ライフサイエンスコーパス: zygotic

1 udies have been conducted to understand post-zygotic accumulation of mutations in cells of the health

2 mount during reprogramming events that drive zygotic activation and the initiation of a new cycle of

3 t Dorsal target genes before Dorsal-mediated zygotic activation.

4 ed signals: maternal and ubiquitous Vg1, and zygotic and localized Nodal.

5 inding site are indeed able to suppress both zygotic and maternal morphant phenotypes.

6 Together, zygotic and maternal SMCHD1 regulate three classic impri

7 f action, timing of multiplication (pre/post-zygotic), and site of action (soma vs. germen).

8 date DNMs in the second generation were post-zygotic, and present in both somatic and germ cells; the

9 nge will have a larger effect on eroding pre-zygotic barriers (eco-geographical isolation and phenolo

10 seen in naturally produced hybrids where pre-zygotic barriers are the largest contributors to reprodu

11 The pre-zygotic barriers between red- and green-fruited species

12 graphical isolation and phenology) than post-zygotic barriers, shifting the relative importance of th

13 ited effects on environment-independent post-zygotic barriers.

14 tide family is required for formation of the zygotic basal cell lineage and proembryo patterning in A

15 as BMP ligand expression in the zebrafish is zygotic, but regulated by maternal factors.

16 rrors in meiosis, mitotic errors during post-zygotic cell division contribute to pervasive aneuploidy

17 Spatial reorganization of cytoplasm in zygotic cells is critically important for establishing t

18 chibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair

19 An understanding of this zygotic chromatin 'ground state' could potentially provi

20 tivation relates to the reprogramming of the zygotic chromatin architecture.

21 s thought to result mostly from pre- or post-zygotic chromosome missegregation.

22 ifferent cell lineages during the first post-zygotic cleavage division.

23 isabling pancreatogenesis in pig embryos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeti

24 requires the concomitant development of two zygotic compartments, the embryo and the endosperm.

25 These animals, relying on maternal but not zygotic contribution of ribosomal components, are capabl

26 ent insights into the balance of gametic and zygotic contributions to imprint specification should he

27 f genetic crosses that separate parental and zygotic contributions, we show that the H2A.B status of

28 The handover from maternal to zygotic control has to be carefully orchestrated.

29 yogenesis is the transition from maternal to zygotic control.

30 Here, we report the use of zygotic CRISPR/Cas9 injections to generate a knock-in GF

31 Mouse embryos lacking intact maternal/zygotic CTNNB1 from two knockout strains were examined i

32 The effects of maternal and zygotic CTNNB1 on embryogenesis have each been separatel

33 ion by maternal factors or late induction by zygotic cues.

34 indicate the events leading to noncanonical zygotic cytokinesis, segregating the parental genomes in

35 Maternal-zygotic deletion of ZFP57 in mice presents a highly pene

36 Consistently, zygotic depletion of Zmym2 compromises the totipotency-t

37 This mechanism is critical for initiating zygotic development and developmental reprogramming.

38 between maternal reproductive fitness, early zygotic development and genomic imprinting.

39 Mammalian zygotic development is initiated by sperm-mediated intra

40 However, proof that PAWP initiates mammalian zygotic development relies on demonstration that it acts

41 ant of mammalian oocyte competence and early zygotic development.

42 oocytes that are competent to sustain early zygotic development.

43 velopment during oocyte maturation and early zygotic development.

44 y shows that organellar restructuring during zygotic diploidization does not occur by default but is

45 We propose that during the first zygotic division, PLK-1-dependent chromosome congression

46 licates chimerism arising at the juncture of zygotic division, termed heterogonesis, as the likely in

47 Before the first zygotic division, the nuclear envelopes of the maternal

48 In Arabidopsis thaliana, zygotic embryo divisions are highly regular, but it is n

49 mic changes were similar between somatic and zygotic embryogenesis.

