ライフサイエンスコーパス: why

1 019 to assess which approaches work best and why.

2 However, it is unclear why a functional ETC is necessary for tumour growth in v

3 The reasons why a given pathogen may present difficulties for vaccin

4 e significant implications for understanding why a hypomorphic loss of BCCIP functions is more releva

5 design and provide mechanistic insights into why a leading INSTI retains efficacy against a broad spe

6 ts that support the understanding of how and why a model works.

7 Identifying reasons why a population of a native species is extirpated follo

8 This rationalizes why a radical mechanism is detected only in the presence

9 0S generation and offer an explanation as to why a subtle dysfunction of BCCIP can be tumorigenic but

10 igin, have latent skin competence explaining why aberrant hair follicles or sebaceous glands are some

11 Understanding why adult hippocampal neurogenesis (AHN) is impaired in

12 tonic inhibition at low glucose, explaining why alpha-cells are electrically active under hypoglycae

13 wth than previously assumed, helping explain why alternative nitrogenase genes persist in diverse dia

14 To explain why an action is wrong, we sometimes say, "What if every

15 age is underappreciated as a determinant for why an insulin granule is selected for secretion and may

16 rovide some answers to the question "How and why anchoring metal nanoparticles, clusters, or single a

17 Typically we are interested in why and how graph convolution networks can help in drug-

18 ew the importance of stereology, and propose why and how it should be applied to the study of adult n

19 ovement sleep (REM), raising the question of why and how specialized sleep evolved.

20 Recent medication approvals highlight why and how the distribution of clinically beneficial no

21 We discuss why and how these MTases can be prioritized to enable a

22 To assess why and where rates differ, here we compile 13,112 geore

23 we lack a framework for understanding when, why, and how rain affects endotherms.

24 Understanding why animals (including humans) choose one thing over ano

25 and misleading-that clearly explain how and why anthropogenic sensory pollutants impact organisms.

26 ng epitopes is crucial for the understanding why antibodies display different therapeutic activities

27 inance contrast in future work investigating why aposematic patterns take the particular forms that t

28 It remains unclear why AR utilizes a different AF domain from other recepto

29 Why are the low-affinity sites retained?

30 cond, ungulates are large and long-lived, so why are they occasionally intermediate instead of defini

31 ed with non-bHLH motifs, possibly explaining why Ascl1 is less context dependent.

32 sensitive to feedback inhibition, explaining why assembly occurs under physiological conditions that

33 e perirolandic cortex and it remains unknown why atrophy in different locations would cause the same

34 ariables indicate about the speaker-that is, why attention to vocal cues may be favored in intrasexua

35 Our results help to explain why beta(2) -m and RBP4 are more sensitive markers of PT

36 It has been perplexing as to why both enzymatically activating and inactivating mutat

37 A repair is poorly understood, it is unclear why BRCA-deficient cells require APE2 for viability.

38 stem service outcomes and identify where and why bright spots exist.

39 Why can we not see nanoscale objects under a light micro

40 mulate its lipid kinase activity, explaining why catalytically active Fig4 is required for maximal PI

41 nce of RDH expression on CDK11 could explain why CDK11 is essential for the growth of many cancers.

42 However, why cells require acidic lysosomes to proliferate and wh

43 time evolution as a way to begin deciphering why certain aspects of flowering are seemingly so conser

44 Identifying why certain individuals are more susceptible is essentia

45 For example, the reason why certain proteins compact the DNA coil in certain env

46 ralizing Marcus theory framework, we explain why charge-transfer-dynamic modulations can only be unve

47 's entire hospitalization, including reasons why chemoprophylaxis was not given.

48 ides important information for understanding why children of depressed mothers may be more vulnerable

49 in chronic back pain, which helps explaining why chronic pain can be resistant to change, and where c

50 However, it is not clear why cleavage is required for Rb degradation.

51 The editorialist discusses the findings and why closing the intention-to-behavior gap for those will

52 re not polyploid, and (e) speculations as to why CMs become polyploid at all.

