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1 e, suggesting that combined inhibition of C, xenoreactive Ab responses, and cellular immunity may be
2                                     Elicited xenoreactive Abs (EXA) are thought to initiate hamster t
3 +/- 1.7 days) by promoting production of IgG xenoreactive Abs (XAb).
4 s of mammalian origin, even while generating xenoreactive, and potentially autoreactive, antibodies a
5  in a xenograft, human serum, as a source of xenoreactive anti-endothelial Abs and complement, induce
6 pha1,3Gal (Gal) as the main target for human xenoreactive (anti-pig) antibodies and the development o
7  isolectin B4, and elicited primate anti-pig xenoreactive antibodies (decomplemented cynomolgus monke
8                   Production of IgM elicited xenoreactive antibodies (EXA) peaked on day 4 after tran
9                                          The xenoreactive antibodies accompanying acute or late xenog
10 formation could explain the peculiar fate of xenoreactive antibodies after pulmonary xenotransplantat
11 normalities in eicosanoid release induced by xenoreactive antibodies and complement might provide one
12 protective genes, and deposition of elicited xenoreactive antibodies and complement on the graft endo
13 n (PG) I2, endothelial cells stimulated with xenoreactive antibodies and complement released PGE2 and
14 s hyperacute rejection, which is mediated by xenoreactive antibodies and complement, and results in r
15 we investigated endothelial cells exposed to xenoreactive antibodies and complement, as might occur i
16           These recipients developed de novo xenoreactive antibodies and experienced xenograft reject
17          We investigated whether circulating xenoreactive antibodies are a useful indicator of this x
18 ic lectins as compared with XNAs or elicited xenoreactive antibodies can directly elicit type II porc
19 pig xenoantigens recognized by natural human xenoreactive antibodies has led to the development of st
20 on of complement regulation and depletion of xenoreactive antibodies improves the outcome of pulmonar
21                                 Depletion of xenoreactive antibodies is more effective than membrane-
22 ds reduced the level of anti-pig IgM and IgG xenoreactive antibodies to nearly background, but column
23 fts is thought to be triggered by binding of xenoreactive antibodies to the graft.
24 rvested and the functional activities of the xenoreactive antibodies were quantitated by in vivo pass
25 to limit xenograft rejection by NK cells and xenoreactive antibodies will need to incorporate carbohy
26                   Thought to be initiated by xenoreactive antibodies, acute vascular rejection might,
27                                     Elicited xenoreactive antibodies, and to non-Gal epitopes alone,
28 ly by components of natural immunity such as xenoreactive antibodies, complement and natural killer c
29 of the previously known anti-alpha-galactose xenoreactive antibodies.
30 rejection and the accompanying production of xenoreactive antibodies.
31 eans of overcoming the rejection mediated by xenoreactive antibodies.
32 on, which is associated with a rise in serum xenoreactive antibody (Ab) and a cellular infiltrate, tr
33  splenectomy influences the magnitude of the xenoreactive antibody (XAb) response and thus hamster he
34 iopsy specimens were obtained for studies of xenoreactive antibody binding and tissue factor expressi
35        Many waitlisted patients have minimal xenoreactive antibody binding to the triple KO pig, but
36 is histologically characterized by extensive xenoreactive antibody deposition and cellular infiltrati
37 umptive coagulopathy occurred when there was xenoreactive antibody deposition and increase of tissue
38             In vivo, AVR was associated with xenoreactive antibody deposition in the graft.
39 to conventional immunosuppression, extensive xenoreactive antibody deposition, and cellular infiltrat
40 tomized rats, only about one tenth of normal xenoreactive antibody levels.
41 sociated with 7.7-fold and 78.0-fold rise in xenoreactive antibody titers after first and second trea
42 ection but are rejected within 3-4 days when xenoreactive antibody titers rise exponentially to level
43         When vascular endothelial binding of xenoreactive antibody was combined with the expression o
44                                    Titers of xenoreactive antibody were monitored until elective deat
45   These results suggest strategies to remove xenoreactive antibody-secreting cells prior to transplan
46 xenoreactive counterparts (P<0.05), although xenoreactive CD4+ CD25+ T cells proliferated more than a
47 xenografts revealed the presence of residual xenoreactive cells.
48 e was not due to complete clonal deletion of xenoreactive cells.
49 sponder T cells proliferated more than their xenoreactive counterparts (P<0.05), although xenoreactiv
50 s, endothelial cell activation, and positive xenoreactive crossmatches.
51 antigen on porcine endothelium recognized by xenoreactive human antibodies.
