ライフサイエンスコーパス: waning

1 ew therapies when resources and interest are waning.

2 ic that began in West Africa in late 2013 is waning.

3 ugs, the use of alphaIIbbeta3 antagonists is waning.

4 t a time when acute inflammation is normally waning.

5 g within an inflamed environment are weak or waning.

6 e of small dense LDL particles appears to be waning.

7 s were used to investigate anti-nucleocapsid waning.

8 ding ice sheet melting or prolonging glacial waning.

9 is no difference in the profile of antibody waning.

10 unodeficient persons, data indicate relevant waning.

11 with 3 mRNA vaccine doses, without signs of waning.

12 d metformin legacy effects showed no sign of waning.

13 hallenge, while innate immune responses were waning.

14 activation, which then occurs when IFN-I is waning.

15 es demonstrated significant IgG boosting and waning above seropositivity cutoffs, underscoring the va

16 There is accumulating literature on waning acellular pertussis vaccine-induced immunity, con

17 as 15 min with activation peaking by 2 h and waning after 4 h.

18 workers in 6 US states, we assessed antibody waning after messenger RNA (mRNA) dose 2 and response to

19 By ~2800 BC, this phenomenon was waning, although Neolithic traditions persisted to at le

20 Acceptance of childhood vaccinations is waning, amplifying interest in developing and testing in

21 nduced protection, such as those produced by waning and boosting.

22 parameters, such as antibody titre boosting, waning and cross-reaction, as well as latent epidemiolog

23 Uncertainties about vaccine waning and effects of a delay on vaccine coverage sugges

24 Accounting for waning and immune escape, effective protection against t

25 heir variable age at onset, their waxing and waning and the variability of body surface environment.

26 heavily on influenza season timing, rate of waning, and overall VE.

27 such as vaccine efficacy, coverage, immunity waning, and population susceptibility-to the dynamics of

28 Waning anti-circumsporozoite antibody titres predict the

29 pport for transmission hypotheses permitting waning antibodies but retained immunity in adult-age bat

30 ccine are 97% effective against measles, but waning antibody immunity to measles and failure of the 2

31 months after the second vaccination, despite waning antibody levels.

32 rt-lived, and preliminary evidence indicates waning antibody titers following SARS-CoV-2 infection.

33 exposure to influenza viruses, combined with waning antibody titres, could result in larger and/or mo

34 umented in one individual (subject 1), while waning antibody with eventual seroreversion was observed

35 as the result of weak, narrowly targeting or waning antiviral T-cell responses.

36 hronology has been great, but its potency is waning as it decays and diffuses.

37 ly when organic disease has been excluded is waning,as we now have evidence to support symptom-based

38 ted humoral immune responses over time, with waning at day 180.

39 ective effect was most evident at 4 to 12 h, waning at later times.

40 Two Apa-boosters markedly improved waning BCG-immunity and significantly reduced Mycobacter

41 ility, the passenger lymphocyte syndrome, is waning because anti-B-cell immunosuppressive therapy is

42 fully vaccinated, suggesting no differential waning between the two vaccines.

43 proficiency in physical diagnostic skills is waning, but few data have examined the question critical

44 19 and 57% (95%CI:46-66) against long COVID, waning by 6 months.

45 ventricular tachyarrhythmias and waxing and waning cardiomyopathy.

46 t's dorsal ganglia and can reactivate due to waning cell-mediated immunity, causing HZ.

47 genic system can be used to model waxing and waning, childhood and growth and development-related bio

48 ion of w increases the critical fraction for waning commitment and decrease this fraction for increas

49 Increasing w lowers critical fraction for waning commitment but increases this fraction for increa

50 overcoming the natural tendency for rapidly waning coronavirus immunity.

51 Crohn's (CD) typically displays a waxing and waning course punctuated by disease flares that are char

52 aries, and complete resolution, a waxing and waning course, and progression to gallstones are all pos

53 ures include premonitory urges, a waxing and waning course, and to a much lesser degree, coprolalia.

