ライフサイエンスコーパス: T4

1 have 4 stages of translational research (T0-T4).

2 males had a higher thyroid hormone ratio (T3/T4).

3 triiodothyronine (T3) and higher thyroxine (T4).

4 PBDEs is associated with a decrease in serum T4.

5 ss) DNA binding protein of the bacteriophage T4.

6 he TH receptor, whereas DIO3 degrades T3 and T4.

7 e seven found in the equivalent structure in T4.

8 m3 cells provide most synaptic contacts onto T4.

9 ypothalamus was only minimally affected by L-T4.

10 4.(LiOH)2.HMPA4], that we refer to as pseudo-T4.

11 ses were dissimilar to the endogenous ligand T4.

12 us is wired to have increased sensitivity to T4.

13 found at T0 in two sites persisted up until T4.

14 ies competition relative to incubations with T4.

15 O2 of T4 and O4' ribosyl oxygens of A23 and T4.

16 l proteins of bacteriophages phi29, SPP1 and T4.

17 erent triangulation numbers in bacteriophage T4.

18 Physiologically relevant T3 (1 nM) and T4 (100 nM) concentrations in OVCAR-3 (high alphavbeta3)

19 TRH (30 nM), TSH (10 mU ml(-1)), thyroxine (T4) (100 nM), and triiodothyronine (T3) (100 pM) alter i

20 s (0: 62% v 52%; P = .04) and lower T stage (T4: 26.5% v 35.3%; P = .002) but were otherwise similar.

21 ceptor, binds thyroid hormones (L-thyroxine, T4; 3,5,3'-triiodo-L-thyronine, T3) and is overexpressed

22 tion and PEf1 eliminated E. coli faster than T4 (36 vs 42 h).

23 group had higher pathologic T stage (pT3 and T4: 86% v 73%; P < .01), higher positive lymph nodes (73

24 th a 2.6-mug/dL decrease in total thyroxine (T4) (95% CI: -4.7, -0.35).

25 ss called sigma appropriation, bacteriophage T4 activates a class of phage promoters using an activat

26 While L-T4 administration decreased whole-body D2-dependent T4 c

27 ents with hypothyroidism is levothyroxine (L-T4) along with normalization of serum thyroid-stimulatin

28 DNA-binding protein gp32 from bacteriophage T4 and a strand-displacing DNA polymerase.

29 representative DNA and RNA viruses, namely, T4 and influenza.

30 nt homologous recombination in bacteriophage T4 and is the functional analog of the eukaryotic Rad52

31 nd indicate that only constant delivery of L-T4 and L-T3 fully normalizes T3-dependent metabolic mark

32 Both T4 and metformin alleviated contextual fear memory defic

33 We propose that neonatal administration of T4 and metformin post FAE affect memory via elevating Dn

34 The present results indicate that T4 and metformin, administered during the neonatal perio

35 umors were associated with higher Ca19.9, T3-T4 and N1, higher grade, perineural invasion, R1 resecti

36 uttressed by Asp85, interacts with the O2 of T4 and O4' ribosyl oxygens of A23 and T4.

37 he genomes of bacteriophages lambda, T5, T7, T4 and R1-37 and investigated the ability of these strai

38 subcellular fractions with thyroid hormones (T4 and rT3 separately) and measuring changes in thyroid

39 e associated with maternal concentrations of T4 and T3 during pregnancy.

40 riction assays, Eco94GmrSD weakly restricted T4 and T4gt, whereas T4 IPI*-deficient phage (Deltaip1)

41 Treatment groups T4 and T5 (n = 12 each) received three 10 or 30 mg/kg IV

42 Both T4 and T5 cells comprise four subtypes with directional

43 We found that all four subtypes of both T4 and T5 cells implement both mechanisms, that is prefe

44 In the fruit fly optic lobe, T4 and T5 cells represent the first direction-selective

45 ee of direction selectivity observed in both T4 and T5 cells within each subpopulation.

46 lobe, directional responses first appear in T4 and T5 cells.

