ライフサイエンスコーパス: CDP

1 CDP (3.0 mg/kg) administered alone did not disrupt escap

2 CDP ameliorated deleterious effects of DZP in both setti

3 CDP coadministered with 0.3 mg/kg SCP impaired escape on

4 CDP combines the use of ion-exchange membranes and porou

5 CDP is also related to disruption of vitamin K-dependent

6 CDP protects alpha from its inhibition.

7 CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase (E1

8 CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E(

9 CDP-6-deoxy-l-threo-d-glycero-4-hexulose-3-dehydrase (E1

10 CDP-Chase is the first identified member of a novel Nudi

11 CDP-choline also elevated hypothalamic extracellular tot

12 CDP-choline caused a dose- and time-dependent increase i

13 CDP-choline liposomes deliver the agent intact to the br

14 CDP-choline treatment significantly attenuated PLA2 acti

15 CDP-choline treatment significantly attenuated the infar

16 CDP-D-glucose 4,6-dehydratase catalyzes the conversion o

17 CDP-treated mice exhibited reductions in stress-induced

18 CDP/Cut is a transcriptional repressor that decreases FI

19 CDPs from Batf3(-/-) mice that were specified toward dev

20 lent labeling of alpha with the sugar of F(2)CDP (one label/alpha2beta2).

21 beta' with [1'-(3)H]-F(2)CDP or [5-(3)H]-F(2)CDP and reisolation of the protein by Sephadex G-50 chro

22 complex, when incubated with 1 equiv of F(2)CDP catalyzes the release of two fluorides and cytosine

23 chanisms share many common features with F(2)CDP inactivation of the class I RNRs.

24 20 nmol min(-1) mg(-1)) establishes that F(2)CDP is a substoichiometric inactivator of RNR.

25 ation of this alpha/beta' with [1'-(3)H]-F(2)CDP or [5-(3)H]-F(2)CDP and reisolation of the protein b

26 entify the new radical formed, [1'-(2)H]-F(2)CDP was studied with wt- and C225S-RNR by 9 and 140 GHz

27 Incubation of [1'-(3)H]-F(2)CDP with active site mutants C444S/A, C218S/A, and E431Q

28 Gemcitabine 5'-diphosphate (F(2)CDP) is a potent inhibitor of ribonucleotide reductases

29 psed to a doublet) relative to [1'-(1)H]-F(2)CDP.

30 ylation but not reverse sialylation; (ii) 5'-CDP, a potent forward sialyltransferase inhibitor, did n

31 A CDP molecule anchors the Hda domains in a conformation t

32 cofactor, forming the reduced cofactor and a CDP-4-keto-d-glucose intermediate.

33 o process a C-2 deoxygenated substrate and a CDP-linked substrate was also demonstrated.

34 o transfers a ribitol phosphate group from a CDP -ribitol present in muscles to alpha-DG, while in vi

35 and catalyse the displacement of CMP from a CDP-alcohol by a second alcohol.

36 sfer of a substituted phosphate group from a CDP-linked donor to an alcohol acceptor.

37 ional cloning strategy, we here identified a CDP-ethanolamine:ceramide ethanolamine phosphotransferas

38 ISPD is a CDP-ribitol (ribose) pyrophosphorylase that generates th

39 One of the enzymes was a CDP-choline pyrophosphatase, the first Nudix hydrolase a

40 criptional corepressor in association with a CDP/cut complex.

41 review [the acyl-CoA dehydrogenases (ACDs), CDP-6-deoxy-l-threo-d-glycero-4-hexulose-3-dehydrase red

42 g (ANX), and cell death protease activation (CDP).

