ライフサイエンスコーパス: wiring

1 ms involving disordered maturation of brain 'wiring'.

2 usion MRI are common techniques to map brain wiring.

3 tex of mammals exhibits intricate interareal wiring.

4 hy because they do not require sophisticated wiring.

5 sponses to understand the underlying network wiring.

6 rk characteristics of fetal macroscale brain wiring.

7 s for homophilic and heterophilic binding in wiring.

8 dynein regulator required for motor circuit wiring.

9 test principles of cell identity and network wiring.

10 anism that outweighs the cost of inefficient wiring.

11 should be located in close vicinity to save wiring.

12 the genetic mechanisms that govern neuronal wiring.

13 en areas that can accommodate lamps/LEDs and wiring.

14 some, although not all, of their stereotypic wiring.

15 e that there is no need for any percutaneous wiring.

16 s are subject to some degree of localised re-wiring.

17 profiling in discovering regulators of brain wiring.

18 tial for axon guidance during nervous system wiring.

19 e apparently random structure of Kenyon cell wiring.

20 f the importance of such demise for cortical wiring.

21 axon translation and is required for neural wiring.

22 de instructive regulations in nervous system wiring.

23 are highly informative of the intracellular wiring.

24 nterrupted 7-0 Vicryl sutures without cheese-wiring.

25 (standard deviation): 12.87 m (+/-4.5), CST wiring: 9 contralateral, 9 ipsilateral, 6 bilateral) com

26 Wiring a complex brain requires many neurons with intric

27 In most junctions built by wiring a single molecule between two electrodes, the ele

28 FB and how alterations in FB neural-circuit wiring affect animal behaviors are unknown.

29 that Nrp1 inactivation leads to two distinct wiring alterations, depending on the time at which Nrp1

30 teome, playing an important role in neuronal wiring and axon maintenance.

31 ural differentiation, yet its role in neural wiring and brain organization is not known.

32 vity-dependent mechanisms also contribute to wiring and circuit assembly, but whether and how they re

33 hat moraphology is tightly tuned to minimize wiring and conduction delay of synaptic events.

34 trategy will facilitate understanding of the wiring and developmental principles of cortical inhibito

35 ning of dendritic arbors is critical for the wiring and function of neural circuits.

36 vous system is essential for the appropriate wiring and function of neural networks.

37 uring development is critical for the proper wiring and functioning of the brain.

38 experience with measures for both brain-wide wiring and molecular phenotype.

39 rons in the Drosophila central complex whose wiring and physiology provide a means to rotate an angul

40 s activity patterns that are crucial for the wiring and refining of developing sensory circuits.

41 of human plasma reveals unforeseen metabolic wiring and regulation, suggesting that HPLM should be of

42 oss a complex CTO lesion, subintimal knuckle wiring and subintimal tracking and reentry resulted in l

43 e multiple sequential functions during brain wiring and supports a general role of tangential migrati

44 d contribute to long-term differences in CNS wiring and synaptic function.

45 CDK4/6 inhibitors is dependent on kinase re-wiring and the redeployment of signalling cascades previ

46 nment, genetics, and species affect neuronal wiring and to integrate these with functional activity a

47 rplay during development specifies selective wiring and transmission of cone signals.

48 ations of stents included canalicular cheese-wiring and tube prolapse in approximately 4% each.

49 of secondary areas based on activity-driven wiring and wiring-density limits within the cortical sur

50 tates mutually suppress each other, both in "wiring" and in dynamical cooperation.

51 Here, we examine the morphologies, wiring, and architectures of single synapses of projecti

52 their causal impact on behavior, long-range wiring, and gene expression profiles, with the major dis

53 undergo activity-dependent migration arrest, wiring, and programmed cell-death.

54 re studies of RGC-subtype specific function, wiring, and projection.

55 genesis as a switch to control motor circuit wiring, and provide novel insight into the relationship

56 s connect neurons together, establishing the wiring architecture of neuronal networks.