54 s characterized by a heterogenous waxing and waning course, with variable age of onset and persistenc

55 limited in their ability to model waxing and waning diseases and frequently superimpose development-d

56 ere, we conducted a systematic comparison of waning dynamics of nAb and VE over time and against vari

57 However the waning effect noted requires further study.

58 Despite a waning effect, antibody levels remained high at 6 months

59 Given the waning effectiveness of decolonization, we evaluated per

60 This waning effectiveness supports the need for annual revacc

61 ysis reveals the differential protection and waning effects for the vaccines as a function of biotype

62 umber of infections, variants, and the known waning effects of vaccination, future mRNA vaccinations

63 data indicate that, rather than boosting the waning efficacy of BCG, a vaccination schedule involving

64 intain periodontal health in situations with waning efficacy of personal oral hygiene.

65 sential to identify any signals of potential waning efficacy or type-replacement.

66 boptimal Ag found in lymphoid tissues at the waning end of the effector phase and microbial clearance

67 rvations support a competition model whereby waning ER stress passively partitions ERdj4 and BiP to I

68 MB-435 tumors infected with Ad-HA-SSTR2 from waning expression at the later time point (P < .05).

69 een the last eruptions, we conclude that the waning/extinguishment of eruptive activity shifted progr

70 ncluding backset bedforms that are formed in waning flows by an upstream-propagating granular bore.

71 Antibody waning following influenza vaccination has been repeated

72 h, w, defining their willingness to lose (in waning), gain (for increasing) or both (in variable) com

73 Waning gamma interferon production in gene gun-immunized

74 ccination has been repeatedly evaluated, but waning has rarely been studied in the context of longitu

75 out vaccination safety further contribute to waning herd immunity in developed countries, resulting i

76 Waning humoral immunity and the circulation of divergent

77 es have emerged, particularly concerning the waning immune response over time and the evolving landsc

78 To mimic a waning immune response, and to assess priming for ERD un

79 model for wild poliovirus that incorporates waning immunity (which affects both infection risk and t

80 although ongoing surveillance for potential waning immunity after a single dose is needed.

81 Concerns about waning immunity against severe acute respiratory syndrom

82 Waning immunity among measles cases, associated with sec

83 rgences of the epidemic, we go on to include waning immunity and a mechanism explicitly accounting fo

84 rces (instantaneous rates) of infection, but waning immunity and clinical consequences that depend on

85 Combination of waning immunity and lower effectiveness against new SARS

86 s has been an effective strategy to overcome waning immunity and neutralization escape by emerging SA

87 pertussis resurgence has been attributed to waning immunity and other factors, vaccine refusal was s

88 that a model with either partial immunity or waning immunity and reinfection, where individuals becom

89 he remarkable efficacy of COVID-19 vaccines, waning immunity and the emergence of SARS-CoV-2 variants

90 COVID-19 booster vaccine can strengthen waning immunity and widen the range of immunity against

91 cine, and to evaluate age at vaccination and waning immunity as risk factors for vaccine failure.

92 These findings could indicate waning immunity but could also occur if vaccine effectiv

93 rome coronavirus 2 (SARS-CoV-2) variants and waning immunity call for next-generation vaccine strateg

94 Onward transmission from 1 waning immunity case was documented.

95 Waning immunity cases had higher IgG titers than indeter

96 Seven (54%) waning immunity cases reported receiving measles-contain

97 ared with nonimmune and indeterminate cases, waning immunity cases were more likely to be male; less

98 te history of vaccination also suggests that waning immunity could have contributed to susceptibility

99 oupled with exposure to infected caregivers, waning immunity despite complete vaccination, inferior l

100 Due to waning immunity following primary immunization with COVI

101 Our results demonstrate waning immunity following vaccination with either Tdap b

102 t to which influenza recurrence depends upon waning immunity from prior-infection is undefined.