43 the presence of a mixture of 20 microM ADP, CDP, GDP, and UDP, the Km for the phosphorolysis of the

44 the appropriate second subunit beta(alpha), CDP and effector ATP to trap an amino tyrosyl radical (N

45 Y122*-beta2, Y731F-alpha2 (or Y730F-alpha2), CDP, and ATP at different temperatures (2-37 degrees C)

46 quench analysis of the F3Y(*)-beta2, alpha2, CDP, and ATP (effector) reaction show generation of 0.5

47 y, the reaction of F(3)Y(356)-beta2, alpha2, CDP, and ATP has been examined by stopped-flow (SF) abso

48 yrosine at Y122 (F3Y122*-beta2) with alpha2, CDP (substrate), and ATP (effector) has now afforded the

49 analysis of its reaction with Y731F-alpha2, CDP, and ATP at pH 8.2 and 25 degrees C shows F2Y356* ge

50 strategy used by A. phagocytophilum to alter CDP activity and thereby globally influence neutrophil f

51 f R293A ScRR1 complexed with dGTP and AMPPNP-CDP [AMPPNP, adenosine 5-(beta,gamma-imido)triphosphate

52 structures of the apo-, AMPPNP only-, AMPPNP-CDP-, AMPPNP-UDP-, dGTP-ADP- and TTP-GDP-bound complexes

53 of ScRR1 are crucial in facilitating ADP and CDP substrate selection.

54 In the presence of rNrdE, ATP, and CDP, Mn(III)(2)-Y(*) and Fe(III)(2)-Y(*) rNrdF generate

55 oning of dietary choline between betaine and CDP-PC among NP (MTHFR rs1801133 and MTR rs1805087 WT) a

56 uctures in the apo, CMP-bound, CDP-bound and CDP-glycerol-bound states define functional roles for ea

57 Brain UTP, CTP, and CDP-choline were all elevated 15 min after UMP (from 254

58 line, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); m

59 tingent on the interaction with CDP/cut, and CDP/cut is directly associated with an increase in the m

60 nomolar concentrations of ADP, UDP, GDP, and CDP are shown.

61 We find that interaction models of HNF1 and CDP motifs provide excellent prediction of both HNF1 loc

62 ne by several homeodomain proteins: MSX2 and CDP/cut repress whereas DLX3 and DLX5 activate endogenou

63 Unlike eukaryotic Cls (that use PG and CDP-diacylglycerol as substrates) or ClsA, the combined

64 hosphatidylglycerol, phosphatidylserine, and CDP-diacylglycerol) and inhibited by zwitterionic (phosp

65 athway intermediates phosphoethanolamine and CDP-ethanolamine, and an increase in the methylated deri

66 r in P. falciparum, thus making the SDPM and CDP-choline pathways the only routes for phosphatidylcho

67 ADP is not bound at the catalytic site, and CDP binds farther from the catalytic site compared to wi

68 Both mutants exhibited hyper-PRM, -ANX, and -CDP responses to RP-1 at both pHs and hypo-ENR at pH 5.5

69 CUTL1, also known as CDP (CCAAT Displacement Protein), Cut, or Cux-1, is a ho

70 e identify other possible substrates such as CDP-choline, ATP, and ADP.

71 ria for the quantification of AMP, ADP, ATP, CDP, CTP, FAD, GDP, GTP, UDP, and UTP.

72 N(4)-Benzyloxy-CDP (15, MRS2964) and N(4)-methoxy-Cp(3)U (23, MRS2957)

73 The reaction of F(3)Y(356)-beta2, CDP, and ATP has also been examined with NH(2)Y(731)-alp

74 Studies with NH(2)Y(731(730))-alpha2, beta2, CDP, and ATP resulted in detection of NH(2)Y radical (NH

75 EPR spectroscopies in the presence of beta2, CDP, and ATP.

76 he first time a potential connection between CDP and FIH that could lead to the development of future

77 R293A ScRR1 is unable to bind ADP and binds CDP with 2-fold lower affinity compared to wild-type ScR

78 Both CDP and HIF levels are increased in several cancers and

79 cterium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 A resolution, respecti

80 substrate/specificity effector-pairs bound (CDP/dATP, UDP/dATP, ADP/dGTP, GDP/TTP) that reveal the c

81 Structures in the apo, CMP-bound, CDP-bound and CDP-glycerol-bound states define functiona

82 UMP dose that significantly increased brain CDP-choline was 0.05 mmol/kg.

83 hatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes t

84 nal step of PtdCho synthesis is catalyzed by CDP-choline:1,2-diacylglycerol cholinephosphotransferase

85 membrane phospholipids and was inhibited by CDP-diacylglycerol and sphingoid bases.