52       We report here the characterization of xenoreactive human natural antibodies against antigens w
53 herefore, HLA-E protected porcine cells from xenoreactive human NK cells through a CD94/NKG2-dependen
54  that porcine chimerism induces tolerance of xenoreactive human T cells.
55 These data indicate that Ts induce anergy of xenoreactive human Th cells upon specific recognition of
56                                    Allo- and xenoreactive IgG and IgM, measured by T cell and B cell
57 n resulted in approximately 90% reduction in xenoreactive IgM levels, as measured by ELISA.
58 s HAR with prolongation of survival and that xenoreactive IgM may be the predominant immunoglobulin i
59 rgan survival was negatively associated with xenoreactive IgM nAb levels measured immediately before
60             Previous studies have implicated xenoreactive IgM natural antibody (nAb) as the predomina
61 determined and the levels of alloreactive or xenoreactive immunoglobulin (Ig)M and IgG were determine
62 ) by CD16+ NK cells in the presence of human xenoreactive immunoglobulin G.
63 -cells were analyzed via flow cytometry, and xenoreactive lymphocytes via ELISPOT, 90 days after impl
64               We also present two additional xenoreactive MAIT TCR/MR1 complexes that recapitulate th
65                               The TCR from a xenoreactive murine cytotoxic T lymphocyte clone, AHIII
66                      The orientation of this xenoreactive murine TCR atop human MHC deviates from the
67 vitro, was also strongly associated with IgM xenoreactive nAb levels (r=0.92; P<0.0001).
68 level of alphaGal-reactive IgM suggests that xenoreactive NAbs may be the product of germ-line genes.
69                              The majority of xenoreactive natural Abs in humans recognize the carbohy
70  known about the B-cell subsets that produce xenoreactive natural antibodies (NAb).
71  from pig to human, is rejection mediated by xenoreactive natural antibodies (XNA) that bind the carb
72                        In additional groups, xenoreactive natural antibodies (XNA) were depleted by p
73 as purified by protein-G chromatography, and xenoreactive natural antibodies (XNA) were depleted by p
74                                        Human xenoreactive natural antibodies (XNA), both IgM and IgG
75                                        Human xenoreactive natural antibodies (XNA), of IgM and IgG su
76       Hyperacute rejection (HAR) mediated by xenoreactive natural antibodies (XNA), which are thought
77 rminant recognized on porcine cells by human xenoreactive natural antibodies (XNA).
78                                              Xenoreactive natural antibodies (XNAs) and complement me
79  consequence of the failure to fully deplete xenoreactive natural antibodies and block complement, or
80                                              Xenoreactive natural antibodies and complement were depl
81 (HAR) is prevented by strategies directed at xenoreactive natural antibodies and/or complement activa
82 e previously demonstrated very low levels of xenoreactive natural antibodies in newborns, suggesting
83 gher primates is initiated by the binding of xenoreactive natural antibodies of the recipient to bloo
84 edicted, this resulted in reduced binding of xenoreactive natural antibodies to endothelial cells of
85 nts is initiated by the binding of preformed xenoreactive natural antibodies to the vascular endothel
86 vels, except in NOD-scid-beta2 m-, including xenoreactive natural antibodies.
87 ft recipients with complement inhibitors and xenoreactive natural antibody depletion leads to delayed
88 , naive or sensitized baboon sera containing xenoreactive natural or elicited antibodies were used to
89 rmine the frequency and cytokine profiles of xenoreactive PBLs from a panel of human volunteers.
90            Levels of CD4+-effector cells and xenoreactive splenocytes showed similar results.
91 iters, frequency of CD4+-effector cells, and xenoreactive splenocytes were 2- to 4-fold lower (P<0.00
92 l and specifically sensitized mice activated xenoreactive T and B cells.
93 splantation in humans, but whether analogous xenoreactive T cell immunity develops is not known.
94 MHC-bound peptide to the responding allo- or xenoreactive T cell repertoire is not clear.
95 ated whether these EVs proficiently initiate xenoreactive T cell responses via direct xenorecognition
96 notransplant and indicates that pre-existing xenoreactive T cells and induced antibodies to unknown e
97     Cloning studies identified two groups of xenoreactive T-cell clones.
98                                    The human xenoreactive T-cell receptor (TCR) repertoire is not wel
99        These novel observations suggest that xenoreactive T-independent humoral responses can be dele
100 their ability to inhibit early activation of xenoreactive Th (up-regulation of CD40 ligand).
101       Ts drastically reduced the capacity of xenoreactive Th cells to produce interleukin (IL)-2 in r
102 iomedical benefits, for example, ablation of xenoreactive transplantation antigens, inactivation of g
103 nsion and precursor frequencies of allo- and xenoreactive Tregs were assessed by labeling with FoxP3

 
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