ライフサイエンスコーパス: TH

1 TH activation of FOXO1 was directly linked to an increas

2 TH did not blunt fibrosis in Ppargc1a- or Pink1-knockout

3 TH immunoreactivity overlapped with PNs, LNs, and ORNs,

4 TH is highly regulated, notably by phosphorylation of se

5 THs are key during embryonic and postembryonic developme

6 These epitopes elicited either TH 2 or TH 2/TH 17 responses in allergic subjects, which were either

7 x PH: 20%, 95% confidence interval: -57, 59; TH: 27%, 95% credible interval: -23, 58) and highest for

8 x PH: 40%, 95% confidence interval: -49, 76; TH: 52%, 95% credible interval: 7, 75).

9 ctivate cashew-reactive T cells and elicit a TH 2-type response at an epitope-specific level.

10 ology, and fast-scan cyclic voltammetry in a TH-cre mouse line, we demonstrated that these neurons al

11 Sobetirome, a TH mimetic, also blunted bleomycin-induced lung fibrosis

12 arval recruitment therefore corresponds to a TH-controlled metamorphosis, sensitive to endocrine disr

13 Abnormal TH signaling in early pregnancy is associated with signi

14 Here we selectively activated TH(VTA) neurons in transgenic rats and measured resultin

15 eiodinase 2 (DIO2), an enzyme that activates TH, were higher in lungs from patients with idiopathic p

16 umventing the diseased BBB to deliver active TH to the brain could be a viable therapeutic strategy.

17 ssion of proapototic (BMF, BIM), adrenergic (TH), and cell-cycle genes (e.g., CDC25A, CDK1).

18 Aerosolized TH delivery increased survival and resolved fibrosis in

19 dition, neonatal hyperoxia promoted allergic TH responses to house dust mite exposure.

20 rotein Hsp70 nor the unrelated Hsp60 altered TH activity, confirming the specificity of the Hsc70 eff

21 To examine TH 1 and TH 17 immunity infection with Anaplasma phagocytophilum

22 e is selective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaffected.

23 (DBH, TPH1, TPH2, DDC, MAOA, MAOB, BCHE and TH), neurodevelopment (BDNF and others), the SNARE syste

24 pheral blood for IgG4-expressing B cells and TH subsets.

25 roduction, inflammatory gene expression, and TH and group 2 innate lymphoid cell (ILC2) responses.

26 NP-(CD/Azo)-siRNA/PEG NPs with both GE11 and TH peptides display a high level of cellular uptake and

27 djacent to some colocalizations of GluR1 and TH in the inner plexiform layer.

28 ytochemical studies indicated that Hsc70 and TH co-localize in midbrain dopaminergic neurons.

29 strate a novel interaction between Hsc70 and TH that regulates the activity and localization of the e

30 l significance to MTA1, we analyzed MTA1 and TH levels in the substantia nigra region of a large coho

31 CSF showed significant induction of MTA1 and TH with rescue of phenotype in the mouse model.

32 No colocalization was noted between NPY and TH or DbetaH immunoreactivities.

33 However, the cross talk/link between TAT and TH in the heart is unclear.

34 Thyroid hormone (TH) and TH receptors (TRs) alpha and beta act by binding to TH r

35 Thyroid- and TH-associated upstream regulators as well as thyroid-rel

36 ations between serum PBDE concentrations and THs in a North American adult cohort.

37 Therefore, topically applied THs deserve further exploration as candidate agents for

38 c-fos expression and spike frequency in ARC TH neurons.

39 Optogenetic stimulation of mouse ARC TH neurons increased food intake; attenuating transmitte

40 Optogenetic stimulation of ARC TH cells inhibited pro-opiomelanocortin (POMC) neurons t

41 ogether these data support the view that ARC TH cells play an unrecognized and influential positive r

42 These neurons are TH positive and subdivide the medial lobe of the mushroo

43 t more profusely than ventral tegmental area TH(+) neurons to the hippocampus, optogenetic activation

44 s response is selective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaffected.

45 To assess TH involvement, Wistar rats were treated with alpha-meth

46 both group of hospitals (crude rates: 88% at TH versus 86% at NTH, adjusted odds ratio 0.99, 95% conf

47 and trends of guideline-recommended care at TH and NTH for patients with HF.

48 over time, with no significant difference at TH (adjusted odds ratio 1.20, 95% confidence interval 1.