86 rokaryotes and eukaryotes, being produced by CDP-DAG synthase (CDS).

87 PtdCho, which was significantly restored by CDP-choline treatment.

88 ha protein, which were partially restored by CDP-choline.

89 gdoms of life, and it is catalysed solely by CDP-APs.

90 ling, rdgB (retinal degeneration B) and cds (CDP-diacylglycerol synthase).

91 tions of a benzodiazepine, chlordiazepoxide (CDP), with a noncompetitive N-methyl-d-aspartate recepto

92 the anxiolytic efficacy of chlordiazepoxide (CDP; 15 mg/kg) on 24 hr retest.

93 effects of the anxiolytic chlorodiazepoxide (CDP; 10 mg/kg) on subjects' performance in a battery of

94 oline into the cytidine diphosphate-choline (CDP-choline) PC biosynthetic pathway relative to betaine

95 nthesis of phosphatidylcholine from choline (CDP-choline pathway), the parasite synthesizes this majo

96 that included methotrexate (MTX), cisplatin (CDP), and doxorubicin (ADM) with or without ifosfamide (

97 robe on cathepsin L, a protease that cleaves CDP into a form with increased DNA binding ability.

98 th the residues from an absolutely conserved CDP-AP signature motif (D(1)xxD(2)G(1)xxAR...G(2)xxxD(3)

99 tion of mice with MMTV proviruses containing CDP binding site mutations elevated viral RNA levels in

100 In contrast, CDP-diacylglycerol synthases that provide PIS with its s

101 vel posttranslational process controls Cutl1/CDP activity and gene expression in the mammary gland.

102 n of the transcription factor Cut, a Cut/Cux/CDP family member, at 10B.

103 TP:glucose-1-phosphate cytidylyltransferase, CDP-Glc 4,6-dehydratase, NADH-dependent SAM:C-methyltran

104 irst human disorder arising due to defective CDP-ethanolamine biosynthesis and provide new insight in

105 ted a 4-epimer CDP-3-C-methyl-6-deoxyallose (CDP-cillose).

106 nantly yielded CDP-3-C-methyl-6-deoxygulose (CDP-cereose) and likely generated a 4-epimer CDP-3-C-met

107 T. denticola does contain a licCA-dependent CDP-choline pathway for phosphatidylcholine biosynthesis

108 hosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Trepone

109 SAM:C-methyltransferase, and NADPH-dependent CDP-3-C-methyl-6-deoxyhexose 4-reductase.

110 Cytidine diphosphate diacylglycerol (CDP-DAG) is a central lipid intermediate for several pat

111 Heterozygous mice with a different CDP mutation that eliminated the entire C terminus and t

112 ) biosynthesis via the cytidine diphosphate (CDP)-choline pathway at the expense of betaine synthesis

113 naturally occurring nucleoside diphosphates, CDP, GDP, and ADP exhibited agonist potencies over 100-f

114 m radiolabeled cytidine 5'-diphosphocholine (CDP-choline) in HCCs.

115 rdic effect of cytidine 5'-diphosphocholine (CDP-choline).

116 Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (i

117 se enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis.

118 ment and the inclusion of convective drying (CDP) and ohmic heating (OHP) were assayed.

119 ycero-4-hexulose-3-dehydrase reductase (E3), CDP-4-aceto-3,6-dideoxygalactose synthase (YerE), UDP-ga

120 onents of the liposomes and the encapsulated CDP-choline.

121 C59-encoded dolichol kinase and CDS1-encoded CDP-diacylglycerol synthase enzymes.

122 aled reduced expression of the gene encoding CDP-diacylglycerol synthase 1 (Cds1), an enzyme that cat

123 A photoreceptor-specific form of the enzyme CDP-diacylglycerol synthase (CDS), which catalyzes the f

124 CDP-cereose) and likely generated a 4-epimer CDP-3-C-methyl-6-deoxyallose (CDP-cillose).

125 DP binding and a 2-fold loss of affinity for CDP compared to the wild type.

126 The binding pocket for CDP-glucose is shared between two subunits.

127 reas they are 20% and 23%, respectively, for CDP reduction.

