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1 teins that play a prominent role in drug and xenobiotic metabolism.
2 regulate the expression of genes involved in xenobiotic metabolism.
3 y glucosides and may play a critical role in xenobiotic metabolism.
4 aling pathways, transcription regulators, or xenobiotic metabolism.
5 s of SXR/PXR expression that are critical in xenobiotic metabolism.
6 ave an important role in thyroid hormone and xenobiotic metabolism.
7 compounds that regulate mammalian enzymes of xenobiotic metabolism.
8 renal cortex and its relationship to adrenal xenobiotic metabolism.
9 est a major role for this isozyme in adrenal xenobiotic metabolism.
10 s, coinciding with the major site of adrenal xenobiotic metabolism.
11 P3A4) is the dominant P450 involved in human xenobiotic metabolism.
12 ucial roles in both estrogen homeostasis and xenobiotic metabolism.
13 NO(x) included several involved in lipid and xenobiotic metabolism.
14 olism on ingested compounds, and elucidating xenobiotic metabolism.
15 ticipated in xenobiotic transport, lipid and xenobiotic metabolism.
16 erimental animal models poorly predict human xenobiotic metabolism.
17 tor of the cellular antioxidant response and xenobiotic metabolism.
18 as an important cellular role in addition to xenobiotic metabolism.
19 tor (PXR) plays a central role in regulating xenobiotic metabolism.
20 tion enzymes, including some associated with xenobiotic metabolism.
21 l molecular link between innate immunity and xenobiotic metabolism.
22 bpopulations in the gut responsible for this xenobiotic metabolism.
23 ptor that functions as a master regulator of xenobiotic metabolism.
24 eceptor (CAR) is a central regulator of drug/xenobiotic metabolism.
25  mechanisms associated with the silencing of xenobiotic metabolism.
26 regulates enzymes involved in endobiotic and xenobiotic metabolism.
27 ting the toxicological effects of dioxin and xenobiotic metabolism.
28 mic reticulum (ER)-proteins, responsible for xenobiotic metabolism.
29  were found for genes related to estrogen or xenobiotic metabolism.
30 ic enzyme with an important role in drug and xenobiotic metabolism.
31 iosynthesis, steroid hormone metabolism, and xenobiotic metabolism.
32 tion factors controlling pathways modulating xenobiotic metabolism.
33         AhR is traditionally associated with xenobiotic metabolism.
34  important implications for both hormone and xenobiotic metabolism.
35 as specific to the group of NRs that control xenobiotic metabolism.
36 molecular mechanisms lead to enhancements in xenobiotic metabolism.
37  acid metabolism, nucleotide metabolism, and xenobiotics metabolism.
38 olism, purine and pyrimidine metabolism, and xenobiotics metabolism.
39 ent were enriched with genes associated with xenobiotics metabolism.
40 uctural relationships among these enzymes of xenobiotic metabolism, a structure-based evolutionary se
41 says for cytotoxicity, endocrine disruption, xenobiotic metabolism, adaptive stress responses, mitoch
42 eceptor-controlled cholesterol/bile acid and xenobiotic metabolism among the top deregulated pathways
43 eeks post-smoking-cessation were involved in xenobiotic metabolism and anti-apoptotic functions respe
44 ways involved in asthma pathogenesis such as xenobiotic metabolism and antioxidant defenses.
45 lated factor 2 (Nrf2) in regulating phase II xenobiotic metabolism and antioxidant response.
46          These genes are largely involved in xenobiotic metabolism and antioxidative and anti-inflamm
47 ptor that plays a crucial role in regulating xenobiotic metabolism and detoxification, energy homeost
48 r (AhR) is a nuclear receptor that regulates xenobiotic metabolism and detoxification.
49  commonly studied for its role in regulating xenobiotic metabolism and dioxin toxicity, a development
50 gnane X receptor (PXR) is a key regulator of xenobiotic metabolism and disposition in liver.
51 esterol, fatty acid, bile acid, steroid, and xenobiotic metabolism and homeostasis.
52 nd the Mediator complex in the regulation of xenobiotic metabolism and lipid homeostasis.
53 y, loss of PNPLA3 also caused a reduction in xenobiotic metabolism and predisposed PNPLA3(KO) cells t
54 have previously reported functions involving xenobiotic metabolism and protein-folding machinery of t
55       We identified potential candidates for xenobiotic metabolism and steroidogenesis.
56                 Additional research suggests xenobiotic metabolism and subcellular components, such a
57 ation of multiple cellular pathways, such as xenobiotic metabolism and Th17 cell differentiation.
58 atic cytochrome P450 (CYP) genes involved in xenobiotic metabolism and that exposure to xenobiotic ch
59 d with immune barrier function and lipid and xenobiotic metabolism and that human-specific genetic fe
60 chrome P450 3A7 (CYP3A7) is involved in both xenobiotic metabolism and the estriol biosynthetic pathw
61 ent effects on transcriptional regulation of xenobiotic metabolism and transporter genes.