49 we describe a reciprocal regulation between TH action and the cancer-associated microRNA-21 (miR21)

50 -133a plays a role in the cross talk between TH and TAT and regulates contractility by influencing NE

51 the functional relevance of these bioactive THs, RNA-seq analysis was conducted in the cerebellum, t

52 an effect of protein with Ca+/-D on LS BMD, TH BMD, or forearm fractures; there was insufficient evi

53 VE was estimated in both TH and Cox proportional hazards (PH) models.

54 ggested that downstream metabolic effects by TH can post-translationally activate other transcription

55 es (e.g. GRIN2A, DRD1, DRD2, HTR2A, CACNA1C, TH, BDNF, SLC6A3, P2RX7, DRD3, and DRD4) and also highli

56 The ratio of neurons expressing Calbindin, TH, and VIP is selectively decreased while, for instance

57 DNA and leads to complete loss of canonical TH action.

58 We analyzed the differentiation of CD4(+) TH cell subsets in control and DOCK8-deficient subjects.

59 Profiling of aeroallergen-specific CD4(+) TH memory responses revealed positive associations betwe

60 d tyrosine hydroxylase-immunopositive cells (TH cells) modulate visually driven signals as they flow

61 The cellular TH level is mainly regulated by deiodinase iodothyronine

62 ication for BDE-99 interfering with cellular TH signaling during O4(+) cell formation.

63 xplored integrated signaling among classical TH 2 cytokines (IL-4, IL-5, and IL-13), which together w

64 Thus, locus coeruleus TH(+) neurons can mediate post-encoding memory enhanceme

65 s, optogenetic activation of locus coeruleus TH(+) neurons mimics the novelty effect, and this novelt

66 ve to environmental novelty, locus coeruleus TH(+) neurons project more profusely than ventral tegmen

67 Surprisingly, two effects of locus coeruleus TH(+) photoactivation are sensitive to hippocampal D1/D5

68 ever, the blood-brain barrier (BBB) controls TH entry into the brain, and reduced TH availability to

69 cent nAChR subunits showed that the cultured TH+ neurons displayed alpha4, alpha6, and beta3 nAChR su

70 0 by short hairpin RNA resulted in decreased TH activity and dopamine levels.

71 r data underline the need for MCT8-dependent TH uptake in neural progenitors and stress the importanc

72 These results indicate that MCT8-dependent TH uptake in the neural progenitors is essential for ear

73 yers after glutamatergic synapses depolarize TH cell dendrites in the inner plexiform layer and these

74 Aggressive double- and triple-hit (DH/TH) diffuse large B-cell lymphomas (DLBCLs) feature acti

75 an be used to enrich in vitro differentiated TH neurons.

76 even those that receive little to no direct TH(VTA) input.

77 helper 17 (TH17) cells represent a discrete TH cell subset instrumental in the immune response to ex

78 In this study, DNA tetrahedron (DNA TH) with a hollow structure is anchored on gold electrod

79 In addition, this DNA-TH-based immunosensor exhibits good sensing performance

80 vity of ventral tegmental area dopaminergic (TH(VTA)) neurons, as well as from more global maladaptat

81 activatable cell-penetrating peptides (i.e., TH peptide), and imaging probes (i.e., Cy5 fluorophore).

82 These epitopes elicited either TH 2 or TH 2/TH 17 responses in allergic subjects, which

83 iseased retinas, suggesting locally elevated TH signaling.

84 Importantly, endogenous TH is required during this transition for the functional

85 and beta-cells become targets of endogenous TH signaling during the larval-to-juvenile transition.

86 We find that endogenous TH locally regulates neurogenesis at developmental stage

87 tion against these variants should eradicate TH.

88 Together, our results establish TH action as a critical hub of multiple oncogenic pathwa

89 To examine TH 1 and TH 17 immunity infection with Anaplasma phagocy

90 We found that exogenous TH precociously activates the beta-cell differentiation

91 -tissue-resident macrophages did not express TH.

92 Before their action on gene expression, THs require cellular uptake, a process facilitated by th

93 id hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-di

94 ished as the canonical or type 1 pathway for TH action.

95 This response is selective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaf

96 Gene expression profile in cultures from TH-eGFP mice showed that the TH+ neurons also express se

97 Using sorted DA neuron preparations from TH-eGFP mice we found that DA neurons express FA transpo

98 In NB tissues from TH-MYCN mice, high immunoreactivity of both NPY and Y5R

99 Global TH treatment caused large-scale morphological effects in

100 cribed individual-based transmission hazard (TH) model and assessed its utility for analyzing data fr

101 stroke) and diffusion of the trailing head (TH) that contributes in propelling the motor by 16 nm ha

102 (MUMs), 25 via trained traditional healers (THs), and 26 through trained community-chosen personnel

103 d an alpha-helical hairpin [trigger helices (TH)] required for rapid nucleotide addition.

