ライフサイエンスコーパス: zonula occludens

1 s is the postsynaptic density 95/discs large/zonula occludens 1 (PDZ) domain, involved in scaffolding

2 and an integrated component of the occludin/zonula occludens 1 (ZO-1) adhesion complex at the BTB, s

3 se cells express the tight junction proteins zonula occludens 1 (ZO-1) and occludin and form a barrie

4 s of the tight junctional complex, including zonula occludens 1 (ZO-1) and occludin.

5 We previously found that depleting zonula occludens 1 (ZO-1) family proteins in MDCK cells

6 udin-18 to interact with a scaffold protein, zonula occludens 1 (ZO-1), demonstrating that one claudi

7 relationship between neuronal Connexins and Zonula Occludens 1 (ZO1), an intracellular scaffolding p

8 t proteins, including tight junction protein zonula occludens 1 and aquaporin 4.

9 2 mechanisms: it maintained localization of zonula occludens 1 and occludin at apical tight junction

10 e 2), and the outer limiting membrane (OLM) (zonula occludens 1 and occludin).

11 nolocalization of the tight junction protein zonula occludens 1 and of the junction-associated actin

12 Reduced zonula occludens 1 expression was observed after HbG tra

13 he GCD had a small decrease in expression of zonula occludens 1 in SB mucosa and significant decrease

14 n claudin-1 protein level, relocation of the zonula occludens 1 protein (ZO-1) to the TJ, and redistr

15 so shown by the disengagement of the protein zonula occludens 1 protein from the tight junctional com

16 Zonula occludens 1 protein redistribution after bacteria

17 In contrast, zonula occludens 1 was well preserved along intercellula

18 including MUPP1 (multi-PDZ protein-1), ZO1 (zonula occludens 1), and Af6.

19 nd eosin), apoptosis (M30), tight junctions (zonula occludens 1), and neutrophil influx (myeloperoxid

20 ssion of the tight junction scaffold protein zonula occludens 1, and disrupted junctional localizatio

21 Upon calcium repletion, occludin, zonula occludens 1, and E-cadherin failed to redistribut

22 smoplakin, plakoglobin, claudin-4, occludin, zonula occludens 1, and tricellulin were decreased at ce

23 creased, transient disruption of claudin-18, zonula occludens 1, and zonula occludens 2 localization

24 a and significant decreases in expression of zonula occludens 1, claudin-1, and occludin in rectosigm

25 sion of endothelial tight junction proteins (zonula occludens 1, claudin-5, and occludin), astrocyte

26 nce of Ca2+ as revealed by the relocation of zonula occludens 1, the establishment of transepithelial

27 al effects on the cytoplasmic plaque protein zonula occludens 1.

28 pool of ROCK with the tight junction protein zonula occludens 1.

29 expression of the TJ molecules occludin and zonula occludens 1.

30 ly restored the expression of E-cadherin and zonula occludens 1.

31 second post-synaptic density-95/discs large/zonula occludens-1 (PDZ) domain of the human protein tyr

32 the post synaptic density, discs large, and zonula occludens-1 (PDZ) domain protein SAP97 is a compo

33 ffolding postsynaptic density-95/disks large/zonula occludens-1 (PDZ) domain-containing protein melan

34 single post-synaptic density-95/discs large/zonula occludens-1 (PDZ) domain.

35 ontaining postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domains have been shown to play

36 three postsynaptic density 95, discs large, zonula occludens-1 (PDZ) domains to engage the transport

37 postsynaptic density protein 95/disks large/zonula occludens-1 (PDZ)-domain proteins and A-kinase an

38 te pore above the tight junctions defined by zonula occludens-1 (ZO-1) and also immediately below the

39 ctomyosin ring (PAMR), and redistribution of zonula occludens-1 (ZO-1) and cadherins.

40 lantation, we investigated the expression of zonula occludens-1 (ZO-1) and E-cadherin, two molecules

41 nal barrier using the tight junction markers zonula occludens-1 (ZO-1) and occludin.