53 tical work has been devoted to understanding why colloidal nanocrystals (NCs) self-assemble into such

54 his work provide a framework for determining why common groundwater constituents affect the E(H)-depe

55 contradicting evidence in cells, focusing on why controversies about the composition, properties, and

56 However, gaining insight into why core metabolism uses the molecules, reactions, pathw

57 s with comorbidities may offer insight as to why COVID-19 symptoms are often more severe in these ind

58 o elucidate the role of the CR and determine why CR deletion generates toxicity, we designed PrP(C) c

59 This may explain why DCs respond faster and more vigorously to TLR ligand

60 d to voluntary action, but an explanation of why decisions to act emerge at particular points in time

61 This may explain why defects in a single component often produce combined

62 taxa, leading to new knowledge about how and why developmental pathways are rewired and elaborated th

63 Such functionality plausibly explains why DNA methylation, a well-known mutagen, has been main

64 Why do our eyes linger longer on things we value more?

65 Why do people sometimes report that they remember dreams

66 Why do some ABC transporters have connectors and others

67 Why do we run toward people we love, but only walk towar

68 ty in the fusiform arise in development, and why does it develop so systematically in the same locati

69 ss two unresolved fundamental questions: (i) why does repeat behavior differ between model systems an

70 Why does the country that spends the most on healthcare

71 tor occupation in the striatum, and explains why dopamine ramps are an effective signal to occupy dop

72 ptimal iliofemoral access options or reasons why early mobilization is desirable.

73 Can the Second Law of Thermodynamics explain why ecosystems naturally organize into a complex structu

74 This may explain why eliminating HIV susceptibility in circulating T cell

75 not fully characterize the AF mechanism and why endocardial ablation may not be sufficient.

76 imensional interactions provide insight into why endocardial mapping alone may not fully characterize

77 We use canard theory to explain why enlarging the size of the window region elicits EADs

78 Our results help explain why eukaryotic cells possess multiple resection nuclease

79 D risk genes, and explain, at least in part, why every HSV1-infected person is not equally likely to

80 nt a conceptual framework to explain how and why females might evaluate a male's BT before mating.

81 oncerned with understanding whether, how and why genetic differences between human beings are linked

82 eed to be taken to authentically communicate why genomic research is necessary and how data donation,

83 e discuss the optimal group size and explain why, given the highly infectious nature of the disease,

84 Understanding the reasons why gp41 ectodomain-targeting antibodies are associated

85 CC1B) domain of p150(Glued), thus explaining why H2 is necessary for tight binding.

86 nce of most species, this is the main reason why habitat loss has been highlighted as the main threat

87 e perceptual-inference hierarchy may explain why hallucinations and delusions tend to cluster togethe

88 Why hasn't this been detected earlier?

89 However, why HCN channels are activated by hyperpolarization wher

90 Furthermore, our results explain why higher plants have a narrow range of grana diameters

91 other equally, but he has not yet explained why human morality also allows and enables much inequali

92 into account, we can address the question of why humans seek to learn, teach, and innovate - three pr

93 th unrelated and unfamiliar individuals, and why humans' unprecedented cooperative flexibility is nev

94 Understanding why identical stimuli give differing neuronal responses

95 e purpose of this Perspective is to consider why identification rates continue to be low in untargete

96 This view would explain why immunotherapy at best delays progression of type 1 d

97 These results provide new insight into why implicit learning increasingly takes over from expli

98 proteins to MCL-1 and vice versa, explaining why in vivo combinations of BCL-2 and MCL-1 antagonists

99 These results suggest why inactivating mutations in any of the three human gen

100 To determine why individuals with MRS specifically lack pancreatic en

101 clinical-radiological paradox could explain why individuals with similar injuries can respond differ

102 Important clinical questions include: Why is there a variable occurrence of coallergy among th

103 Why is there such prominent variation in sexual receptiv

104 comes in cardiovascular diseases but exactly why is unclear.

