endoderm of the late blastocyst and the visceral endoderm after implantation.

44 Maspin was specifically expressed in the visceral endoderm after implantation; deletion of maspin

45 se through interactions between epiblast and visceral endoderm alone.

46 The mouse anterior visceral endoderm, an extraembryonic tissue, expresses s

47 ) were recently shown to be expressed in the visceral endoderm and anterior endomesoderm, respectivel

48 sh a primitive streak, although the anterior visceral endoderm and anterior epiblast fates are specif

49 r Nodal and Cripto in the differentiation of visceral endoderm and AVE from XEN cells and provide new

50 sceral endoderm (AVE), and can contribute to visceral endoderm and AVE in chimeric embryos.

51 moting, and required for differentiation of, visceral endoderm and cavitation of embryoid bodies.

52 ory enhancer eliminates transcription in the visceral endoderm and decreases Nodal expression in the

53 s nodal expression in the early epiblast and visceral endoderm and disrupts asymmetric expression in

54 helium and extensive mixing between cells of visceral endoderm and epiblast origin.

55 lin in nutrient internalization by the early visceral endoderm and highlight its involvement in the f

56 ene expressed in the extraembryonic anterior visceral endoderm and in primitive streak-derived tissue

57 embryos, Cerr1 is expressed in the anterior visceral endoderm and in the anterior definitive endoder

58 hly expressed by the epithelial cells of the visceral endoderm and localized to the brush-border memb

59 RT-PCR analysis of markers for visceral endoderm and mesoderm development indicates the

60 m in blood islands located between layers of visceral endoderm and mesoderm in the yolk sac.

61 oderm, which subsequently gives rise to both visceral endoderm and parietal endoderm.

62 GATA6(-/-) ES cells lack a covering layer of visceral endoderm and severely attenuate, or fail to exp

63 the primitive streak; first in the posterior visceral endoderm and soon after in the adjacent posteri

64 sterior proximal epiblast and its associated visceral endoderm and subsequently to the primitive stre

65 sible for maintaining VEGF in the developing visceral endoderm and that a VEGF-responsive paracrine s

66 SL is the functional equivalent of the mouse visceral endoderm and that extraembryonic structures may

67 ed for forebrain specification, the anterior visceral endoderm and the anterior definitive endoderm,

68 distinct organizing centres in the anterior visceral endoderm and the distal primitive streak.

69 To understand the function of GATA-6 in the visceral endoderm and to identify genes regulated by GAT

70 tion of Nodal expression in the epiblast and visceral endoderm, and at later stages governs asymmetri

71 es of XX embryos, including the trophoblast, visceral endoderm, and parietal endoderm.

72 ate, early definitive endoderm, and anterior visceral endoderm appear to be expanded, likely due to d

73 r Nodal, display upregulation of markers for visceral endoderm as well as anterior visceral endoderm

74 at, while Smad1 is uniquely expressed in the visceral endoderm at 6.5 dpc, in other tissues Smad1 is

75 scripts are present only in a small patch of visceral endoderm at the distal tip of the egg cylinder.

76 characteristic localized outpocketing of the visceral endoderm at the posterior embryonic/extra-embry

77 rabbit suggest patterning roles for anterior visceral endoderm (AVE) and ADE.

78 meobox gene Hex is expressed in the anterior visceral endoderm (AVE) and rostral definitive endoderm

79 ignalling centres, most notably the anterior visceral endoderm (AVE) and the node, respectively.

80 he head organizer is located in the anterior visceral endoderm (AVE) and the trunk organizer in the n

81 Cnbp is first expressed in the anterior visceral endoderm (AVE) and, subsequently, in the anteri

82 chanism regulating migration of the anterior visceral endoderm (AVE) by BMP signaling through BMPRIA.

83 drives the collective migration of anterior visceral endoderm (AVE) cells in the early mouse embryo.

84 The anterior visceral endoderm (AVE) differs from the surrounding vis

85 oper morphogenetic movements of the anterior visceral endoderm (AVE) during pre-gastrulation stage.

86 thought to take place only when the anterior visceral endoderm (AVE) emerges and starts its asymmetri

87 The mouse anterior visceral endoderm (AVE) has been implicated in embryonic

88 The formation of the anterior visceral endoderm (AVE) in the pre-gastrulation mouse em

89 The anterior visceral endoderm (AVE) is an extra-embryonic tissue req

90 This anterior visceral endoderm (AVE) is then displaced away from the

91 The anterior visceral endoderm (AVE) of the mouse embryo is a special

92 Anterior visceral endoderm (AVE) promotes early mouse head develo

93 The anterior visceral endoderm (AVE) signaling center emerges at the

94 maintain cell-cell contacts in the anterior visceral endoderm (AVE) signalling centre that normally