47 We find that the receptive fields of both T4 and T5 exhibit spatiotemporally offset light-preferri

48 ionally selective small-field neurons called T4 and T5 form a spatial map in the lobula plate, where

49 ection selective signals in the dendrites of T4 and T5 neurons, detectors of local motion.

50 ion selectivity emerges in two neuron types, T4 and T5, but the computational algorithm underlying th

51 fly's visual motion pathways, two cell types-T4 and T5-are the first known relay neurons to signal sm

52 se correlations in Drosophila's EMD neurons, T4 and T5.

53 ized in model systems provided by coliphages T4 and T7.

54 eased follicular heat production, whereas T3/T4 and TRH stimulated ATP production in cultured HF kera

55 NIS KO mice showed undetectable serum T4 and very low serum T3 levels when fed a diet supplyin

56 23.42%) and 2,491 (76.58%) patients with pT3/T4 and/or pN+ UTUC received AC and observation, respecti

57 ived AC versus observation after RNU for pT3/T4 and/or pN+ UTUC.

58 received AC or observation after RNU for pT3/T4 and/or pN+ UTUC.

59 lating levels of thyroid hormones thyroxine (T4) and triiodothyronine (T3) averaged 46.9 and 64%, res

60 hyroglobulin), which contain both thyroxine (T4) and triiodothyronine (T3), were the first pharmacolo

61 ed by N-status (N1 vs N2), T-status (T1-3 vs T4), and obstruction or perforation status (no obstructi

62 gland secretes primarily tetraiodothyronine (T4), and some triiodothyronine (T3).

63 through thyroid histology, plasma thyroxine (T4), and triiodothyronine (T3), and hepatic outer ring d

64 sites, by using resveratrol and radiolabeled T4 as probes.

65 y selective neuron in the ON motion pathway (T4) as well as its primary input neurons (Mi1, Tm3, Mi4,

66 ed on long-period gratings (LPG) coated with T4 bacteriophage (phage) adhesin.

67 We show for the T4 bacteriophage DNA replication system that primer-prim

68 ed GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin foldon (Fd) trimerization doma

69 midine nucleotide biosynthetic pathway using T4 bacteriophage genes to achieve approximately 63% repl

70 a form of interdigital capacitor coated with T4 bacteriophage gp37 adhesin.

71 ding protein [gene product 32 (gp32)] of the T4 bacteriophage is a central integrating component of t

72 Combining biophysical measurements on T4 bacteriophage replication complexes with detailed str

73 re might decrease the binding of T4 to serum T4 binding proteins.

74 WT-TTR with small molecules that occupy the T4 binding site eliminated the inhibitory capacity of th

75 RNA, suggesting subspecialization of T3 and T4 binding to the integrin receptor pocket.

76 In addition, novel data indicated that T4, but not T3, controls integrin's outside-in signaling

77 G]n /[T2 C]n , [A3 G]n /[T3 C]n , [A4 G]n /[T4 C]n , [A9 G]n /[T9 C]n , [GATC]n /[CTAG]n , and [ACTG

78 hormones triiodothyronine and thyroxine (T3/T4) can impact metabolism, body composition, and develop

79 60-A-diameter isometric mutant bacteriophage T4 capsid has been determined.

80 hree tumors were Tis, 37 were T1, 19 were T2-T4 carcinomas, and 233 were benign lesions.

81 e had previously found that upward-sensitive T4 cells implement both preferred direction enhancement

82 In Drosophila, the T4 cells of the medulla are directionally selective and

83 the first direction-selective neurons, with T4 cells responding selectively to moving brightness inc

84 the circuits of Drosophila's motion-sensing T4 cells using a novel EM technique.

85 of the connections between these neurons and T4 cells using neuronal photoactivation.

86 patially offset input to direction-selective T4 cells, thereby forming the two input lines of a motio

87 the neuron types with the most synapses onto T4 cells.

88 /T4) consisted of 23,022, and group B (no T3/T4) consisted of 17,102 donors.

