ライフサイエンスコーパス: well-conserved

1 elatively early in vertebrate history and is well conserved.

2 roup of proteins involved in this pathway is well conserved.

3 ted, and consequently, hotspot positions are well conserved.

4 ioxygenase superfamily and is evolutionarily well conserved.

5 ry rarely and highlight that its function is well conserved.

6 pecies but for which primary sequence is not well conserved.

7 the immediate Schiff base vicinity are very well conserved.

8 p), required for the catalytic activity, are well conserved.

9 structure of the archaeal NTD domain is very well conserved.

10 that the dual-functioning nature of MSH1 is well conserved.

11 ne methyltransferase has been evolutionarily well conserved.

12 d in relation to the eve stripes, are rather well conserved.

13 nt segmental chromosome duplications are not well conserved.

14 tly, between these species, CESA motility is well conserved.

15 ore maintaining the structural integrity are well-conserved.

16 rosophila, midline expression of link is not well-conserved.

17 meres, telomeres and chromatin packaging are well-conserved.

18 heptamer and nonamer sequences flanking less well-conserved 12- or 23-bp spacers.

19 edominantly expressed E1c variant revealed a well conserved 400 bp DNA region that contains five E-bo

20 The well-conserved 5'-isomiRs have several features, includi

21 alignment of KRs led to a hypothesis that a well-conserved 94-XGG-96 motif may be involved in contro

22 shown in 2011-2012 to be substantial against well-conserved A(H1N1)pdm09 and lineage-matched influenz

23 rophic transfers, and traits were relatively well conserved across a wider array of river food webs.

24 chlorophyll in laminar leaves was remarkably well conserved across diverse lineages (ferns, cycads, c

25 Although the major topoisomers were well conserved across many cell and tissue types, unique

26 contains HPV-neutralizing epitopes that are well conserved across numerous high-risk HPVs.

27 onstrate that CTCF-mediated interactions are well conserved across populations, but enriched with dis

28 stent with the breach cluster residues being well conserved across the HSP47 family.

29 esting that regulation of these receptors is well conserved across the two species.

30 as1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established

31 results show that the expression of MORs is well-conserved across multiple mammalian species, indica

32 While the TERT protein is well-conserved across taxa, TR is highly divergent among

33 Rb), dissimilar to each other but especially well-conserved across the fungal lineage.

34 ment for ZipA suggesting that this atypical, well-conserved, actin homologue has a more critical role

35 SAMNs resulted structurally and magnetically well conserved after citrinin binding.

36 c damage, however, herpesvirus sequences are well conserved after reactivation from latency.

37 Although both pathways are relatively well conserved all the way from plants to invertebrates

38 on why large lipid transfer proteins have a well conserved alpha-helical domain, because we locate t

39 We also show that the normally well-conserved amino acid sequence of the autoproteolyti

40 with the phenotype in these families, affect well-conserved amino acids, and are predicted to be dama

41 Kdp system has a distinct arrangement and is well conserved among A. baumannii strains.

42 encoded by open reading frame 50 (Orf50), is well conserved among all known gammaherpesviruses and is

43 possess amino acid sequence motifs that are well conserved among all lipoyl protein ligases.

44 Some miRNAs are well conserved among different plant lineages, whereas o

45 However, trimer interfaces are well conserved among flaviviruses, so it is likely the d

46 way, which has been studied in detail and is well conserved among higher plants.

47 general structure of MHC genes is relatively well conserved among mammalian species, it is notably di

48 The C-terminal region of OPN is particularly well conserved among mammalian species, which suggests a

49 and the charge of the FcgammaRI FG loop are well conserved among mammalian species.

50 trol via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mous

51 This binding site is not well conserved among PCs, and only a subset of these bac

52 he biophysical properties of the machine are well conserved among phylogenetically distant bacterial

53 Tyr(137) is well conserved among RAS orthologs and is part of a tran

54 e mitochondrial matrix in eukaryotes, and is well conserved among species.

55 e mitochondrial matrix in eukaryotes, and is well conserved among species.