95 BMP2 expressed in anterior visceral endoderm (AVE) signals to epiblast derivatives

96 the mouse embryo, migration of the anterior visceral endoderm (AVE) to the prospective anterior esta

97 The anterior visceral endoderm (AVE), a specialised subset of VE cell

98 ation and migration of cells of the Anterior Visceral Endoderm (AVE), an early extraembryonic organiz

99 or normal migration of cells of the Anterior Visceral Endoderm (AVE), an extraembryonic organizer tha

100 ammalian embryo is laid down by the anterior visceral endoderm (AVE), an extraembryonic signaling cen

101 rs for visceral endoderm as well as anterior visceral endoderm (AVE), and can contribute to visceral

102 LRT3 expression is activated in the anterior visceral endoderm (AVE), and during gastrulation appears

103 follow the step-wise development of anterior visceral endoderm (AVE), critical for establishing AP po

104 ments that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and defin

105 blast, extraembryonic ectoderm, and anterior visceral endoderm (AVE), resulting in phenotypes that ar

106 A-P) axis formation by inducing the anterior visceral endoderm (AVE), the extraembryonic signaling ce

107 ts in abnormal morphogenesis of the anterior visceral endoderm (AVE).

108 is expressed primarily in the extraembryonic visceral endoderm before gastrulation and later in both

109 at Indian hedgehog (Ihh) is expressed in the visceral endoderm both in the visceral yolk sac in vivo

110 opment, showing that Dab2 is required in the visceral endoderm but dispensable in the embryo proper.

111 Dab2 is expressed in the extra-embryonic visceral endoderm but not in the epiblast.

112 l signals from the epiblast also pattern the visceral endoderm by activating the Smad2-dependent path

113 p a normal patterned embryo with a polarized visceral endoderm by E6.5 and die by E7.5.

114 ed that spatial distribution of cells in the visceral endoderm can be traced back to polarity present

115 mesoderm indicating that loss of YY1 in the visceral endoderm causes defects in the adjacent yolk sa

116 ds to a switch from AVE to an extraembryonic visceral endoderm cell identity, and second, by demonstr

117 stimplantation conceptus involves asymmetric visceral endoderm cell movement.

118 for upregulation of MT-I gene expression in visceral endoderm cells and that optimal expression also

119 eformed primitive egg cylinder; however, the visceral endoderm cells are not organized, the cells of

120 nexpectedly that a significant population of visceral endoderm cells does contribute, along with epib

121 endoderm cells and the derived parietal and visceral endoderm cells gain the capacity to produce col

122 l surfaces of enterocytes, acinar cells, and visceral endoderm cells in mice fed a zinc-adequate diet

123 reduction in apical vacuoles in the columnar visceral endoderm cells in the extraembryonic region.

124 e of elevated levels of message in the outer visceral endoderm cells relative to the core cells in ma

125 Visceral endoderm cells remained associated with the epi

126 ith the stereotyped shift in the position of visceral endoderm cells reveal similarities among amniot

127 cted a morphological and lineage analysis of visceral endoderm cells spanning pre- and postprimitive

128 g that is produced by distal (ectoplacental) visceral endoderm cells that migrate into the allantoic

129 We found that visceral endoderm cells that originated near the polar b

130 Expression of MT-I in visceral endoderm cells was dependent on maternal dietar

131 ein at the apical surface of enterocytes and visceral endoderm cells.

132 phology, which distinguishes them from other visceral endoderm cells.

133 t activates cell-specific MT-I expression in visceral endoderm cells.

134 bly, clusters of AVE cells also form in pure visceral endoderm cultures upon activation of Nodal sign

135 ct4 expression stain positive for markers of visceral endoderm (DAB2, alpha-fetoprotein (AFP), HNF4).

136 r, FLK1, recapitulates both the mesoderm and visceral endoderm defects observed in the cKO yolk sac.

137 iblast, which does not occur in the adjacent visceral endoderm, depends on cells losing contact with

138 Exogenous provision of visceral endoderm-derived factors (VEGF-A, IHH, and bFGF

139 sac mesoderm, is required to promote normal visceral endoderm development.

140 bryoid bodies and embryos at the stages when visceral endoderm differentiation and cavitation are occ

141 cell line, a model for retinoic acid-induced visceral endoderm differentiation in which we demonstrat

142 s, by stable siRNA silencing of Dab2, blocks visceral endoderm differentiation.

143 Notably, visceral endoderm dispersal is impeded in Cubilin null e

144 enesis in part due to severe disturbances in visceral endoderm displacement.

145 estigated the cell behaviors and fate of the visceral endoderm during gut endoderm formation in the m

146 ation is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms.

147 nvolves the directed migration of the distal visceral endoderm (DVE).

