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1 tive inhibitor for miRNAs, termed 'small RNA zipper'.
2 rs self-assemble using electrostatic 'charge zippers'.
3 interface to allow the formation of a serine zipper.
4 C terminus is mediated by a putative leucine zipper.
5 he CA-SP1 junction region fused to a leucine zipper.
6 Ne/Epi) boundary just ahead of the advancing zipper.
7 -beta structure and assembly of a dry steric zipper.
8 nce attached to N-terminal of bZIP53 leucine zipper.
9 ckdown of miRNA levels by 30-50 nM small RNA zippers.
10 d disfavoring formation of pathogenic steric zippers.
11 tions, such as those between pairing leucine zippers.
12 h propensity to form fibers, known as steric zippers.
13 ition to the structural properties of steric zippers.
14 as a fusion clamp that restricts full SNARE zippering.
15 abilized the CTD, facilitating further SNARE zippering.
16 l contraction mechanism for robust efficient zippering.
17 ng, known to be faster than N-terminal SNARE zippering.
18 osine interacting with PH domain and leucine zipper 1 (APPL1) signaling endosomes and MYO6+ expressio
19 atory pathway in which spermatogenic leucine zipper 1 (SPZ1) promotes EMT through its transactivating
21 sociated transcription factor, BASIC LEUCINE ZIPPER 17 (bZIP17), and the membrane-associated RNA spli
22 egron-pathway(4,5) substrate known as LITTLE ZIPPER 2 (ZPR2)-which evolved to control the activity of
23 inding activity of protagonist basic leucine zipper 53 (bZIP53) transcription factor and its heterodi
24 quiring protein-1) and bZIP60 (basic leucine zipper 60), two RSRE containing unfolded protein-respons
25 yosin II along Ne/Epi junctions ahead of the zipper and inhibiting myosin II along newly formed Ne/Ne
26 pact pseudoknot, dock via an extended ribose zipper and jointly create a binding groove specific to t
28 rodimers and bind to DNA via a basic leucine zipper and regulate the cell cycle, apoptosis, different
29 s to a helical state when fused to a leucine zipper and that these helical molecules further associat
30 AP-25 C terminus promote tight SNARE complex zippering and are required for high release frequency an
32 ractility along tissue boundaries to control zippering and neural tube closure in the basal chordate,
33 each other through their shafts, leading to zippering and unzippering behavior that regulates their
34 pathogenic seeds of alpha-syn contain steric zippers and suggest a therapeutic approach targeted at t
35 s that promote tetramerization when fused to zippers and those that permit the proper assembly of ful
36 el homodimer linked by an N-terminal leucine zipper, and we show that the WT chain in WT-RQ heterodim
37 ant when the SNAREpins are nearly completely zippered, and from this state, each SNAREpin can deliver
41 ne and 2,6-diaminopurine, and +1 interstrand zipper arrangements of intercalator-functionalized nucle
43 full-length myosin-X construct with leucine zipper at the C-terminal end of the tail (M10(Full)LZ) a
44 er vaccination, both migratory basic leucine zipper ATF-like transcription factor 3 (BatF3)-dependent
45 In addition, we demonstrate that the miR-221 zipper attenuates doxorubicin resistance with higher eff
46 alleles of wallenda (wnd, encoding a leucine zipper bearing kinase similar to human DLK and LZK) were
52 s), SFH3 (SEC14-like 3), bZIP (basic-leucine zipper), bHLH (basic helix-loop-helix) and SBP (SQUAMOSA
53 rtner Mlx are basic helix-loop-helix leucine zipper (bHLHZip) transcription factors that sense and ex
54 gnificantly reduced the energy of C-terminal zippering by 10 kBT, but did not affect N-terminal assem
55 IRs identified a heterodimeric basic leucine zipper (bZIP) complex between an uncharacterized protein
56 protein consists of the basic region-leucine zipper (BZip) domain of the CCAAT/enhancer-binding prote
57 leukemia virus type 1 (HTLV-1) basic leucine zipper (bZIP) factor (HBZ) could be used for immunothera
59 ED HYPOCOTYL 5 (HY5), a basic domain/leucine zipper (bZIP) transcription factor, acts as a master reg
60 nts identified to date, HY5, a basic leucine zipper (bZIP) transcription factor, has been investigate
61 act with TGACG-motif binding (TGA) basic Leu zipper (bZIP) transcription factors for recruitment to D
62 ive dimerization of the basic-region leucine-zipper (bZIP) transcription factors presents a vivid exa
64 ng Locus T 1 (RFT1), OsFD-like basic leucine zipper (bZIP) transcription factors, and Gf14 proteins a
66 d ICIRD spectroscopy on basic-region leucine zipper (bZIP)-LOV of aureochrome 1a from the diatom Phae
67 long newly formed Ne/Ne junctions behind the zipper, Cadherin2 promotes tissue-level contractile asym
68 periment, and show that 2 populations of DNA zippers can be distinguished using per-molecule statisti
69 tion factors in hematopoiesis is the leucine zipper CCAAT-enhancer binding protein alpha (C/EBPalpha)
70 conserved mechanism of general relevance for zippering closure of epithelial gaps whose disturbance c
71 tyrosine Interaction, PH domain, and leucine zipper containing 1 (APPL1) that were identified by mean
73 e MAP3K ZAK (Sterile alpha motif and leucine zipper-containing kinase) has also been proven to positi
74 brosarcoma oncogene homolog (MAF), a leucine zipper-containing transcription factor of the AP1 superf
75 en the NC domain was replaced with a leucine zipper dimerization motif that promotes Gag multimerizat
76 ion between the LOV and basic region leucine zipper DNA-binding domain that together with LOV dimeriz
79 cid-binding domain with a dimerizing leucine zipper domain leads to the assembly of RNA-free VLPs.