89 In this cohort, group A (received T3/T4) consisted of 23,022, and group B (no T3/T4) consiste

90 nistration decreased whole-body D2-dependent T4 conversion to T3, D2 activity in the hypothalamus was

91 one (triiodothyronine [T3] or levothyroxine [T4]), corticosteroids, antidiuretic hormone, and insulin

92 jority of T3 present is generated locally by T4 deiodination via the type 2 deiodinase (D2); this pat

93 selective and that selectivity arises in the T4 dendrites.

94 ria do not propagate coliphages and hindered T4 diffusion through the biofilm.

95 e identified which neurons are necessary for T4 directional selectivity and ON motion behavioral resp

96 e (kappa = 0.021), nor could it discriminate T4 disease (kappa = 0.445).

97 tumor characteristics: 263 (80%) with T3 or T4 disease, 215 (66%) N1, and 62 (19%) with celiac nodal

98 t loss were significantly associated with T3/T4 disease.

99 For patients with locally advanced (T3, T4) disease, organ-preservation surgery, combined chemot

100 SplintR Ligase is 100X faster than either T4 DNA Ligase or T4 RNA Ligase 2 for RNA splinted DNA li

101 1 nM at 25 degrees C under conditions where T4 DNA ligase produced only 5'-adenylylated DNA with a 2

102 The development and in-depth analysis of T4 DNA ligase-catalyzed DNA templated oligonucleotide po

103 We describe the application of T4 DNA ligase-catalyzed DNA templated oligonucleotide po

104 We have developed a method for the T4 DNA ligase-catalyzed DNA-templated polymerization of

105 ded by DNA exonucleases or ligated by T3 and T4 DNA ligases.

106 ases such as pol delta and the bacteriophage T4 DNA polymerase replicating 8-oxo-G in an error-prone

107 to interactions with other components of the T4 DNA replication complex are discussed.

108 e-stranded DNA binding protein (gp32) of the T4 DNA replication complex with longer ssDNA (and dsDNA)

109 might interact with other components of the T4 DNA replication complex.

110 posed ssDNA sequences within the functioning T4 DNA replication complex.

111 n-dependent ATP-stimulated REase activity on T4 DNA with glucosyl-5-hydroxymethyl-cytosines (glc-5hmC

112 p at the modification site that is sealed by T4-DNA ligase, yielding a product strand missing the mod

113 o an oral liquid formulation with the same L-T4 dosage, TSH circulating levels were normalized.

114 Tailed bacteriophage T4 employs one of the fastest and most powerful packagin

115 Four homozygous transgenic lines (T4) expressing the mutant 1Ax1 gene (mut1Ax1) were produ

116 nd neuropil, or medulla, that relay input to T4 from L1, the ON-channel neuron in the first neuropil,

117 mum tHb, oxyHb, and deoxyHb of Tis-T1 and T2-T4 groups were 89.3 mumol/L +/- 20.2 (standard deviation

118 commended for patients with thick melanomas (T4; > 4.0 mm in Breslow thickness), after a discussion o

119 The severe asthma clusters (T2, T3, and T4) had higher sputum eosinophilia than cluster T1, with

120 WT T4 has a prolate capsid characterized by triangulation n

121 The structure and assembly of bacteriophage T4 has been extensively studied.

122 The tail of phage T4 has long served as the paradigm for understanding con

123 Escherichia coli and selective phages T4 have been used as case study.

124 A resolution cryo-EM map of an empty prolate T4 head shows how the dodecameric portal assembly intera

125 During T4 homologous recombination, the UvsX recombinase has to

126 nts (35.1%), T3 in 789 patients (24.5%), and T4 in 185 patients (5.8%).

127 cy of polyvalent phage PEf1 versus coliphage T4 in suppressing a model enteric bacterium (E. coli K-1

128 In all patients who received L-T4 in tablet form after switching to an oral liquid form

129 e hypothyroid range) while in therapy with L-T4 in tablet.

