ライフサイエンスコーパス: zonation

1 ion on postsettlement survival (i.e., allele zonation).

2 of parameter uncertainty, and (iii) dynamic zonation.

3 ographic and elevational differentiation and zonation.

4 e with concentric chemical and mineralogical zonation.

5 h mechanisms, including mineralogic/chemical zonation.

6 onal fluctuations and as a function of liver zonation.

7 ndrial heterogeneity in the context of liver zonation.

8 ture, cellular communication, and hepatocyte zonation.

9 greatly increased our understanding of liver zonation.

10 zonal" hepatocytes, causing loss of distinct zonation.

11 tivity gradient required for metabolic liver zonation.

12 ons, corresponding to the typical salt marsh zonation.

13 is patterned by sinusoidal and hepatocyte co-zonation.

14 tic Wnt/beta-catenin signaling and metabolic zonation.

15 and overall homeostasis in hepatic metabolic zonation.

16 allenged the establishment of distinct redox zonation.

17 es along a portocentral axis is called liver zonation.

18 t role in establishing and maintaining liver zonation.

19 ation of beta-catenin, which regulates liver zonation.

20 found to have a severe perturbation of liver zonation.

21 d spectrum of Fzd receptors can induce liver zonation.

22 d have implications on intertidal biological zonation.

23 degradation, and drug conjugation metabolic zonation.

24 ntegrating the concept of longitudinal river zonation.

25 lates the establishment of hepatic metabolic zonation.

26 d to describe ammonia detoxification and its zonation.

27 iable but did not show any defect in hepatic zonation.

28 not the source of Wnts in regulating hepatic zonation.

29 my in biosynthesis that coincides with redox zonation.

30 tion of c-Myc did not perturb the pattern of zonation.

31 viously been shown to play a role in hepatic zonation.

32 y impressive biogeomorphic features, such as zonation, a mosaic of extensive vegetation patches of ra

33 ltiple histological scales, including tissue zonation according to the portal-central (liver), crypt-

34 reference map of metabolic heterogeneity and zonation across liver functional units at tissue level.

35 nstrate the creation of spatially-controlled zonation across multiple hepatocyte metabolism levels th

36 Although their functioning hinges on habitat zonation along >km-scale sea-to-land gradients, infrastr

37 Their zonation along an elevation gradient supports specific c

38 Meristems show a functional zonation along the apical-basal axis and the radial axis

39 beta-Catenin regulates hepatic metabolic zonation and adaptive response to oxidative stress.

40 l that aging causes loss of distinct hepatic zonation and alters intercellular communication through

41 mosaics is challenging, requiring effective zonation and bio regionalization strategies.

42 , we analyze the effect of cytokinin on root zonation and cellular growth.

43 Hepatocytes lose their zonation and considerable reorganization of the biliary

44 e of 4127 +/- 4 Ma) shows normal oscillatory zonation and constant oxygen isotope ratios (delta(18)O

45 1-/- mice displayed disrupted adrenocortical zonation and defective expression of steroidogenic enzym

46 consideration of disease-relevant hepatocyte zonation and effects of steatosis, and facilitate the de

47 s and their contributions to fibrosis, liver zonation and function, regeneration, and cancer.

48 d also analyzed for cytochrome P450 (CYP3A4) zonation and glycogen accumulation through PAS staining.

49 -catenin signaling is involved in regulating zonation and hepatocyte proliferation during homeostasis

50 e, its deregulation disturbs metabolic liver zonation and is responsible for the development of a lar

51 was observed across sites, the overall depth zonation and key species characterizing depth zones were

52 y pathway in the liver, playing key roles in zonation and mediating contextual hepatobiliary repair a

53 the mouse liver, regulating metabolic liver zonation and promoting hepatocyte proliferation, resulti

54 ese findings demonstrate that adrenocortical zonation and regeneration result from lineage conversion

55 unique hepatic attributes such as metabolic zonation and regeneration.

56 interfere with beta-catenin-dependent tumor zonation and responsiveness to beta-catenin inhibition.

57 s a fundamental and dominant role in hepatic zonation and signals to orchestrate various functions of

58 rtant questions about its role in functional zonation and the response to stress.