104 ns contribute to the expression of T helper (TH) lineage-defining factors is unknown.

105 d with persistent pro-inflammatory T-helper (TH)2 and TH17 responses.

106 netic diseases such as transverse hemimelia (TH), a congenital developmental abnormality characterize

107 lop NAFLD without down-regulation of hepatic TH signaling or decreased hepatic lipid utilization.

108 The combined schizophrenia group had higher TH and GAD67 protein levels than controls (an increase o

109 -resistant subjects had significantly higher TH and GAD67 levels than controls (an increase of 121.0%

110 I(2): 0%; n = 5) but no effect on total hip (TH), femoral neck (FN), or total body BMD or bone biomar

111 isease characterized by low thyroid hormone (TH) and high thyroid-stimulating hormone (TSH) levels in

112 Thyroid hormone (TH) and TH receptors (TRs) alpha and beta act by binding

113 thyroid, the first step in thyroid hormone (TH) biosynthesis.

114 ake plays a pivotal role in thyroid hormone (TH) biosynthesis.

115 dies have shown PBDEs to be thyroid hormone (TH) disruptors.

116 to be the primary bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (T

117 terestingly, both FOXO1 and thyroid hormone (TH) have similar effects on carbohydrate and energy meta

118 Thyroid hormone (TH) is critical for the maintenance of cellular homeosta

119 An effect of thyroid hormone (TH) on erythropoiesis has been known for more than a cen

120 Thyroid hormone (TH) regulates many cellular events underlying perinatal

121 r in tissues that depend on thyroid hormone (TH) regulation for normal physiologic function.

122 7-10, when serum levels of thyroid hormone (TH) rise.

123 ts are suspected to involve thyroid hormone (TH) signaling disruption.

124 ent studies have implicated thyroid hormone (TH) signaling in cone photoreceptor viability.

125 Thyroid hormone (TH) signaling promotes tissue maturation and adult organ

126 Thyroid hormone (TH) signaling regulates cell proliferation, differentiat

127 activating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter 8 (MCT8) cau

128 and subsequent function of thyroid hormones (TH).

129 re, we investigate whether thyroid-hormones (TH) and their receptors (TR) coordinate the larval recru

130 Thyroid hormones (THs) are essential for establishing layered brain struct

131 nts.SIGNIFICANCE STATEMENT Thyroid hormones (THs) are essential to establish the stereotypical layere

132 ince it is unknown whether thyroid hormones (THs) regulate mitochondrial function in human epidermis,

133 (HF) quality of care at teaching hospitals (TH) and nonteaching hospitals (NTH).

134 How TH cells acquire pathogenicity and communicate with myel

135 zebrafish as a model to test whether and how TH signaling affects pancreatic islet maturation, and co

136 However, THs neither raised reactive oxygen species production or

137 mine synthesis enzymes tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase, providing a n

138 , we evaluated whether tyrosine hydroxylase (TH) and cytochrome P450s (CYPs) catalyzed this process.

139 nd 5-HT, respectively, tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), and draw an evolut

140 Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA,

141 ere was a reduction in tyrosine hydroxylase (TH) density in the striatum in these cases when compared

142 d negatively regulates tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catechol

143 rgic (DA), revealed by tyrosine hydroxylase (TH) immunoreactivity.

144 ne into the endogenous tyrosine hydroxylase (TH) locus enables rapid and easy quantification of dopam

145 unexpected neuron, the tyrosine hydroxylase (TH) neuron of the arcuate nucleus (ARC), that we show ma

146 with somatostatin and tyrosine hydroxylase (TH) or dopamine beta-hydroxylase (DbetaH), respectively.