128 tial, base-catalysed mechanism universal for CDP-APs, in which the fourth aspartate (D4) acts as the

129 62%) compared to the equivalent dose of free CDP-choline (by 26%) after 1 h focal cerebral ischemia a

130 in vitro phosphatidylcholine formation from CDP-choline and diacylglycerol, and full activity requir

131 fferent hydrolysates were produced: (i) from CDP (IC(50)=287 mug/mL) and (ii) from beta-lactoglobulin

132 athway forming phosphatidylethanolamine from CDP-ethanolamine.

133 s the formation of phosphatidylinositol from CDP-diacylglycerol and inositol.

134 l-phosphate synthase is not synthesized from CDP-DAG, as was previously thought.

135 Using an in vitro [(3)H]CDP reduction assay, the activity of RR reconstituted wi

136 a method that localizes membrane-bound [(3)H]CDP-diacylglycerol (DAG) produced from the precursor [(3

137 sex-differentially enriched motifs for HNF6/CDP factors.

138 However, CDP-treated mice did not exhibit facilitated acquisition

139 in turn develops into monocytes, and a human CDP (hCDP) that is restricted to produce the three major

140 electrodes and its suitability for improving CDP.

141 Levels of furosine were higher in CDP (46.6-110.1mg/100g protein) than in OHP (13.7-42.0mg

142 ne caused concentration-related increases in CDP-choline levels, and that this effect was mediated by

143 ternal resistance and overall performance in CDP.

144 defined a potential phosphorylation site in CDP (serine 987) that modulates FIH expression.

145 Irf8 expression in CDPs required prior autoactivation of Irf8 that was depe

146 hanism by which A. phagocytophilum increases CDP activity, we assessed the effects of this microbe on

147 ransferase (lyso-PAF-AT) and DTT-insensitive CDP-choline 1-alkyl-2-acetyl-sn-glycerol cholinephosphot

148 st integral membrane proteins from the large CDP-alcohol phosphatidyltransferase family are involved

149 mmary glands have high levels of full-length CDP (200 kDa) that binds to negative regulatory elements

150 omeodomain into cells containing full-length CDP also abrogated NRE binding.

151 During late pregnancy, full-length CDP levels decline, and a 150-kDa form of CDP (CDP150) a

152 and below a lesion at the lumbar 3/4 level, CDPs recorded from transplanted animals were significant

153 line cytidylyltransferase (CCT), which makes CDP-choline.

154 nsferase domain (IPCT) fused with a membrane CDP-alcohol phosphotransferase domain (DIPPS) at 2.65 A

155 IFO added to MTX, CDP, and ADM from the preoperative phase does not improv

156 who have a poor histologic response to MTX, CDP, and ADM.

157 toperatively when pathologic response to MTX-CDP-ADM was poor (arm A) or given in the primary phase o

158 n the primary phase of chemotherapy with MTX-CDP-ADM (arm B).

159 g mammary extracts or transfection of mutant CDP cDNAs missing the homeodomain into cells containing

160 istration of DCS (7.5 and 15 mg/kg), but not CDP (15 mg/kg) or DCS (30 mg/kg), significantly and sele

161 Thus, CCR9(-) pDC-like cells are novel CDP-derived circulating DC precursors with pDC and cDC p

162 y also caused increases in the activities of CDP-diacylglycerol synthase, phosphatidylserine decarbox

163 AP kinase, and modulation of the activity of CDP/cut and C/EBPalpha, two transcription regulators of

164 erebroventricular (i.c.v.) administration of CDP-choline was made and blood pressure and heart rate w

165 hilum infection also enhances the binding of CDP to the promoters of human neutrophil peptide 1 and C

166 the identification of G9a as a component of CDP/cut complex.

