ライフサイエンスコーパス: well-established

1 a consequence, treatment strategies are not well established.

2 atients with biochemical recurrence (BCR) is well established.

3 (HCPs) in bioprocess, however, has yet to be well established.

4 the precise regulation of gene expression is well established.

5 gms with Pavlovian cue-food conditioning are well established.

6 al infarction (MI) in type 2 diabetes is not well established.

7 t of this system on neuroplasticity has been well established.

8 disorders, and pain states has been somewhat well established.

9 in evaluating and quantifying AS is not yet well established.

10 ariant discovery to return of results is not well established.

11 F) and body mass index on risk for HF is not well established.

12 ded network topology nor its conservation is well established.

13 ential between rifamycin antibiotics are not well established.

14 with lipodystrophy and leptin deficiency is well established.

15 M(2.5) level and measurement schemes are not well established.

16 risk of depressive symptoms in adulthood is well established.

17 ealth Stroke Scale [NIHSS] score <=6) is not well established.

18 oducts, anticancer potential of phenolics is well established.

19 ion on patient outcomes following EGS is not well established.

20 ection (AMR) and kidney allograft failure is well established.

21 demia and inflammation in atherosclerosis is well established.

22 -risk HPV and anal lesion progression is not well established.

23 r routine oculofacial plastic surgery is not well established.

24 involvement, and age of onset have not been well established.

25 in vivo mechanisms of cross-linking are not well-established.

26 ion between asthma and COVID-19 has not been well-established.

27 chanisms that underlie these effects are not well-established.

28 Although profilins are well-established actin regulators, the distinct roles of

29 ical age using Horvath's epigenetic clock, a well-established aging biomarker based on DNA methylatio

30 replaced by exclusive homologous pairing in well-established allopolyploids, an evolutionary process

31 ug discovery and development paradigm is now well established among the pharmaceutical industry and r

32 ant development and ripening is now becoming well established and new information about the role of p

33 he synthetic strategies for size control are well established and widely applicable to various QD sys

34 nique sensitivity and the possibility of the well-established and developed silicon photonics technol

35 s enable large enrollment, field methods are well established, and the predatory relationship between

36 x 10(-4) mol L(-1), a linear relationship is well established, and the value of the correlation coeff

37 bolism and anemia resolution in 2 different, well-established, and clinically relevant rodent models

38 development are predominantly derivatives of well-established antibiotic classes and were selected to

39 IFIT2, is an interferon-stimulated gene with well-established antiviral activity but limited mechanis

40 Sixfold phenyl embraces are well-established aromatic interactions that are strong a

41 pothalamus ventrolateral area (VMHvl) is now well established as a critical locus for the generation

42 Although bariatric surgery is well established as an effective treatment for patients

43 PIK3CA hotspot mutation is well established as an oncogenic driver event in cancer

44 Mitochondria are well established as bioenergetic hubs for generating ATP

45 While some environmental factors are well established as carcinogens, there remains a large k

46 Reward-evoked dopamine transients are well established as prediction errors.

47 unusual properties of fluorous materials are well established, at the other extreme on the periodic t

48 In a well-established BALB/c mouse model of pulmonary tubercu

49 for monitoring brain function, together with well-established behavioral readouts for CTD mice, to lo

50 3a and 4, we examined the efficacy of other well-established behavioural interventions: non-cash inc

51 cRNA-Seq detection workflows when applied to well-established benchmarks.

52 site that catalyzes multiple reactions is a well-established biochemical theme, but how one nuclease

53 that were common to all 3 data sets included well-established biomarkers of post-MI HF: N-terminal B-

54 ase definitions exist, there is currently no well-established biomarkers or laboratory tests to diagn

55 between ELA and risk for psychopathology is well established but the developmental mechanisms remain

56 odistribution and tissue pharmacokinetics is well established, but current PET systems lack the sensi

57 The physiological importance of kindlins is well established, but how the scaffolding functions of k

58 The physiological connections are relatively well established, but less is known about how sensorimot

59 mal isomerizations of overcrowded alkenes is well established, but rotary cycles based purely on phot

60 hanisms regulating phosphate (Pi) uptake are well established, but the function of chloroplast Pi hom

61 ive enhancing effects of methylphenidate are well established, but the mechanisms remain unclear.