103 ges in sustaining high vaccination coverage, waning immunity in HIV-1-infected children, and clusteri

104 genic evolution of the circulating virus and waning immunity in humans.

105 tious Diseases held the workshop "Overcoming Waning Immunity in Pertussis Vaccines" in September 2019

106 Imported food products combined with waning immunity in some adult populations might make thi

107 Given suboptimal global vaccination rates, waning immunity in vaccinated individuals, and the emerg

108 and 2014-2017, the proportion of cases with waning immunity increased from 0 of 87 (0%) to 13 of 103

109 any developed countries has been linked with waning immunity induced after immunization with acellula

110 In countries using acellular vaccines, waning immunity is at least part of the problem.

111 lusters of nonmedical vaccine exemptions and waning immunity may have been factors contributing to co

112 he role of nonmedical vaccine exemptions and waning immunity may have had on the resurgence of pertus

113 but inequities in vaccine administration and waning immunity may limit vaccine effectiveness.

114 Raising concerns about the waning immunity of cohorts receiving hepatitis B virus (

115 oncerns remain about lower effectiveness and waning immunity of rotavirus vaccines in resource-poor p

116 nts), or decrease vaccine effectiveness (eg, waning immunity or escape variants), or increase social

117 Waning immunity or secondary vaccine failure (SVF) has b

118 ong vaccinated young adults, suggesting that waning immunity played a role.

119 ine improved mumps outbreak control and that waning immunity probably contributed to propagation of t

120 rmation for both primary vaccine failure and waning immunity provide essential information for our pr

121 Analysis of waning immunity rates and oral polio vaccine transmissib

122 vaccine transmissibility reveals that higher waning immunity rates make eradication more difficult be

123 We evaluated waning immunity to 14 pneumococcal serotypes, pertussis

124 Waning immunity was not identified as a risk factor sinc

125 sibility, clearance of initial infection and waning immunity were derived in a Bayesian framework by

126 and laboratory profile of measles cases with waning immunity with other measles cases.

127 d studies highlight the growing evidence for waning immunity within a single influenza season among v

128 e), IgM+/IgG+ (indeterminate), or IgM-/IgG+ (waning immunity).

129 ixing, resurgent epidemic waves, patterns of waning immunity, and emerging variants that have shown s

130 c drift phenomenologically with continuously waning immunity, and the second epochal evolution model

131 By considering the waning immunity, we suggest a new booster dose with BNT

132 porating high asymptomatic ratio and rapidly waning immunity, with infection both from human and envi

133 in highly vaccinated populations, indicating waning immunity.

134 ause of impaired initial vaccine response or waning immunity.

135 ed frequently in vaccinated individuals with waning immunity.

136 ntinues to change due to viral evolution and waning immunity.

137 26 (14%) were indeterminate, and 13 (7%) had waning immunity.

138 ut mumps vaccine effectiveness and potential waning immunity.

139 ren ages 10 to 14 years old, consistent with waning immunity.

140 d dose for outbreak control and assessed for waning immunity.

141 emoval of a hypoxic dilator stimulus that is waning in 7CH rats.

142 glutination inhibition antibody boosting and waning in a longitudinal cohort of older children and ad

143 Despite a slight waning in antibody titers after primary challenge, enhan

144 Our analysis accounted for waning in antibody titers over time, and could be partic

145 After initial waning in BNT162b2 booster protection against infection,

146 e presence of ATP, with all three activities waning in concert when Glu-tRNA(Gln) levels become exhau

147 A progressive waning in Foxp3(+) regulatory T cell (Treg) functions is

148 f enhancing specific T-cell responses during waning in the lung and spleen.

149 ulsed daily manner, starting after dusk, and waning in the morning, as photosynthesis resumed.

150 that biomedical research as a profession is waning in the United States (see "Rescuing US biomedical

151 With interest waning in the use of cyclooxygenase-2 (COX-2) inhibitors

152 Greater waning in vaccine effectiveness against hospitalization

153 ssive vaccinations, but the rate of antibody waning increased with each vaccination.