130 ts who were switched back again to receive L-T4 in tablets, maintaining the dosage, TSH levels worsen

131 these "drivers" and translational phases (T0-T4) in the past decade, we analyzed cancer epidemiology

132 gy budget during the infection reveal that a T4 infection consumes about a third of its host's energy

133 tructural intermediates during initiation of T4 infection.

134 Bacteriophage T4 infects the bacterial host (Escherichia coli) using a

135 vanced invasive breast cancer (tumor size T3/T4), inflammatory breast cancer, or ductal carcinoma in

136 ctions of the energetics and dynamics of the T4 injection machinery using a novel dynamic model.

137 he energetics, timescale, and pathway of the T4 injection process as well as the force available for

138 We uncover complex T4 inputs and reveal that putative excitatory inputs clu

139 GmrSD weakly restricted T4 and T4gt, whereas T4 IPI*-deficient phage (Deltaip1) were restricted more

140 en, leads us to believe that absorption of L-T4 is greater with oral liquid formulations in these pat

141 Although the atomic structure of T4 is largely known, the dynamics of its fascinating inj

142 Mutation of the zinc-hook in bacteriophage T4 is lethal, indicating the ability to bind Zn(2+) is c

143 similar for patients classed as T4a and T4b, T4 is no longer subdivided in the re-termed ICON-S T cat

144 Cluster T4 is predominantly composed of obese female patients wi

145 teristics, with a lower proportion of T3 and T4 lesions (27.9% v 39.8%), fewer patients with positive

146 %), 13 of 116 T2 lesions (11.2%), and 3 of 5 T4 lesions (60.0%).

147 l (0.08 to 3.99 mU per liter) and a low free T4 level (<0.86 ng per deciliter).

148 usted to attain a normal thyrotropin or free T4 level (depending on the trial), with sham adjustments

149 more per liter and a normal free thyroxine (T4) level (0.86 to 1.90 ng per deciliter [11 to 24 pmol

150 For example, we estimated that maternal free T4 levels decreased 0.019 ng/dL (95% CI: -0.028, -0.009)

151 ymorphism is associated with increased serum T4 levels in a human cohort.

152 Serum T3 and T4 levels were checked in Alb/AEG-1 mice and human HCC p

153 r cord total triiodothyronine (T3) and total T4 levels, and maternal perfluorodecanoic acid (PFDeA) w

154 iiodothyronine (T3) with normal l-thyroxine (T4) levels, is associated with malignancy.

155 then PLP is circularized upon the action of T4 ligase enzyme.

156 opical Pacific Ocean, composing up to 28% of T4-like cyanomyophages.

157 This cyanophage, P-TIM68, belongs to the T4-like myoviruses, has a prolate capsid, a long contrac

158 No T4-like prophages were identified.

159 , while only about 29% of the identified non-T4-like viruses and 30% of the contigs in the study pote

160 we estimate that about 95% of the identified T4-like viruses in viral tagging experiment infect Synec

161 patients were switched to receive an oral L-T4 liquid formulation maintaining the same dosage.

162 % and 96%, respectively, for patients with < T4, < N2c, and </= 10 pack-year smoking history who were

163 re investigated in the L99A cavity mutant of T4 lysozyme and derivatives thereof using site-directed

164 ance histograms from ESR/DEER experiments on T4 lysozyme are accurately reproduced.

165 ir thermodynamics using the variant 118R1 of T4 lysozyme as an example.

166 nding of 1,2-azaborines to model cavities in T4 lysozyme in direct comparison to their carbonaceous c

167 r a model system as well as for spin-labeled T4 lysozyme in explicit water, and show how EBMetaD repr

168 ocyclohexyl labels were attached to sites on T4 lysozyme introduced by site-directed spin labeling.

169 The leucine-99-to-alanine (L99A) mutant of T4 lysozyme is a model system that has an experimentally

170 e an 85% accuracy predicting outcomes of the T4 lysozyme mutation variants.

171 use them to predict effects of mutations in T4 lysozyme structures.