147 differentiation ( 40% tyrosine hydroxylase (TH) positive, maturing into 25% cells exhibiting mDA neu

148 P under control of the tyrosine hydroxylase (TH) promoter, we found that mu opioid receptor activatio

149 uces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway

150 n, BRF110 up-regulates tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase (AADC), and GTP

151 pare protein levels of tyrosine hydroxylase (TH), glutamate decarboxylase (GAD67), and vesicular glut

152 ith antibodies against tyrosine hydroxylase (TH), melanin-concentrating hormone (MCH), and hypocretin

153 Immunostaining for tyrosine hydroxylase (TH), sodium channels (Nav ) and ankyrin-G (Ank-G) was us

154 demonstrated >300,000 tyrosine hydroxylase (TH)-positive grafted cells per side with normalized stri

155 on against the loss of tyrosine hydroxylase (TH)-positive neurons of substantia nigra.

156 ion of VGluT2 mRNA and tyrosine hydroxylase (TH; for identification of dopamine neurons).

157 fted dopamine neurons (tyrosine hydroxylase: TH+).

158 This identifies THs as potent endocrine stimulators of mitochondrial fun

159 Recent studies have implicated TH signaling in cone photoreceptor viability.

160 In TH::Cre rats, the dopaminergic pathways from the ventral

161 ppressed MYCN-driven neuroblastoma growth in TH-MYCN homozygous transgenic mice and MYCN gene-amplifi

162 s, purified Hsc70 facilitated an increase in TH activity.

163 Local increases in TH, accomplished by injecting suspensions of tri-iodothy

164 DCs play an essential role in TH cell differentiation, and we show that RIG-I and MDA5

165 way as a novel target that is upregulated in TH cells of obese asthmatic children, suggesting its rol

166 The thyroid hormone-inactivating (TH-inactivating) enzyme type 3 iodothyronine deiodinase

167 N9D cells consistently resulted in increased TH activity whereas knockdown of Hsc70 by short hairpin

168 For each individual, TH models estimated hazards of infection from the commun

169 ct the number of mouse O4(+) cells inhibited TH-induced mMog transcription by a yet unknown mechanism

170 ssion of TAT demonstrated that TAT inhibited TH.

171 After bleomycin-induced injury, TH promoted mitochondrial biogenesis, improved mitochond

172 dor-sugar reward learning and require intact TH function in this process.

173 Interestingly, TH-Cre;ErbB4(f/f) mice manifest deficits in learning, sp

174 he reciprocal control of distinct intestinal TH cell responses by autophagy, with important implicati

175 the significance of targeting intracellular TH components locally in the retina.

176 rocyte to osteoblast transdifferentiation is TH-dependent.

177 a high prevalence of VGluT2 neurons lacking TH; their paranigral and parabrachial pigmented nuclei h

178 t costimulatory molecule expression, limited TH-polarizing cytokine production, and significant cell

179 ere the inflammatory signal, chemerin, links TH and RA signaling to hypothalamic remodeling.

180 ogenitors and stress the importance of local TH action in early development.

181 in have been described, the effects of local TH signaling are poorly understood.

182 o time-lapse imaging demonstrated that local TH first increased tectal progenitor cell proliferation,

183 oles for CD4(+) T-helper type-2 lymphocytes (TH 2 cells), their associated cytokines, and eosinophils

184 We determined the effects of manipulating TH signaling on development of the optic tectum in stage

185 A dopaminergic marker (TH), serotonin (5-HT) or GABA do not co-localize with Ga

186 Cs represent a novel strategy for modulating TH 2 immune responses and IgE production.

187 Moreover, TH increased FOXO1 nuclear localization, DNA binding, an

188 Moreover, TH treatment increased intracutaneous fibrillin-rich mic

189 nd parabrachial pigmented nuclei have mostly TH neurons, and their parabrachial pigmented nuclei have

190 T8-deficient neural cells that showed normal TH-dependent neuronal properties and maturation.

191 e visualized TH target tissues using a novel TH-responsive reporter line and found that both alpha- a

192 enes (hMBP, mMog) in presence and absence of TH and/or BDE-99.

193 with reduced levels of Hsc70, the amount of TH associated with synaptic vesicles was decreased.

194 On the background of TH 2 inflammation, we have demonstrated that innate immu

195 hological role of D3 and the contribution of TH metabolism in cancer have yet to be fully explored.

196 ating maternal versus fetal contributions of TH.

197 cription is causally linked to the degree of TH cell deficiency and genomic instability in the XLT/WA

198 cell differentiation; specific depletion of TH from the culture medium completely blocked terminal e

199 ection by MCH axons, whereas it is devoid of TH projections.

200 4(+) cells) by BDE-99 involves disruption of TH action in human and mouse (h,m)NPCs.