167 However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear.

168 4,6-dehydratase catalyzes the conversion of CDP-D-glucose to CDP-4-keto-6-deoxyglucose in an NAD(+)-

169 ase (E3), catalyzes the C-3 deoxygenation of CDP-4-keto-6-deoxy-D-glucose to form the dehydrated prod

170 e (E1), which catalyzes C-3 deoxygenation of CDP-4-keto-6-deoxyglucose in the biosynthesis of 3,6-did

171 es of this design for further development of CDP into a mature technology.

172 Beneficial effects of CDP-choline liposomes in stroke may derive from a synerg

173 id not compromise the anxiolytic efficacy of CDP in control mice, the results showed that posttrainin

174 th CDP levels decline, and a 150-kDa form of CDP (CDP150) appears concomitantly with a decline in DNA

175 athway that is initiated by the formation of CDP-D-glucose.

176 hase (CDS), which catalyzes the formation of CDP-diacylglycerol from phosphatidic acid, is a key regu

177 The transcriptional repressor function of CDP/cut is mediated through HKMT activity of G9a associa

178 nd in the endoplasmic reticulum by fusion of CDP-ethanolamine and diacylglycerol.

179 Bacillus cereus catalyzes the hydrolysis of CDP-choline to produce CMP and phosphocholine.

180 s inhibitor] 5 min prior to the injection of CDP-choline to determine the effects of these inhibitors

181 CCT1 exhibited a V max of 23904 nmol of CDP-choline min (-1) mg (-1) and apparent K m values for

182 atalyzes the first step in the production of CDP-tyvelose.

183 cathepsin L activity and the proteolysis of CDP.

184 Developmental regulation of CDP was recapitulated in the normal mammary epithelial l

185 idylcholine is balanced by the repression of CDP-diacylglycerol pathway enzymes and the induction of

186 s report, we demonstrate the central role of CDP-diacylglycerol synthetase (CDS) in the regulation of

187 of the high-resolution crystal structure of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberc

188 a uridine source, enhances the synthesis of CDP-choline, the immediate precursor of PC, in gerbil br

189 rogenitors (CDPs), but not for transition of CDP to mature DCs.

190 d cell-intrinsic defects in the formation of CDPs and all splenic DC subsets.

191 Interestingly, the accumulation rate of CDPs is inversely correlated with longevity, suggesting

192 , contrary to the membrane topology of other CDP-alcohol phosphotransferases.

193 P-CDP performed particularly well for positively charged M

194 CCAC and 30 and 40000 g mg(-1) min(-1) for P-CDP.

195 These data highlight advantages of P-CDP adsorbents relevant to MP removal during water and w

196 AC and faster but more selective uptake on P-CDP.

197 ance of porous beta-cyclodextrin polymers (P-CDP) as adsorbents of MPs in aquatic matrixes.

198 d almost no effect on adsorption of MPs to P-CDP.

199 a-lactoglobulin and casein-derived peptides (CDP) from whey.

200 chrinate (CS), choline dihydrogen phosphate (CDP), choline lactate (CL), and choline tartarate (CT))

201 categorized as a cellodextrin phosphorylase (CDP).

202 The CDP-alcohol phosphotransferase (CDP-AP) family of integral membrane enzymes catalyses th

203 le cationic cyclodextrin-containing polymer (CDP)-based siRNA nanoparticles and, thereby, facilitate

204 action based on capacitive Donnan potential (CDP) is a recently suggested technique for sustainable p

205 When cord dorsum potentials (CDPs), evoked by electrical stimulation of the L4/L5 dor

206 rs of the B. cereus sensu lato group produce CDP-3-C-methyl-6-deoxy sugars for the formation of cereo

207 ella typhi enzyme complexed with the product CDP-glucose is a fully integrated hexamer displaying 32

208 haracteristic carbamylation-derived product (CDP), over time in skin of mammalian species with differ

209 xy-D-glucose to form the dehydrated product, CDP-4-keto-3,6-dideoxy- d-glucose, in the ascarylose bio

210 crystallized in the presence of its product, CDP-glucose.

211 nitor (MDP) cells; and common DC progenitor (CDP) and DC precursor (pre-DC) cells.

212 rose directly from the common DC progenitor (CDP).