42 3 with retention of Cx43 scaffolding protein Zonula Occludens-1 (ZO-1) at cell surfaces, suggesting t

43 ning the steady-state levels of occludin and zonula occludens-1 (ZO-1) at the BTB site via the p38 MA

44 cing the steady-state levels of occludin and zonula occludens-1 (ZO-1) at the BTB via the p38 mitogen

45 protection against IL-1beta-induced loss of zonula occludens-1 (ZO-1) at the tight junctions and alt

46 We found that the accumulation of Zonula Occludens-1 (ZO-1) at TJs closely scales with ten

47 Zonula occludens-1 (ZO-1) binds the carboxy terminus of

48 10 reduced podocyte tight junctional protein zonula occludens-1 (ZO-1) but did not affect its mRNA le

49 nction (TJ)-associated proteins occludin and zonula occludens-1 (ZO-1) following stimulation of brain

50 s serine and threonine residues, we screened zonula occludens-1 (ZO-1) immunoprecipitates for the exi

51 ding G proteins) have been co-localized with zonula occludens-1 (ZO-1) in the tight junction of epith

52 lar, c-Src can disrupt the connexin43 (Cx43)-zonula occludens-1 (ZO-1) interaction, leading to down-r

53 a hallmark of polarized epithelial cells and zonula occludens-1 (ZO-1) is a known key regulator of ti

54 Zonula occludens-1 (ZO-1) is a submembrane scaffolding p

55 calcium levels, the tight junctional protein Zonula Occludens-1 (ZO-1) is distributed intracellularly

56 s also a marked decrease in beta-catenin and zonula occludens-1 (ZO-1) localization to the intercalat

57 c-Src binds to the Cx43 scaffolding protein zonula occludens-1 (ZO-1) with a higher affinity than do

58 sed expression of TTF-1, aquaporin-5 (AQP5), zonula occludens-1 (ZO-1), and cytokeratins.

59 TJ complex with established interaction with zonula occludens-1 (ZO-1), and was building homophilic c

60 used to assay for the presence of occludin, zonula occludens-1 (ZO-1), cadherin-5, and beta-catenin.

61 MP22 and known junctional proteins including zonula occludens-1 (ZO-1), occludin, and claudin-5.

62 ial cell-cell contacts in close proximity to zonula occludens-1 (ZO-1), oxLDL treatment induced a dis

63 Zonula occludens-1 (ZO-1), the major scaffolding protein

64 o activate tight-junction-associated protein Zonula Occludens-1 (ZO-1), which in turn plays a critica

65 n of the BBB-related tight junction protein, Zonula occludens-1 (ZO-1).

66 d with the tight junction-associated protein zonula occludens-1 (ZO-1).

67 ion of tight junction proteins, occludin and zonula occludens-1 (ZO-1).

68 ion of another element of the E-cad complex, zonula occludens-1 (ZO-1).

69 ght junction membrane proteins, occludin and zonula occludens-1 (ZO-1).

70 ased detection of the tight junction protein zonula occludens-1 (ZO-1).

71 ased detection of the tight junction protein zonula occludens-1 (ZO-1).

72 n of the BRB-related tight junction protein, Zonula occludens-1 (ZO-1).

73 n E-cadherin and tight junction (TJ) protein Zonula Occludens-1 (ZO-1).

74 tight junction proteins such as occludin and zonula occludens-1 (ZO-1).

75 inal fatty-acid binding protein [I-FABP] and zonula occludens-1 [ZO-1]) and microbial translocation (

76 The junctional proteins zonula occludens-1 and beta-catenin stained positively i

77 the dexamethasone-stimulated localization of zonula occludens-1 and beta-catenin to sites of cell-cel

78 actin and tight-junction-associated proteins zonula occludens-1 and occludin.

79 n levels of tight junction proteins, such as zonula occludens-1 and Occludin.

80 served alterations in the adherens junctions zonula occludens-1 and partitioning defective 3, reduced

81 striking upregulation of dermal N-cadherin, Zonula Occludens-1 and the gap junction protein Connexin

82 ed its composition, with concomitant loss of zonula occludens-1 and upregulation of VE-Cadherin expre

83 sed paracellular flux, and redistribution of zonula occludens-1 and VE-cadherin but failed to induce

84 to the postsynaptic density-95, discs large, zonula occludens-1 binding motif in the C terminus of KV

85 d in large gap junction plaques, had reduced zonula occludens-1 binding, and displayed increased stab

86 In addition, zonula occludens-1 co-localized with Muller cells within

87 ell adhesion via its effects on the occludin-zonula occludens-1 complex.

88 ression of epithelial markers E-cadherin and Zonula occludens-1 decreased while expression of mesench

89 calization with both endogenous occludin and zonula occludens-1 demonstrating that exogenous occludin

90 uated cytokine-induced hyperpermeability and zonula occludens-1 downregulation in NS-398-treated C2BB

91 of Id1 suppressed epithelial E-cadherin and zonula occludens-1 expression.