201 The liver showed a clear dominance of TH-responding genes.

202 and SMARCA4 are necessary for expression of TH and selection against these variants should eradicate

203 y for polarized influx of the active form of TH across the BBB.

204 er, it is difficult to probe the function of TH in early brain development in mammals because of the

205 We demonstrate an increase of TH-levels and TR-expressions in pelagic-larvae, followed

206 hough our data show a complex inheritance of TH, we predict that homozygous variants in WNT7A and SMA

207 ave provided evidence that the initiation of TH 2 responses is regulated by airway epithelial cell-de

208 d mechanistic evidence of the involvement of TH metabolism in BCC tumorigenesis.

209 Due to the lack of TH immunoreactivity in this region, the hypothalamic CSF

210 esenting cells in priming and maintenance of TH cell responses.

211 These findings disclose a new mechanism of TH regulation by phosphorylation and reveal its interact

212 us (AAV-ErbB4.DIO) into the mesencephalon of TH-Cre;ErbB4(f/f) mice, which selectively restores ErbB4

213 These data suggest that modulation of TH(VTA) neurons can impact brain dynamics across many di

214 Furthermore, explicit pairing of TH(VTA) neuronal activation with a forepaw stimulus of a

215 conclude that the antifibrotic properties of TH are associated with protection of alveolar epithelial

216 ely hypothyroid mice show down-regulation of TH signaling in their livers and profound suppression of

217 Here we demonstrate an essential role of TH during terminal human erythroid cell differentiation;

218 However, the functional role of TH phosphorylation at the Ser-31 site (THSer(P)-31) rema

219 te that selective optogenetic stimulation of TH(VTA) neurons enhanced cerebral blood volume signals i

220 ented upregulation of TAT and suppression of TH in the heart after streptozotocin was administered.

221 cell line and patient-derived tumorgrafts of TH-DLBCL, even in the presence of elevated Hsp90 activit

222 rat's heart concomitant with upregulation of TH, cardiac NE, beta-AR, and downregulation of TAT and p

223 pressed TAT with concomitant upregulation of TH, whereas knockdown and overexpression of TAT demonstr

224 IO-hm4D-mCherry was injected into the VTA of TH::Cre adult male rats.

225 ter 8 (MCT8), involved in cellular uptake of THs before their action, results in severe neurological

226 ms that impose spatiotemporal constraints on TH action in the brain have been described, the effects

227 dritic spines, spines have not been found on TH cells of most species examined to date or on TH cell

228 cells of most species examined to date or on TH cell somata that release dopamine when exposed to glu

229 f9), suggesting regulation by temperature on TH-gene expression.

230 These epitopes elicited either TH 2 or TH 2/TH 17 responses in allergic subjects, which were ei

231 Responses in IR- or TH-associated gene signatures were tissue-specific and v

232 to evaluate the relative impact from IR- or TH-induced regulation.

233 Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell recept

234 y diseases driven by autoreactive pathogenic TH cells that elicit demyelination and axonal damage.

235 We show that several important physiological TH effects are preserved despite the disruption of DNA b

236 current paradigm that in vivo physiological TH action is mediated exclusively via regulation of gene

237 king ErbB4 in tyrosine hydroxylase-positive (TH+) neurons, but not in PV+ GABAergic interneurons, exh

238 ors, including TRAIL and MID1, which promote TH 2 cell development via STAT6-dependent pathways.

239 ynapse-related immunoreactivity of adult rat TH cells.

240 ontrols TH entry into the brain, and reduced TH availability to neural cells could instead underlie t

241 FLD has generally been attributed to reduced TH signaling in the liver with a consequent decrease in

242 ate that Ser-31 phosphorylation may regulate TH subcellular localization by enabling its transport al

243 the mice a high-I(-) diet partially rescued TH biosynthesis, demonstrating that, at high I(-) concen

244 We demonstrate that a second TH gene (TH2) is expressed in the CSF-c cells of all the

245 mma(-)IL-17(+) subsets constituted secondary TH types, and BAL fluid CD8(+) T cells were almost exclu

246 gE production and do not develop significant TH 2 immune responses.

247 and restimulate in vivo-primed HDM-specific TH cells.

248 were unable to make cytokines that stimulate TH 2 cells and cytokines.

249 fted cells per side with normalized striatal TH-immunoreactive fiber innervation and bidirectional sy

250 es were found in the on-medication subjects (TH 88.3%, P=0.008; GAD67 40.6%, P=0.003).