83 ore, we introduce a biophysical model of the zippering dynamics, and we quantitatively relate the ind
84 key biophysical SNARE properties such as the zippering energy landscape and the surface charge distri
87 hese unprecedented findings show that steric zippers exhibit a characteristic nanomechanical signatur
88 ts proviral genome, the HTLV-1 basic leucine zipper factor (HBZ), which inhibits Tax-1-mediated viral
89 Ala-Ala in many members of the basic leucine-zipper family of transcription factors, important in gen
91 shortening of Ne/Epi junctions, driving the zipper forward and drawing the neural folds together.
93 Induction of glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a key role in the
95 ssion of glucocorticoid (GC)-induced leucine zipper (GILZ) in bone marrow mesenchymal lineage cells o
97 ine 211 and expression of GC-induced leucine zipper (GILZ) were significantly reduced in ASM cells fr
99 at GTPase activation and trans-SNARE complex zippering have opposing effects on fragment formation an
100 e gamma-clade of class I homeodomain-leucine zipper (HD-Zip I) transcription factors (TFs) constitute
102 expression of CLASS III HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIP III) transcription factors, promotes xyle
103 Members of the class III homeodomain-leucine zipper (HD-ZIPIII) gene family are critical players in t
104 ree paralogous class III homeodomain leucine zipper (HD-ZIPIII) genes leads to aberrations in ovule i
105 members of the class III homeodomain leucine zipper (HD-ZIPIII) transcription factor family specify t
106 orm stable homodimers, whereas c-Fos leucine zipper homodimers were found to be much less stable in e
107 Characterization of the homeodomain leucine zipper I transcription factor AtHB13, which is expressed
108 Pull in plants using the HOMEODOMAIN LEUCINE ZIPPER III (HD-ZIPIII) and LITTLE ZIPPER (ZPR) interacti
109 porter system, we defined a putative leucine zipper in the N terminus of human pro-EMAP II protein (a
112 cell-cell contacts, filopodia, and membrane zippers, indicative of involvement in cell-cell adhesion
114 eveal tightly packed beta-sheets with steric zipper interfaces characteristic of the amyloid state.
115 orm a dimer driven by formation of a glycine zipper involving alpha helix formed by amino acid residu
117 In contrast, when complete C-terminal SNARE zippering is prevented, fusion strictly requires Sec18 a
118 dent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without r
121 uch as the widely used GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin foldon (Fd
122 ress response controlled by the Dual Leucine Zipper Kinase (DLK) and contributes to DLK-mediated neur
123 ation in neurons is mediated by dual leucine zipper kinase (DLK) and JNK-interacting protein 3 (JIP3)
124 After axonal insult and injury, Dual leucine-zipper kinase (DLK) conveys retrograde pro-degenerative
130 ing to ApoE receptors activates dual leucine-zipper kinase (DLK), a MAP-kinase kinase kinase that the
132 ule dynamics was independent of dual leucine zipper kinase (DLK)-mediated stress but was rescued by c
137 ly partially protective, we identify leucine zipper kinase (LZK) as cooperating with DLK to activate
140 a novel selective maternal embryonic leucine zipper kinase (MELK) inhibitor HTH-01-091, CRISPR/Cas9-m
141 rotein kinase maternal and embryonic leucine zipper kinase (MELK) is critical for mitotic progression
142 injury is regulated in part by dual-leucine zipper kinase 1 (DLK-1), a conserved regulator of axon r
143 tivity of type II maternal embryonic leucine zipper kinase inhibitors by applying these two complemen
144 tein kinase MELK (maternal embryonic leucine zipper kinase) has been considered an attractive therape
145 lain the increased rate for C-terminal SNARE zippering, known to be faster than N-terminal SNARE zipp
146 ned targeting, we introduce here the "Killer Zipper" (KZip(+)), a suppressor that makes Split GAL4 ta
147 cing can interlock with multiple TLR9 like a zipper, leading to multivalent electrostatic interaction
148 an self-assemble to form supramolecular DNA "zipper" like structures through intermolecular hydrogen
150 e-specific figure-of-eight, dumbbell-shaped, zipper-like and multi-loop quaternary structures were fo
152 w that the C-terminal helices, arranged in a zipper-like fashion, play a crucial role in guiding the
