ライフサイエンスコーパス: zinc finger motif

1 which these transcription factors bind via a zinc finger motif.

2 yeast ribosomal protein that has a C(2)-C(2) zinc finger motif.

3 he TAG1 DNA binding domain revealed a C(2)HC zinc finger motif.

4 ssor functions is contained within the first zinc finger motif.

5 the cell cycle; AfVIP2 contains a ring-type zinc finger motif.

6 A factors based upon inclusion of a class IV zinc finger motif.

7 Came-DAB1), a serine-threonine kinase, and a zinc finger motif.

8 rminal protein domain that includes a likely zinc finger motif.

9 copies of a previously uncharacterized CCCH zinc finger motif.

10 r inter-zinc-motif spacer but shorter second zinc finger motif.

11 tiation via an evolutionarily conserved C2H2 zinc finger motif.

12 ntains conserved primase motifs, including a zinc finger motif.

13 of a yeast protein, Nab2, that contains this zinc finger motif.

14 molecule including all four cysteines in the zinc-finger motif.

15 etal ion is required for the function of the zinc-finger motif.

16 interaction extends beyond such a canonical zinc-finger motif.

17 ntegral membrane protein that has a DHHC-CRD zinc-finger motif.

18 onserved cysteine-rich motifs reminiscent of zinc finger motifs.

19 ly containing three characteristic C2H2-type zinc finger motifs.

20 , a 555-amino-acid protein with two separate zinc finger motifs.

21 d, KRAB-ZFP that contains only four C(2)H(2) zinc finger motifs.

22 inger genes that encode 10 or more C(2)-H(2) zinc finger motifs.

23 lated domain and arginine-rich region but no zinc finger motifs.

24 an evolutionarily conserved protein with two zinc finger motifs.

25 r proteins based on arsenic interaction with zinc finger motifs.

26 domains and a zinc finger domain with eight zinc finger motifs.

27 analyzed Gag proteins that contain one or no zinc finger motifs.

28 esis and encodes a transcription factor with zinc finger motifs.

29 H2-terminal domain consisting of four double zinc finger motifs.

30 amino acid level and 85.5% within the seven zinc finger motifs.

31 in a region separating the SCAN box from the zinc finger motifs.

32 eage, contains two adjacent highly conserved zinc finger motifs.

33 romatic residue in each of its two CCHC-type zinc finger motifs.

34 o acid protein, which contains two potential zinc finger motifs.

35 nd the other is present within the first two zinc finger motifs.

36 box (KRAB) at the N terminus and 12 adjacent zinc finger motifs.

37 ain in the NH-terminal region followed by 16 zinc finger motifs.

38 Members of one group include C2H2 zinc finger motifs.

39 factors characterized by seven to nine C2H2 zinc finger motifs.

40 ctor that contains a BTB/POZ domain and C2H2 zinc finger motifs.

41 TIP27 is a 27 kDa protein containing two zinc finger motifs.

42 d on the number and structures of their WRKY zinc-finger motifs.

43 n single amino acid changes within different zinc-finger motifs.

44 e activity of a family of proteins with CCCH zinc-finger motifs.

45 e deduced sequence contains a novel putative zinc finger motif, 10 ankyrin-like repeats, and shows ho

46 ecific alanine substitutions in the putative zinc finger motif (30-ZF3A) or in a conserved region (re

47 family that contains 10 different C(2)-H(2) zinc finger motifs, 9 clustered at the C terminus with a

48 contains a cysteine-rich region resembling a zinc finger motif, a potential G-protein-binding region,

49 Lnp1 dimerizes in vitro via its C-terminal zinc finger motif, a property that is required for prope

50 odes a transcription factor with a C2H2-type zinc finger motif, a serine/proline-rich domain, a basic

51 sequence contains 13 adjacent C(2)H(2)-type zinc finger motifs, a Kruppel-associated box, and is loc

52 In addition to the zinc-finger motifs, a 44- to 45-bp repeat is conserved i

53 alysis provides evidence that the engineered zinc finger motif adopts a folded structure in which the

54 actor-beta-inducible Sp1-like proteins whose zinc finger motifs also bind GC-rich sequences.