251 D3 terminates TH action within the tumor microenvironment, thereby enh

252 erred from the data: L-triiodothyronine, TH, TH receptor, and triiodothyronine (reverse) were inferre

253 GluR1, GluR4, NR1, PSD-95, and PSD-93), that TH cell somata and tapering neurites are also immunoposi

254 onocrystallization differ markedly, and that TH and IRI activities are not correlated.

255 storation of mitochondrial function and that TH may thus represent a potential therapy for pulmonary

256 We report here that TH cell somata, tapering and varicose inner plexiform la

257 In vitro studies revealed that TH acting via TRalpha1 promoted expression of SHH while

258 The results show that TH activities determined by cryoscopy and sonocrystalliz

259 hermore, in vitro binding assays showed that TH directly binds the substrate binding and carboxyl-ter

260 Previous studies suggested that TH cells release dopamine from varicose axons arborizing

261 Genome-wide analysis suggests that TH promotes NCOA4 recruitment to chromatin regions that

262 nfancy, can cause mental retardation, as the TH decrease results in improper development of the nervo

263 ellular uptake, a process facilitated by the TH transporter monocarboxylate transporter 8 (MCT8).

264 blastic tumors and in tumor tissues from the TH-MYCN NB mouse model.

265 There were more deaths in the TH cluster than elsewhere (RR, 2.7 [95% CI, 1.4-5.6]; P

266 residue has been proposed to function in the TH form as a general acid in RNA synthesis and as a gene

267 l lines and blocked tumor development in the TH-MYCN transgenic NB mouse model.

268 idney cortex, kidney medulla, and lungs, the TH-associated signature was detected to at least an exte

269 to model choice, although the ability of the TH model to accurately describe transmission of influenz

270 gated the effectiveness of inhibition of the TH receptor (TR).

271 rs by bidirectional stochastic motion of the TH.

272 ngly, we find that during a single step, the TH stochastically hops multiple times between the geomet

273 We also found that the TH microsomal fraction content decreases after inhibitio

274 n cultures from TH-eGFP mice showed that the TH+ neurons also express several other genes associated

275 to triiodothyronine (T3), which binds to the TH receptor, whereas DIO3 degrades T3 and T4.

276 The precise roles of the TL/TH in RNA synthesis and hydrolysis remain unclear.

277 ared between 197 187 HF patients admitted to TH and 106 924 patients admitted to NTH between 2005 and

278 ptors (TRs) alpha and beta act by binding to TH response elements (TREs) in regulatory regions of tar

279 ic-pituitary-thyroid axis with resistance to TH, while mutation of TRalpha causes a severe delay in s

280 in perinatal periods and fail to respond to TH by enhanced erythropoiesis.

281 The expression profiles in response to TH treatment were tissue-specific, and the diversity of

282 effectiveness of docetaxel plus trastuzumab (TH) with or without pertuzumab in US patients with metas

283 bel, randomised, phase 3, multicentre trial (TH CR-406/SARC021) at 81 academic or community investiga

284 inferred from the data: L-triiodothyronine, TH, TH receptor, and triiodothyronine (reverse) were inf

285 ntered in coral-reefs, impairs A. triostegus TH-levels, transformation, and grazing activity, hence d

286 ifferent functional strategies that underpin TH pleiotropy.

287 Unlike TH and MCH axons, Hcrt axons are scattered throughout th

288 rabrachial pigmented nuclei have dual VGluT2-TH neurons.

289 We visualized TH target tissues using a novel TH-responsive reporter l

290 a total of 169, 154 and 2863 genes that were TH-responsive (FDR < 0.05) in the tilapia cerebellum, th

291 findings demonstrate that NAFLD occurs when TH levels are mildly reduced, but, paradoxically, not wh

292 However, whether TH(VTA) activity affects large-scale brain-wide function

293 tury but the molecular mechanism(s) by which TH affects red cell formation is still elusive.

294 ults reveal the molecular mechanism by which TH functions during red blood cell formation, results th

295 sed on our data, we propose a model in which TH acting through TRalpha1 and TRbeta1, respectively, fi

296 These events were associated with TH-mediated oxidative phosphorylation and NAD(+) product

297 uctions revealed that Ank-G colocalized with TH only at the AIS.

298 cells demonstrated that Hsc70 interacts with TH and aromatic amino acid decarboxylase.

299 0 physically and functionally interacts with TH to regulate the enzyme activity and synaptic vesicle

300 Treatments with TH or TR-antagonist, as well as relocation to the open-o