154 spacing of the trans-Golgi cisternae through zipper-like interactions, thereby forcing cargo to the t
156 cadherin gammaB4 ectodomain, which reveals a zipper-like lattice that is formed by alternating cis an
157 Golgin45 and GM130, we found that a leucine zipper-like motif in the central coiled-coil region of G
160 om apposed cell surfaces, possibly forming a zipper-like protein assembly, and thus providing a size-
164 e revealed hitherto unrecognized actin-based zipper-like structures (ZLSs) that arise between MGCs fo
165 etry, we detected a RIT1 interactor, leucine zipper-like transcription regulator 1 (LZTR1), that acts
167 ith NS harboring mutations of LZTR1 (leucine zipper-like transcription regulator 1), an adaptor for C
169 Furthermore, DUSP23 knockdown produced "zipper-like" cell-cell adhesions, caused defects in tran
172 with target membrane-associated t-SNAREs, a zippering-like process releasing approximately 65 kT per
173 circle transcription acts as both the "smart zipper lock" and the delivery carrier to alternately loc
174 be sealed into the RNA sequence-programmed "zipper lock" by controlled loading, avoiding mutual nons
176 Ne/Epi --> Ne/Ne + Epi/Epi) just behind the zipper lower tissue resistance to zipper progression by
177 scaffold assembly requires conserved leucine zipper (LZ) and Cnn-motif 2 (CM2) domains that co-assemb
178 l coiled-coil domain (CC) and/or the leucine zipper (LZ) domain of the myosin light-chain phosphatase
180 a C(2) H(2) -zinc finger (ZF), and a leucine zipper (LZ), whose roles in FOXP2 remain largely unknown
181 arting from the experimentally observed half-zippered metastable state, the SNAREpins have to mechani
182 ina, we used Nrl(-/-) (neural retina leucine zipper) mice, to generate Rpgr(ko)::Nrl(-/-) double-knoc
184 rA8; another proposed a so-called 'staggered zipper' model in which oligo(rA) strands overlap in mult
185 hosphotyrosine-binding domain, and a leucine zipper motif (APPL)1, an early endosomal protein, is req
186 ional orientation places an extended glycine zipper motif (G(40)xxxS(44)xxxG(48)) together with a pat
189 evolutionarily conserved, truncated leucine zipper motif near the N terminus as well as a strictly c
191 pans the crystal lattice, featuring a steric-zipper motif that is common in structures of amyloid-for
193 , phosphotyrosine binding domain and leucine zipper motif) mediates rab5 overactivation in Down syndr
194 n-like proteins CdzC and CdzD harbor glycine-zipper motifs, often found in amyloids, and CdzC forms l
195 dimer association featuring a "phenylalanine zipper" notable for the dual roles of phenylalanines in
196 bp) of Frmpd1 binds to neural retina leucine zipper (NRL) and cone-rod homeobox protein (CRX), two ro
197 rried out a detailed biophysical analysis of zippering, occurring either spontaneously or induced by
198 ons assemble into beta-hairpins via top down zippering of backbone hydrogen bonds to form the membran
199 The expanding integrin wave facilitates the zippering of Fcgamma receptors onto the target and integ
200 ted microtubule transport and oMAP4-mediated zippering of microtubules drives formation of a paraxial
201 tant hemocytes coupled with impaired midline zippering of mutant epithelium creates a situation in so
203 O goes beyond its participation in the final zippering of the complex, because mutations of residues
204 1 molecules unlocks the complex, allows full zippering of the SNARE complex, and triggers membrane fu
205 NARE serves as a spring to prevent premature zippering of the SNARE complex, thereby reducing the lik
207 st that the SM protein Munc18-1 promotes the zippering of trans-SNARE complexes and accelerates the k
209 l aspects of KYE28, constituting an aromatic zipper, of potential importance for the development of n
210 ly binds microtubules, mediating microtubule zippering or end-on microtubule interactions, depending
211 ins unclear how these mutations affect SNARE zippering, partly due to difficulties to quantify the en
213 nalysis revealed tissue expansion around the zippering point after ablation, but predominant tissue c
216 This zone is biomechanically coupled to the zippering point by a supracellular F-actin network, whic
217 ransitory semi-rosette-like structure at the zippering point that promotes juxtaposition of cells acr
218 n vivo to generate a sufficient pause in the zippering process for the regulators to set in place.
