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1 daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy
2 XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiol
5 ritical insight into rational development of wide spectrum antiviral therapeutics to treat infections
6 with orientation-dependent responses over a wide spectrum by focused-ion-beam based patterning and f
9 es are widely distributed, archaic, and have wide spectrum, including digesting anticancer and beta-l
10 olymer networks are readily modulated over a wide spectrum, including white-light emission, simply by
12 m interactions and Doppler effect, a 7.8-kHz-wide spectrum is observed for the (1)S0-(3)P1(m=0) trans
14 ers have the potential advantage of having a wide spectrum of action, neutralizing a variety of known
16 mma isozymes found in several cancers have a wide spectrum of activities, and highlights how these ac
23 ressed in brain and periphery activated by a wide spectrum of agonists that include, but are not limi
24 Hepatic RNA-seq analysis of patients with a wide spectrum of ALD revealed that expression of the cGA
25 ering microscopy paves the way for imaging a wide spectrum of alkyne-labeled small biomolecules with
27 evelopment of medulloblastomas, which bear a wide spectrum of alterations involving the Sonic Hedgeho
28 indicate that Alzheimer's disease exhibits a wide spectrum of amyloid-beta42 structural states and im
29 in that 5-HT2B receptor deficiency confers a wide spectrum of antipsychotic-sensitive schizophrenic-l
30 ave revolutionized medicine, but they have a wide spectrum of applications in other fields of science
31 derived, large market volume chemical with a wide spectrum of applications in plastics, adhesives and
32 ed biocatalyst could provide the basis for a wide spectrum of applications including detection, ident
33 They have been extensively exploited for a wide spectrum of applications ranging from biomedical de
34 ction of explosive components is vital for a wide spectrum of applications ranging from national secu
40 de effects of photothermal therapy against a wide spectrum of bacterial infections, promoting future
44 tionally, the presented peptides exhibited a wide spectrum of binding affinity and HLA-DM susceptibil
45 d in various interactions characterized by a wide spectrum of binding scenarios and an even wider spe
50 ately measure physiological O(2) fluxes in a wide spectrum of biological models and physiological res
51 oietic system, TGF-beta signaling controls a wide spectrum of biological processes, from homeostasis
53 reonine Kinase Receptors (STKR1) transduce a wide spectrum of biological signals mediated by TGF-beta
55 fication, localisation and manipulation of a wide spectrum of biological, physical and chemical agent
58 the critical AKT3 gene are associated with a wide spectrum of brain involvement ranging from focal or
61 Bcl-2 family proteins are overexpressed in a wide spectrum of cancers and have become well validated
62 ing proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemi
65 jor features include a distinctive facies, a wide spectrum of cardiac defects, short stature, variabl
71 indings support a genetic pathogenesis for a wide spectrum of CHDs and suggest that the disruption of
72 ated Bcl2L13 inhibits apoptosis induced by a wide spectrum of chemo- and targeted therapies upstream
73 e canalicular phospholipid flippase, cause a wide spectrum of cholangiopathy phenotypes in humans.
74 culture with glomerular transcripts across a wide spectrum of CKD disease confirmed co-regulation of
77 , a rare recessive disease associated with a wide spectrum of clinical features including ichthyosis,
78 us, we find mutations in GMPPB can lead to a wide spectrum of clinical features where deficit in neur
79 S5/SPG11/KIAA1840 is the causative gene of a wide spectrum of clinical features, including autosomal
81 e bacterium Burkholderia pseudomallei, has a wide spectrum of clinical manifestations ranging from ac
82 spiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from as
83 balamin C deficiency can be accompanied by a wide spectrum of clinical manifestations, including prog
87 nsense-mediated decay of the mRNA leads to a wide spectrum of clinical phenotypes including progressi
93 of CNS repair processes, brain aging, and a wide spectrum of CNS disorders, including acute injuries
94 ylate as an inducer of MarA, we found that a wide spectrum of concentrations can increase burden in r
96 ed review of low-dose diagnostic images of a wide spectrum of congenital pathologies may serve as an
97 allmark of this disease; however, the genome-wide spectrum of cooperating mutations in this disease s
98 ressive aphasia who collectively displayed a wide spectrum of cortical atrophy sites and language imp
99 , shows significant antitumour activity in a wide spectrum of cultured cancer cells harbouring high T
100 trated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs
104 because its mutations are responsible for a wide spectrum of defects called filaminopathies A, affec
108 ause of human bacterial infection, causing a wide spectrum of disease ranging from skin and soft tiss
112 mportant bacterial pathogen that can cause a wide spectrum of diseases in humans and other animals.