55 The PIE-1 protein contains potential zinc-finger motifs also found in the mammalian growth-fa

56 ions in the Gag matrix (MA) domain or the NC zinc finger motifs altered condensate number and size in

57 The absolute conservation of the zinc finger motif among oncoretroviruses and lentiviruse

58 ARs alpha, delta, and gamma that contain the zinc finger motif and a CTE display binding to core reco

59 erved C-terminal domain consisting of a H2C2 zinc finger motif and an acetyltransferase domain that i

60 ARF GAPs, the GAP domain of ARD1 contains a zinc finger motif and arginine residues that are critica

61 The N-terminal domain includes a zinc finger motif and has been shown to bind Zn2+, where

62 ly and genetically separable; the N-terminal zinc finger motif and the central sorting motif are invo

63 To further understand the role of the zinc finger motif and the RKLKR domain in viral assembly

64 -ZFa cDNA encodes a protein containing seven zinc finger motifs and an acidic C-terminal domain.

65 of a basic N-terminal region with seven C2H2 zinc finger motifs and an acidic C-terminal region that

66 In addition, SDC-3 requires its own zinc finger motifs and an amino-terminal region for its

67 nscription factor contains C-terminal tandem zinc finger motifs and an N-terminal SNAG repression dom

68 nt encompassing the three N-terminal, unique zinc finger motifs and another encompassing the last thr

69 NC contains two Cys-His boxes that form zinc finger motifs and are responsible for encapsidation

70 Crz1p contains zinc finger motifs and binds specifically to the CDRE.

71 These overlap the zinc finger motifs and function to provide the proper de

72 id carcinoma tissues, among them a cDNA with zinc finger motifs and homology to other zinc finger pro

73 inger protein with six C2H2-type, C-terminal zinc finger motifs and is activated by provirus integrat

74 predicted to bind DNA based on its multiple zinc finger motifs and nuclear localization.

75 JMJ27 is a nuclear protein containing a zinc-finger motif and a catalytic JmjC domain with conse

76 Rim is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domain

77 s a 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain, suggest

78 INSM1 (formerly IA-1) contains five zinc-finger motifs and functions as a transcription fact

79 as9d, a new CRISPR type II subtype, contains Zinc-finger motifs and high arginine content, features t

80 ins two putative zinc-binding RING motifs, a zinc finger motif, and a coiled-coil motif.

81 on of ARD1 required two arginines, an intact zinc finger motif, and a group of residues which resembl

82 up of a three-helical bundle stabilized by a zinc finger motif, and wraps tightly around the disc-sha

83 The last four zinc finger motifs, and the linkers that join them, are

84 TR3 features two RNA recognition motifs, two zinc-finger motifs, and four intrinsically disordered re

85 bosomal proteins, transcription factors with zinc-finger motifs, and proteins associated with protein

86 Mutations in CCHH, the putative zinc finger motif, apparently do not play an important r

87 Instead, residues from these other zinc finger motifs appeared to participate in an alterna

88 All five zinc finger motifs are critical for efficient binding of

89 ifs, whereby amino acid substitutions in the zinc finger motifs are demonstrated to abolish or impair

90 Zinc finger motifs are distributed amongst many eukaryot

91 Further analyses show that only three zinc finger motifs are essential for PAR recognition.

92 is attached to a tandem array of DNA-binding zinc-finger motifs, are specific to tetrapod vertebrates

93 CF comprises 727 amino acids and contains 11 zinc finger motifs arranged in tandem that are flanked b

94 nd to encode a protein having the same C2-H2 zinc finger motif as Sp1.

95 the LIM protein family, has a unique double zinc finger motif as the defining feature.

96 contains both a Plant homeodomain (PHD)-like zinc finger motif as well as an ATPase domain of the SNF

97 BRCA1 protein includes an amino-terminal zinc finger motif as well as an excess of negatively cha

98 ve been mapped to two independent regions: a zinc finger motif at amino acid positions 148 to 162 and

99 to the following two independent regions: a zinc finger motif at amino acid positions 148 to 162 and

100 gions (basic amino acids 101RKLKR105 and the zinc finger motif at amino acids 148 to 162) had varied

101 x-loop-helix domain but does not include the zinc finger motif at the C terminus.