154 Although the rate of antibody waning increased with successive vaccination, the estima

155 Despite waning indications in the general population for preoper

156 stelae strain, a finding consistent with its waning infection status, whereas lesions characteristic

157 Children with waxing and waning inflammation of less than 15 eosinophils/hpf for

158 drug development failures and punctuated by waning interest and presumed intractability toward direc

159 Furthermore, imperfect, waning intestinal immunity among older children and adul

160 hat its incidence rose just as H. pylori was waning is best explained by changes in gastric microecol

161 As the epidemic appears to be waning, it is unclear whether transmission is still ongo

162 cholecystitis subsequently developed waxing waning jaundice and recurrent episodes of upper gastroin

163 e efficacy and coverage, and slower immunity waning led to shorter time-to-elimination.

164 d subset of the data highlighted evidence of waning maternal antibodies in neonates, increasing serop

165 ing after age 24 months, possibly indicating waning maternal antibodies.

166 Waning measles immunity among vaccinated individuals may

167 n of large floods after A.D. 1200, driven by waning midcontinental aridity, marks the onset of sociop

168 Patterns of boosting and waning might be different with the influenza A(H3N2) sub

169 We infer the viral transmissibility, rate of waning natural immunity and rates of progression and cle

170 the post-awakening period [in particular, a waning negative correlation between prefrontal cortex an

171 these fluctuations are due to the waxing and waning of a common cognitive resource, attention and wor

172 Waxing and waning of a global authigenic carbonate sink helps to ex

173 This waning of activity is called homologous desensitization

174 of OP development, which featured waxing and waning of amplitudes, was observed and might have been c

175 t in 90% (anti-RBD) and 76.7% (anti-NP) with waning of anti-NP titers and stability of anti-RBD over

176 Rapid waning of anti-polysaccharide bactericidal Ab and vaccin

177 s 2 (SARS-CoV-2) vaccination with subsequent waning of anti-spike antibody levels.

178 nd adults (n = 4478) experience boosting and waning of antibodies during and after major Zika and den

179 Besides waning of antibody responses, suboptimal induction of T-

180 dy responses to measles vaccine, their rapid waning of antibody suggests that measles vaccination cam

181 from 2017 to 2021, we show that the rate of waning of antibody titres against influenza virus during

182 um ice volume estimates show that waxing and waning of at least approximately 85 to 110% of the volum

183 Waning of both the concentration as well as the avidity

184 ves induce memory CTL, may contribute to the waning of CTL memory pool to earlier viruses as the immu

185 healthcare-seeking behavior, or evidence of waning of detectable anti-SARS-CoV-2 antibody levels at

186 extremes, changing inter-annual variability, waning of dominant inter-decadal quasi-periodic dynamics

187 We also demonstrated that waning of EEHV1-specific antibodies can occur in the fir

188 pt of the second vaccine dose to investigate waning of effectiveness separately for the B.1.1.7 (alph

189 upled receptors (GPCRs) characterized by the waning of effector activity despite continued presence o

190 However, the waning of effects over follow-up, although moderated by

191 s association is consistent with intraseason waning of host immunity, but bias or residual confoundin

192 participants aged 65 years and older, faster waning of IgG and neutralizing antibodies (ratio of mean

193 Less waning of immune responses was seen after the fifth vacc

194 Unexpected waning of immunity after pertussis vaccination is now we

195 oV-2 from vaccination and natural infection, waning of immunity and variant emergence will continue t

196 sub)variant, changes in behavior, or ongoing waning of immunity could lead to a new SARS-CoV-2 wave.

197 Rapid waning of immunity during the early years after vaccinat

198 t increased risk of measles infection due to waning of immunity following vaccination.