114 se aberrant levels of Gli activity lead to a wide spectrum of diseases ranging from neurodevelopmenta
115 They are also strongly associated with a wide spectrum of diseases, including infections, autoimm
120 rrant UPR(mt) signaling is associated with a wide spectrum of disorders, including congenital disease
123 molecular information for the detection of a wide spectrum of dominant monogenic diseases, complement
124 cting over three million people worldwide, a wide spectrum of drugs is considered for the treatment i
125 ronal M-current, have been associated with a wide spectrum of early-onset epileptic disorders ranging
126 n rhythm of the population, and generate the wide spectrum of empirically observed mobility behaviors
127 TTR demonstrated a great influence on a wide spectrum of endothelial cell functions to control t
128 ment of electric potential gradients, with a wide spectrum of environmental applications ranging from
129 ss talk between the actin cytoskeleton and a wide spectrum of essential cellular functions such as or
131 m monosynaptic excitatory connections onto a wide spectrum of excitatory projection neurons in this a
132 the different values of l corresponding to a wide spectrum of experiments, we find that for a range o
136 ABE complex is highly pliable and displays a wide spectrum of flexible structures that are facilitate
138 The reaction is scalable and tolerates a wide spectrum of functional groups delivering fully subs
139 ional movement disorders (FMDs), part of the wide spectrum of functional neurological disorders (conv
141 , VO2(A), VO2(B), VO2(M1) and VO2(R), have a wide spectrum of functionalities useful for many potenti
145 e respective genetic signatures implicates a wide spectrum of Gene Ontology terms and KEGG pathways w
146 ns by integrating tumor genomics data with a wide spectrum of gene-specific properties to search for
149 encing and analysis methods, we identified a wide spectrum of genome characteristics in HepG2: copy n
150 otyping and array CGH analysis to identify a wide spectrum of genome characteristics in K562: copy nu
153 ors (KIRs) on NK cells have been linked to a wide spectrum of health conditions such as chronic infec
154 immunoglobulin heavy chain and neutralize a wide spectrum of HIV-1 strains via targeting the CD4 bin
157 mixture of bioactive molecules that target a wide spectrum of host defense mechanisms to allow ticks
160 25 is significantly focally deleted across a wide spectrum of human cancers, suggesting STK25 loss ma
162 ubiquitously in the environment and cause a wide spectrum of human disease, including infections ass
165 Defective primary cilia are causative to a wide spectrum of human genetic disorders, termed ciliopa
166 eroids derived from single PGCCs grew into a wide spectrum of human neoplasms, including germ cell tu
167 in1 at ciliary rootlets and suggest that the wide spectrum of human pathologies linked to truncating
168 in or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT recep
171 ruses have evolved protein containers with a wide spectrum of icosahedral architectures to protect th
173 domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence
178 ent influenza virus strains; (iii) inhibit a wide spectrum of influenza A viruses, which includes the
179 antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes.
182 is of the GPI anchor are reported to cause a wide spectrum of intellectual disabilities (IDs) with ch
183 ally unfold new paradigms of research into a wide spectrum of interfacial reactions in powder materia
188 opulations in areas of endemicity revealed a wide spectrum of invasion phenotypes and expression prof
190 osis (ALS) is a heterogeneous disease with a wide spectrum of involvement of cognitive functions.
191 or hypoplastic pectoralis major muscle and a wide spectrum of ipsilateral thoracic and upper extremit
193 henotypes should be distinguished within the wide spectrum of irritant-related asthma: (i) definite I
194 n in the hematopoietic compartment develop a wide spectrum of leukemias, including myeloid, erythroid
199 es revealed that Gfi-1b directly regulates a wide spectrum of megakaryocytic and erythroid genes, pre
203 istence and ubiquity of double descent for a wide spectrum of models and datasets, and we posit a mec
204 us tissue with unique genetic profiles and a wide spectrum of morphologic features, which makes accur
207 evolution of AR and provide the first genome-wide spectrum of mutations associated with the developme
208 inically heterogeneous disorders caused by a wide spectrum of mutations in genes encoded by either th
211 adly reactive, with the ability to inhibit a wide spectrum of N1 NAs on viruses isolated between 1918
215 cts of brain development and thus generate a wide spectrum of neurodevelopmental phenotypes observed
216 ude that SPTAN1-related disorders comprise a wide spectrum of neurodevelopmental phenotypes ranging f
219 SARS-CoV-2 infection is associated with a wide spectrum of neurological syndromes affecting the wh
223 crustacean shell waste-derived chitin into a wide spectrum of nitrogen-containing chemicals (NCCs) is
224 to obtain a history of FB ingestion and its wide spectrum of nonspecific clinical presentations make
225 sing sequence similarity with hsp/hsc70 of a wide spectrum of organisms and some characteristic featu
226 ns and intra-chromosomal translocations in a wide spectrum of organisms from bacteria to humans.