102 Tcn1p contains three zinc finger motifs at its carboxyl terminus resembling t

103 taining two potential CX(2)CX(11)HX(3)C-type zinc finger motifs at its carboxyl-terminal region.

104 er domain with a tandem array of four FLYWCH zinc finger motifs at its N-terminus and a C-terminal do

105 Sequence analysis reveals eight C2H2 zinc finger motifs at the C-terminus of ZNF210 and five

106 ins a PR domain in the middle region and six zinc finger motifs at the carboxyl-terminus.

107 protein C4SR contains two cysteine(4) (C(4)) zinc-finger motifs at its amino terminus, a stretch of a

108 eins possess a highly selective PI3P binding zinc finger motif belonging to the FYVE domain family.

109 The C terminus of Pam containing the RING zinc finger motif binds to tuberin.

110 MZF1 and MZF1B contain 13 C(2)H(2) zinc finger motifs, but only MZF1B contains an amino-ter

111 tant that lacks the N-terminal zinc RING and zinc finger motifs, but retains the coiled coil and TRAF

112 ants in the GST system indicates that the E7 zinc-finger motif, but not the pRb binding domain, is in

113 a 55-amino acid protein containing a single zinc finger motif, C26C29H34C39, that includes Y at posi

114 ene (NbRar1), which encodes a protein with a zinc finger motif called CHORD (Cys- and His-rich domain

115 Jade-1 has two zinc finger motifs called plant homeodomains (PHD).

116 dsRBP-ZFa must contain more than one type of zinc finger motif capable of binding dsRNA.

117 cular mass of 80.3 kDa that contains the two zinc-finger motifs characteristic of other HypF proteins

118 of a recently discovered family of putative zinc finger motif coding genes consisting of YPEL1-5, is

119 The C-terminal domain has an unusual zinc-finger motif composed of Cys-250, Cys-255, Cys-263,

120 cold shock domain and retroviral-type (CCHC) zinc finger motifs, consistent with a role for LIN-28 in

121 It contains five tandem Cys(2)-His(2) zinc finger motifs consisting of the consensus sequence

122 is NEIL3 C terminus has two highly conserved zinc finger motifs containing GRXF residues (designated

123 and that arsenite interacts selectively with zinc finger motifs containing three or more cysteine res

124 y regulate the growth promoting signals as a zinc-finger motif containing nuclear transcription facto

125 ene-1) is an immediate early gene encoding a zinc finger motif-containing transcription factor.

126 iants affect a single conserved residue in a zinc finger motif crucial for DNA binding and are delete

127 a putative DNA-binding protein with a single zinc finger motif defined by the C-X2-C-X17-C-X2-C seque

128 protein kinase C (PKC) isozymes contain two zinc finger motifs, designated "C1a" and "C1b" domains,

129 ding compared to the Wt M1, but mutations of zinc finger motif did not.

130 ved RBM5/RBM10 peptide sequence, including a zinc finger motif, disrupted U2 interaction and rendered

131 A mutant lacking the region between the zinc finger motifs (DJA2-Deltam2) was able to bind subst

132 e fusion of the Fok I cleavage domain to the zinc finger motif does not change the DNA sequence speci

133 In contrast, mutations in the third zinc finger motif eliminate the nuclease activity of the

134 Its five tandem zinc finger motifs exhibit highest homology with those o

135 Its five tandem Cys(2)-His(2) zinc finger motifs exhibit the highest homology to those

136 hooks (exon 3), repression domain (exon 6), zinc finger motifs (exon 8) and activation domain (exon

137 It contains one PHD-type zinc finger motif followed by a bromodomain.

138 The LIM domain is a specialized double-zinc finger motif found in a variety of proteins, in ass

139 -amino-acid protein with conservation of the zinc finger motif found in SPT4.