172 ehalose matrix the Tm for the doubly labeled T4 lysozyme was long enough to measure an interspin dist

173 ere, we analyze the folding and unfolding of T4 lysozyme with optical tweezers under a chemo-mechanic

174 nergy landscape of the L99A cavity mutant of T4 lysozyme.

175 e histograms between spin-labels attached to T4 lysozyme.

176 hexylbenzene, bound to an enclosed cavity in T4 lysozyme.

177 rotein model systems: barnase, spectrin, and T4 lysozyme.

178 L-thyroxine (L-T4) malabsorption is a potential concern in patients wit

179 However, normalization of serum TSH with L-T4 monotherapy results in relatively low serum 3,5,3'-tr

180 tly resolved structures of the bacteriophage T4 motor protein gp17 suggests that this motor generates

181 somes translating a particular bacteriophage T4 mRNA bypass a region of 50 nt, resuming translation 3

182 The analysis of the T4 mutant head assembly gives guidance to how other icos

183 before and after 6 weeks of treatment with L-T4 (n=15) or placebo (n=10) in 12 volumes of interest (V

184 utional trial wherein women with clinical T0-T4,N1-N2,M0 breast cancer underwent SLN surgery and axil

185 with a telescope while recording from single T4 neurons, we find both mechanisms at work implemented

186 The kinetics of T4 O and IRD were also investigated, although a definiti

187 pproach is based on using label-free phages (T4), obligate parasites of bacteria, which are attractiv

188 f six marine phages and two coliphages (MS2, T4) on transport in sand-filled percolated columns.

189 ) engraftment in locally advanced tumors (T3-T4 or N+) predict poor prognosis in patients with bladde

190 tage II (T1-T2N2 or T3N0-N2), and stage III (T4 or N3).

191 grouping (stage I/II/III: T1-3N0-N2b/T1-3N2c/T4 or N3, with M1 as stage IV) is proposed for HPV-relat

192 (T1-3N0-2b), RPA-II (T1-3N2c), and RPA-III (T4 or N3; 5-year OS: 82%, 76%, and 54%, respectively; P

193 up III (T4 or N3_age </= 70), and group IVA (T4 or N3_age > 70; 5-year OS: 89%, 64%, 57%, and 40%, re

194 ), group II (T1-3N0-N2c_> 20 PY), group III (T4 or N3_age </= 70), and group IVA (T4 or N3_age > 70;

195 Patients with cT3/T4 or Tx N+ tumors of the mid or lower rectum who had re

196 We administered vehicle, thyroxine (T4) or metformin to neonatal rats post FAE and rats were

197 a clinical isolate of Acanthamoeba (genotype T4) or stimulated with amoeba-derived cell-free conditio

198 iated with total triiodothyronine (T3), free T4, or thyroid-stimulating hormone (TSH).

199 These results suggest that the L-T4 oral liquid formulation could circumvent the pH alter

200 T) T3 and TT4, thyroid histology and hepatic T4-ORD were determined at the final 18 day exposure.

201 e (T3), and hepatic outer ring deiodination (T4-ORD).

202 was no effect on plasma FT3, TT3, or hepatic T4-ORD.

203 cteria (36 degrees C) in 6/11 (55%) sites at T4 (p = 0.0004), by contrast the contamination of P. aer

204 gglutinin skin test, p < 0.0001), thyroxine (T4, p = 0.042), and glutathione (GSH, p = 0.034) concent

205 ts chronically implanted with subcutaneous L-T4 pellets.

206 We show that T4 phage adhesin binds E. coli B LPS in its native or de

207 Interestingly, the costs of building a T4 phage and a single influenza virus are nearly the sam

208 cumulation and persistence of mucus-adherent T4 phage and nonadherent T4hoc phage in the mucus.

209 quilibrium (un)folding intermediate state of T4 phage gene product 45 (gp45, also known as DNA polyme

210 r burst size, however, the overall cost of a T4 phage infection is only 2-3% of the cost of an influe

211 lar insights into the mechanistic pathway of T4 phage infection.