50 E at the dedifferentiation step using VS-535 zygotic embryos collected at distinct developmental stag

51 ore-derived embryos and Arabidopsis thaliana zygotic embryos, and demonstrate that AUX1, LAX1 and LAX

52 ish tp53(M214K)(w/m) line and the ewsa(w/m), zygotic ewsa(m/m), and Maternal-Zygotic (MZ) ewsa(m/m) l

53 Overall, zygotic exposure to venlafaxine disrupts early developme

54 Zygotic expression of BBM1 is initially specific to the

55 We show that zygotic expression of gdf3 is dispensable for embryonic

56 zebrafish embryos lacking both maternal and zygotic ezh2 to form a normal body plan provides a uniqu

57 and are actively suppressed by parental and zygotic factors such as the conserved exonuclease ERI-1.

58 ecular "hand-off" between maternal Foxh1 and zygotic Foxa at these CRMs to maintain enhancer activati

59 s hypothesis on one gene with an exclusively zygotic function, tbx5a, and one gene with strong matern

60 layer specification is tightly coupled with zygotic gene activation and, in most metazoans, is depen

61 nal transcript turnover and failure in early zygotic gene activation appeared to associate with the a

62 histone locus body (HLB) assembles prior to zygotic gene activation early during development and con

63 NAs required for patterning decisions before zygotic gene activation.

64 e revised rates permit substantial levels of zygotic gene activity prior to the mid-blastula transiti

65 ility is counteracted by PI(3,4,5)P3 and the zygotic gene bottleneck, which acts by limiting myosin r

66 embryos, haploids exhibited a delay in both zygotic gene expression and cell cycle lengthening, whil

67 ited an intermediate effect on the timing of zygotic gene expression and cell cycle lengthening.

68 delayed into developmental time periods when zygotic gene expression is upregulated and demonstrates

69 nce sex determination in C. elegans requires zygotic gene expression to read the sex chromosome karyo

70 for activation, beginning with the onset of zygotic gene expression.

71 oneer factor that drives a secondary wave of zygotic gene expression.

72 tazoan embryogenesis shifts from maternal to zygotic gene products as the zygotic genome becomes tran

73 aternal-to-zygotic transition, which enables zygotic gene products to replace the maternal supply tha

74 patterned by maternal inductive signals and zygotic gene products.

75 les and is needed for robust accumulation of zygotic gene products.

76 MBT embryos leads to premature activation of zygotic gene transcription and early onset of longer cel

77 N/C volume ratios showed early expression of zygotic genes and premature lengthening of cell cycles.

78 At mitotic cycle 8, when few zygotic genes are being transcribed, embryonic chromatin

79 yos depend on maternally deposited RNA until zygotic genes become transcriptionally active.

80 orpholino binding sites in both maternal and zygotic genes can ascertain the specificity of morphant

81 regulating histone acetylation on the first zygotic genes in zebrafish.

82 cycle lengthening and the expression of some zygotic genes.

83 latory program centered on the expression of zygotic genes.

84 d direct recruitment, regulated by different zygotic genes.

85 sions limit transcription unit size of early zygotic genes.

86 action and applied the system to investigate zygotic genome activation (ZGA) and RNA localization in

87 bryo, global epigenetic changes occur during zygotic genome activation (ZGA) at the 2-cell stage.

88 expectedly, we found cohesin represses minor zygotic genome activation (ZGA) genes (2-cell-specific g

89 In Drosophila, zygotic genome activation (ZGA) has been thought to occu

90 assays suggest that Jumu controls the proper zygotic genome activation (ZGA) in early embryos, at lea

91 ly provided histones can alter the timing of zygotic genome activation (ZGA) in frogs and fish.

92 e in the promoters of genes activated during zygotic genome activation (ZGA) in human embryos.

93 hanges in histone modification levels during zygotic genome activation (ZGA) in living zebrafish embr

94 The molecular regulation of zygotic genome activation (ZGA) in mammals remains an ex

95 How maternal factors in oocytes trigger zygotic genome activation (ZGA) is a long-standing quest

96 Zygotic genome activation (ZGA) is a major genome progra

97 Zygotic genome activation (ZGA) is mechanistically coord

98 Zygotic genome activation (ZGA) is the first transcripti

99 Zygotic genome activation (ZGA) is thought to occur grad

100 first 10 cell cycles, until the main wave of zygotic genome activation (ZGA) occurs, accompanied by f

101 , when maternal regulators are destroyed and zygotic genome activation (ZGA) occurs.