56 e regions involved in these interactions are well conserved among the different HCV genotypes, these

57 with the PTB domain of Numb through a region well conserved among vertebrate Kanks containing the NGG

58 ifferentiation of thrombocytes from HSPCs is well conserved among vertebrate organisms, positing the

59 lecular modeling indicates that this fold is well conserved among vertebrates.

60 ish embryo, lens organogenesis appears to be well conserved among vertebrates.

61 s of the protein, (R/N)(Y/F)(R/S)E(F/W), was well-conserved among AvrLm4-7 homologs.

62 stems and found that most TA orthologues are well-conserved among the members of the M. tuberculosis

63 se iron import systems tend to be relatively well conserved and are promising vaccine targets, having

64 equence on IC and its interface with LC7 are well conserved and are, thus, likely representative of a

65 etworks between human and mouse PSCs are not well conserved and better resemble their respective blas

66 kable tripartite structure is evolutionarily well conserved and can be found in almost all sexually r

67 tides 2 through 7 of the toxbox sequence are well conserved and contain an invariant tract of four co

68 The HSR is evolutionarily well conserved and has been widely studied in bacteria,

69 tructural bases for stomatal development are well conserved and increasingly well understood in extan

70 e show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other

71 specific, secreted CEACAM16 is exceptionally well conserved and specifically expressed in the inner e

72 eam region of human and mouse PEG3, which is well conserved and thus predicted to harbor several cis-

73 rface, and ranks the waters according to how well conserved and tightly clustered they are in the set

74 ighly-relevant channels contain structurally well-conserved and characterized extracellular and trans

75 sential, sporulation-specific homolog of the well-conserved and essential SEDS (shape elongation, div

76 human and mouse teeth establishes this as a well-conserved and fundamental biological process direct

77 Feeding is arguably one of the most well-conserved and important adaptive behaviors across a

78 deum, we find that, like OCRL, Dd5P4 acts at well-conserved and physically distinct endocytic station

79 nslated regions of the transcriptome are not well conserved, and functional annotation of these seque

80 und in 5'-UTRs and non-coding RNAs, are less well conserved, and have no bioinformatic indicators of

81 that the Rab1-regulated secretory pathway is well conserved, and hemoglobin receptor trafficking foll

82 trary to expectations in that PINB is not as well conserved as PINA.

83 omosome passenger complexes (CPCs) exhibit a well-conserved association with the anaphase spindle and

84 While the pathway is well conserved at a molecular and functional level, bran

85 wnstream ATGs in PB1-F2 plasmids lacking the well-conserved ATG start codon.

86 ent and niche-specific requirements for this well-conserved auxiliary factor.

87 gan identity genes are more diverse than the well-conserved B and C floral organ identity functions.

88 Cytoskeletal proteins are well conserved between animal and plant kingdoms; nevert

89 Although many basic cellular processes are well conserved between animals and plants, cell-to-cell

90 n years ago, many translational features are well conserved between Arabidopsis and tomato.

91 of PPIases is shallow, solvent-exposed, and well conserved between family members, making selective

92 While the RNA sequence of LncMyoD is not well conserved between human and mouse, its locus, gene

93 Although TERT is well conserved between most organisms, TER is highly div

94 ree plant homeodomain (PHD) fingers that are well conserved between species but whose potential roles

95 subunit of ATP synthase, which is unusually well conserved between the 2 organelles and the only sha

96 nthesis, signaling, and response, which were well conserved between the two rice cultivars.

97 visiae The mechanism of protein synthesis is well conserved between yeast and other eukaryotes, and m

98 These sites are generally well-conserved between equine and human SAs, but ibuprof

99 Since Ebp1 is well-conserved between mouse and chick, we switched to c

100 (LR) asymmetry (handedness, chirality) is a well-conserved biological property of critical importanc

101 ition of LlaGI and LlaBIII were structurally well-conserved but sequentially less-conserved.

102 clan CD of cysteine peptidases and contain a well-conserved C-terminal catalytic protease domain simi

103 hree point mutations altered residues in the well-conserved C-terminal motif or close to the glycine

104 acterial orthologs because of an additional, well-conserved C-terminal region.