199 However, waning of immunity from acellular vaccines may be drivin

200 No waning of immunity was evident during the first 4 years

201 ch factors contribute to the maintenance and waning of immunological memory, the following study exam

202 In human and mouse periodontitis, waning of inflammation was correlated with DEL-1 upregul

203 lifornia confirmed a finding of intra-season waning of influenza vaccine effectiveness.

204 During waning of insulin effect, GLUT4 was re-internalized to b

205 a century of investigation with a waxing and waning of interest, the role of sleep in memory processi

206 track pattern associated with the waxing and waning of Late-Pleistocene Northern Hemisphere ice sheet

207 re is a gap in neonatal immunity between the waning of maternal protection and routine infant immuniz

208 by MCh was maintained for 30 minutes despite waning of MCh concentration over that period, measured a

209 the contraction phase or protect against the waning of memory T cell numbers at later times after inf

210 Sparsely infiltrated tumours exhibited a waning of neoantigen editing during tumour evolution, in

211 ogenesis whose exhaustion contributes to the waning of olfaction with age.

212 rge of magma from deep in the crust and with waning of overpressure in the magma reservoir.

213 tion of smallpox vaccination and concomitant waning of population-level immunity.

214 IV vaccine trial, which demonstrated a rapid waning of protective immunity with time, have underscore

215 th platelet recovery with inversely parallel waning of serum-induced heparin-independent serotonin re

216 iking structure that followed the waxing and waning of spindles; firing rates increased, spikes were

217 A general waxing and waning of staining intensity were observed over this dev

218 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic

219 ecific effects such as the normal waxing and waning of symptoms over time and the quality of the doct

220 was slight but not statistically significant waning of the efficacy of BCG vaccination over time, gre

221 disease symptoms often appear subsequent to waning of the Th1-like immune response.

222 d over time and was highly correlated with a waning of the vaccine-mediated protection against HZ.

223 s well as themselves as they practice, and a waning of this dependence as they mature.

224 t smoking cessation can be achieved, but the waning of this effect by 12 months means more effort is

225 Waning of transplacentally acquired NTS LPS-specific ant

226 An apparent waning of treatment effect with time was seen.

227 amics of cancer evolution and the waxing and waning of tumor subclones over time in advanced metastat

228 Estimates of the rate of waning of vaccine effectiveness (VE) against COVID-19 ar

229 cohort effects, and potential within-season waning of vaccine protection.

230 (II) frequent primary vaccine failure, (III) waning of vaccine-derived protection, and (IV) vaccine "

231 mps in highly vaccinated populations suggest waning of vaccine-induced immunity and primary vaccine f

232 Waning of vaccine-induced immunity is considered to play

233 istent with long-lasting BCG protection, but waning of VE with time.

234 l influenza season, approximately 7% monthly waning of VE, and that between 0% and 50% of individuals

235 Despite waning of virus-neutralizing antibodies, protection agai

236 A novel, low power, waxing-and-waning optogenetic stimulation paradigm preferentially i

237 BV infection and may present as a waxing and waning or fulminant syndrome.

238 role for cellular immunity in the context of waning or subprotective antibody titres.

239 Despite SARS-CoV-2 immunity waning over time in older adults, booster vaccines can e

240 protection against reinfection, with minimal waning over time.

241 both groups experience substantial antibody waning over time.

242 ble uncertainty in our estimates of antibody waning parameters, our results suggest that both short a

243 disease in question and the acquisition and waning patterns of immunity.

244 To dissect the contributions of waning pertussis immunity and repeat infections to pertu

245 t during the waxing phase as compared to the waning phase.

246 mal injection of capsaicin, (iv) and (v) the waning phases of capsaicin pain; and (vi) allodynia.

247 action of an adaptive immune response in its waning phases.

248 ion during airway reopening, with or without waning phasic or tonic activation in the first half of t

249 changes considerably between the waxing and waning portions of the eruption.