230 d potentially be used for the treatment of a wide spectrum of PCs including castration-resistant, Enz
232 hension of self-organization processes and a wide spectrum of physical, chemical, and biological phen
234 .IMPORTANCE RelA/NF-kappaB participates in a wide spectrum of physiological processes, including shap
239 normal placentation are common features of a wide spectrum of pregnancy-related disorders such as int
240 erative for a radiologist to be aware of its wide spectrum of presentation on ultrasound in first tri
241 en who met criteria for PIMS-TS, there was a wide spectrum of presenting signs and symptoms and disea
242 studies at low temperature, which revealed a wide spectrum of pressure-related functionalities includ
243 broblasts, the binding of MYXV and VACV to a wide spectrum of primary human leukocytes could not be c
245 on onto solid surfaces is of importance in a wide spectrum of problems, including environmental micro
246 nd can be applied to the identification of a wide spectrum of protein features that lack sequence con
247 d in vivo by MHC II molecules derives from a wide spectrum of proteins produced by different cell typ
248 hildhood are associated with lower risk of a wide spectrum of psychiatric disorders later in life.
249 Primary cutaneous lymphomas encompass a wide spectrum of rare lymphoproliferative disorders orig
250 logy promises flexibility in the design of a wide spectrum of ratiometric biosensors and expanded in
251 t patterns for moving collectively involve a wide spectrum of reasons, such as evading predators or o
253 tors allows the sensors to function across a wide spectrum of refractive indices, such as that encoun
257 ect has always been challenging owing to the wide spectrum of roles of these molecules in multitude o
259 absorber unit, a process known to produce a wide spectrum of secondary amine products that are more
260 Pathogen-controlled processes, involving a wide spectrum of secreted factors, are responsible for t
261 signature of reading proficiency across the wide spectrum of selected languages, whether their writi
263 simplex virus type 1 (HSV-1) infection has a wide spectrum of severity in immunocompetent persons.
265 orelay (MSP) cascades mediate responses to a wide spectrum of stimuli, including plant hormonal signa
267 d in natural resources such as wood, and the wide spectrum of structural diversity of cellulose nanom
269 ein misfolding process and is effective on a wide spectrum of substrate proteins, including alphaSyn
270 al-independent manner, which may explain the wide spectrum of substrate specificities of EcEndoV.
273 uals which we use to discover and genotype a wide spectrum of SV and STR variants using five algorith
274 d has demonstrated superior performance on a wide spectrum of synthetic and real world networks espec
275 ssenger via differential interactions with a wide spectrum of targets to modulate their diverse bioch
279 s or surgeries that do not fully address the wide spectrum of these conditions; therefore, an urgent
281 he cytotoxic potential of NK cells against a wide spectrum of tumor subtypes could be markedly enhanc
282 solid malignant tumor in children, covers a wide spectrum of tumors with significant differences in
284 a relatively rare congenital anomaly with a wide spectrum of ultrasound features depending on the sp
286 Patients with LCA and CEP290 mutations had a wide spectrum of VA that was not related to age or lengt
287 venular PAMM with en face OCT demonstrates a wide spectrum of variation with narrow fern-like periven
288 Patients with coronavirus disease 2019 had a wide spectrum of vascular and inflammatory involvement o
290 he same genetic material also morphed into a wide spectrum of viruses and other parasitic genetic ele
291 uch antibodies can act antivirally against a wide spectrum of viruses by targeting relatively conserv
293 intelligently incorporate predictions from a wide-spectrum of strategies in order to form aggregate p
295 o confine acoustic waves in an all-angle and wide spectrum range due to tremendous impedance mismatch
296 des (MDPs) and their analogs have emerged as wide-spectrum, stress response factors protective in amy
298 he mean proliferation index with cytokeratin wide-spectrum was 2.55 vs 1.13 (P = .06), and the mean p
299 avelength narrow-band green or red light, or wide-spectrum white light, and thereby provide extra vis