92 with HDM-induced AR, with lower occludin and zonula occludens-1 expression.

93 ed FD4 permeability and reduced occludin and zonula occludens-1 expression.

94 al PDZ (postsynaptic density-95/discs-large /zonula occludens-1 homology) motif SSAV, and yeast Sacch

95 correlated with an increase in claudin-5 and zonula occludens-1 immunofluorescence at cell-cell contr

96 Mechanistically, human breast milk reduces Zonula occludens-1 levels, suggesting a regulatory role

97 t was associated with a potent protection of zonula occludens-1 linear border pattern in endothelial

98 Zonula occludens-1 molecules are also highly dynamic in

99 ein, drosophila disc large tumor suppressor, zonula occludens-1 protein (PDZ) consensus binding motif

100 osophila disc large tumor suppressor (Dlg1), zonula occludens-1 protein (zo-1) (PDZ) domain proteins.

101 phosphorylation regulates the known role of zonula occludens-1 protein (ZO-1) in gap junction (GJ) f

102 n addition, immunofluorescent assessments of zonula occludens-1 tight junction protein cellular distr

103 TJ complex proteins claudin-1 and zonula occludens-1 were upregulated following TLR2 stimu

104 e PDZ (postsynaptic density 95, discs large, zonula occludens-1) domains and other regions.

105 ing PDZ (postsynaptic density 95/discs large/zonula occludens-1) domains are believed to provide rela

106 PDZ (post-synaptic density-95/discs large/zonula occludens-1) domains are small, protein-protein b

107 PDZ (Post-Synaptic Density-95, Discs Large, Zonula Occludens-1) domains followed by a short carboxyl

108 creased tight junction protein (occludin and zonula occludens-1) expression.

109 gulated by several PDZ (PSD-95, discs large, zonula occludens-1) proteins, which mediate protein-prot

110 (connexin 43), Cx45 (connexin 45), and ZO-1 (zonula occludens-1) were identified as novel mRNA target

111 e synthetase, expressed by Muller cells, and zonula occludens-1, a tight-junction protein.

112 Knockdown of Cx43 and N-cadherin, but not Zonula Occludens-1, accelerated cell migration in a scra

113 ecreased levels of alanine aminotransferase, zonula occludens-1, and interleukin-1beta compared with

114 lit diaphragm-associated protein P-cadherin, zonula occludens-1, and nephrin, a change consistent wit

115 ychaetoid (pyd), the Drosophila homologue of Zonula Occludens-1, are characterized by two phenotypes

116 ted proteins, including occludin, claudin-5, zonula occludens-1, junctional adhesion molecule-A, and

117 In vivo, in addition to loss of nephrin and zonula occludens-1, mesenchymal markers such as desmin,

118 nic epithelial cells such as cytokeratin 18, zonula occludens-1, mucins-1 and -2, antigen A33, and di

119 ed expression of the tight junction proteins zonula occludens-1, occludin, and claudin-1 in the ileum

120 e expression of junctional proteins, such as zonula occludens-1, occludin, and claudin-4.

121 representative tight junction proteins (ie, zonula occludens-1, Occludin, Claudin-1) that critically

122 and tracer permeability, junctional protein zonula occludens-1, occludin, claudins and E-cadherin ex

123 with the postsynaptic density-95/discs large/zonula occludens-1-and WW domain-containing scaffold pro

124 binding post-synaptic density-95/discs large/zonula occludens-1-domain-containing (PDZ) proteins and

125 ce staining of the TJ molecules occludin and zonula occludens-1.

126 foil factor 3, Toll-interacting protein, and zonula occludens-1.

127 protein kinase and increasing expression of zonula occludens-1.

128 protein kinase and increasing expression of zonula occludens-1.

129 audin-1, junctional adhesion molecule-A, and zonula occludens-1.

130 Zonula occludens-1/NF-kappaB/CXCL8: a new regulatory axi

131 R and its target genes FGF19 and TJ proteins zonula, occludens-1, occludin, and claudin-1, along with

132 d suppression of TJ transcripts, claudin-11, zonula-occludens-1 (ZO-1) and tricellulin in human SC en

133 The scaffold protein zonula-occludens-1 (ZO-1), a member of the MAGUK family

134 ption of claudin-18, zonula occludens 1, and zonula occludens 2 localization to lung tight junctions

135 Zonula occludens-2 (ZO-2) is a tight junction (TJ) cytop

136 specifically interact with the protein ZO-2 (zonula occludens-2).