62 icularly muscle hypertrophy and fat loss are well established, but the underlying chemical and physio

63 death from tuberculous meningitis (TBM) are well established, but whether outcome can be predicted m

64 orylation for proper contractile function is well-established, but the physiological and pathological

65 ting farmland and sparing land for nature is well-established, but the spatial overlap of this potent

66 We leverage the knowledge of well-established cancer driver genes to define a positiv

67 Perhaps the most well established candidate signature is the P3b event-re

68 occur in the absence of, or in addition to, well-established cardiovascular risk factors.

69 Smoking is a well-established cause of lung cancer and there is stron

70 ss of receptor-mediated endocytosis (RME) is well established, certain specific aspects, like the end

71 gh rates of glycolysis in cancer cells are a well-established characteristic of many human tumors, pr

72 proposes cyclizations utilizing a library of well-established chemical reactions and reagents.

73 x and heterogeneous genetic disease that has well-established clinical diagnostic criteria.

74 ten NIH funded than are papers that build on well-established clinical knowledge.

75 substantial improvement in skin scarring and well-established clinical safety profile, locally admini

76 k stratification of these patients on top of well-established clinical variables.

77 cy Model-Argentina), a local adaptation of a well-established computer simulation model that projects

78 of enteric neurons from the neural crest is well established, conflicting evidence exists regarding

79 Here we used the well established connections of the human visual system

80 y of PPs is intriguing because dolichol is a well-established constituent of human neuromelanin.

81 Cardiac sympathetic overactivity is a well-established contributor to the progression of neuro

82 ecurrence and metastasis after adjusting for well-established CSCC risk factors.

83 o the photoreceptor outer segments, form the well-established "dark" regeneration pathway known as th

84 Despite the well-established dependence of cartilage mechanical prop

85 Many types of cancers have a well-established dependence on glutamine metabolism to s

86 crystals that incorporate particles with the well-established designer properties of MOFs and, theref

87 compare a relatively new laser source to two well-established designs.

88 cular mechanism of complex formation are not well established, despite numerous structural, spectrosc

89 arks angiogenesis and metabolic rewiring are well-established drivers of breast cancer aggressiveness

90 h TLR9 and STING ligands within liposomes, a well-established drug delivery system that enables paylo

91 altered TFs and coregulator genes, including well-established (e.g. ERG) and underexplored (e.g. PPAR

92 s group show that the overall morphology was well established earlier in its history.

93 ferral program, we used the framework of our well-established ECMO service-line to outline specific t

94 B lymphocytes have well-established effector roles during viral infections,

95 proteins are quantitatively measured against well-established electrophoretic and diffusive processes

96 We demonstrate that GABAC outperforms well-established (entropy) codecs in a significant set o

97 We validate Padhoc with a set of well-established Escherichia coli pathways and demonstra

98 memory requirement in the perceptual task, a well-established event-related potential (ERP) index of

99 hat increase prediction of ASCVD beyond some well-established factors of ASCVD, and also suggest a po

100 While research on this reinforced pathway is well established, far less research has explored the neu

101 C4d staining in peritubular capillaries is a well-established feature of antibody-mediated rejection

102 g prevalence with age contributes to several well-established features of immunosenescence, including

103 Even some seemingly well-established findings have failed to replicate.

104 While this organization is well established for the auditory and trigeminal systems

105 onitoring progress towards these outcomes is well established for women of reproductive age (15-49 ye

106 omic diversity of their microbiomes has been well-established for corals and sponges, their functiona

107 ic connections and neurophysiological map is well-established for sensory cortical areas, but our stu

108 a framework invokes the modular organization well-established for sensory cortical areas.SIGNIFICANCE

109 erium exchange mass spectrometry (HDX/MS) is well-established for the analysis of the structure and d

110 We focus on a well-established form of NC, tuning-compatible noise cor

111 Besides this well-established function, there is strong evidence that

112 lineage-defining transcription factors have well-established functions beyond their role in CD4(+) T

113 nic polaritons as a serious contender to the well-established GaAs platform for a wide range of appli

114 e, we leverage the sea urchin embryo for its well-established gene regulatory network to interrogate

115 th cardiac structure and function, many near well-established genes for Mendelian cardiomyopathies.

116 Instead, we rely on well-established genetic models of linkage disequilibriu

117 reader, provides a rapid alternative to the well-established GM-EIA, potentially detecting more GM e

118 emonstrate that river deposition was already well established >3.7 Ga.