212 Subsequently, T4 phage markers were detected by liquid chromatography

213 We demonstrated that T4 phage particles displayed subdiffusive motion in mucu

214 Nevertheless, T4 phage reduced bacterial colonization of the epitheliu

215 edness opposite that of contracted sheath of T4 phage tail and is organized in an interlaced two-dime

216 Our previous work demonstrated that T4 phage with Hoc proteins exposed on their capsid adher

217 Unlike T4 pilins, where E5 residue substitutions also abolish N

218 luorescence assay for sensitive detection of T4 PNK activity has been developed by multifunctional ma

219 nd accomplished exceptional characterization T4 PNK activity in cell extracts, offering a powerful to

220 Sensitive detection of T4 PNK activity is critical to both clinical diagnosis a

221 The aberrant activity of T4 PNK has been proven to be associated with a variety o

222 esign, the HP-MBs here serve together as the T4 PNK, DNA polymerase, and endonuclease recognition pro

223 Then, in the presence of T4 PNK, the 3'-phosphoryl of HP-MBs was hydrolyzed to 3'

224 riant show that it docks better into the TTR T4 pocket than tafamidis, so far the only drug on the ma

225 T4 polynucleotide kinase (PNK) plays critical roles in r

226 ingle-stranded cDNA (ss-cDNA) ligation using T4 polynucleotide kinase and CircLigase, and polymerizat

227 we report the structure of the bacteriophage T4 portal assembly, gene product 20 (gp20), determined b

228 h that of single subunits of Phi29, SPP1 and T4 portal proteins revealed remarkable similarity.

229 Comparison of the Myoviridae T4 portal structure with the known portal structures of

230 Patients with locally advanced disease (T3/T4) presented with more symptoms (p < 0.01) and more phy

231 Controversies in the management of T4 primaries and the opportunities for conservation lary

232 helial cell height ratio indicated sustained T4 production and release by the thyroid glands.

233 Thyroidal T4 production results from iodination of thyroglobulin (

234 unds to changes in thyrocyte function and T3/T4 production.

235 to identify novel mechanisms that impact T3/T4 production.

236 rects sigma, and therefore RNAP activity, to T4 promoter DNA, and demonstrate at a molecular level ho

237 The Gp59 protein of bacteriophage T4 promotes DNA replication by loading the replicative h

238 to perturb this domain in the bacteriophage T4 Rad50 homolog.

239 perchlorate and decreasing total thyroxine (T4) [regression coefficient (beta) = -0.70; 95% CI: -1.0

240 roportions with combined tumour stage T3 and T4 remained constant.

241 The T4 replisome has provided a unique opportunity to invest

242 suggesting a need for more translational (T2-T4) research.

243 (O and IRD) of T3 and 3,3'-T2 formation from T4, respectively, with an estimated IC50 of 160 nM; no s

244 Neonatal T4 restored maternal allelic expressions of the imprinte

245 ation-free, adapter adenylation method using T4 RNA ligase 1.

246 bers of the ATP-dependent RNA ligase family (T4 RNA ligase 1; Rnl1) and the NAD(+)-dependent DNA liga

247 and 3'-ends of target RNAs, respectively, by T4 RNA ligase 2 (Rnl2).

248 is 100X faster than either T4 DNA Ligase or T4 RNA Ligase 2 for RNA splinted DNA ligation.

249 LISH utilizes the T4 RNA Ligase 2 to efficiently join adjacent chimeric RN

250 on of Y-shaped adapter to mature tRNAs using T4 RNA Ligase 2.

251 ase-paired targets in bacteria co-expressing T4 RNA ligase, followed by sequencing to identify the ch

252 l that putative excitatory inputs cluster at T4's dendrite shafts, while inhibitory inputs localize t

253 erichia coli ribosomes during translation of T4's gene 60 mRNA.