57 ure synaptic correlations and thus infer the wiring architecture qualitatively.

58 Using the graphlet degrees to represent the wiring around proteins in PINs and gene ontology (GO) an

59 n detector achieves this through 'space-time wiring' at its dendrites.

60 ect to supervised plasticity, however, dense wiring becomes advantageous, suggesting that the type of

61 The mechanical wiring between cells and their surroundings is fundament

62 iated in S-phase utilize a different form of wiring between DNA-PKcs/ATM/ATR: The checkpoint activate

63 Robo receptors also contribute to wiring brain circuits.

64 regulated by extrinsic signals during neural wiring, but its control mechanisms remain elusive.

65 ntext of evolutionary changes in human brain wiring by comparing in vivo neuroimaging data from human

66 t the race-specific aspects of transcriptome wiring by discussing in detail the metastasis-related MA

67 idney cancer data indicate that the tRF-mRNA wiring can also depend on a patient's sex.

68 etic approaches to establish in male mice, a wiring chart between the insula cortex (IC), a major sen

69 catalytic heme 4 (P460) and of the electron-wiring circuit comprising seven His/His-ligated c-type h

70 ortant role, but the nature of the molecular wiring controlling InR transcription has not been elucid

71 ng an optimal trade-off model between neural wiring cost and the representative functional requiremen

72 imal spanning neurite trees constrained by a wiring cost equation and find that STG neurons do not ad

73 amined the relationship between topology and wiring cost in the mouse connectome by using data from 4

74 between the efficiency of a network and its wiring cost.

75 We show that empirical wiring-cost constraints inadequately explain connectome

76 The strategies for reducing wiring costs are shared across phyla and point to the po

77 the locations of neurons based on minimizing wiring costs for any given connectivity.

78 estimated brain-wide weights, distances, and wiring costs of axonal projections and performed a multi

79 acts as a potent regulator of neuromuscular wiring decisions.

80 endosomal compartments, leading to aberrant wiring defects.

81 xpression, to suggest causality for cortical wiring defects.

82 ion, electrical conductivity, and electronic/wiring density.

83 ry areas based on activity-driven wiring and wiring-density limits within the cortical surface.

84 nectivity of the sensorimotor network is CST-wiring-dependent, although the impact on upper limb func

85 of Drosophila larvae by mapping the synaptic wiring diagram and neurotransmitters.

86 and subsequently reconstructed the complete wiring diagram by volumetric electron microscopy.

87 Because the wiring diagram is far too complex to be specified explic

88 nt is essential for survival, but a complete wiring diagram of a higher-order circuit supporting asso

89 We established a synaptic wiring diagram of amphid sensory neurons and amphid inte

90 n the present study we extend the functional wiring diagram of the ACx with an investigation of the c

91 These results reveal the long-range wiring diagram of the BF circuit with highly convergent

92 In prior work, we used a wiring diagram of the brain called the human connectome

93 plex and pathway modules to map a functional wiring diagram of the cell.

94 , providing new insights into the functional wiring diagram of the cell.

95 mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, a

96 The complete synaptic wiring diagram of the LON paves the way to understanding

97 The complete wiring diagram of the nervous system, the complete cell

98 re mediated by higher-order structure in the wiring diagram that is adapted to natural input patterns

99 This complete wiring diagram will support experimental and theoretical

100 ly available method for determining a neural wiring diagram with single synapse precision-a 'connecto

101 oday's neuroscience is to study the brain's 'wiring diagram'.

102 ues of parameters, and are based only on the wiring diagram.

103 on Language) format, electronic circuits and wiring diagrams as well as software code.

104 s allow direct access to the outlines of the wiring diagrams of adapting systems.

105 establishing precise layer-by-layer synaptic wiring diagrams of excitatory neurons in the visual cort

106 Laminar-specific synaptic wiring diagrams of excitatory neurons were constructed o

107 ause it is difficult to directly measure the wiring diagrams of neural circuits, there has long been

108 understanding of such computations requires wiring diagrams of neuronal networks.