59 dictate vascular heterogeneity and capillary zonation, and how this system is maintained through tiss

60 inusoid capillarization or loss of metabolic zonation are common.

61 emonstrates that metabolic and non-metabolic zonation are established non-synchronously during matura

62 and intra- organ vascular heterogeneity and zonation are shaped during development and fully specifi

63 ite) formation within hepatic lobules (NAPQI zonation) are necessary and sufficient prerequisites to

64 ed single nuclear transcriptomics to explore zonation as a function of nutrition, revealing that the

65 lts from phase transitions and compositional zonation associated with extensive metasomatism involvin

66 ategies are being leveraged to dissect liver zonation at unprecedented resolution and how this new in

67 While principles of depth zonation broadly held, our findings expose limitations o

68 at least one additional feature must exhibit zonation by decreasing in the CV direction.

69 e phytohormone cytokinin contributes to this zonation by positioning the boundary between the meriste

70 t that NGFIB plays a crucial role in adrenal zonation by regulating HSD3B2 gene transcription.

71 thesize a dynamic and annular biogeochemical zonation by which the bacteria capitalize on periodic fl

72 , cell-type-specific and cell-type-invariant zonation-dependent transcriptomes, and gene programs und

73 reduced liver growth and impaired metabolic zonation due to suppression of hepatic angiocrine Wnt si

74 of gradual molecular level changes with age, zonation due to the water table, and hot spots due to mi

75 S-Patcher, revealed mechanisms of progenitor zonation during bone and joint formation.

76 ufficient to instruct a functional metabolic zonation during the differentiation of human embryonic s

77 f hourly precipitation displayed latitudinal zonation, especially for light and moderate precipitatio

78 renal cortex physiology relies on functional zonation, essential for production of aldosterone by out

79 n the temporal evolution and origin of plume zonation for both the Tristan-Gough and Hawaiian hotspot

80 the molecular pathways that dictate vascular zonation from embryos to adulthood.

81 illarization, with effacement of endothelial zonation functionally paralleled by reduced tumor cell a

82 provide support for the chromatographic and zonation hypotheses.

83 uts to the striatum suggests a medio-lateral zonation imposed on the classical dorso-ventral distinct

84 aset to show the existence of clear regional zonation in abyssal communities across the 5,000 km span

85 da or USVI, despite strong patterns of depth zonation in algal symbionts at two of these locations.

86 Rspo3 ) led to disruption of metabolic liver zonation in Alk1HEC-KO mice and in liver specimens of pa

87 The age and compositional zonation in crystals from the Youngest Toba Tuff record

88 the establishment of a functional metabolic zonation in differentiating hESCs.

89 clear factor-4alpha expression and defective zonation in livers have not been recognized so far as fe

90 delineated a consistent pattern of metabolic zonation in mouse liver.

91 d observed partial to complete loss of lipid zonation in NASH.

92 Our data indicates a clear zonation in porosity according to burrow structure, with

93 ratodon purpureus displays a complex plastid zonation in that only some amyloplasts sediment along th

94 lial secreted Wnt ligands maintain metabolic zonation in the adult murine liver but whether those lig

95 e functional significance of liver metabolic zonation in the chronically overfed state in vivo, we fe

96 cover their subtypes, their organization and zonation in the embryonic and adult brain, and how dysfu

97 ther those ligands are necessary to initiate zonation in the immature liver has been only partially e

98 No evidence was found for significant zonation in the pattern of expression of either the phen

99 These relations suggest that plant zonation (in particular for strand "dune-building" speci

100 Here, we describe the principles of liver zonation, introduce metabolomic approaches to study the

101 Metabolic heterogeneity or functional zonation is a key characteristic of the liver that allow

102 hway components and show critically that the zonation is c-Myc independent but beta-catenin dependent

103 Hepatic zonation is critical for most metabolic functions in liv

104 The origin of this zonation is currently unclear.

105 These findings explain how arteriovenous zonation is established and maintained in the BRB and re

106 s reduced and a different root developmental zonation is established.