219 icient to explain the speed and direction of zipper progression and highlight key advantages of a seq
220 behind the zipper lower tissue resistance to zipper progression by allowing transiently stretched cel
224 and we quantitatively relate the individual zipper properties to global characteristics of the devel
225 show that the glucocorticoid-induced leucine zipper protein (GILZ), already known to regulate effecto
226 ription of three related Homeodomain leucine zipper protein (HD-ZIP)-encoding genes: HOMEOBOX PROTEIN
228 -negative mutant of the basic region leucine zipper protein c-Jun, a major constituent of the AP-1 tr
229 human fibroblasts, we uncovered the leucine-zipper protein LUZP1 as an interactor of truncated SALL1
231 encoding for Neural retina-specific leucine zipper protein, a rod fate determinant during photorecep
232 c transcription factors: bZIP (basic leucine-zipper) proteins, exemplified by the AP-1 and CEBPbeta r
234 a switch to enable fast and controlled SNARE zippering required for synaptic vesicle fusion and neuro
235 ion conversion, four of which were in steric zipper segments where side chains from amino acids tight
236 inding) is shown to be dominated by a simple zipper sequence, only occasionally accelerated by loop f
239 arrier transiently traps SNAREpins in a half-zippered state similar to the partial assembly that enga
244 remains disordered, the H1 tail serves as a zipper that closes and stabilizes the structure through
245 eceptor, vimentin, fibrin, and phenylalanine zippers that vary in size and topology of their alpha-he
246 of the mammalian embryo involves a wave of "zippering" that passes down the elongating spinal axis,
250 the receptor extracellular domains with Jun zippers to control the position of its transmembrane (TM
252 and vesicle-attached (v-SNARE) proteins that zipper together to form a coiled-coil SNARE bundle that
254 virus (IBV), induces regions of ER that are zippered together and tethered open-necked double membra
256 artner BTB and CNC homology 1, basic leucine zipper transcription factor 1 (BACH1), the chromatin rem
260 A complex between FT and the basic leucine-zipper transcription factor FD is proposed to form in th
261 ual specificity T-box/basic-helix-loop-helix-zipper transcription factor Mga is expressed in the plur
264 photomorphogenesis promoting a basic leucine zipper transcription factor that is degraded by COP1 ubi
265 s (Arabidopsis thaliana) homeodomain-leucine zipper transcription factor that participates in hypocot
266 its is MLX, a basic helix-loop-helix leucine-zipper transcription factor that regulates metabolic pro
267 ugh the interaction with FD, a basic leucine zipper transcription factor which plays a critical role
268 essential and conserved plant basic leucine zipper transcription factor whose level controls seed ge
270 his correlated inversely BATF (basic leucine zipper transcription factor, ATF-like) and IRF4 (interfe
271 zinc deficiency B. distachyon basic leucine zipper transcription factor, BdbZIP10, and its role in o
275 g a newly developed BBS mouse model [Leucine zipper transcription factor-like 1 (Lztfl1)/Bbs17 mutant
276 lies in the supernode network, BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR1-TGA and HYPERSENSITIVITY TO
278 6 and BBF2H7 are transmembrane basic leucine zipper transcription factors and are subjected to RIP by
279 ich revealed that the group S1 basic leucine zipper transcription factors bZIP1 and bZIP53 reprogram
280 ctivity of the class-III homeodomain-leucine zipper transcription factors(6-8)-and thereby regulates
284 SM subunit Vps33, is followed by subsequent zippering transitions that increase the probability of f
288 eukaryotic life, requiring SNARE proteins to zipper up in an alpha-helical bundle to pull two membran
289 ease of an inserted tryptophan, facilitating zippering up of 20-bp guide RNA:target DNA heteroduplex
290 uently forming successive evaginations that "zipper" up proximally, but at their leading edges are fr
291 ally unwound and unpaired DNA duplex forms a zipper via alternating interstrand base stacking, rather
292 e ability of Munc18-1 to promote trans-SNARE zippering, whereas other known Munc18-1/SNARE-binding mo
293 oorly understood feature of this process is "zippering," whereby a fusion point moves directionally a
294 nal association followed by rapid C-terminal zippering, which serves as a power stroke to drive membr
295 y is the formation of a three-protein charge zipper with interdigitated complementary charged residue
296 ctivated the t-SNARE complex to initiate NTD zippering with the v-SNARE, a mechanism likely shared by
297 ex on the target plasma membrane, which then zippers with the vesicle (v)-SNARE on the vesicle to dri
298 ucture provides direct evidence for a steric zipper within a fibril formed by full-length Abeta pepti