109 Interareal connectomes are whole-brain wiring diagrams of white-matter pathways.

110 by their synaptic connectivity, yet synaptic wiring diagrams often provide limited insight into netwo

111 Revised wiring diagrams that take into account this updated arch

112 ct circuits and create anatomically enriched wiring diagrams.

113 rich clubs as structural hallmarks of these wiring diagrams.

114 date and then probe the underlying neuronal "wiring diagrams." This has changed with the advent of ne

115 scriptional networks underlie these cortical wiring differences.

116 t is delivered by the mechanisms of OSN axon wiring, differentially for the various OSN populations e

117 gated the role of Slit and Robo receptors in wiring Drosophila higher-order brain circuits and identi

118 We conclude that proper axonal wiring during brain development depends on the precise m

119 ynchronous dynamics and forming microcircuit wiring during development, however, is not yet fully und

120 te specific functions such as nervous system wiring during development.

121 imal combination of the two basic factors of wiring economy and processing efficiency, clearly higher

122 ining, studies suggest that it improves both wiring economy and the V1 population code read downstrea

123 As the developmental mechanisms underpinning wiring economy are only now being elucidated, whether th

124 ganization, and neural networks reveals that wiring economy is a significant determinant of nervous s

125 es that encompass but also extend beyond the wiring economy principle imposed by the physical embeddi

126 The wiring economy principle proposes that animals have evol

127 tely explained by evolutionary pressures for wiring economy, but that the other hallmarks are not exp

128 largely neglected models of cortico-cortical wiring established by postmortem anatomical studies and

129 odular transcriptional programs for distinct wiring features are assembled in different combinations

130 vidence for independent control of different wiring features.

131 ers and the prediction of how changes in GRN wiring, for example through mutations or artificial inte

132 has identified an OS mechanism in selective wiring from lateral geniculate nucleus (LGN) to primary

133 and three-Ig domain molecules with neuronal wiring functions, which we refer to as Wirins.

134 trategies are being explored for efficiently wiring glucose dehydrogenase (GDh) enzymes capable of gl

135 (controls vs. uCP; and controls vs. each CST-wiring group).

136 er, this study reveals how molecular network wiring helps to establish a multipotent progenitor state

137 the importance of lamination-mediated neural wiring in a central brain region critical for normal sle

138 e of these substances can alter normal brain wiring in different ways depending on the consumed cockt

139 resolution, enabling reconstruction of dense wiring in Drosophila melanogaster and mouse nervous tiss

140 e responses, similar to those underlying the wiring in electronics.

141 that control brain development and neuronal wiring in higher animals.

142 ne receptor, to prevent aberrant VD synaptic wiring in later larval and adult stages.

143 has the ability to function without external wiring in nano or molecular circuitry since it is powere

144 single-cell phosphoproteomics and network re-wiring in predicting cancer treatment responses.

145 , three exposed layer interfaces, and carbon wiring in the design.

146 a-associated gene C4 causes aberrant circuit wiring in the developing prefrontal cortex and leads to

147 ostatic plasticity shapes cell-type-specific wiring in the developing retina to stabilize visual info

148 lecular mechanism regulates neuronal circuit wiring in the Drosophila brain, partly in response to si

149 Correct wiring in the neocortex requires that responses to an in

150 e intellectual disability via abnormal brain wiring induced by the defective differentiation of corti

151 m, with new olfactory sensory neurons (OSNs) wiring into highly organized olfactory bulb (OB) circuit

152 DC patterns (including Shift, Cross, and Re-wiring) into one uniform Bayes factor.

153 regularities of the cortex suggest that such wiring is based on the repeated initiation of a small se

154 Correct wiring is crucial for the proper functioning of the nerv

155 t is often assumed that this "topography" of wiring is essential for decoding sensory stimuli.