148 Instead, we observed dispersal of the visceral endoderm epithelium and extensive mixing betwee

149 ells of the wild-type AVE migrate within the visceral endoderm epithelium from the distal tip of the

150 Endocytosis across the visceral endoderm epithelium involves specific cell surf

151 ng the gastrulating embryo and indicate that visceral endoderm-expressed BMP2 coordinates morphogenet

152 meras developing in the context of wild-type visceral endoderm fail to undergo ventral closure, axial

153 We show that, in Tmem132a mutant embryos, visceral endoderm fails to be excluded from the medial r

154 in both primitive streak-derived tissues and visceral endoderm for head formation and that its inacti

155 terior axial mesendoderm but not in anterior visceral endoderm for head induction.

156 n in the visceral endoderm promotes anterior visceral endoderm formation and anterior-posterior axis

157 In contrast with the failure of visceral endoderm formation resulting in embryonic day (

158 he growth of the inner cell mass stopped, no visceral endoderm formed, and finally the egg cylinder d

159 that Dab2 is pleiotropic and regulates both visceral endoderm function and lipoprotein receptor traf

160 isoform-independent requirement for NM II in visceral endoderm function.

161 N cells do not contribute efficiently to the visceral endoderm in chimeric embryos.

162 The absence of an organized visceral endoderm in Dab2-deficient conceptus leads to t

163 One such tissue, the hypoblast (visceral endoderm in mouse), acquired a role in fixing t

164 The role of visceral endoderm in primitive hematopoiesis and vasculo

165 normally gives rise to the parietal and the visceral endoderm in vivo, but XEN cells do not contribu

166 blood islands and vessels when juxtaposed to visceral endoderm in vivo.

167 ocessing occurs in vivo in the intestine and visceral endoderm, in mouse Hepa cells that express the

168 The visceral endoderm is a polarized epithelial monolayer ne

169 At the egg cylinder stage, the distal visceral endoderm is columnar, and these cells begin to

170 d mesoderm whereas activity in the posterior visceral endoderm is dispensable.

171 r Endothelial Growth Factor A (VEGFA) by the visceral endoderm is essential for normal growth and dev

172 sient nodal expression in the extraembryonic visceral endoderm is essential for patterning the rostra

173 ults suggest that regional patterning of the visceral endoderm is independent of primitive streak for

174 We conclude that the visceral endoderm is not essential for the differentiati

175 expressed exclusively in the extra-embryonic visceral endoderm layer during gastrulation.

176 derm or embryoid bodies, containing an outer visceral endoderm layer.

177 t embryoid bodies do not develop an external visceral endoderm layer.

178 Inactivation of Aurora A in the epiblast or visceral endoderm layers of the conceptus leads to apopt

179 In contrast, mutation of Aurora A in the visceral endoderm, leads to posteriorization of the conc

180 ted protease activity is not observed in the visceral endoderm-like cell line, PSA-5E, or in the diff

181 In E5.5 dab2 (-/-) conceptus, visceral endoderm-like cells are present in the deformed

182 embryoid bodies contained an outer layer of visceral endoderm-like cells surrounding an inner layer

183 and differentiation into primitive and then visceral endoderm-like cells, accompanied by a suppressi

184 m cell precursors, and formation of anterior visceral endoderm-like tissues.

185 te the epiblast, extraembryonic ectoderm and visceral endoderm lineages, respectively.

186 f BMP receptor IB inhibits expression of the visceral endoderm marker, Hnf4, and prevents cavitation

187 bodies induces expression of Hnf4 and other visceral endoderm markers and also cavitation.

188 or-posterior neural patterning, but anterior visceral endoderm markers are expressed and correctly po

189 mal layer is evident, as cells with positive visceral endoderm markers are scattered throughout the d

190 Etv4/Etv5-deficient embryos exhibit anterior visceral endoderm migration defects post-implantation, a

191 arly gastrulation stage, displaying abnormal visceral endoderm morphology and severe disruption of me

192 ression as well as a failure to displace the visceral endoderm occurs despite the formation of a norm

193 expression is evident first in the posterior visceral endoderm of 5.5 dpc embryos and later in the po

194 e cells in mature embryoid bodies and in the visceral endoderm of Day 6.5 embryos.

195 tially, Alk2 transcripts are detected in the visceral endoderm of gastrula stage mouse embryos, sugge

196 n Dab2 promoter and Dab2 is expressed in the visceral endoderm of GATA-4 null embryos.

197 endoderm of wild-type embryos but not in the visceral endoderm of GATA-6-deficient embryos.