140 Sulfolobus SSB lacks the zinc finger motif found in the eucaryal and euryarchaeal

141 LIM domain proteins, first defined by the zinc finger motifs found in the Lin11, Isl-1, and Mec-3

142 ein was found to have acquired an additional zinc finger motif from that of Crz1 and showed Pkc1-depe

143 Conservation of this zinc finger motif from yeast to mouse and human implies

144 pressors by binding DNA through their tandem zinc finger motifs.Gene silencing is mediated by the hig

145 Deletion or mutation of A20 C-terminal zinc finger motifs had no effect on the inhibition of IR

146 a KRAB domain protein (KRAB-O) that lacks a zinc finger motif has been demonstrated to interact with

147 (KRAB-ZFP) and few proteins with 10 or more zinc finger motifs have been shown to bind DNA in a sequ

148 brate GATA factors have two highly conserved zinc finger motifs, how the two fingers act together to

149 role of residues adjacent to the CXXCX17CNAC zinc finger motif (i.e. non-finger residues) in the spec

150 We thereby conclude that the zinc finger motif in NEIL2 is essential for its structur

151 A single zinc finger motif in REST is required for CoREST interac

152 ational analysis further identifies a single zinc finger motif in the carboxyl-terminal domain as bei

153 he F interaction was mapped to the conserved zinc finger motif in the NH2-terminus of the beta' subun

154 phosphates but involves interactions with a zinc finger motif in the Sin3-associated protein 30 (SAP

155 Disruption of the zinc finger motifs in GATA-1, such as produced by germli

156 an cells revealed that intact PIN domain and Zinc finger motifs in human hUTP23 are essential for 18S

157 allmark of this domain is the packing of two zinc finger motifs in one globular unit.

158 The zinc finger motifs in retroviral nucleocapsid (NC) prote

159 pts were found to contain multiple C2H2-type zinc finger motifs in tandem arrays, indicating that the

160 binding by Roaz reveals the role of specific zinc finger motifs in the Roaz protein for homodimerizat

161 required for this interaction, the specific zinc finger motifs in these domains were not.

162 eriments suggest the possible involvement of zinc finger motifs in X chromosome recognition and the a

163 residue (C97) that is part of an N-terminal zinc-finger motif in APO3G abolished multimerization of

164 wn silencer for Thpok, and requires the last zinc-finger motif in Bcl11b protein, which by contrast i

165 Crystal structure analysis reveals a unique zinc-finger motif in BTB for interacting with ankyrin re

166 ently, we described a novel function for the zinc-finger motif in regulation of RPA's ssDNA binding a

167 bonucleoproteins with a distinctive array of zinc-finger motifs, including two to four C(3)H zinc-fin

168 mini-protein that adopted the betabetaalpha zinc-finger motif independent of zinc binding, was inves

169 The motion of Npl4 results from its zinc finger motifs interacting with the N domain of p97,

170 Because the 8th zinc finger motif is also present in the oncoprotein EVI

171 An N-terminal zinc finger motif is essential for enzyme activity; dele

172 is suggests that hydrogen bonding within the zinc finger motif is important for cDNA production and b

173 inase gene is likely functional, whereas the zinc finger motif is likely nonfunctional.

174 th DNA repair proteins containing functional zinc finger motifs is one proposed mechanism to account

175 Unlike other zinc-finger proteins, RPA zinc-finger motif is not a DNA-binding component, and de

176 terminal trans-membrane domain and a RING-H2 zinc-finger motif located at the C-terminus.

177 h a molecular mass of 40 kDa, with a RING-H2 zinc-finger motif located at the extreme end of the C-te

178 The versatility and modular nature of the zinc finger motif makes it an ideal candidate for engine

179 ular structure of Fok I endonuclease and the zinc finger motifs makes it possible to create "artifici

180 modeling reveals that the Vif Cullin box and zinc finger motif may be positioned adjacent to the N te

181 domain in REST containing eight GL1-Kruppel zinc finger motifs mediates DNA binding.

182 Together, our results suggest that the zinc-finger motif mediates the transition of RPA-ssDNA i

183 Although the CDGSH domain is annotated as a zinc finger motif, mitoNEET was shown to contain iron.

184 A zinc finger motif near the amino terminus of the ARF1 GA

185 NC contains two CCHC zinc finger motifs numbered 1 and 2 from the N terminus.

186 in vivo, the expression of the isolated 8th zinc finger motif of EVI1 is sufficient to block the gra

187 Altering the zinc finger motif of M1 only slightly affected viral gro

188 Altering the zinc finger motif of M1 reduces viral growth slightly.

189 ons in the coding sequences of RKLKR and the zinc finger motif of M1 were constructed using a PCR tec

190 Here, we show that the 8th zinc finger motif of MDS1/EVI1 is an oligomerization dom

191 eracts with PKC at the cysteine-rich region, zinc finger motif of the enzyme.