156 How circuit wiring is specified is a key question in developmental n

157 A very common feature of brain wiring is that neighboring points on a sensory surface (

158 to the C-terminal PDZ-binding motif of PTHR, wiring it to retromer for endosomal sorting.

159 iclib occurred as a result of tumour cell re-wiring leading to increased expression of EGFR, MAPK, CD

160 ten while preserving connectivity, aggregate wiring length would remain low.

161 inability to decipher their transcriptional wiring limits our ability to derive new biology from the

162 We propose that this unusual wiring logic evolved around the divergence of the terres

163 opy dataset to comprehensively determine the wiring logic of a broadly projecting serotonergic neuron

164 Drosophila, we comprehensively determine the wiring logic of a broadly projecting serotonergic neuron

165 rcalated mass (IM) inhibitory neurons, whose wiring may help modulate autonomic function.

166 s would be expected if a global principle of wiring minimization applied.

167 tential functional roles in brain evolution, wiring minimization, and the emergence of functional spe

168 tter across mammals and is not optimized for wiring minimization.

169 age-specific molecular substrates of circuit wiring, miswiring, and the potential for regeneration.

170 e there has been progress in elucidating rod wiring, molecular mechanisms used by cones to establish

171 protein known as Fish-lips (Fili) as a novel wiring molecule in the assembly of the Drosophila olfact

172 The axonal wiring molecule Slit and its Round-About (Robo) receptor

173 and adults revealed global downregulation of wiring molecules and upregulation of synaptic molecules

174 PTPs are thought to function as synaptogenic wiring molecules that promote neural circuit formation b

175 Identification of wiring molecules with novel mechanisms of action will pr

176 rison for two constraint models and a random wiring null model.

177 unique opportunities to study the molecular wiring of a cell.

178 in vitro systems benefit from the efficient wiring of a highly active enzyme pair and allow for the

179 key axonal molecule that participates in the wiring of amygdala circuits and helps bring about fear e

180 redox-active minerals, also facilitates the wiring of cells to electrodes.

181 ecule ELFN2 to be pivotal for the functional wiring of cones with the ON type of BC.

182 revealed the differences in the extensive re-wiring of dynamic transcriptional organization and regul

183 enhancing EGFR signalling, leading to the re-wiring of ER.

184 drifting gratings.SIGNIFICANCE STATEMENT The wiring of excitatory and inhibitory neurons in cortical

185 of transient immature neurons and the proper wiring of functional cortical circuits.

186 The activity-dependent rules that govern the wiring of GABAergic interneurons are not well understood

187 This mismatching is caused by an aberrant wiring of glutamatergic presynaptic boutons with GABAerg

188 hus, we demonstrate a dramatically different wiring of Hpo signaling in neighboring cell populations

189 ion, revealed that MYOD directs extensive re-wiring of interactions involving cis-regulatory and stru

190 me course of cellular development and axonal wiring of interneurons expressing GFP under control of t

191 refines and stabilizes before directing the wiring of its downstream target.

192 ng growth, which in turn ensures the correct wiring of neocortical circuitry.

193 indows of opportunity that ensure the proper wiring of neural circuits, as well as windows of vulnera

194 nervous system might adopt partially random wiring of neurons for colour processing.

195 The stable and efficient electric wiring of nitrogenase within the redox polymer matrix en

196 communications remain opaque, unraveling the wiring of organelle networks is critical to understand h

197 However, the wiring of peripheral neural circuits that regulate heart

198 It also opens the door for the direct wiring of robust brain-machine interfaces as well as for

199 Cell, Wei et al. (2016) identify adaptive re-wiring of signaling nodes in glioma as major mechanisms

200 d provide insight into tissue origin and the wiring of signaling proteins at membranes to predict ons

201 ne kinase receptor ErbB4 is critical for the wiring of specific populations of GABAergic interneurons

202 in MacTel patients, suggesting metabolic re-wiring of sphingomyelin metabolism in MacTel patients.