105 licing rate using a species-specific SL over well-conserved Caenorhabditis elegans SL-like sequences.

106 Autophagy is a well-conserved catabolic process essential for cellular

107 me that all occipital tissues participate in well-conserved cell movements.

108 in their ability to dissect more than a few well-conserved cell populations across a tumor data set.

109 cell-surface protein families, overlaid on a well-conserved cell template.

110 -sequencing datasets revealed a surprisingly well-conserved cellular architecture that enables matchi

111 Macroautophagy (hereafter autophagy) is a well-conserved cellular process through which cytoplasmi

112 tin immunoprecipitation assays have revealed well conserved cis-elements for FoxOs and Clock/Bmal1 in

113 are not conserved between kingdoms, CK2 is a well-conserved clock component modulating the stability

114 larly perform saturation genome editing of a well-conserved coding region of an essential gene, DBR1,

115 ex conservation follows one of three models: well-conserved complexes, complexes with a conserved cor

116 While many are familiar with actin as a well-conserved component of the eukaryotic cytoskeleton,

117 inally, we identify 183 complexes containing well-conserved components and uncharacterized proteins w

118 Well conserved consensus sites at lysine 122 and 275 in

119 The promoters of MHC class I genes contain a well-conserved core module, the W/S-X-Y motif, which ass

120 ulin acetyltransferase displays a relatively well-conserved cosubstrate binding pocket but is unique

121 These lie in a small, well-conserved cytoplasmic domain of FlhA, located betwe

122 ming cysteines critical for Tg function, are well conserved despite overall divergence of amino acid

123 Our results show that genes with well-conserved developmental functions can be re-used at

124 Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular

125 Besides the well-conserved DNA repair machineries, organisms thrivin

126 Ebp1 is a well-conserved DNA/RNA binding protein that is implicate

127 and herpesviruses consist of a structurally well conserved dodecameric portal at a special 5-fold ve

128 An RWD domain is a well conserved domain found through bioinformatic analys

129 n addition, atom and electron economies were well-conserved during this CRC reaction.

130 tiated mesodermal cells is controlled by two well-conserved E box elements in the large first intron.

131 emerteans, and polyclad flatworms) display a well-conserved early developmental program called spiral

132 The aligned blocks contain well-conserved elements of secondary structure and well-

133 shows that the antibody binds to a novel and well-conserved epitope on the globular head of H3 HA and

134 Leu-27 is evolutionarily well conserved even though it is exposed in the monomeri

135 easure of steady-state network function, was well conserved even when all parameters were rounded to

136 Midasin contains a well conserved extension region upstream of the MIDAS do

137 , the Arabidopsis KIN17 homolog belongs to a well-conserved family of essential eukaryotic nuclear pr

138 Over 300 promoter sequences from a small, well-conserved family of plant transcription factors kno

139 POT transporters represent an evolutionarily well-conserved family of proton-coupled transport system

140 , their 3D relationships are considered, and well-conserved (feedback-like) functions are estimated.

141 states, and DNA methylation preferences are well conserved for TF-occupied sequences.

142 This ability to polymerize is well conserved for the few metabolic enzyme paralogs tha

143 The well conserved formin homology 1 and 2 domains were orig

144 r misfolded protein disposal pathway that is well conserved from yeast to mammals.

145 merging from such structures may distinguish well-conserved from recently developed host-microbial in

146 d by one or more databases, suggesting their well-conserved functions.

147 of the Fur box established the existence of well-conserved Fur boxes in the promoters of numerous kn

148 However, the biological function of this well-conserved gene in filamentous ascomycetes is not cl

149 e set is supported by its tight overlap with well-conserved genes and its enrichment for core biologi

150 nment of different Cxs shows the presence of well conserved glutamate residues in the C terminus of T

151 s a single Endos protein with a surprisingly well-conserved Gwl target site.