105 an and animal minds, it becomes clearer: (1) why it is reasonable to assume that cognitive mechanisms

106 Lemon describes this distinct community, and why it matters so much for human health.

107 eep is ubiquitous across animal species, but why it persists is not well understood.

108 lopments in the postwar period and considers why it took so long to hold up a mirror to the past.

109 Why Jupiter's vortices occupy this middle range is unkno

110 n is still missing to understand and predict why large differences between TPEs exist.

111 he present interglaciation(7), understanding why LIG global mean sea level may have been six to nine

112 eedles may be the missing link in explaining why lightning flickers with multiple discharges, but thi

113 Why lightning sometimes has multiple discharges to groun

114 which provides a mechanistic explanation for why Lis1 is required for efficient transport of many dyn

115 Why living forms develop in a relatively robust manner,

116 urther metabolic stress, which could explain why local neurodegeneration does not remain confined, bu

117 and alterations in this map may help explain why lonely individuals endorse statements such as "peopl

118 affinities for the mu and KOR could explain why lower doses of naltrexone can have greater clinical

119 red in arcs with thick crust, which explains why magmatism and differentiation in continental arcs, l

120 ation, and this stress tolerance may explain why many cancers aberrantly express MAGEs Here, we prese

121 Results may explain why many CNVs affect a similar range of neuropsychiatric

122 Its volatility is one reason why many cross-metathesis or ring-closing metathesis pro

123 lin T1 than primary cells, which may explain why many LRAs are functional in model systems but relati

124 tline will deliver new insights into how and why masting patterns might respond to a changing environ

125 d then we consider possible explanations for why MCU-deficient mice are spared from energy crises und

126 Why metalloenzymes often show dramatic changes in their

127 ration, providing a potential suggestion for why metformin increases acid secretion and reduces gastr

128 The aim of this study was to determine why mice are resistant to NASH development and the invol

129 This explains why mice lacking the IL-6 receptor only in osteoblasts e

130 This prediction suggests why misassembled hemoglobins often get trapped as hemich

131 that we can better understand how, when, and why moonlighting proteins may take on multiple roles.

132 We provide evidence for why most reported synthetic lethals are not reproducible

133 For example, one would like to understand why mu-OR is more selective to G(i) than a stimulatory G

134 of specific DNA-bridging proteins like LacI, why multiple bridges are required to create stable indep

135 hydrophobic active-site subpocket explaining why N6-methyl-dATP is a good MTH1 substrate.

136 incing theories are still lacking to explain why natural evolution and human design have failed to op

137 le is selected for secretion and may explain why newly synthesized insulin is preferentially secreted

138 levels at median exposure levels may explain why no relationship between exposure to TTR-binding comp

139 this provides a theoretical explanation for why noninteger dimensions are useful in many branches of

140 We wondered why norepinephrine (NE) that differs from dopamine only

141 -cell level(13) means that precisely how and why nuclei reorganize remains an area of intense investi

142 e concept of empathy within nursing, explain why nurses are sometimes warry of adapting concepts from

143 This perspective can predict when and why obligation will be experienced.

144 OMVs with host cell membranes to understand why OMV uptake depends on the length of constituent lipo

145 further investigation is needed to determine why only a minority of those trained have begun treating

146 stinct AD phenotypes here could help explain why only a subset of AD patients typically respond to an

147 By tracing their fate, we could explain why only the upper first molar reacts via elongation of

148 We discuss possible reasons why only two cross-feeding interactions have been discov

149 A critical question remains why P. vivax selectively invades reticulocytes?

150 ation but left unresolved the question as to why parents show the preference.

151 Precisely why patients with PD-L1 negative tumors respond to PD-1/

152 These data likely explain why patients with PMNs are frequently resistant to plati

153 of NLRP3 inflammasome activation and explain why patients with XLA are prone to develop Crohn's disea

154 ships, it has proven difficult to understand why patterns are so variable.