254 interactions of Gp59 with DNA and Gp32, the T4 single-stranded DNA (ssDNA)-binding protein, are rela

255 First, optimization experiments with phage T4 spiked in complex matrices (without a phage amplifica

256 gomers or fibrils of wild-type TTR or to its T4-stabilized form, which resists tetramer disassembly,

257 ociated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stag

258 Pathologic T3b/T4 stage, Gleason score 8-10, lymph node invasion, and D

259 The GalNAc-T4 structure bound to a monoglycopeptide shows that the

260 e PhiM9 capsid closely resembles that of the T4 superfamily cyanophage Syn9.

261 enes in both PhiM9 and S. meliloti-infecting T4 superfamily phage PhiM12, which comes from a complete

262 nd structural study of S. meliloti-infecting T4 superfamily phage PhiM9 provides new insight into the

263 ture of the Sinorhizobium meliloti-infecting T4 superfamily phage PhiM9.

264 The T4 superfamily phages are among the most complex phages;

265 um phage vB_RleM_P10VF define a new group of T4 superfamily phages.

266 y) and measuring changes in thyroid hormone (T4, T3, rT3, and 3,3'-T2) concentrations.

267 es in D2 ubiquitination account for the high T4/T3 serum ratio in adult thyroidectomized (Tx) rats ch

268 othyronine (T3) and high serum thyroxine/T3 (T4/T3) ratio.

269 tigmatism doubled after surgery) than in the T4-T6 subgroup (1.88 +/- 1.28 D; P = 0.013).

270 mutations of basic residues that line phage T4 TerS (gp16) channel do not disrupt DNA binding.

271 Here we report studies on GalNAc-T4 that reveal the origins of its unique N-terminal long

272 For phage T4, the most obvious change is the contraction of its ta

273 T3/T4 therapy was associated with procurement of significan

274 One year later (T4), there was a significant reduction (p = 0.0002) at 8

275 the kestrels increased elimination of plasma T4 through Phase II enzymes.

276 Plasma free T4, thyroid-stimulating hormone (TSH), and 8 am cortisol

277 PBDE exposure might decrease the binding of T4 to serum T4 binding proteins.

278 The accelerated conversion of T4 to T3 within myocytes mediates part of the PGC-1a ind

279 type I 5'-deiodinase (DIO1), which converts T4 to T3, contributes to NTIS.

280 area regions at the C2 to C3, C4 to C5, and T4 to T9 levels.

281 ) T-cell frequency (p = 0.04) correlate with T4 to T9 spinal cord cross-sectional area in HAM/TSP.

282 sm was generated by addition of L-thyroxine (T4) to drinking water.

283 g supraphysiologic doses of levothyroxine (L-T4) to standard treatment for bipolar depression shows p

284 2b, responsible for conversion of thyroxine (T4) to T3.

285 DIO2 converts thyroxine (T4) to triiodothyronine (T3), which binds to the TH rece

286 tification of peripheral deiodinase-mediated T4-to-T3 conversion provided a physiologic means to just

287 d by a rapid increase in Mct8 expression (T3/T4 transport), peaking early-September before gradually

288 Adjunctive L-T4 treatment produced a significant decline in depressio

289 In a previous pilot study, L-T4 treatment reduced depression scores and activity with

290 cases vs. 35% in controls; P = 0.0009), and T4 tumor was more common in cases (13% in cases vs. 4% i

291 and 61% (95% CI, 49%-71%) (5-year only) for T4 tumors, respectively.

292 Total T4 was inversely associated with each PBDE congener.

293 Although T4 was more effective than PEf1 in infecting E. coli K-1

294 Low T3 with normal T4 was observed in the sera of HCC patients and Alb/AEG-

295 T4 was slightly more effective in suppressing E. coli in

296 d de novo independently of deiodination from T4 We found that upon iodination in vitro, de novo T3 fo

297 In patients treated with L-T4, we found a significant decrease in regional activity

298 rgets the thymidylate synthase gene of phage T4, we readily isolated variants that dramatically broad

299 Building on our estimates for T4, we show how the energetic costs of double-stranded D

300 Plasma free (F) T3 and T4 were measured at baseline, and at 9 days and 18 days

301 AJCC and UICC high-stage tumors (T3/T4) were rare at 0.3% and 3% of the cohort, respectively