ライフサイエンスコーパス: 12alpha-hydroxylase

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1 lase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase).

2 ceptor, oxysterol 7alpha-hydroxylase, sterol-12alpha-hydroxylase, and hepatic bile acid transporters

3 Sterol 12alpha-hydroxylase catalyzes the synthesis of cholic ac

4 esterol 7alpha-hydroxylase (Cyp 7a1), sterol 12alpha-hydroxylase (Cyp 8b1), and the intestinal bile a

5 BA composition, in part by regulating the BA 12alpha-hydroxylase CYP8B1.

6 effects of the level of expression of sterol 12alpha-hydroxylase (CYP8b1) and cholesterol 7alpha-hydr

7 Sterol 12alpha-hydroxylase (CYP8B1) is required for cholic acid

8 Sterol 12alpha-hydroxylase (CYP8b1) is required for the biosynt

9 terol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) partly through inducing sma

10 d bile acid homeostasis, notably cholesterol 12alpha-hydroxylase (CYP8B1), which was strongly reexpre

11 sterol 7alpha-hydroxylase (CYP7A1) or sterol 12alpha-hydroxylase (CYP8B1).

12 terol-7alpha-hydroxylase (CYP7A1) and sterol 12alpha-hydroxylase (CYP8b1).

13 chain fatty acids-like 3, Elovl3 and sterol 12alpha-hydroxylase, Cyp8b1, by enhancing their expressi

14 The sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase) promote

15 One of these enzymes is sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase), the sp

16 ylase/CYP7A1 (7alpha-hydroxylase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase).

17 Sterol 12alpha-hydroxylase/CYP8b1 is the specific enzyme requir

18 on times still resulted in lower 7alpha- and 12alpha-hydroxylase expression, but unchanged SHP expres

19 ic cholesterol 7alpha-hydroxylase and sterol 12alpha-hydroxylase expression.

20 the FTF-mediated suppression of 7alpha- and 12alpha-hydroxylase expression.

21 Disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) in mice prevents the s

22 Targeted disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) results in complete ab

23 Expression of the 12alpha-hydroxylase gene is tightly down-regulated by hy

24 e bile acid biosynthetic pathway, the sterol 12alpha-hydroxylase gene.

25 10-fold lower expression of the 7alpha- and 12alpha-hydroxylase genes and up to 8-fold higher SHP ex

26 This higher expression of the 7alpha- and 12alpha-hydroxylase genes resulted in a 33% higher bile

27 heterozygous FTF knockout mice, 7alpha- and 12alpha-hydroxylase genes were expressed at 5-7-fold hig

28 n transcription factor (FTF) is required for 12alpha-hydroxylase promoter activity and bile acid-medi

29 DNA elements that are required for both the 12alpha-hydroxylase promoter activity and bile acid-medi

30 NF-4 is the factor involved in regulation of 12alpha-hydroxylase promoter activity by bile acids thro

31 e short heterodimer partner (SHP) suppresses 12alpha-hydroxylase promoter activity via an interaction

32 pha-hydroxylase promoter and is required for 12alpha-hydroxylase promoter activity.

33 not involved in SHP-mediated suppression of 12alpha-hydroxylase promoter activity.

34 Mutation of these elements suppresses 12alpha-hydroxylase promoter activity.

35 ear factor-4 (HNF-4) binds and activates the 12alpha-hydroxylase promoter and is required for 12alpha

36 isplaces FTF binding to its sites within the 12alpha-hydroxylase promoter.

37 n a non-liver cell line activates the sterol 12alpha-hydroxylase promoter.

38 The sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase) promoter is also down-regulated by

39 the C-36-mediated regulation of 7alpha- and 12alpha-hydroxylase promoters mapped to the alpha1-fetop

40 NF-4 recognition site within the 7alpha- and 12alpha-hydroxylase promoters, which can otherwise be oc

41 nzymes is sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase), the specific enzyme required for c

42 on factor (FTF) are activators of 7alpha-and 12alpha-hydroxylase transcription and that the small het

43 which results in suppression of 7alpha- and 12alpha-hydroxylase transcription.

44 n of bile acid-mediated regulation of sterol 12alpha-hydroxylase transcription.

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