198 Cxcr4 in primitive endoderm was confirmed in visceral endoderm of mouse embryos.

199 In the visceral endoderm of Mttp-/- yolk sacs, lipoprotein synt

200 KO) strategy was used to delete YY1 from the visceral endoderm of the yolk sac and the definitive end

201 oth the livers of adult Mttp+/- mice and the visceral endoderm of the yolk sacs from Mttp+/- embryos

202 ith these findings, Dab2 is expressed in the visceral endoderm of wild-type embryos but not in the vi

203 have assessed the consequences of a lack of visceral endoderm on blood cell and vessel formation usi

204 for by an inhibitory effect of Nodal-induced visceral endoderm on pluripotent cell differentiation in

205 Immunohistochemical staining revealed a visceral endoderm pattern of Indian hedgehog (Ihh) in wi

206 Smad2 and not Smad3 mRNA is expressed in the visceral endoderm, potentially explaining why the primar

207 ented transient nodal.lacZ expression in the visceral endoderm prior to and during early streak forma

208 Slightly later, expression in the visceral endoderm promotes anterior visceral endoderm fo

209 The anterior visceral endoderm protects the pre-specified anterior ne

210 normally expressed in the anterior proximal visceral endoderm (PxVE), is downregulated in Bmpr-null

211 hydrogenase-2 (Raldh2), was expressed in the visceral endoderm, RA receptors alpha1 and alpha2 were e

212 In Cnbp(-/-) embryos, the visceral endoderm remains in the distal tip of the conce

213 amphibian dorsal morula, mammalian anterior visceral endoderm) require stabilised nuclear beta-caten

214 s with a tetraploid embryo-derived wild-type visceral endoderm rescues this early developmental arres

215 We discover that Smad2 inactivation in the visceral endoderm results in increased numbers of PGCs d

216 Because the visceral endoderm shares many properties with the liver

217 Hex(-/-) cells developing within a wild-type visceral endoderm show forebrain defects indicating that

218 e, resembles the functioning of the anterior visceral endoderm signalling centre of the mouse embryo,

219 Furthermore, expression of HNF4, a key visceral endoderm-specific transcription regulatory fact

220 WNT antagonists Dkk1 and Sfrp5, although the visceral endoderm subtype has much higher cardiac-induci

221 artments in the Snx1(-/-);Snx2(-/-) yolk-sac visceral endoderm, suggesting SNX1 and SNX2 may be requi

222 alpha5, which was associated with decreased visceral endoderm survival and production of VEGF-A, Ind

223 embryo culture restored vascular remodeling, visceral endoderm survival, as well as integrin alpha5 e

224 initially covered by a layer of cells called visceral endoderm that despite its name (visceral means

225 signals are thought to reside in an area of visceral endoderm that expresses the Hex gene.

226 This region of visceral endoderm thickening (VET) is found overlying fi

227 gulated by dietary zinc in the intestine and visceral endoderm, tissues involved in nutrient absorpti

228 iew, our data reveal no mass displacement of visceral endoderm to extraembryonic regions concomitant

229 he middle streak by acting in the underlying visceral endoderm to modulate a BMP signaling pathway.

230 development and reveals the contribution of visceral endoderm to the endoderm in the early mouse emb

231 murine embryo consists of an outer layer of visceral endoderm (VE) and an inner layer of ectoderm.

232 embryonal carcinoma cells differentiate into visceral endoderm (VE) and parietal endoderm (PE).

233 endoderm (AVE) differs from the surrounding visceral endoderm (VE) in its migratory behavior and abi

234 Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcri

235 The visceral endoderm (VE) is a simple epithelium that forms

236 The visceral endoderm (VE) is an epithelial tissue in the ea

237 In the mouse, the finding that the visceral endoderm (VE) is required for forebrain develop

238 In pregastrula stage mouse embryos, visceral endoderm (VE) migrates from a distal to anterio

239 ed exclusively in an extra-embryonic tissue, visceral endoderm (VE), during the early post-implantati

240 Phenotypic analysis revealed that visceral endoderm (VE)-restricted translation of otd(2)

241 ryonic day 9.5 chimeric embryos in which the visceral endoderm was composed of predominantly Lim1(-)(

242 In chimeric embryos in which the visceral endoderm was composed of predominantly wild-typ

243 riptional differences between definitive and visceral endoderm, we performed microarray analysis on E

244 ras in which the extraembryonic ectoderm and visceral endoderm were derived from homozygous mutant bl

245 to migrate anteriorly to create the anterior visceral endoderm, which assumes a squamous shape.

246 omes delineate the emergence of the anterior visceral endoderm, which is hallmarked by conserved (HHE

247 impairment of the nutritive functions of the visceral endoderm, which otherwise appears to differenti

248 essed, at least in part because the anterior visceral endoderm, which provides signals that regulate

249 mother to the fetus and is expressed in the visceral endoderm, yolk sac and placenta.