107 How zonation is induced and maintained and how renewal of th

108 the cellular growth profile underlying root zonation is not well understood, and the cellular mechan

109 Impaired zonation is recapitulated in a model of constant supply

110 onmental constraints, and ecologic controls, zonation is still poorly understood in terms of the unde

111 servations and modeling interpretation, that zonation is the result of coupled geomorphological-biolo

112 Although replicating hepatocyte metabolic zonation is vitally important for physiologically-releva

113 The concept of hepatocyte functional zonation is well established, with differences in metabo

114 e spatially organized in a phenomenon called zonation, linked to the differential exposure of portal

115 HSC depletion on hepatocyte gene expression, zonation, liver size, regeneration and cytochrome P450-m

116 This redox zonation may be the major cause for the Earth's upper ma

117 Such changes in subsurface biogeochemical zonation need to be taken into account to assess the rol

118 ice, Lrp-LKO exhibited a defect in metabolic zonation observed as a lack of glutamine synthetase (GS)

119 s represent a foundational framework for the zonation of absorption across the mammalian small intest

120 As control experiments where no zonation of acetyl-CoA enrichment would be expected, iso

121 sterols from liver and bile still revealed a zonation of acetyl-CoA enrichment.

122 atenin, and c-Myc) of the Wnt pathway in the zonation of ammonia metabolizing enzymes.

123 Firstly, the periportal zonation of both glycogen synthase and the oxidative pho

124 liver injury, intravital microscopy revealed zonation of CD8 + but not CD4 + T cells at necrotic area

125 d matrix production concomitant with partial zonation of chondrocytes having proliferative and hypert

126 e 'snowball Earth' hypothesis-or the present zonation of climate with respect to latitude must have b

127 others) even though strong vertical (depth) zonation of corals and sponges was observed on all flank

128 idation was achieved against data on hepatic zonation of CYP1A2 mRNA expression caused by three diffe

129 reefs down to 150 m, the structure and depth zonation of deep-reef communities below 150 m remains la

130 le, SMC in elastic and muscular arteries and zonation of elastic artery SMC along the direction of bl

131 ents in precursor enrichment revealed marked zonation of enrichment of lipogenic acetyl-CoA.

132 Their ablation is associated with perturbed zonation of enterocyte genes induced at the villus tip.

133 l transcriptomics have demonstrated profound zonation of epithelial gene expression along the villus

134 primarily due to Wnt2 and Wnt9b rather than zonation of Fzd mRNA expression.

135 orporation during gluconeogenesis as well as zonation of gluconeogenic enzymes and a [(13)C]glycerol

136 We also showed that zonation of glycerol kinase activity is minor in rat liv

137 and stromal cell states, revealing abnormal zonation of growth factors and morphogens linked to esta

138 We conclude that zonation of hepatic acetyl-CoA enrichment occurs under a

139 This probably results from the zonation of hepatic metabolism and, in some cases, from

140 c depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations i

141 mblages at deep-sea hydrothermal vents, with zonation of invertebrate species typically occurring alo

142 ofiling based on 500 genes recapitulates the zonation of L2/3 cell types along the pial-ventricular a

143 itasking theory, we suggest that the spatial zonation of L2/3 cell types is linked to the continuous

144 eir delta(13)C values also indicate possible zonation of nutritional modes of the vent fauna.

145 We conclude that zonation of other processes than glycerol phosphorylatio

146 anwhile was most sensitive variations in the zonation of proteins mediating FFA uptake or triglycerid

147 Biogeochemical zonation of redox active species implies significant mod

148 ow, oxygen, depth, and substrate type on the zonation of seamounts, we created an Alexander Von Humbo

149 ous selection factors, which can result in a zonation of species distributions and gradient evolution

150 microbial community genes reflected vertical zonation of taxonomic groups, functional gene repertoire

151 may play an important role in the functional zonation of the adrenal gland.

152 esent an important aspect in the biochemical zonation of the adrenal.

153 iscuss the role of beta-catenin in metabolic zonation of the adult liver.

154 To test for zonation of the enrichment of lipogenic acetyl-CoA, cons

155 Secondly, the periportal zonation of the enzymes mediating beta-oxidation and oxi

156 ntral Adriatic and islands, highlighting the zonation of the expected isotopic signatures.