203 Within TNBC, the wiring of the affected pathways with isomiRs and tRFs di

204 Improved understanding of the molecular wiring of the AKT signaling network continues to make an

205 ating the functional properties and neuronal wiring of the AL are conducted in vivo, although so far

206 Yet, importantly, the fine wiring of the brain is not returned to the presurgery st

207 Understanding the cytoarchitecture and wiring of the brain requires improved methods to record

208 How EVs help to orchestrate the wiring of the brain while allowing for plasticity associ

209 nd connectivity are essential for functional wiring of the brain.

210 is key to an understanding of the functional wiring of the brain.

211 ynamics intuitively depend upon the internal wiring of the brain; but to which extent the individual

212 s-specific identity can actively control the wiring of the cortical microcircuit.

213 that the spatiotemporal control of synaptic wiring of the D-type neurons is controlled by an interse

214 e the seemingly complex neural superposition wiring of the fly visual map without an elaborate molecu

215 itic morphologies is crucial for the precise wiring of the nervous system that ultimately leads to th

216 he developing axon is crucial for the proper wiring of the nervous system.

217 ored cell adhesion molecules involved in the wiring of the nervous system.

218 fields for neurons and are essential for the wiring of the nervous system.

219 rogram the enhancer landscape and change the wiring of the promoter interactome.

220 Here, we demonstrate distinct wiring of the sphingolipidome across the human hematopoi

221 these results uncover the basic logic of the wiring of the taste system at the periphery, and illustr

222 es (PR) present, organization of the eye and wiring of the underlying neural circuit.

223 spatio-temporal control that governs axonal wiring of the zebrafish spinal cord.

224 Neural circuits rely upon a precise wiring of their component neurons to perform meaningful

225 efinition of muscle shapes and topographical wiring of their tendon attachments.

226 circuits, but the mechanisms controlling the wiring of these cells remain largely unknown.

227 The molecular wiring of this enzymatic pathway defines the ability of

228 PDM3 controls the wiring of wake-promoting dopaminergic (DA) neurites to a

229 This polymer facilitates the "wiring" of in situ enzymatically generated CdS QDs, whic

230 n the enzyme surface promoted the effective "wiring" of the GOX active site to an external electrode.

231 without prior experience, suggesting a "hard wiring" of underlying neural circuits.

232 we demonstrate in vivo polymerization ("hard-wiring") of a microbial community to a growing layer of

233 neurite outgrowth, synaptogenesis, and the 'wiring' of the cortex.

234 nel subunits can result in aberrant neuronal wiring often associated with neuropsychiatric disorders

235 However, the impact of such CST-wiring on functional connectivity remains unknown.

236 ot adhere to prevailing hypotheses regarding wiring optimization principles.

237 sensitivity and resolution, and the need for wiring or external cameras, have limited their applicati

238 nary intervention, especially when antegrade wiring or retrograde approaches are not feasible.

239 merging evidence suggests disruptions in the wiring organization of the brain's network in schizophre

240 s differing in biophysical properties, input wiring, output wiring to dorsomedial striatum (DMS) vers

241 from the major input that shape the H3 HC's wiring pattern during development persist to restrict mi

242 each type generate a unique and stereotypic wiring pattern with cone photoreceptors by gaining synap

243 nal programs defining each dendrite and axon wiring pattern.

244 r mechanisms that together shape stereotypic wiring patterns along the visual pathway, from within th

245 Local wiring patterns are typically quantified by counting how

246 les uncovering the relationships between the wiring patterns around nodes in a directed network and t

247 such as its gross domestic product, from its wiring patterns in the WTN for up-to ten years in the fu

248 are also skewed towards ventral retina, with wiring patterns matching the distribution of true S-cone

249 l palsy (uCP), the corticospinal tract (CST)-wiring patterns may differ (contralateral, ipsilateral o

250 er genes are characterized by specific local wiring patterns not only in the CS network of CLL cells,

251 similarity scores by fusing information from wiring patterns of all aligned PPI networks and sequence

252 graphlets as a tool for analyzing the local wiring patterns of probabilistic networks.