152 domain within a short tract that includes a well conserved His-Gly motif, where mutations have been

153 iB from N. gonorrhoeae and E. coli reveals a well-conserved homodimeric structure consisting of two o

154 Defects in the well-conserved human homologue could play a similar role

155 ion of TAD) upon binding to TAZ1 through its well-conserved hydrophobic sites in a series of grooves

156 more, BIR mutations that abrogate binding of well-conserved IAP antagonists did not affect Op-IAP3's

157 This epitope is well conserved in all 16 subtypes of the HA protein of i

158 (Ub) is a small protein of 8.5 kDa, which is well conserved in all eukaryotes.

159 mpetence regulators SigX, ComR, and ComS are well conserved in both groups.

160 These functions are well conserved in CCTs across diverse phyla, although th

161 these regulators (termed reference TFs) are well conserved in Desulfovibrionales, while the remainin

162 buting to MT nucleation and organization are well conserved in different kingdoms, the centrosome, re

163 clase (AC) IV (encoded by BB0723 [cyaB]) are well conserved in different species of Borrelia.

164 components of mRNA export machinery are not well conserved in divergent supergroups.

165 cap-mediated snRNP import in humans, is not well conserved in flies.

166 TAGteam motifs are present and well conserved in highly bound regions, and are associat

167 RHEX is well conserved in Homo sapiens and primates but absent f

168 ression level of their gene content, and are well conserved in induced pluripotent stem cells derived

169 a small protein of unknown function that is well conserved in low-GC Gram-positive bacteria.

170 While the imprinting status of genes is well conserved in mammals, clear estimates for the degre

171 The carrageenan utilization system is well conserved in marine Bacteroidetes but modified in o

172 Further, TBC-domain architecture has been well conserved in modern eukaryotes.

173 osS/DosT, an oxygen and redox sensor that is well conserved in mycobacteria.

174 e largely conserved, alternative splicing is well conserved in only a subset of tissues and is freque

175 equence in humans that is not evolutionarily well conserved in rodents.

176 r analysis indicates that VLRC sequences are well conserved in sea lamprey (Petromyzon marinus), L. c

177 The majority of these residues are well conserved in the AraR orthologs in Bacteroidetes.

178 e mechanism of IPS recognition is remarkably well conserved in the eukaryotic kingdom, as mammalian a

179 tes +1 to +4 in the S. coelicolor enzyme are well conserved in the M. tuberculosis enzyme so their id

180 While residue S375 is well conserved in the majority of group M HIV-1 isolates

181 ifs in the N terminus of VGLUT1 that are not well conserved in the other isoforms.

182 mal RNAs [rRNAs] and ribosomal proteins) are well conserved in the plastid ribosome, little is known

183 These residues are well conserved in the T antigens from the polyomaviruses

184 tructural and electronic characteristics are well conserved in their stacked form, possibly due to th

185 g that cpDNA architecture has been extremely well conserved in these deep-branching lineages of green

186 ological features of the locomotor drive are well conserved in vertebrates.

187 elda and single-minded midline expression is well-conserved in Drosophila, midline expression of link

188 This residue is well-conserved in other DJ-1 homologues, including two (

189 dues phosphorylated in our model systems are well-conserved in other human SH3 domains, but that the

190 ) s(-1)) and show that molecular markers are well-conserved in the bulk of solid BBA particles but un

191 Sets of R2R3 and R1R2R3 orthologs are well-conserved in three Phytophthora species.

192 de pockets have structural elements that are well-conserved in two human small-molecule kinases, inos

193 Well-conserved infrastructure may be useful for Agrobact

194 The Oxa1 protein is a well-conserved integral protein of the inner membrane of

195 It contains an exceptionally well-conserved interface that docks the MELT(P) sequence

196 Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loop

197 Matrix protein 1(M1) is a well-conserved internal protein.

198 Matrix protein 1 (M1) is a well-conserved internal protein.

199 These well-conserved isomiRs are functionally important and ha

200 Metazoan CTDs have well-conserved lengths and sequence compositions arising

201 nt, rodent models hold promise in dissecting well-conserved limbic circuits.

202 peptidase (Spase) cleavage site along with a well conserved lipobox motif.

