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1 r inducers of p16 tumor suppressor gene than zebularine.
2 ucleotide-diphosphate reductase required for zebularine.
3 ssion is reduced shortly after withdrawal of zebularine.
4  expression in maltreated dams normalized by zebularine.
5  mechanism of action of the anti-cancer drug zebularine.
6 epair of DPCs induced by the cytidine analog zebularine.
7 he potent cytidine deaminase inhibitor (CDA) zebularine [1-(beta-D-ribofuranosyl)-1, 2-dihydropyrimid
8                   Recently, we reported that zebularine [1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidi
9  2% sodium alginate containing high loads of zebularine (240 mg/ml) and retinoic acid (0.8 mg/ml) pro
10 ar dynamics and free energy simulations that zebularine 3,4-hydrate may in fact be unstable in the en
11 ed that the TSA formed at the active site is zebularine 3,4-hydrate.
12 ation of dZ and the inefficient reduction of zebularine 5'-diphosphate by ribonucleotide-diphosphate
13                  In this study, we show that zebularine (a demethylating agent) treatment of cancer c
14                                 Infusions of zebularine (a DNA methyltransferase inhibitor) significa
15                                              Zebularine, a cytosine analog, elevated all classes.
16                              We administered zebularine, a drug known to alter DNA methylation, to da
17                                 Furthermore, zebularine, a drug that selectively traps and depletes n
18 hypermethylation was significantly abated by Zebularine, a potent demethylating agent, with a consequ
19 interferon-stimulated genes (ISGs) following zebularine administration.
20 In syngeneic tumor models, administration of zebularine alone reduced tumor burden and extended mice
21  oligonucleotides with a single incorporated zebularine also did not disrupt editing in vitro, sugges
22                                              Zebularine, an orally administerable DNA methyltransfera
23                                    Moreover, zebularine and 5-aza-2-deoxycytidine, inhibitors of DNMT
24 ism for coping with the genotoxic effects of zebularine and identify several components of the zebula
25 rimidinone, an analogue often referred to as zebularine and known to give rise to high-affinity compl
26 on of two putative transition-state analogs, zebularine and tetrahydrouridine, failed to disrupt RNA-
27 NitroC), 2-pyrimidinone (P; the free base of zebularine) and 6-methylfuranopyrimidinone (MefP), were
28 g capecitabine, the gene silencing inhibitor zebularine, and the blood vessel inhibitor bevacizumab.
29 Cytidine deaminase (CDA) binds the inhibitor zebularine as its 3,4-hydrate (K(d) ~ 10(-12) M), captur
30 lation inhibitors 5-aza-2'-deoxycytidine and zebularine as well as DNA methyltransferase-specific siR
31   In vitro studies showed rapid discharge of zebularine but not retinoic acid from the alginate formu
32 e the greater thermodynamic stability of the zebularine complex.
33 es have shown that ssDNA containing 2'-deoxy-zebularine (dZ-ssDNA) is an inhibitor of A3s such as A3A
34 d, we show that maltreated-dams treated with zebularine exhibit lower levels of adverse care toward t
35 ment with 5-aza-2'-deoxycytidine followed by zebularine hindered the remethylation of the p16 5' regi
36 e of the transition state analogue inhibitor zebularine hydrate (1.2 x 10(-12) M) is very much lower
37 en the deazacytidine, dihydrozebularine, and zebularine--hydrate inhibitor complexes suggest that the
38        Third, we show that administration of zebularine in control dams (history of nurturing care) e
39               This study unveils the role of zebularine in sensitizing the cGAS-STING pathway to prom
40 ent with the DNA methyltransferase inhibitor Zebularine increases miR-124 expression and retards CC c
41 tors as well as with the demethylating agent zebularine induced a strong apoptotic response.
42 arine and identify several components of the zebularine-induced DNA damage repair pathway.
43                                The repair of zebularine-induced DPCs was associated with SMC5/6-depen
44  show that the nonmethylable cytidine analog zebularine induces a DNA damage response in Arabidopsis
45 ge in a cell cycle stage-independent manner, zebularine induces damage specifically during strand syn
46                             Incorporation of zebularine into genomic DNA caused demethylation and ele
47                                              Zebularine is a riboside that must undergo a complex met
48 ate competition assays show that in solution zebularine is released from CDA (k(off) > 0.14 s(-1)) mu
49 xes (other than E(2)Zn(2)) are observed when zebularine is used in place of 5-fluorozebularine.
50                                However, when zebularine is withdrawn from the cells, the reestablishm
51 an CDA, but it was 16 times less potent than zebularine (Ki = 38 microM vs Ki(apparent) = 2.3 microM)
52                  Without causing DNA damage, zebularine led to accumulation of DNA species in the cyt
53      Based on our observed effect of SAM and zebularine on DC subset development, we sought to clarif
54 es and a noncanonical pyrimidine nucleoside (zebularine) phosphate can be formed from the direct coup
55                                              Zebularine promoted infiltration of CD8 T cells and natu
56 ic analogues appeared to be more stable than zebularine, replacement of the electronegative CO4' oxyg
57  DNA hypomethylating agents (azacitidine and zebularine) restored Kupffer cell autophagy, M1/M2 polar
58          The DNA methyltransferase inhibitor zebularine reverses the methylation of the p53 promoter,
59               We used the demethylating drug zebularine to induce changes in DNA methylation, then ex
60  Here we show that continuous application of zebularine to T24 cells induces and maintains p16 gene e
61                      In addition, continuous zebularine treatment effectively and globally demethylat
62                              The efficacy of zebularine was abolished in nude mice and in cGAS(-/-) o
63           Even at a non-toxic concentration, Zebularine was effective in suppressing CC cell invasion
64     These three carba-nucleoside versions of zebularine were fashioned to overcome the inherent insta
65         The nucleoside analogs (DAC, 5AC and zebularine) were the most potent DHAs and increased the
66 therapy that combines a demethylating agent, zebularine, with retinoic acid, acting as a transcriptio
67 olism of the DNA methytransferase inhibitor, zebularine (Z).
68                                              Zebularine (ZEB) binds to CDA, and the binding process l
69 ious cell densities with the DNMT1 inhibitor zebularine (ZEB) followed by a 3D culture to identify ce
70 nd liver cancer cell lines were treated with zebularine (ZEB), a potent DNA methyltransferase-1 inhib
71 r codelivery of anti-PD1 antibody (aPD1) and Zebularine (Zeb), an HMA, is engineered.