62 anscriptional regulator of the expression of xenobiotic metabolism and transporter genes.
63 tile enzymes that function in endobiotic and xenobiotic metabolism and undergo meaningful structural
64 t CYP6 family (both of which are involved in xenobiotic metabolism) and to the insect CYP9 family (of
65 (body weight, protein, chitobiase, catalase, xenobiotic metabolism, and acetylcholinesterase) were me
66 etabolism, peroxisome, bile acid metabolism, xenobiotic metabolism, and adipogenesis.
67 ioxin (dioxin) hepatotoxicity, regulation of xenobiotic metabolism, and hepatovascular development.
68 ne X receptor (PXR) is a master regulator of xenobiotic metabolism, and its activity is critical towa
69 sses, such as glucose and lipid homeostasis, xenobiotic metabolism, and regeneration.
70 tant toxicity pathways, such as induction of xenobiotic metabolism, and some integrative indicators d
71 nal substrate and energy used to up-regulate xenobiotic metabolism, and therefore not available for p
72 tive phosphorylation, amino acid metabolism, xenobiotic metabolism, and transcriptional regulation.
73 t absorption, mucosal barrier fortification, xenobiotic metabolism, angiogenesis, and postnatal intes
74                      Although alterations in xenobiotic metabolism are considered causal in the devel
75                   Finally, genes involved in xenobiotic metabolism are down-regulated, and cells are
76 e cytochrome P450 (CYP) isoforms involved in xenobiotic metabolism are enzymes whose substrate select
77 gut microbes, genes, and enzymes involved in xenobiotic metabolism are poorly understood.
78                            CYPs critical for xenobiotic metabolism are prone to catalytic cycle uncou
79 egulates the expression of genes involved in xenobiotic metabolism as well as hormone, energy, and li
80 xide hydrolase (mEH) plays a central role in xenobiotic metabolism as well as mediating the sodium-de
81 l gene groups, with carbohydrate, lipid, and xenobiotics metabolism belonging to the EPE and MPE clus
82 d phase II (e.g. glutathione S-transferases) xenobiotic metabolism, bioenergetics (e.g. cytochrome ox
83  a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and compounds that re
84 he constitutive androstane receptor (CAR) in xenobiotic metabolism by inducing expression of cytochro
85 ed nuclear receptor VDR regulate steroid and xenobiotic metabolism by inducing the phase I cytochrome
86 cilitate studies of the role of this gene in xenobiotic metabolism, cancer, and other human diseases.
87 factor that regulates genes involved in drug/xenobiotic metabolism, cell cycle progression, cell fate
88         These pathways include regulation of xenobiotic metabolism; control of genomic stability, inc
89                       An inherited defect of xenobiotic metabolism could result in increased suscepti
90 P70), metal-binding (metallothionein-A), and xenobiotic metabolism (Cyp1a1) utilizing quantitative po
91  gene families with functions in steroid and xenobiotic metabolism (Cyp2d), reproduction (MUPs), and
92 cant changes in expression of genes encoding xenobiotic metabolism (cyp4) and moulting (cut).
93 -8 (IL-8) and cyclooxygenase-2 (COX-2)], and xenobiotic metabolism [cytochrome P4501A1 (CYP1A1)].
94 ulated genes included genes corresponding to xenobiotic metabolism, detoxification, and antioxidant c
95 d to several functional categories including xenobiotic metabolism, detoxification, disease, and stre
96        Differences in amino acid, lipid, and xenobiotic metabolism distinguished ASD and typically de
97 n sites were involved in pathways including, xenobiotic metabolism (e.g., Cyp1a4), lipid/bile acid ho
98 ne receptor (CAR) plays an important role in xenobiotic metabolism, energy homeostasis, and cell prol
99 ancer effects with the induction of phase II xenobiotic metabolism enzymes via activation of the Keap
100 nscriptional regulation of genes that encode xenobiotic metabolism enzymes.
101  weight and body composition) and extrinsic (xenobiotic metabolism) factors were the main causes of d
102 of cell growth, neurodevelopment, vision and xenobiotic metabolism functions.
103 including (i) transcriptional control of the xenobiotic metabolism genes Cyp1a1 and Cyp1b1 and (ii) i
104 rs, the function of PXR in the regulation of xenobiotic metabolism has been extensively studied, and
105 t in recent years, since its contribution in xenobiotic metabolism has not always been identified bef
106 nism-based inactivation of P450s involved in xenobiotic metabolism has the potential to lead to adver
107 de axonal transport, vesicle trafficking and xenobiotic metabolism have been implicated in neurodegen
108  and gene coexpression networks enriched for xenobiotic metabolism, hormone metabolism, and immune re
109                                  In insects, xenobiotic metabolism (i.e., metabolism of insecticides
110 indicates four pathways (starch, sucrose and xenobiotic metabolism; immune response and inflammation;
111 sible role for DNA methylation in perturbing xenobiotic metabolism in bladder cancer.