119 single-center experiences, and there are no well-established guidelines for diagnosis or management.

120 jections, we tested the impact of altering a well-established HCC oncogene (either MYC or beta-cateni

121 of bulk high-entropy carbides and borides is well established, high-entropy nitrides have only been p

122 te specification of cortical interneurons is well established, how these interact with extracellular

123 of genetic background on driver mutations is well established; however, the mechanisms by which the b

124 Given the well-established importance of NK cells in resistance to

125 Despite the well-established importance of trifluoromethylated compo

126 eatly hindered by various phenomena that are well established in animal studies: changes in local ion

127 onic properties and although their impact is well established in elemental semiconductors such as sil

128 onstrated in affected males but has not been well established in female carriers.

129 lergy relies on the hapten concept, which is well established in inducing adaptive reactions of the i

130 Whilst mathematical modelling is well established in informing biological systems, many m

131 This association is well established in microsatellite instable CRC.

132 Only two hemoglobin functions are well established in nodules: Lbs deliver O(2) to the bac

133 rial across branches of the tree of life, is well established in prokaryotes and uncontroversial.

134 In contrast, early feeding has become well established in the adult population, where meta-ana

135 Preprints are becoming well established in the life sciences, but relatively li

136 reports, the utility of native MS has become well established in the structural biology community.

137 term implication of renal dysfunction is not well established in this population.

138 hough a genetic basis of depression has been well established in twin studies, identification of geno

139 r association with inflammatory mediators is well-established in depression.

140 e roles of the ClpP1P2 protease subunits are well-established in Mtb, but the potential roles of the

141 MGP is a well-established inhibitor of calcification gene, highly

142 rk, we hypothesize that, in the context of a well-established injury model of ventricular apex resect

143 on of chromophore-DNA interactions through a well-established intercalation mechanism.

144 gh the basic principles of axon guidance are well established, it remains unclear how axons adjust st

145 Although the cellular phenomenon per se is well established, it remains unclear what role intrinsic

146 Excessive consumption of sugar has a well-established link with obesity.

147 proteins in astrocyte destruction in NMO is well established, little is known regarding the initial

148 To support this choice, we evaluated well-established machine learning (ML) classifiers inclu

149 rucially, our inferences are based only on a well-established mathematical model of recombination and

150 Using 3 well-established mathematical models, we show that low-l

151 A well-established mechanism of CIN is the overproduction

152 der men with low testosterone levels without well-established medical conditions known to cause hypog

153 Salt formation is a well-established method to increase the solubility of io

154 Although there are numerous well-established methods for the determination of DP and

155 antitative accuracy of SPIM-FRAP relative to well-established methods.

156 sponding carbamate and carbamic acid) with a well-established Mn electrocatalyst changes the product

157 The BXSB/MpJ mouse, a well-established model of human SLE, develops elevated a

158 The mitochondrial mutator mouse is a well-established model of premature aging.

159 M on retinal mitochondrial redox status in a well-established model of retinal disease.

160 Using a well-established model of VOR pathways, we demonstrate t

161 acis, the etiological agent of anthrax, is a well-established model organism.

162 In mice and other well-established model organisms, the relatively low rat

163 In scientific research, we often rely on well-established model systems to tackle important quest

164 Using 2 well-established models of corneal transplantation (low-

165 In these well-established models of neuropathic pain, we show tha

166 Purinergic receptors are well-established modulators of inflammatory processes, p

167 ely studied members of TACK archaea and have well-established molecular genetics [6-9].

168 entity of central nervous system tumors with well-established molecular groups.

169 While the causal and clinical links are well established, molecular understanding of how chronic

170 Using the well-established mouse model of TB, our new data provide

171 We evaluate gene editing of HSV in a well-established mouse model, using adeno-associated vir

172 by the retinoblastoma family of proteins is well established, much less is known about their regulat

173 lection to eliminate off-type plants through well-established multigenerational breeding, selection,

174 We used the well-established murine AOM/DSS model to induce inflamma

175 mCSM-membrane derives from our well-established mutation modelling approach that uses g

176 e deeply in the future when integrating with well-established neuroendocrine control of excretion.