102 This transition requires embryo-wide zygotic genome activation (ZGA), but the extent of spati

103 During zygotic genome activation (ZGA), the chromatin environme

104 We hypothesise that following zygotic genome activation (ZGA), the combination of geno

105 Before zygotic genome activation (ZGA), the quiescent genome un

106 epend upon maternally provided factors until zygotic genome activation (ZGA).

107 riptional regulation of maternal mRNAs until zygotic genome activation (ZGA).

108 oint to coordinate cell-cycle remodeling and zygotic genome activation (ZGA).

109 for normal pre-implantation development and zygotic genome activation after fertilization.

110 is likely reflects its preparation for early zygotic genome activation and comparatively accelerated

111 hat transcription factor Nfya contributes to zygotic genome activation and DHS formation at the 2-cel

112 While during the period between zygotic genome activation and gastrulation many regions

113 lases KDM5A and KDM5B is required for normal zygotic genome activation and is essential for early emb

114 rnal epigenome integrity required for proper zygotic genome activation and transfer of developmental

115 gulated by inherited maternal gene products: zygotic genome activation commences at the tenth cell cy

116 s sensitive to rapid cell cycles, but not to zygotic genome activation or cell counting.

117 se pioneering factors is required throughout zygotic genome activation or whether they are only requi

118 lation between pairing, transcription during zygotic genome activation, and binding of the pioneer fa

119 ryo polarization clock reflects the onset of zygotic genome activation, and we identify three factors

120 of m(6)A-modified maternal mRNAs and impedes zygotic genome activation.

121 t program that accelerated degradation after zygotic genome activation.

122 osome 4, is expressed in a sharp peak during zygotic genome activation.

123 embryos, concomitant with the onset of major zygotic genome activation.

124 initiated from long terminal repeats during zygotic genome activation.

125 wing MZT and requires both activation of the zygotic genome and degradation of maternally deposited R

126 rom maternal to zygotic gene products as the zygotic genome becomes transcriptionally activated.

127 se knockout embryos, we demonstrate that the zygotic genome folds into loops and domains that critica

128 will utilize this mechanism to activate the zygotic genome in a robust and precise manner.

129 BT activated widespread transcription of the zygotic genome including genes previously described as N

130 Delayed transcriptional activation of the zygotic genome is a nearly universal phenomenon in metaz

131 During this developmental transition, the zygotic genome is largely transcriptionally quiescent an

132 However, in the nematode Ascaris the zygotic genome is never silent, and the maternal product

133 ion in the field of embryogenesis is how the zygotic genome is precisely activated by maternal factor

134 early egg development, transcription of the zygotic genome is suppressed.

135 ter stages that widespread activation of the zygotic genome occurs.

136 old N/C has been widely proposed to activate zygotic genome transcription and onset of morphogenesis

137 cell-specific differential activation of the zygotic genome, and identify genes that were previously

138 Before activation of the zygotic genome, the maternal genome provides all transcr

139 d infer from them critical activators of the zygotic genome.

140 , and subsequent steps being governed by the zygotic genome.

141 on and for transcriptional activation of the zygotic genome.

142 that controls the initial activation of the zygotic genome.

143 e control is passed from the maternal to the zygotic genome.

144 ssibility in embryos lacking maternal and/or zygotic Grh at three stages of development, we discovere

145 nner that is dependent on the cell cycle and zygotic histone gene activation.

146 en suggested to mediate endosperm-based post-zygotic hybrid barriers depending on genetic variation a

147 and temperature on the strength of the post-zygotic hybridization barrier.

148 t animals, including mice, appear to utilize zygotic inductive cell signals to specify germ cells dur

149 other early metazoan species that allow for zygotic injection.

150 Altogether, our study confirms that one-step zygotic injections of CRISPR/Cas gene editing complexes

151 haracterize the genetic architecture of post-zygotic isolation.

152 h element of Tribolium that spreads via post-zygotic killing.