112 4 is a major contributor to hepatic drug and xenobiotic metabolism in human adults.
113 lates a similar program of genes involved in xenobiotic metabolism in human liver.
114  the distinct evolution of genes involved in xenobiotic metabolism in mites.
115 e anticipated in light of current models for xenobiotic metabolism in plants, evidence for unsuspecte
116 to an enzyme functioning in both primary and xenobiotic metabolism in prokaryotes and eukaryotes.
117      A possible role of genetic variation in xenobiotic metabolism in the carcinogenicity of hair dye
118 ne of the most important enzymes in drug and xenobiotic metabolism in the human body.
119 hich acts as a xenobiotic sensor to regulate xenobiotic metabolism in the liver and intestine.
120 egulates the expression of genes involved in xenobiotic metabolism in the liver.
121  used as a pan-antagonist of NRs involved in xenobiotic metabolism in vivo, which may lead to novel s
122 zymes, suggesting broad influence of ESR1 on xenobiotics metabolism in human liver.
123 is strongly expressed in tissues involved in xenobiotic metabolism including liver and kidney.
124 tration, and significant gene alterations in xenobiotic metabolism, including a decrease in ABCB1/mul
125 inct sets of genes involved in all phases of xenobiotic metabolism, including oxidative metabolism, c
126 link between activation of AhR signaling and xenobiotic metabolism, inhibitors of HDAC6 may alter dru
127 l be important to determine whether enhanced xenobiotic metabolism is also a correlated, rather than
128                                              Xenobiotic metabolism is complex, and accounting for bio
129  liver proteins involved in reproduction and xenobiotic metabolism is induced at puberty by sex-speci
130               The chemistry of gut microbial xenobiotic metabolism is often distinct from that of hos
131 ulation of the genes relevant to steroid and xenobiotic metabolism, is likely to have clinical signif
132 Studies of vitamin E metabolism suggest that xenobiotic metabolism may not only regulate vitamin E co
133 ibrosis, and reduced capacity for apoptosis, xenobiotic metabolism, normal cell-cycling, and DNA repl
134                          We investigated the xenobiotic metabolism of the red-blooded Gobionotothen g
135 ation to therapy is achieved by upregulating xenobiotic metabolism or a redundant signaling pathway,
136 ession of mRNA genes associated with hepatic xenobiotic metabolism, oxidative DNA damage, or alterati
137 several stress related mRNAs and proteins of xenobiotic metabolism, oxidative stress, DNA damage, and
138 ng on the association of starch, sucrose and xenobiotic metabolism pathway with longevity is consiste
139 ular zone exhibited widespread inhibition of xenobiotic metabolism pathways and inhibition of PXR/RXR
140  of the mutant Kras allele and activation of xenobiotic metabolism pathways, suggesting that reductio
141 ve health-relevant endpoints were related to xenobiotic metabolism (pregnane X and aryl hydrocarbon r
142                      These genes function in xenobiotic metabolism, proliferation, heart contractilit
143 ith daily alterations in lipid, glucose, and xenobiotic metabolism, protein turnover, and redox balan
144                    Among stress response and xenobiotic metabolism proteins, selenium-binding protein
145                                              Xenobiotic metabolism serves a critical role in the clea
146  and development, as well as upregulation of xenobiotic metabolism signaling pathways.
147 analyses found a significant enrichment for "xenobiotic metabolism signaling" and "PXR/RXR activation
148 riched with the nonreversible genes included xenobiotic metabolism signaling, bupropion degradation,
149 the toxicity pathways including induction of xenobiotic metabolism, specific and reactive modes of to
150 rane-embedded monooxygenases responsible for xenobiotic metabolism, steroidogenesis, fatty acid metab
151 is a major enzymatic determinant of drug and xenobiotic metabolism that demonstrates remarkable subst
152 validation of previously reported effects in xenobiotic metabolism, the innate immune system, and glu
153 the emerging importance of human P450 2B6 in xenobiotic metabolism, thorough biochemical and biophysi
154  function as a xenobiotic sensor to regulate xenobiotic metabolism through selective transcription of
155 such as virulence, antibiotic resistance and xenobiotic metabolism to spread through the human microb
156    Increased expression of genes involved in xenobiotic metabolism, together with resistance to xenob
157                                              Xenobiotic metabolism, transformation, excretion, and co
158 ear receptor pathway would influence steroid/xenobiotic metabolism using dehydroepiandrosterone sulfo
159 a xenobiotic sensor to coordinately regulate xenobiotic metabolism via transcriptional regulation of
160 ities enriched in genes related to lipid and xenobiotic metabolisms, virulence factors, and antibioti
161 s involved in various aspects of steroid and xenobiotic metabolism was analyzed.
162 ic processes-in particular, those related to xenobiotic metabolism-was decreased.
163 , a molecular understanding of gut microbial xenobiotic metabolism will guide personalized medicine a
164 erences in lipid, drug, steroid hormone, and xenobiotic metabolism, with distinct responses of males

 
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