253 ervation of enzyme function from the network wiring patterns rather than from sequence data.

254 sequences) and functioning similarity (from wiring patterns) are supported by all networks.

255 deviation): 14.54 (+/-4.8)), and between CST-wiring patterns.

256 ely related neuronal subtypes with different wiring patterns.

257 o undamaged cone photoreceptors with correct wiring patterns.

258 Here, we test this by re-wiring PE metabolism in yeast by re-directing Psd1 to th

259 tical circuits is that despite their complex wiring, population-wide shared spiking variability is lo

260 mation and show that such genetically driven wiring predicts the existence of specific biclique motif

261 ecies analyses of connectomes and illuminate wiring principles of cortical connectivity across mammal

262 ss species analysis of brain connectomes and wiring principles of the brain.

263 gnals are modified to fit more complex brain wiring processes is unclear.

264 quires high-precision neuronal expansion and wiring, processes controlled by the transmembrane Rounda

265 electrical power to devices where a physical wiring proved impracticable.

266 dance, synapse targeting, and other neuronal wiring-related functions.

267 lower heat load than conventional electrical wiring, relaxing the requirements for thermal anchoring,

268 Neural circuit wiring relies on selective synapse formation whereby a p

269 ndent of the circuit's complexity, minimizes wiring requirements and allows component reusability wit

270 We found that a degree-modified Hebbian wiring rule best reproduced the pattern of computation a

271 al gradients produce a hierarchical cortical wiring scheme that is concordant with increasing functio

272 is not cone-type specific, but whether these wiring schemes are maintained closer to the fovea remain

273 how remarkable architectural and often local wiring similarity, raising the question: where and how i

274 Our evaluations demonstrate the cortical wiring space bridges across scales of neural organisatio

275 f validation experiments showed that the new wiring space reflects cortical microcircuit features (in

276 The wiring specificity and synaptic diversity have a great i

277 receptor expression in one ORN type and only wiring specificity in another type, (2) one type-restric

278 derstanding of the mechanisms that establish wiring specificity of complex neural circuits is far fro

279 We know considerably less about the wiring strategies of motor networks, where connections c

280 fic roles, suggesting distinct steps in axon wiring, such as elongation, pruning, and synaptogenesis.

281 not all, major features of their stereotypic wiring, suggesting that circuit patterns may be unable t

282 e (GlDH-NAD(+)) apoenzyme-coenzyme molecular wiring system on the base gold electrode.

283 oquinoline quinone-based composite molecular wiring system.

284 and kinetic limitations associated with the wiring systems.

285 tions evolved resistance by genetically hard-wiring the first steps of an induced immune response to

286 Axons are cable-like neuronal processes wiring the nervous system.

287 Axons act like cables, electrically wiring the nervous system.

288 lopment in Drosophila; it can promote neural wiring through homophilic recognition that leads to eith

289 biophysical properties, input wiring, output wiring to dorsomedial striatum (DMS) versus dorsolateral

290 imprinted genes, from neural development and wiring to synaptic function and plasticity, energy balan

291 The subsequent wiring to the naphthylated multi-walled carbon nanotubes

292 This suggests that, although wiring topography could provide a starting point for dec

293 o a structurally accessible form for circuit wiring, translate the input information into an arbitrar

294 mGluR5 is required for several key steps in wiring up the thalamocortical connections to form the co

295 sicle creation are bypassed, we term it "hot-wiring." We use hot-wired endocytosis to describe the fu

296 e a human-relevant "map" of microbial-immune wiring while focusing on animal studies to probe a prior

297 l receiving neurons, while sparse convergent wiring will induce a weak correlation, if any.

298 sub-proteomes by combining acute cellular re-wiring with high-resolution spatial proteomics.

299 scale brain network by comparing human brain wiring with that of the chimpanzee, one of our closest l

300 "structural elements" (SEs) directing their wiring within the "ncRNA interactor networks" through th