157 of PFK-2/FBPase-2 complements the metabolic zonation of the liver by ensuring coherent switching in

158 us, resulting in the break-down of the usual zonation of the lymph gland. which normally consists of

159 cal concepts such as the thermodynamic redox zonation, or the use of steady state transport scenarios

160 involved in the establishment of the hepatic zonation, oxygen could play a key role.

161 proteins in serum and showed a normal liver zonation pattern.

162 S. balanoides, our data show that intertidal zonation patterns are variable across both spatial and t

163 mechanisms that show how and why biomimetic zonation patterns can emerge and change within agent-bas

164 iptomics uncover region-specific markers and zonation patterns of expression.

165 s available to explain how different hepatic zonation patterns of P450 isozyme levels and hepatotoxic

166 Mesophotic reefs exhibit distinct zonation patterns that segregate shallow reef biodiversi

167 and secretion from endothelial cells affects zonation patterns under homeostasis and after acute inju

168 g the tidal cycle) generates strong vertical zonation patterns with distinct growth boundaries regula

169 ethys Ocean, consistent with modern climatic zonation patterns.

170 Increasingly, spatial geochemical zonation, present as geographically distinct, subparalle

171 Here we use diffusion modelling of nickel zonation profiles in primitive olivines from diverse pri

172 Maf inactivation perturbed the villus zonation program by increasing carbohydrate-related tran

173 show that nonproliferative HCCs preserve the zonation program that distributes metabolic functions al

174 -MAF as a regulator of the intestinal villus zonation program, while highlighting the importance of c

175 d hormones for triggering a latent metabolic zonation program.

176 mutually exclusive periportal or perivenous zonation programs.

177 ral meristem with an extensive developmental zonation, provides an optimal system for hormonal and ge

178 tanding the role of Wnt signaling in hepatic zonation, regeneration, and cholestasis-induced injury.

179 ng liver development, homeostasis, metabolic zonation, regeneration, and disease.

180 wn was associated with downregulation of key zonation regulators ( Ctnnb1 , Foxo1 , Tcf7l2 ) and comp

181 ductular proliferation vanishing and lobular zonation restoration, portal inflammation and sinusoidal

182 Ductular proliferation, metabolic zonation, sinusoid capillarization, and hepatic stellate

183 ntation, isotype switching, GC formation and zonation, somatic hypermutation rates, and proliferation

184 This study determines patterns of faunal zonation, species associations, and relationships betwee

185 ls of beta-catenin or cause changes in liver zonation that have been associated with loss of the aden

186 underlying the dynamic control of hepatocyte zonation, the unfolded protein response, and steatosis.

187 of damaged cells and is required to maintain zonation throughout life.

188 CD8 + T cells were characterized by zonation toward necrotic regions and an activated gene e

189 le of cytoskeletal organization, cytoplasmic zonation, vesicle trafficking, cell wall composition, an

190 The zonation was constant over time, with seasonal variabili

191 Recently zonation was found along the last approximately 70 Myr o

192 Before treatment, metabolic zonation was lost, as shown by GS and CYP2E1, in 71% and

193 ediated gene regulation in regard to hepatic zonation, we performed spatial transcriptomics (ST) in t

194 essential role of beta-catenin in metabolic zonation where it regulates pericentral gene expression

195 esigned a Voronoi-based algorithm of hepatic zonation, which also showed an overall zonal accuracy of

196 del caused decreased WNT signaling, aberrant zonation with deficient zG, and reduced aldosterone prod

197 floor reveals a consistent pattern of faunal zonation with increasing distance from vent sources and

198 Faunal zonation with increasing distance from vents is dominate

199 Microbial community shows climatic zonation with orderly successions along elevational grad

200 ltered cell-cell interactions and hepatocyte zonation with zone-specific transcriptomic changes.

201 ggered disorganization of adrenal functional zonation, with induction of Cyp11b2 in glucocorticoid-pr

202 nt pathway is key to imposing the pattern of zonation within the liver.

203 pping techniques that revealed compositional zonation within the nodules.

204 iffering He date, radiation damage, and U-Th zonation yield a self-consistent cooling history that su