203 by pulse radiolysis that the mutation of the well-conserved lysine 48 into isoleucine in the SOR from

204 Members of the well-conserved mannose receptor (MR) protein family have

205 beta/SMAD4/IRF6 signaling cascade might be a well-conserved mechanism in regulating multiple organoge

206 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold prot

207 t of 'index' orthologs representing the most well-conserved members of each ATGC-COG, the phylogeneti

208 ich fold as higher-plant PsbP and contains a well-conserved metal (zinc)-binding site that is also pr

209 Endospore formation (sporulation) is a well conserved microbial developmental strategy in the F

210 y of 141 conditional miRNA sponges targeting well-conserved miRNAs in Drosophila.

211 Among well-conserved miRNAs, we observed unexpected cases of c

212 peared during evolution is the expression of well-conserved molecular chaperones, such as those that

213 Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs)

214 Argonaute (AGO) proteins are a well-conserved multigene family of regulators mediating

215 utL homologs from bacteria to humans contain well-conserved N-terminal and C-terminal domains.

216 sly described in zebrafish, highlighting the well-conserved nature of habenular cell types across the

217 in yeast and human proteins, confirming the well-conserved nature of these systems.

218 target of rapamycin complex 1 (mTORC1) is a well-conserved negative regulator of autophagy.

219 Here we examine the evolutionary history of well-conserved nitrogen-assimilating enzymes to determin

220 Although GSK3 orthologs are well-conserved, none of them have been functionally char

221 We identified cacn-1/cactin, a well-conserved, novel regulator of cell migration in a g

222 re in the Rad2/XPG family and insights how a well-conserved nuclease core acquires versatility in rec

223 ed miRNAs have the same functionality as the well conserved ones.

224 KS, respectively), which are found within a well-conserved operon that may lead to the production of

225 os, which varied over a fourfold range, were well conserved over these durations.

226 ssyn, is HERV-derived, placenta-specific and well-conserved over simian evolution.

227 ditis elegans filamin ortholog, FLN-1, has a well conserved overall structure, including an N-termina

228 r findings provide mechanistic insights on a well-conserved pathway of PP regulation that is critical

229 th mutants, indicative that they are part of well conserved pathways and likely, therefore, to be opt

230 estigation determined that expression of the well-conserved penicillin-binding protein (PBP) 1A, prev

231 structure of the RMI core complex bound to a well-conserved peptide from FANCM shows that FANCM binds

232 Myomaker, encoded by Mymk (Tmem8c), is a well-conserved plasma membrane protein required for myob

233 Surprisingly, while track polarity is well conserved, polarity is nonetheless functionally dis

234 We found that PIP(2) bound to the well conserved polybasic patch of the C2B domain with an

235 e-directed mutagenesis revealed specific and well-conserved posttranslational modifications (PTMs), i

236 n has a strong initiation context and that a well-conserved predicted RNA stem-loop begins 14 nucleot

237 Endocytosis is a well-conserved process by which cells invaginate small p

238 dings that show peroxidase enzymes possess a well-conserved profibrogenic capacity to stimulate the m

239 Homologues of this well conserved protein are found within diverse phyla in

240 de evidence for the methylation of Rpl1ab, a well conserved protein forming the ribosomal L1 protuber

241 The alpha isoforms express a well conserved protein kinase A consensus site, which is

242 A well-conserved protein complex named ClpP (caseinolytic

243 The eukaryotic RNA exosome is a well-conserved protein complex with ribonuclease activit

244 Mice that lack a well-conserved protein kinase A (PKA) phosphorylation si

245 LsrS appears to be a well-conserved protein that is present in many streptoco

246 vidence suggests an important role for these well-conserved proteins in multiple processes and raises

247 CRY couples to membrane depolarization via a well conserved redox sensor of the voltage-gated potassi

248 A well-conserved region called the magnetosome island (MAI

249 a mutations and four polymorphisms affecting well-conserved regions of Poldelta or Polepsilon.