155 hematical framework and provide insight into why people adopt the explanations they do.

156 ovides a computational and neural account of why people learn less from observing outgroups.SIGNIFICA

157 re widely used to investigate when, how, and why people make judgments that are consistent with utili

158 troversy over two competing hypotheses about why people object to randomized experiments: 1) People u

159 lation to energetics, but it remains unclear why people reduce asymmetry in step lengths, but prefer

160 It also helps explain how and why people stray from logic when given deductive reasoni

161 tly, thus revealing the structural basis for why peptidiscs can stabilize such a large variety of mem

162 erapy provides a potential explanation as to why physical therapy may often be ineffective.

163 common double mutations are likely to be and why PI3Kalpha with double mutations responds effectively

164 xosome-deficient mutants, perhaps explaining why plants have evolved mechanisms to suppress PROMPTs.

165 ocal mechanism for CP regulation can explain why plasticity induced by the odorant geranyl acetate (w

166 r experimental testing but also help explain why polarization in beliefs about human-caused climate c

167 n in fledging age among songbird species and why postfledging bottlenecks occur.

168 f new X-ray structures of Thal also explains why premixing of FDHs with reduced flavin adenine dinucl

169 binding and catalysis and clearly elucidate why previous structures of mammalian dCTPase were cataly

170 electrostatic potential to establish how and why protons intercalate in V(2) O(5) in aqueous media.

171 This advance provides an understanding of why psilocybin is showing considerable promise as a ther

172 erefore, to understand not only how but also why psychology varies, we need to grapple with cross-tem

173 Images of large areas provided insight into why published values of ENS density vary up to 150-fold-

174 More generally, these examples suggest why related genes have been maintained by evolutionary f

175 in under EPS inhibitor treatment, explaining why resistance does not evolve.

176 to understand where corals bleach, when and why-resulting in a large-yet still somewhat patchy-knowl

177 e we propose that Gestalt theory may explain why rodent islet architecture has historically been seen

178 S-RNase activity by NaTrxh helps to explain why S-RNase alone could be insufficient for pollen rejec

179 thrombotic strategies, this article explains why safer anticoagulants are needed, provides the ration

180 characteristics contribute to understanding why scope of practice differences exist.

181 roviding a possible unifying explanation for why sea turtles interact with marine plastic.

182 the lack of stereoselectivity, and evaluates why selectivity may not occur and when it will likely oc

183 cell reduces its contractibility and explain why SERCA gene therapy, a change in calcium handling to

184 ference in OCN regulation, which may explain why serum concentrations of OCN are higher in mouse than

185 s in promoting multimerization and explained why several C-terminal domain mutations are remarkably r

186 Understanding how and why sexual dimorphism evolves would contribute to elucid

187 ulus to cause insulin resistance, explaining why short-term, insulin-dependent glucose utilization do

188 e size of the window region elicits EADs and why shrinking the window region can eliminate them.

189 ellular hemoglobin composition also explains why sickle trait, the heterozygous condition, and the co

190 In particular, we wish to understand why simple optimization schemes, such as stochastic grad

191 uration and survival, which may help explain why Slc7a5 mutations prevent normal brain development an

192 more, these results shed additional light on why sleep is important during early childhood, a period

193 These findings may partly explain why smokers and elderly persons with compromised surfact

194 Why some AIV lineages but not others evolve in this way

195 These dynamics also explain why some avulsions are more hazardous than others.

196 It is not clear why some brain regions are impaired and others spared by

197 Furthermore, we examine why some carriers of pathogenic mutations remain of norm

198 of all protein contacts and it is not clear why some contacts are favoured over others.