177 of testosterone on individual behaviour are well established, no study has examined whether hormone-

178 Using our well-established nonhuman primate model of ART-suppresse

179 These results challenge the well established notion of the P3b as a neural marker of

180 Together, our results support the well-established notions that early adversity and weak s

181 Although the basic role of TET enzymes is well established now, the molecular mechanism and specif

182 ying more direct forms of learning have been well established over the last century, we still lack a

183 ned medium from nociceptors treated with the well established pain mediator, nerve growth factor, cou

184 The target region of one well established Pan-CoV assay is highly resistant to mu

185 In the well-established pancreatic ductal adenocarcinoma (PDAC)

186 ily over a minimum period of 30 days using a well-established paradigm for functional MRI of trigemin

187 th uncertain functions, but this goes beyond well-established, parameter-based sensitivity analysis,

188 Immune checkpoint inhibition is a well-established part of kidney cancer treatment, and ra

189 The structural bases of their function are well established, particularly within a model archaeal h

190 involved in chemosensitivity to oxygen, but well-established pathophysiological mechanisms can accou

191 ion to fibrosis were described including the well-established pathway of type 2 CNV progression to FG

192 Remote earthquake triggering is a well-established phenomenon.

193 Extranodal extension (ENE) is a well-established poor prognosticator and an indication f

194 rporeal lipoprotein apheresis systems employ well-established, powerful methods to provide an acute,

195 expose neonates to S aureus colonization, a well-established predisposing factor to invasive S aureu

196 Our results demonstrate that despite well-established preferences toward equal outcomes, peop

197 concentrations, consistent with iron being a well-established primary limiting nutrient in this regio

198 l epidemics where the original D614 form was well established prior to introduction of the G614 varia

199 y cases, larger than the quenching caused by well-established processes such as coupling to X-H oscil

200 In this study, the well-established pyrrolopyrimidine scaffold was modified

201 NSARC expression and tumor aggressiveness is well established, questions remain about how CINSARC gen

202 Our study, using a well-established rat model of alcohol dependence, ex viv

203 Besides binding to well-established receptors, an extended loop in the C-te

204 Our findings support the well-established relationship between smoking and lung c

205 precisely control its regioselectivity with well-established Rh- or Co-catalysts has thus far proven

206 g because they often include genes for which well-established risk estimates, medical management guid

207 Pre-pregnancy hypertension is a well-established risk factor for adverse maternal and of

208 Hyperlipidemia is a well-established risk factor for cardiovascular diseases

209 relative poverty but not with housing age, a well-established risk factor for lead exposure.

210 While chronic inflammation is a well-established risk factor for malignancy, studies eva

211 Parental history of atopic disease is a well-established risk factor for the development of atop

212 Acute infection is a well-established risk factor of cardiovascular inflammat

213 Besides well-established risk factors like age, cardiovascular d

214 alue of polygenic risk scores in addition to well-established risk prediction models for coronary art

215 However, FAV has well-established risks, and its survival benefit remains

216 RGC size distribution over time, using three well-established rodent models of optic nerve injury.

217 CK1alpha has a well-established role in inhibiting the p53 tumor suppre

218 for normal T cell function and that plays a well-established role in leukemogenesis.

219 uctures to regulate transcription beyond its well-established role in safeguarding the genomic integr

220 cytotoxicity is unclear, because MUTYH has a well-established role in the repair of oxidative DNA les

221 Despite the well-established role of actin polymerization as a drivi

222 While studying the well-established role of the conserved nuclear hormone r

223 nsitive retinal ganglion cells (ipRGCs) have well-established roles in a variety of reflex responses

224 tein kinase catalytic subunit (DNA-PKcs) has well-established roles in DNA double-strand break repair

225 of these two components in addition to their well-established roles in promoting Ci processing.

226 trol, and express insulin-like peptides with well-established roles in regulating food intake and met

227 VAPs have well-established roles in the formation of membrane cont

228 orts the robust real-world effectiveness and well-established safety profile of natalizumab.

229 tudy aimed to compare eDNA detection against well-established seasonal changes in blacktip shark (Car

230 and oligosaccharide substrates and reversed well-established secondary neuropathology.

231 ntegration of such biosensors with extremely well-established silicon-based microcircuit chips offers

232 However, this well-established single peptide-binding site alone has m

233 , full-scan and DDA data can be processed by well-established software.

234 highly oligotrophic ecosystems populated by well-established specialized microbial communities.