192 erved and mutationally intolerant retroviral zinc finger motif of the HIV-1 nucleocapsid protein (NC)

193 A single amino acid change in the zinc finger motif of the putative catalytic HAT domain g

194 The ATPase activity and C-terminal zinc finger motif of yejH play an important role in its

195 Although NCp zinc fingers differ from the zinc finger motifs of cellular enzymes, the requirement

196 arsenic interacts with the N- and C-terminal zinc finger motifs of GATA-1, causing zinc loss and inhi

197 and help to explain the requirement for the zinc finger motifs of NC in its role as a nucleic acid c

198 the C terminus of NEIL2 is distinct from the zinc finger motifs of Nei/Fpg, which are of the C4 type.

199 nder oxidative conditions, which disrupt the zinc finger motifs of Npl4, locking the essential confor

200 elements of the promoter and the first three zinc finger motifs of RIZ1.

201 the 78 proteins in yeast ribosomes, six have zinc finger motifs of the C2-C2 variety.

202 em-4 gene encodes a protein containing seven zinc finger motifs of the C2H2 class, four of which are

203 (GenBank accession no. U72621) contain seven zinc finger motifs of the C2H2 type as well as proline a

204 rs characterized by the presence of multiple zinc finger motifs of the Cys2-His2 type at the carboxyl

205 Mutations in the first of the three CCCH zinc finger motifs of the protein abolish RNA binding by

206 Since these two fragments do not share zinc finger motifs of the same sequence, dsRBP-ZFa must

207 We show that thiols in the 4-cysteine zinc-finger motif of DksA, an RNA polymerase accessory p

208 de a putative transcription factor with four zinc-finger motifs of the C2H2 class.

209 e from the open reading frame contains seven zinc-finger motifs of the C2H2 type, as well as proline-

210 (Zfp319) encoding a nuclear protein with 11 zinc-finger motifs of the C2H2 type.

211 d DNA-binding activities of the two putative zinc-finger motifs of Urbs1 were studied by analyzing mu

212 he predicted Tef protein contains three C2H2 zinc-finger motifs, one at the amino terminus and two in

213 s stimulate HDAC activity and that the SAP30 zinc finger motif performs roles similar to that of the

214 These data suggest that the UL52 zinc finger motif plays an important role in the activit

215 domain IIs of Ydj1 monomers that contain the zinc-finger motifs points directly against each other.

216 riptase does not contain the canonical HH-CC zinc finger motif present in all characterized retrovira

217 The interaction is mediated by two unusual zinc finger motifs present at the carboxyl terminus of E

218 This suggests that zinc finger motifs present in Ho are important for cleav

219 The zinc-finger motif, present as two copies in C4SR, is als

220 Ash1p has a zinc finger motif related to those of GATA transcription

221 difications of thiols in the DksA 4-cysteine zinc-finger motif release the metal cofactor and drive r

222 Proteins containing C2H2 type zinc finger motifs represent one of the largest classes

223 Several plant metacaspase prodomains contain zinc finger motifs resembling those in the plant hyperse

224 that clusters of basic residues, but not the zinc finger motif residues themselves, are required for

225 s in two isoforms, containing three and five zinc-finger motifs respectively, due to alternative spli

226 he JmjC domain, the C-terminal domain, and a zinc-finger motif, revealed the unique elements that for

227 Mutation of individual zinc finger motifs reveals that the zinc finger domains

228 MP42, and TbMP81, TbMP63, and TbMP42 contain zinc finger motif(s).

229 ised of conserved Snail/Slug/Gfi1 (SNAG) and zinc finger motifs separated by a linker region poorly c

230 s containing mutations affecting one or both zinc finger motifs showed that effective strand annealin

231 the id1 gene that it encodes a protein with zinc finger motifs, suggesting that the id1 gene product

232 human homologue, Aire contains two PHD-type zinc-finger motifs, suggesting that the Aire protein may

233 ion that interacts with ElonginC and a novel zinc finger motif that interacts with Cullin5.