213 n the common dendritic cell (DC) progenitor (CDP), the committed conventional DC precursor (pre-cDC),

214 In contrast, common DC progenitors (CDP) and pre-DCs, which give rise to lymphoid organ DCs

215 rs differentiate into common DC progenitors (CDPs), and as lymphoid-primed multipotent progenitors (L

216 m/progenitor cells to common DC progenitors (CDPs), but not for transition of CDP to mature DCs.

217 ors (MDPs) and common dendritic progenitors (CDPs), demonstrate increasing commitment to the DC linea

218 layed time to confirmed disease progression (CDP) in pre-planned sub-group analyses.

219 t was time to confirmed disease progression (CDP), a prespecified increase in Expanded Disability Sta

220 oup-I/Y (HMGI/Y), CAAT displacement protein (CDP) and poly(ADP-ribose) polymerase-1 (PARP-1).

221 The CCAAT-displacement protein (CDP) has been implicated in developmental and cell-type-

222 Cutl1/CCAAT displacement protein (CDP) is a transcriptional repressor of mouse mammary tum

223 rotein (CBP) and CCAAT displacement protein (CDP) to rs3289C as the factors responsible for transcrip

224 of a repressor, CCAAT displacement protein (CDP), to the gp91(phox) promoter, thereby diminishing th

225 ammalian homologs CAAT Displacement Protein (CDP; now CUX1) and CAAT Enhancer Binding Protein (C/EBP)

226 at in RCC, the Cut-like homeodomain protein (CDP/Cut) is involved in FIH transcriptional regulation a

227 alized the ER and Golgi, probably to provide CDP-DAG for the phosphatidylinositol synthases.

228 Chondrodysplasia punctata (CDP) is a rare, heterogeneous congenital skeletal dyspla

229 lution crystal structure of a representative CDP-AP from Archaeoglobus fulgidus.

230 deficient in the function of the ER-resident CDP-DG synthase Cds1 exhibit markedly increased triacylg

231 e including DKs, phytol kinases, and several CDP-diacylglycerol synthetases has been identified, and

232 proinflammatory transcription factors Stat4, CDP, GRE, CBF, Ets-1/PEA3, and TFIID, a pattern easily d

233 in the presence of alpha(2) and a substrate (CDP), leading to speculation that HU might intercept a t

234 ability to process the predicted substrate, CDP-4-amino-4,6-dideoxyglucose, using PLP as the coenzym

235 alpha binds NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs

236 he CHO1-encoded phosphatidylserine synthase (CDP-diacylglycerol pathway enzyme) and loss of the zinc-

237 he CHO1-encoded phosphatidylserine synthase (CDP-diacylglycerol:l-serine O-phosphatidyltransferase, E

238 ysteine protease inhibitor demonstrated that CDP is proteolytically processed within the homeodomain

239 Here, we report that CDP/cut interacts with a histone lysine methyltransferas

240 tin immunoprecipitation assays, we show that CDP binds to the FIH-1 promoter in vivo and that this bi

241 Our data show that CDP-choline liposomes significantly (P < 0.01) decreased

242 Immunohistochemical studies showed that CDP-choline increased COX-1 and -2 immunoreactivities in

243 Others showed that CDP-choline liposomes significantly increased brain upta

244 The results suggest that CDP-choline may stimulate prostaglandin synthesis throug

245 Taken together, these results suggest that CDP-choline significantly restores Ptd-Cho levels by dif

246 The CDP-alcohol phosphotransferase (CDP-AP) family of integr

247 se of choline for PC production via both the CDP-choline and PEMT pathways shows the substantial dema

248 synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.

249 tion of phosphatidylcholine synthesis by the CDP-diacylglycerol pathway.

250 ination of diacylglycerol utilization by the CDP-ethanolamine pathway led to a 10-fold increase in tr

251 synthesis of phosphatidylethanolamine by the CDP-ethanolamine pathway.

252 inct from pre-cDCs can be generated from the CDP.