153 Combined maternal and zygotic knockout further revealed Aire's critical functi

154 both Dux zygotic KO (Z-KO) and maternal and zygotic KO (MZ-KO) embryos can survive to adulthood desp

155 Unexpectedly, we found that both Dux zygotic KO (Z-KO) and maternal and zygotic KO (MZ-KO) em

156 Patterns of gametic and zygotic LDs indicate the absence of epistasis among CNV

157 homozygous cpl4 mutant, probably due to the zygotic lethality of this mutation.

158 spore embryos are formed via two pathways: a zygotic-like pathway, characterized by initial suspensor

159 entify missing sequences, and then allow the zygotic macronucleus to reproduce the same deletions.

160 These associations would place CidB at the zygotic male pronucleus where CI defects first manifest.

161 loops, but not compartments, are present in zygotic maternal chromatin, suggesting that these are ge

162 We show that post-zygotic maternal provisioning by means of a placenta is

163 Moreover, we demonstrate that post-zygotic maternal provisioning correlates with superfetat

164 must be positioned properly to establish the zygotic mitotic spindle.

165 S-derived BWMs can be restored by preventing zygotic MOM-2 expression, which removes the inhibitory s

166 require precise spatiotemporal expression of zygotic MOM-2, which is dependent upon two distinct Notc

167 CL has been hypothesized to be due to a post-zygotic, mosaic mutation.

168 with similar ancestry, and confirm that post-zygotic mosaicism is a substantial source of human DNM.

169 These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why mal

170 Furthermore, accumulation of translatable zygotic mRNAs is minimal in 1-cell embryos because of in

171 We show that sphk2 maternal-zygotic mutant zebrafish embryos (sphk2(MZ)) display ear

172 Maternal-zygotic mutants of mondoa showed perturbed epiboly with

173 Elimination of Gdf3 in oocytes of maternal-zygotic mutants results in embryonic lethality that can

174 ngle and double homozygous larp6a and larp6b zygotic mutants revealed no defects in muscle structure,

175 nos 3' UTR led to the generation of maternal-zygotic mutants, as well as increased viability and decr

176 Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to occur

177 gives insight into the contribution of post-zygotic mutations and population-specific mutational pro

178 parent-offspring trios, suggesting that post-zygotic mutations contribute little to the human germ-li

179 ructural mosaic abnormalities are large post-zygotic mutations present in a subset of cells and have

180 also result from multigenic effects or post-zygotic mutations.

181 Unexpectedly, maternal zygotic (MZ) dchs1b mutants show defects in the earliest

182 e ewsa(w/m), zygotic ewsa(m/m), and Maternal-Zygotic (MZ) ewsa(m/m) lines all displayed zero to low i

183 cleosome positions in wild-type and maternal-zygotic (MZ) mutants for pou5f3 and nanog by MNase-seq.

184 man SMN in motoneurons in zebrafish maternal-zygotic (mz) smn mutants.

185 les rapid signaling at low concentrations of zygotic Nodal.

186 sults in a spatially uniform distribution of zygotic nuclei in the early Drosophila embryo.

187 sults in a spatially uniform distribution of zygotic nuclei in the early Drosophila embryo.

188 The developmental failure of Cdx2 maternal-zygotic null embryos is associated with cell death and f

189 rlier lethal phenotype than observed in Cdx2 zygotic null embryos that develop until the late blastoc

190 ssessment of a large cohort of Cdx2 maternal-zygotic null embryos, all individually filmed, examined

191 tologically abnormal tissue, suggesting post-zygotic or somatic mosaicism.

192 In the absence of zygotic paf1 function, definitive premigratory NC progen

193 ctor responsible for initiating the earliest zygotic patterns along the dorsal-ventral axis, have rev

194 we advance these strategies using a combined zygotic perturbation and single-cell RNA-sequencing plat

195 ula stage onwards and that both maternal and zygotic pools of Cdx2 are required for correct pre-impla

196 Ectopic maternal expression of an early zygotic pre-mRNA was sufficient to suppress its splicing

197 Similarly, loss of maternal-zygotic PRMT5 also leads to IAP upregulation.

198 Zygotic production of CaMKII mRNA with a long 3'-untrans

199 Here we describe zygotic ptk7 (Zptk7) mutant zebrafish, deficient in a cr

200 embryonic loss-of-gene function in maternal-zygotic ptk7 mutants (MZptk7) leads to vertebral anomali

201 Moreover, zygotic re-expression of MOF was neither able to restore

202 Although the zygotic regulation of these cell migration processes is

203 one responsible for the maternal storage and zygotic release of histones H2A/H2B.