250 Both groups had waning proportions of B cells in circulation and decreas

251 umors in untreated mice was characterized by waning proportions of TCF1(+) T cells, suggesting self-r

252 Both waning protection and variant-specific immune evasion co

253 against RSV infection and pathogenesis, and waning protection correlated with reduced CD8(+) T cell

254 veloping countries, and evaluations indicate waning protection from rotavirus immunization in the sec

255 mmunity reflects the competing influences of waning protection over time and acquisition or restorati

256 incorporate age structures and progressively waning protection over time.

257 nly weak antibody responses and very modest, waning protection.

258 TaP) coverage, indicating the possibility of waning protection.

259 Waning public support for childhood immunization and sub

260 rsist for several years post-recovery, their waning raises concerns about their durability and role i

261 Antibody waning rates suggested an average IgG persistence of 58

262 hallenge of lpr/lpr mice, in contrast to the waning response in normal mice.

263 ion, with a temporal decline in T-bet in the waning response.

264 (3 of 56) and 16.1% (9 of 56) had waxing and waning responses, respectively.

265 ond half (P=.02 for interaction), suggesting waning risk after cessation of shift work.

266 Consistent with waning RPTPgamma-dependent vasorelaxation at low [HCO(3)

267 ut the protection wanes over time, with more waning seen against infection than severe outcomes.

268 patient over years, and prolonged waxing and waning seropositivity in some subjects, raises the possi

269 fective antiretroviral therapy, demonstrated waning serum anti-gp41 titers and Western blot band inte

270 active epochs up to 1-1.5 sec and introduced waning spindle sequences.

271 arge igneous province (LIP) and represents a waning stage in the emplacement of several temporally di

272 reservoir during ocean deoxygenation in the waning stages of the positive carbon isotope excursion.

273 sponse to positively influence an ongoing or waning Th1 response.

274 Because antibody levels are waning, the fraction of previously infected individuals

275 After maternal antibody waning, there were periodic increases and decreases in H

276 Our findings demonstrate that waning thymic output results in a decrease in CD45RA+CD3

277 eficiency virus (HIV) acquisition at 1 year, waning to 31.2% after 3.5 years.

278 e of the primary course, with no evidence of waning up to 10 weeks.

279 Bias arises in studies of waning vaccine effectiveness when higher-risk individual

280 Despite waning vaccine effectiveness, rates of covid-19 related

281 is group, with suboptimal immunogenicity and waning vaccine efficacy described in small studies being

282 Given waning vaccine efficacy over time, this secondary analys

283 re, we show using our transmission model how waning vaccine immunity reproduces qualitative and quant

284 ed awareness, improved diagnostic means, and waning vaccine-induced immunity among adolescents and ad

285 to control measles is failure to vaccinate, waning vaccine-induced immunity and the possible emergen

286 ection from both primary vaccine failure and waning vaccine-induced immunity.

287 s is likely due to increased recognition and waning vaccine-induced immunity.

288 y transmission (herd immunity) combined with waning vaccine-induced immunity.

289 atistical methods for estimating potentially waning VE against SARS-CoV-2 infection with blood or nas

290 dies were used to estimate IPD incidence and waning VE which were then combined in a cohort model of

291 After accounting for waning VE, we determined that repeat vaccinees were stil

292 Cumulative incidence adjusted for waning was 11.9% (95% credible interval [CrI], 10.5%-13.

293 Statistically significant waning was detected for IIV (P = .03) but not LAIV (P =

294 No evidence of waning was found for RSV.

295 outcomes for individuals up to 79 years old, waning was observed for individuals aged >=80 years, wit

296 etectable antibody response and for antibody waning, we estimate a 66% attack rate in June, rising to

297 esults suggest that both short and long term waning were present and would be identifiable with a lar

298 nd is only marginally attributable to immune waning with age.

299 led cumulative vaccine efficacy (VE) and its waning with time for three mortality strata.

300 ously thought, with some symptoms waxing and waning within symptom dimensions and rarely involving sh