253 ssibility of the clamp binding motifs in the CDP-bound structure of Hda suggests that conformational

254 As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine

255 line by ATP, the first committed step in the CDP-choline pathway for phosphatidylcholine biosynthesis

256 esis of CCT, the rate-limiting enzyme in the CDP-choline pathway, is elevated in fibroblasts overexpr

257 ept-1), which encodes the last enzyme in the CDP-ETA Kennedy pathway.

258 amine kinase catalyzes the first step in the CDP-ethanolamine pathway for the formation of the major

259 regulation correlated with increases in the CDP-ethanolamine pathway intermediates phosphoethanolami

260 le detectable impact on the operation of the CDP-choline metabolic pathway in adult tissues.

261 e to phosphocholine as the first step of the CDP-choline pathway for the biosynthesis of phosphatidyl

262 ng that XBP-1(S) increases the output of the CDP-choline pathway primarily via its effects on CCT.

263 in a decrease in the activity levels of the CDP-diacylglycerol pathway enzymes phosphatidylserine sy

264 this phospholipid occurs via two routes, the CDP-choline pathway, which uses host choline as a precur

265 is in the brain is predominantly through the CDP-choline pathway.

266 synthesis of phosphatidylcholine through the CDP-choline pathway.

267 Thus, the CDP-bound Hda dimer likely represents an inactive form o

268 the synthesis of phosphatidylcholine via the CDP-choline branch of the Kennedy pathway.

269 the synthesis of major phospholipids via the CDP-diacylglycerol pathway.

270 e and the synthesis of phospholipids via the CDP-ethanolamine branch of the Kennedy pathway were cont

271 ynthesis of phosphatidylethanolamine via the CDP-ethanolamine branch of the Kennedy pathway.

272 ur results suggest that interfering with the CDP-DG route of phosphatidic acid utilization rewires ce

273 synthase constitutes a new branch within the CDP-alcohol phosphotransferase superfamily with homologu

274 on in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter

275 The speculative function of this CDP in the carbohydrate metabolism of T. africanus TCF52

276 e for the conversion of phosphatidic acid to CDP-diacylglycerol in phospholipid biosynthesis.

277 holine and cytidine 5'-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylch

278 catalyzes the conversion of CDP-D-glucose to CDP-4-keto-6-deoxyglucose in an NAD(+)-dependent manner.

279 of DCS abolished the anxiolytic response to CDP challenge.

280 ng DCS (15 mg/kg) on behavioral responses to CDP (15 mg/kg) challenge on 24 hr retest.

281 ked the pressor and bradycardic responses to CDP-choline while neomycine or furegrelate partially att

282 se inhibitors on cardiovascular responses to CDP-choline.

283 y, can transaminate the natural substrate to CDP-4,6-dideoxy-4-amino-D-galactose without E3.

284 Although time to CDP between groups was not significant, overall subgroup

285 Differences in time to CDP between rituximab and placebo did not reach signific

286 Subgroup analysis showed time to CDP was delayed in rituximab-treated patients aged <51 y

287 ruginosa dTDP-Glc PPase and Salmonella typhi CDP-Glc PPase.

288 Furthermore, we have defined a unique CDP/Cut binding site on the FIH promoter.

289 transferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction,

290 his phosphocholine transferase activity used CDP-choline as a substrate and required a conserved hist

291 Our data support a model where CDP-choline hydrolysis is catalyzed by the enclosed Nudi

292 nborn metabolic diseases are associated with CDP, including peroxisomal and cholesterol biosynthesis

293 through HKMT activity of G9a associated with CDP/cut.

294 linical symptoms of diseases coexisting with CDP.

295 vious structure of the enzyme complexed with CDP-glucose, those residues defined by Thr(14) to Ile(21

296 ed for the nucleotide radical generated with CDP and E441Q-RNR.

297 omoter is contingent on the interaction with CDP/cut, and CDP/cut is directly associated with an incr

298 Treatment with CDP-choline ameliorated SAND, suggesting that it may be

299 The deletion of the cut repeats within CDP/cut abrogates the interaction with G9a.

300 The last enzyme predominantly yielded CDP-3-C-methyl-6-deoxygulose (CDP-cereose) and likely ge