199 Consequently, the reader will understand why some crystals break during polymerization, while oth

200 Our results explain the reasons why some earlier postulated intermediates have not been

201 To understand why some hosts get sicker than others from the same type

202 A central question concerning COVID-19 is why some individuals become sick and others not.

203 It is unclear why some individuals develop AN while most do not.

204 g studies could advance our understanding of why some individuals develop mental health disorders.

205 counts continue to rise, it remains unclear why some individuals recover from infection, whereas oth

206 why we remember or forget in the moment, and why some individuals remember better than others.

207 However, it is not understood why some OIB host anomalous (182)W while others do not.

208 mportant questions have remained unanswered: why some patients develop severe disease, while others d

209 isease (CVD) is different for every patient, why some patients with type 2 diabetes mellitus (T2DM) d

210 Here, to understand why some people may be more vulnerable to developing aff

211 xclusive competing interactions, may explain why some proteins are dynamic while others are rigid.

212 These results help explain why some species have not transitioned beyond simple gro

213 It still remains enigmatic why some species have numerous AOX enzymes, whereas othe

214 It is unclear why some tissues are refractory to the mitogenic effects

215 Our findings highlight possible reasons why some underrepresented minority and female postdocs c

216 esolved questions remain, such as the reason why SOST binds to LRP6 E1E2 with higher affinity than to

217 ries that, if filled, would clarify when and why speciation succeeds or fails.

218 amylose revives a long-standing question of why starch granules contain amylose, rather than amylope

219 ronmental variability can lead to dispersal: why stay put if it is better elsewhere?

220 They also provide a possible explanation why such connectivity and activity patterns have been pr

221 It is currently unknown why such large corals exist around this particular islan

222 emerge and persist throughout nature(1), and why such structures often exhibit similar scale-invarian

223 However, why sucrose causes severer dental caries than other suga

224 resent in the CO-poisoned layer that explain why, surprisingly, CO desorbs at stepped and flat Pt cry

225 Fe(III) species over several hours explains why SznF was previously purified and crystallographicall

226 It remains unknown why TapA is synthesised at 253 amino acids when the firs

227 studies provide a structural explanation of why TAT-SF1 must be displaced before the stable addition

228 stallography and NMR, providing insight into why tetramer stabilization inhibits amyloid assembly.

229 ntioxidative properties, and speculate as to why that is.

230 plant-pathogen response, which could explain why the 20rDNA line is hyper-resistant to both bacterial

231 Here, we show why the Amazon fires must be understood across spatial s

232 This Essay describes the reasons why the CSB family was overlooked by valence-bond pionee

233 These results explain why the CT can modulate the Env antigenic properties and

234 ings provide a mechanistic explanation as to why the deletion of CFHR3 and CFHR1 is protective in AMD

235 Why the disease-causing mutations are restricted to the

236 countered by the NS1 protein, and establish why the dsRNA-binding activity of NS1 is required for it

237 tive effect of Dantu, and fresh insight into why the efficiency of P. falciparum invasion might vary

238 swer to this vexing problem, while exploring why the Elp1 gene that is mutated in familial dysautonom

239 The editorialist discusses why the findings of this new study and prior research sh

240 In this study, we investigated why the immune system fails to effectively control a mod

241 nt difficult to make and has been the reason why the influence of lens growth on visual function rema

242 We discuss why the influence of the childhood environment on adult

243 The authors describe why the international community should be hesitant in de

244 ated intervention to improve patient safety, why the intervention did or did not lead to safety impro

245 Yet, it has long puzzled geochemists why the laboratory synthesis of todorokite, a tunnel-str

246 This may explain why the net effect of mTOR inhibitors is paradoxical in

247 r study advances an adaptive explanation for why the placenta evolves by arguing that an increased de

248 Our data provide a mechanistic explanation why the same proteins can act either as tolerogens or as

249 Our finding resolves the puzzle on why the single-atom silver dispersion can be spontaneous

250 esponse, we reply to these concerns, discuss why the technical-reasoning hypothesis does not minimize

251 Thus, understanding both how and why the timing and synchrony of parasites are connected

252 Part 1 of this paper discusses why the United States needs to do better in addressing c

253 sis, we begin to illustrate how, and explore why, the developmental decision of metamorphosis relies

254 Additional studies investigate why: The same items are often perceived as less necessar

255 ging survival-by staying in the nest longer: Why then do they fledge so early?