137 omplete dissolution of some tight junctions (zonula occludens) and zonula adherens without loss of de

138 unohistochemistry showed that E-cadherin and Zonula occludens are down-regulated in MCF-7/CXCR4-Delta

139 Staining for the zonula occludens complex (ZO-1) and adherens complex (al

140 e protein, Crumbs, and two PSD95/discs large/zonula occludens domain proteins, protein associated wit

141 The His-ZO-1-PDZ1 (first PDZ domain of zonula occludens) domain that binds Neph1-CD was also an

142 g PDZ (postsynaptic density-95, discs large, zonula occludens) domains play a general role in recruit

143 enous GRHL2 and the junction proteins (e.g., zonula occludens, E-cadherin, claudins, and occludin).

144 The scaffold proteins of the zonula occludens family are required for the correct loc

145 The tight junction, or zonula occludens, is a specialized cell-cell junction th

146 nction is accomplished in vertebrates by the zonula occludens, or tight junction.

147 ial cells, because the presence of an intact zonula occludens prevented passage.

148 lial antigen 2), blood-retinal barrier [anti-zonula occludens protein 1 (ZO-1) and anti-occludin], an

149 llagen-IV, laminin, claudin-5, occludin, and zonula occludens protein 1 was also better preserved in

150 s no obvious change of claudin-1, claudin-4, zonula occludens protein 1, and zonula occludens protein

151 , claudin-4, zonula occludens protein 1, and zonula occludens protein 2 expressions was observed.

152 rotein) PDZ (postsynaptic density/disc large/zonula occludens) protein binding assays, that these sol

153 audins binds to the N-terminal PDZ domain of zonula occludens proteins (PDZ1).

154 Zonula occludens proteins are multidomain proteins usual

155 n of occludin but no change in expression of zonula occludens proteins ZO-1 and -2.

156 and mechanical tension: the tight junction (zonula occludens), the zonula adherens (ZA), and the mac

157 MDCKII cells, this complex localizes to the zonula occludens (tight junctions) and appears to regula

158 Zonula occludens toxin (Zot) is an enterotoxin elaborate

159 ed that these structures can be modulated by Zonula occludens toxin (Zot).

160 The intestinal secretion induced by zonula occludens toxin follows the opening of tight junc

161 Zonula occludens toxin induced a time- and dose-dependen

162 Zonula occludens toxin is a novel toxin elaborated by Vi

163 The tissues were also fixed, exposed to zonula occludens toxin, and processed for fluorescence m

164 elial cells is regulated by tight junctions (zonula occludens), we wished to determine whether they a

165 e structural and functional integrity of the zonula occludens (ZA) induced by ATP depletion of renal

166 We have determined that the zonula occludens (ZO) family of TJ plaque proteins seque

167 ability of this barrier are dependent on the zonula occludens (ZO) membrane-associated guanylate kina

168 The zonula occludens (ZO) protein-1 is a membrane-associated

169 Thus the manner in which the zonula occludens (ZO) proteins multimerize has implicati

170 Specific TJ proteins, such as zonula occludens (ZO) proteins, localize not only at the

171 ility of these junctions is dependent on the zonula occludens (ZO) proteins, members of the membrane-

172 The zonula occludens (ZO) subfamily of membrane-associated g

173 The zonula occludens (ZO)-1 and -2 proteins have context-dep

174 Zonula occludens (ZO)-1 is a member of the MAGUK (membra

175 The tight junction (TJ) protein zonula occludens (ZO)-1 links the intracellular domain o

176 Here, we show that zonula occludens (ZO)-1 localizes preferentially to the

177 l tight junction proteins, namely, occludin, zonula occludens (ZO)-1, and ZO-2 in the caveolar fracti

178 xpression of occludin, claudin-1, claudin-5, zonula occludens (ZO)-1, and ZO-2, and a TJ accessory pr

179 nucleotide exchange factor (GEF) 2, but not zonula occludens (ZO)-1, in epithelial cells, and these

180 nges in the distribution of the TJ proteins, zonula occludens (ZO)-1, ZO-2, and cingulin, examination

181 l adhesion molecule-A (JAM)-A, occludin, and zonula occludens (ZO)-1.

182 In cell culture zonula occludens (ZO)-family proteins are important for

183 ignificant disruption of actin filaments and zonula occludens (ZO-1), and a decrease in transepitheli