1 ndicate that SKK3 mediates the activation of SAPK4.

2 PK1 and/or SAPK2 may be mediated by SAPK3 or SAPK4.

3 des human stress-activated protein kinase-4 (SAPK4), a novel MAP kinase family member whose amino aci

4                    Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 20358

5 SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6).

6       Two close homologues of p38, SAPK3 and SAPK4, are not inhibited by SB 203580 and differ from p3

7 ntain the isoforms SAPK2a, SAPK2b, SAPK3 and SAPK4 as determined by immunoblotting with specific anti

8    Unlike SAPK1 (also called JNK), SAPK3 and SAPK4 did not phosphorylate the activation domain of c-J

9                 The substrate specificity of SAPK4 in vitro was similar to that of SAPK3.

10                                   SAPK2b and SAPK4 incorporated less phosphate, and cPLA2 was a poor

11  of the three amino acids of p38 into SAPK3, SAPK4, or the more distantly related JNK1 resulted in in

12 ctive SAPK4/p38delta mutant, suggesting that SAPK4/p38delta may mediate the inhibition of eEF2K by th

13 y overexpression of a catalytically inactive SAPK4/p38delta mutant, suggesting that SAPK4/p38delta ma

14                                              SAPK4/p38delta phosphorylated eEF2K at Ser359 in vitro,

15  extracts that was phosphorylated rapidly by SAPK4/p38delta, but poorly by SAPK2/p38, SAPK3/p38gamma,

16  agonist that activates all SAPKs, including SAPK4/p38delta.

17               SKK3 was the only activator of SAPK4 that was induced when KB cells were exposed to a c

18  [p21, HMGI(Y), BAK]; immune response (CSBP, SAPK4); transcription activators and zinc finger-contain

19                  When expressed in KB cells, SAPK4 was activated in response to cellular stresses and

20                                              SAPK4 was activated in vitro by SKK3 (also called MKK6)

21                            The mRNA encoding SAPK4 was found to be widely distributed in human tissue

22 acilitates recruitment of the MAPK p38delta (SAPK4), while failing to stimulate binding of JNK, the p