250 Despite being a well-conserved regulatory mechanism in the chloroplasts

251 A phosphorylation event of a well-conserved RelA(Ser276) is prerequisite for the form

252 Well conserved residues were highlighted, and the potent

253 athways, we performed an in vivo analysis of well-conserved residues in Msh3 that are hypothesized to

254 These amino acid substitutions affect well-conserved residues in the prodomain and in the pept

255 Across diverse vertebrate species, TRIO is a well-conserved Rho GTPase regulator that is highly expre

256 TDP-43 is a well-conserved RNA-binding protein known to regulate alt

257 Although many ncRNAs are known to have a well conserved secondary structure, which provides usefu

258 of seven transmembrane helices that contain well-conserved sequence motifs, indicating that they are

259 gion between both RNAs corresponds to a very-well-conserved sequence, it is plausible to admit that t

260 The Hippo pathway is a well-conserved signaling cascade that regulates organ si

261 Notch is a well-conserved signaling pathway and its function in cel

262 To identify upstream receptors of these well-conserved signalling pathways, we systematically ch

263 of a sensor kinase that typically has three well-conserved sites of phosphorylation: autophosphoryla

264 essential regulator of that decision is the well conserved Slit-Robo signaling pathway.

265 Slug (SNAI2), a member of the well-conserved Snail family of transcription factors, ha

266 ially pathogenic variant in a non-canonical, well-conserved splice site within TRAPPC4 (hg19:chr11:g.

267 icularly profound in light of the apparently well-conserved staggered cross-heme wire structural moti

268 d subsequent release of Nle1 by midasin is a well conserved step in the ribosome maturation pathway i

269 inhibition in matrix-attached cells resemble well-conserved stress responses to nutrient and growth f

270 Based on the well-conserved structure, multiple programs were develop

271 ion-coupled repair (TCR) is an important and well-conserved sub-pathway of nucleotide excision repair

272 lification, and these events' linkage to the well-conserved subsequent asymmetric transcriptional cas

273 e and yeast Srv2/CAP homologs are remarkably well conserved, suggesting that the same activities and

274 d evolutionarily distant algal phots is less well conserved than previously thought.

275 ce for sites which are more exposed and less well conserved than random.

276 Although the HA stalk region is relatively well conserved, the evolutionarily dynamic nature of inf

277 These sites are less well-conserved, therefore allosteric ligands have greate

278 Although generally well-conserved, they exhibit important differences.

279 ause regulation of mitotic entry by Cdc25 is well conserved, this mechanism may provide a widespread

280 characterized Protein Family 0016, which are well conserved throughout evolution and share characteri

281 The Nrf2 transcription factor is well conserved throughout metazoan evolution and serves

282 This hydrophobic core was well conserved throughout the m02 family, thereby indica

283 However, this capability also depends on a well-conserved toolkit of different molecular mechanisms

284 Elp3 is the catalytic subunit of the well-conserved transcription Elongator complex; however,

285 ich could be explained by the existence of a well-conserved tryptophan at position 375 (Trp 375) in H

286 LMW-PTPs, the phosphorylation status of two well conserved tyrosine residues, typically located in t

287 wo residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR

288 crown area-to-diameter allometry exponent: a well-conserved value across tropical forests.

289 ates, SOX9's functions in chondrogenesis are well conserved, while they vary in sex determination.

290 Mammalian DREAM is well conserved with Drosophila and Caenorhabditis elegan

291 l priming mechanisms, these proteins are not well conserved with heterodimeric (p48/p58) primases in

292 om fatty acid and TAG synthesis appear to be well conserved with plants, the pathways of TAG cataboli

293 e amino acid sequences of S. aureus PSMs are well conserved with two exceptions, one of which is the

294 The MAR family of transcription factors is well conserved, with members playing central roles in pa

295 erine-rich tract (SRT) of VZV IE62, which is well conserved within the alphaherpesviruses, is needed

296 Gene colinearity in the region is well conserved within the genus Zea.

297 ding network around the cis-peptide bond are well conserved within the metallopeptidase subfamily M9B

298 lored microbial interactomes and to focus on well-conserved yet uncharacterized interactors for furth

299 t chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes va

300 wo high affinity (K(d) approximately 20 nm), well conserved Zn(2+)-binding sites near its N terminus,