235 chondrial morphology in a live organism with well-established stress assays and well-characterized st

236 Here, based on the well-established synergy between histone deacetylase inh

237 HER2 kinase as a well-established target for breast cancer (BC) therapy i

238 ning (1)H NMR spectroscopy (HR-MAS NMR) is a well-established technique for assessing the biochemical

239 complete genome being sequenced coupled with well-established techniques for genetic manipulation.

240 ter electrolysis to hydrogen and oxygen is a well-established technology, whereas fundamental advance

241 f bed bugs would represent a novel use for a well-established technology, which can enable pest contr

242 g cessation aids, during abstinence), on two well-established tests of inhibitory control, the Go-Nog

243 Although well-established textbook arguments suggest that static

244 It is well established that auxin dynamics depend on the spati

245 It is well established that binding of HR1 and HR2 is key to f

246 It is well established that cellulose is crystalline, although

247 It is well established that childhood maltreatment is a signif

248 It is well established that chronic cognitive problems after t

249 It is well established that chronic viral infections can cause

250 Although it is well established that diatoms are common first responder

251 It is well established that different sites in healthy human s

252 It is now well established that dysregulation of both the innate a

253 Although it is well established that EBOV results in severe organ damag

254 It is well established that fingolimod, a modulator of the sph

255 It is now well established that glasses feature quasilocalized non

256 It is well established that Huntington's disease (HD) gene car

257 undant without relevant functions, it is now well established that ncRNAs identify a class of regulat

258 It is now well established that PDACs originate via a multistep pr

259 It is well established that people living in adverse condition

260 Although it is now well established that physical forces are essential for

261 Although it is well established that phytohormones contribute to antixe

262 It is well established that pluripotent stem cells in fetal an

263 It is well established that the adult brain contains a mosaic

264 to task demands.SIGNIFICANCE STATEMENT It is well established that the high-level visual cortex is co

265 It is well established that the structural differences between

266 While it is well established that the virus resides in the telomere

267 ndrome is incompletely understood, but it is well established that there is disordered communication

268 Although it is well established that toners contain multiple engineered

269 It is well-established that complexes of plasminogen-activator

270 It is well-established that dopaminergic drugs modulate risk-t

271 It is well-established that food proteins, such as egg, soya,

272 It is well-established that glycosylation of IgG dictates its

273 While it is well-established that mutations in the LC's V(L) domain

274 It is well-established that people can factor into account the

275 Although it is well-established that transcription factors bind to spec

276 ctivation of iNKT cells have been relatively well established, the exact contributions of IL-12, IL-1

277 n individual's lifespan and reproduction are well established, the interplay between feeding behaviou

278 Although the pathway of PIC assembly is well established, the mechanism of assembly and the dyna

279 However, while these features of FBGCs are well established, the molecular mechanisms underlying th

280 ematopoietic cells to the monocytes has been well established, the underlying mechanisms remain elusi

281 hemokine receptor (CXCR) 4 axis represents a well-established therapeutic target for cancer treatment

282 l phenotypes to their natural environment is well-established, there is a lack of knowledge about how

283 for GluN2A and GluN2B-containing NMDARs are well established, those that target GluN2C and GluN2D ar

284 o accessory proteins (NS1 and NS2) which are well established to block interferon signaling.

285 RNFL thickness variance as was age, which is well established to have a substantial impact on cRNFL t

286 We adapted a well-established tool for measuring inequity-the Lorenz

287 Particle image velocimetry (PIV) is a well-established tool to collect high-resolution velocit

288 In contrast to the well-established transition-metal-mediated activation of

289 sions in the treated cells accorded with the well-established translesion synthesis bypass caused by

290 )Lu-labeled somatostatin ligand analogs is a well-established treatment for neuroendocrine tumors, wi

291 y our findings identify a new role for these well-established tumor suppressor proteins at an early s

292 The host transcription factor IRF-1, a well-established tumor suppressor, selectively attenuate

293 their doctoral theses once their careers are well established, unfamiliarity with the new system can

294 Here, we employ a well-established visual object categorisation task in wh

295 of cardiovascular events in breast cancer is well established, whether such events impact cancer path

296 Of these, five pairs can be considered well-established, while another thirteen pairs have both

297 ce, both face-to-face and computer-based, is well established within healthcare education, allowing r

298 t plasma) for COVID-19 as examples, a valid, well-established yet underused procedure is presented fo

299 The antimicrobial functions of Nod2 are well-established, yet the cellular mechanisms by which d

300 In contrast, the well-established zinc-catalyzed carbonic anhydrase activ