234 A (RPA) contains an evolutionarily conserved zinc finger motif that lies outside of the domains requi

235 de synthesis as well as a putative Cys(3)His zinc finger motif that may be involved in DNA binding.

236 ntains a conserved Cys-X2 Cys-X14-Cys-X2-Cys zinc finger motif that may be involved in interactions w

237 ts human homolog also share similar putative zinc finger motifs that are absent in other group I RNA

238 JAZ contains four C(2)H(2)-type zinc finger motifs that are connected by long (28-38) am

239 In addition, TRAFs 2-6 have RING and zinc finger motifs that are important for signaling down

240 munodeficiency virus type 1 NC possesses two zinc finger motifs that are required for specific recogn

241 ino acid nuclear protein that contains eight zinc finger motifs that are structurally related to thos

242 defined by three highly homologous C(2)H(2) zinc finger motifs that bind GC-rich sequences found in

243 characterized by three conserved C-terminal zinc finger motifs that bind GC-rich sequences found in

244 erized by three highly homologous C-terminal zinc finger motifs that bind GC-rich sequences.

245 The ER-DBD contains two (Cys)(4)-liganded zinc finger motifs that cooperate to stabilize a rigid D

246 Three L-complex proteins contain zinc finger motifs that could be involved in these inter

247 otein containing five C2H2-type Kruppel-like zinc finger motifs that exhibit 93% identity with those

248 that it belongs to the family of cross-brace zinc finger motifs that include the PHD, RING, and FYVE

249 that it encodes a protein with six CCCH-type zinc finger motifs that is also found in yeast, Caenorha

250 727 amino acids and contains a domain of 11 zinc finger motifs that is flanked by 267 amino acids on

251 ption factors that contain either one or two zinc finger motifs that recognize and bind to GATA-conta

252 reover, both ZNF644 and WIZ contain multiple zinc finger motifs that recognize consensus DNA sequence

253 RPA) contains a conserved four cysteine-type zinc-finger motif that has been implicated in regulation

254 a RING (C3HC4) zinc-finger and multiple C3H zinc-finger motifs, the former being closely related to

255 minal region containing two C2H2and one CCHC zinc finger motifs; the phosphorylation site critical fo

256 could directly bind TOR mRNA via its tandem zinc finger motif to affect TOR mRNA stability.

257 Notably, ZC3H11A uses the same zinc finger motifs to interact with PABPN1 and viral mRN

258 which is predicted to change a cysteine in a zinc-finger motif to tyrosine.

259 mation, and the adaptability of the Cys2His2 zinc finger motif, to target virtually any site in the g

260 The zinc-finger motif was discovered during biochemical stud

261 playing an amino acid arrangement resembling zinc finger motifs, was studied by genetic and biochemic

262 ts with C42S, C57S, or C60S mutations in the zinc finger motif were able to rescue the null mutant.

263 wo highly conserved cysteine residues in the zinc finger motif were replaced with alanine residues.

264 st ribosomal protein YL37a, which has such a zinc finger motif, were disrupteXXPd.

265 The Osr1 protein contains three zinc-finger motifs whereas Osr2 exists in two isoforms,

266 n length which have the C-X4-C-X22-23-H-X1-H zinc finger motif which is present in WRKY proteins, a f

267 277 amino acids, containing the first seven zinc finger motifs, which confers weak monomeric binding

268 n one significant aspect: Tsh contains three zinc finger motifs while Tio has four such domains.

269 ociated protein (THAP) domain is an atypical zinc finger motif with sequence-specific DNA-binding act

270 pombe TFIIIA sequence includes ten potential zinc finger motifs, with a 53-amino acid spacer between

271 an comprising four DNA-binding domains and a zinc-finger motif within a single polypeptide of 645 ami

272 an evolutionarily conserved 4-cysteine-type zinc finger motif (X(3)CX(2-4)CX(12-15)CX(2)C) that has

273 DNA binding structure of four and five C2H2 zinc finger motifs (ZF), respectively.

274 which is largely dependent on A20's seventh zinc-finger motif (ZnF7), induces specific binding to NE