204 d with habitat, dietary preferences and post-zygotic reproductive isolation.

205 the dawn of new species with intrinsic post-zygotic reproductive isolation.

206 These results reveal that zygotic rest is unable to compensate for deficits in mat

207 oci could not be attributed entirely to post-zygotic selective loss of F2 individuals that failed to

208 ed to the sex-determining region because the zygotic sex ratio is determined by the relative number a

209 A potential complication is that zygotic sex-ratios become biased when haploid selected l

210 Despite causing biased zygotic sex-ratios, we find that a period of sex-specifi

211 Despite this, maternal zygotic single and double mutants were viable and fertil

212 We also found zygotic SMCHD1 had a dose-dependent effect on the imprin

213 s, zebrafish carrying a homozygous, maternal zygotic snx14 genetic loss-of-function mutation were bot

214 etic parameters play important roles in post-zygotic species barriers, pointing at evolutionary scena

215 nnot be inactivated, resulting in multipolar zygotic spindles.

216 f the maternal genome, and by the end of the zygotic stage the genome-wide methylation level in male

217 development of organisms starting from their zygotic state involves a tight integration of the myriad

218 Zygotic TE expression is elevated in male embryos relati

219 ) compositions of the oils stored in the two zygotic tissues.

220 Maternal-zygotic tmem2 mutants (MZtmem2) exhibit muscle fiber det

221 Reprogramming is essential for zygotic totipotency and to prevent transgenerational inh

222 Furthermore, a small early zygotic transcript with multiple introns was poorly spli

223 distinct mechanisms regulating the onset of zygotic transcription and changes to the cell cycle duri

224 s gambiae Yob, activated at the beginning of zygotic transcription and expressed throughout a male's

225 ryos can partially proceed in the absence of zygotic transcription and is a multi-level hierarchical

226 sely, decreasing the N/C volume ratio delays zygotic transcription and leads to additional rapid cell

227 rrently experiences a receding first wave of zygotic transcription and the surge of a massive second

228 il to sufficiently decelerate, the levels of zygotic transcription are dramatically reduced, and the

229 on is the midblastula transition (MBT), when zygotic transcription begins and cell cycles elongate.

230 wing this period of transcriptional silence, zygotic transcription begins, the maternal influence on

231 n (MZT) when maternal mRNAs are degraded and zygotic transcription begins.

232 deposited messenger RNAs are degraded while zygotic transcription begins.

233 ion of maternal transcripts; a broad wave of zygotic transcription detectable as early as the seventh

234 er factors such as Zelda (Zld) help initiate zygotic transcription in Drosophila early embryos, but w

235 Initiation of zygotic transcription in mammals is poorly understood.

236 e of alternate cell divisions we manipulated zygotic transcription induced by beta-catenin or downreg

237 Activation of zygotic transcription is broadly delayed in H. erythrogr

238 In mice, zygotic transcription is first detected shortly after pr

239 How the onset of zygotic transcription is regulated remains unclear.

240 The results also suggest that the first zygotic transcription itself is an active component of c

241 m of CaMKII mRNA and a process that requires zygotic transcription of CaMKII mRNA.

242 Mechanistically, we demonstrate that zygotic transcription of the micro RNA miR-430 promotes

243 Zygotic transcription of these genes largely retained fe

244 Zygotic transcription was primarily from the maternal ge

245 nsition (MBT) marks the onset of large-scale zygotic transcription, as well as an increase in cell cy

246 Decreasing histone concentration advances zygotic transcription, cell cycle elongation, Chk1 activ

247 ns are specified prior to the broad onset of zygotic transcription, yet when transcription initiates

248 lf-organizing mechanisms before the onset of zygotic transcription.