256 Why, then, are perceptual decisions so variable despite

257 beta-adrenergic sensitivity may help explain why therapies that work in HFrEF are ineffective in HFpE

258 , and less so Ca(V)3 channels, it is unclear why there have not been major shifts toward dependence o

259 This explains why there is no energy conservation in cNOR.

260 properties that led to such widespread use, why there is now an increasing drive to minimize usage,

261 -down MALDI-ISD FT-ICR mass spectra and show why these distributions can deviate from theoretical pro

262 es in synapsis, providing an explanation for why these genes have evaded previous genetic screens.

263 ion are processed by fSTS neurons and how or why these might depend on SC activity.

264 these pfk13 variants, potentially explaining why these resistance alleles have not increased in frequ

265 s do not destabilize, for instance, although why they are resilient is mostly unknown.

266 have become ubiquitous, our understanding of why they are so effective is lacking.

267 to be weakly oncogenic, probably explaining why they did not give rise to discernible lesions.

268 survive in changing environments can explain why they encode multiple eIF4E (LeishIF4Es) and eIF4G (L

269 w descriptions of RHV-specific responses and why they fail to prevent persistent infection in this mo

270 eptual framework to experimentally determine why they have survived selection.

271 gically relevant cues, offering insight into why they lead to mitochondrial removal.

272 s and supply rates of nutrients, and how and why they vary across communities and ecosystems.

273 embly pathway and inspire a suggestion as to why this aggregate does not grow to larger sizes.

274 ice lacking muscle-derived IL-6 (mIL-6), and why this deficit is correctable by osteocalcin but not b

275 We demonstrate why this is the case using bacteria-expressed proteins:

276 ve impairments, it remains poorly understood why this is.

277 We reflect on why this might be and make specific recommendations for

278 To understand why this might be the case, we investigated the neural r

279 Here, we explain why this photochemical synthetic approach was overlooked

280 as the "bamboo ceiling." It remains unclear why this problem exists and whether it applies to all As

281 investigations, our understanding of how and why this recovery occurs is very limited.

282 R9 and low levels of TLR7, which may explain why TLR9 dysregulation is particularly consequential ear

283 Our results help explain why toe springs have been a pervasive feature in shoes f

284 alling pathways in the cell, and this may be why TP53 is the most commonly mutated gene in human canc

285 me community practitioners as evidence as to why transplants should not be performed at this time, co

286 e cerebellum in SCA17 raises the question of why ubiquitously expressed polyQ proteins can cause neur

287 babilities do not capture the varied reasons why vaccines fail to advance to regulatory approval.

288 A long-standing mystery in the field is why vertebrates have two non-visual arrestins, arrestin-

289 Mechanisms that can explain why vitamin D deficiency is associated with mobility sho

290 ral replication in macrophages or to explain why Vpr is carried in the virus particle.

291 goal of this research has been to determine why VZV, when grown in cultured cells, invariably is mor

292 stematically to address questions of how and why we age.

293 grafts for corneal transplantation, which is why we are working toward on expanding cooperation with

294 over human evolutionary history may explain why we cooperate readily with unrelated and unfamiliar i

295 Attention lapses partially account for why we remember or forget in the moment, and why some in

296 s review, we present a brief overview of (a) why we should be interested in stress in the context of

297 and insightful theory of obligation explains why we sometimes sense an obligation to treat each other

298 That is why we studied the molecular features of iron effect and

299 onavirus disease 2019 (COVID-19) and discuss why we think that a clinical trial of a drug in this cla

300 Tim Caro introduces why zebras are striped.