249 tion between metabolism, the cell cycle, and zygotic transcription.

250 s present that predicted the initial wave of zygotic transcription.

251 of time immediately after the activation of zygotic transcription.

252 ly fast nuclear cleavages and interfere with zygotic transcription.

253 The subsequent zygotic transcriptional activation further elevated over

254 This switch complements an earlier switch to zygotic transcriptional control and explains why the pre

255 hich presumptively derive from divergent pre-zygotic transcriptional states established in the gamete

256 how that the transition from the maternal to zygotic transcriptome is characterized by a switch betwe

257 rs gain access to the genome and remodel the zygotic transcriptome.

258 Numerous zygotic transcripts are sensitive to histone concentrati

259 erochromatin is triggered by the maternal to zygotic transition (MZT) during zebrafish embryogenesis.

260 The maternal-to-zygotic transition (MZT) is a conserved step in animal d

261 Maternal-to-zygotic transition (MZT) is essential for the formation

262 The maternal-to-zygotic transition (MZT) is one of the most profound and

263 Drosophila development, when the maternal-to-zygotic transition (MZT) takes place.

264 plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental proces

265 ion in vertebrate embryos is the maternal-to-zygotic transition (MZT) when maternal mRNAs are degrade

266 ogenesis is characterized by the maternal to zygotic transition (MZT), in which maternally deposited

267 During the maternal-to-zygotic transition (MZT), thousands of maternal transcri

268 During the maternal-to-zygotic transition (MZT), transcriptionally silent embry

269 in a process referred to as the maternal-to-zygotic transition (MZT).

270 pufferfish and zebrafish during maternal to zygotic transition and annotated 1120 long non-coding RN

271 rk that is shedding light on the maternal to zygotic transition and the interrelated but distinct mec

272 e clearance of maternal mRNA during maternal zygotic transition in embryonic development.

273 one modifications throughout the maternal-to-zygotic transition in embryos of Drosophila melanogaster

274 The maternal-to-zygotic transition in the Drosophila embryo requires acc

275 ternal mRNA clearance during the maternal-to-zygotic transition in zebrafish, Xenopus, mouse, and Dro

276 The maternal-to-zygotic transition is a conserved developmental progress

277 sequencing during key stages of maternal to zygotic transition of Tetraodon nigroviridis and report

278 Maternal to zygotic transition represents the most marked change of

279 murine zygotes prior to the maternal to the zygotic transition yet absent in oocytes, consistent wit

280 The zygotic transition, from a fertilized egg to an embryo,

281 Before this maternal-to-zygotic transition, many species execute rapid and synch

282 During the maternal-to-zygotic transition, maternal mRNAs are cleared by multip

283 d through a process known as the maternal-to-zygotic transition, which enables zygotic gene products

284 f the zygotic translatome at the maternal-to zygotic transition.

285 scriptionally inactive until the maternal-to-zygotic transition.

286 ome system (UPS) accompanies the maternal-to-zygotic transition.

287 d embryos failing to undergo the maternal-to-zygotic transition.

288 dual-initiation promoters during maternal to zygotic transition.

289 trolling gene expression during the maternal-zygotic transition.

290 oskar and other mRNAs during the maternal-to-zygotic transition.

291 maternal factor to regulate the maternal-to-zygotic transition.

292 canonical ORFs during the activation of the zygotic translatome at the maternal-to zygotic transitio

293 n A/T-rich (W-box) motif, is replaced with a zygotic TSS selection grammar characterized by broader p

294 We previously showed that zygotic venlafaxine deposition alters larval behavior in

295 Maternal or zygotic vpr-1 expression is sufficient to induce gonadog

296 rcupine inhibitor C59, which interferes with zygotic Wnt ligand secretion.

297 Remarkably, zygotic Wnt-signaling inputs are required for only three

298 Our results also show that zygotic wnt16 expression depends on both Fzl5/8 and Wnt/

299 s expressed ubiquitously during cleavage and zygotic wnt16 expression is concentrated in the endoderm

300 Zygotic XND-1 turns on shortly thereafter, at the approx