ライフサイエンスコーパス: TSH receptor

1 G(s) and G(q) compete for activation by the TSH receptor.

2 ated a series of LHR mutants and chimeric LH-TSH receptors.

3 along with the thyroid-stimulating hormone (TSH) receptor and adenylyl cyclase isotypes differing wi

4 lso occur in the extracellular domain of the TSH receptor, and support a model in which the extracell

5 icularly thyroid peroxidase and thyrotropin (TSH) receptor] and of high affinity monoclonal antibodie

6 AM, and porin could be abolished by K1-70, a TSH-receptor antagonist, suggesting a TSH receptor-media

7 firmed the increased affinity of stimulating TSH receptor antibodies for the shed A subunit rather th

8 ccording to the currently most reliable anti-TSH receptor antibody-ELISA used to diagnose Graves dise

9 and activation to the hTSH chimera, whereas TSH receptor binding and activation were abolished.

10 ment of the seat-belt was more important for TSH receptor binding and signal transduction than the Cy

11 hCG chimera that bound to and activated the TSH receptor but not the CG/lutropin (LH) receptor.

12 ractionation chromatography, activated human TSH receptors, but not LH and FSH receptors, and showed

13 se of human FSH/thyroid-stimulating hormone (TSH) receptor chimeras suggested a novel mechanism for r

14 ch shares equal identity to the FSH, LH, and TSH receptors from mammals.

15 TSH/cAMP-induced negative regulation of the TSH receptor gene in thyrocytes, suppression of MHC clas

16 Direct sequencing of the TSH receptor gene revealed a mutation in one allele resu

17 vating somatic mutations in the thyrotropin (TSH) receptor have been identified as a cause of hyperfu

18 To examine thyrotropin (TSH) receptor homophilic interactions we fused the human

19 r homophilic interactions we fused the human TSH receptor (hTSHR) carboxyl terminus to green fluoresc

20 d FSH receptors, and showed high affinity to TSH receptors in a radioligand receptor assay.

21 -70, a TSH-receptor antagonist, suggesting a TSH receptor-mediated action.

22 Fluorescent TSH receptors on the plasma membrane were functional as

23 The thyroid-stimulating hormone (TSH) receptor signals via G(s) to produce cAMP and via G

24 n in the anterior pituitary known to express TSH receptors suggested a paracrine mechanism.

25 of the physiological roles of extra-thyroid TSH receptor systems and the structural-functional basis

26 viously reported that the human thyrotropin (TSH) receptor tagged with green fluorescent protein (TSH

27 54-alpha(s) was co-expressed with either the TSH receptor that activates both alpha(s) and alpha(q) o

28 ssociated with mutations in the thyrotropin (TSH) receptor, the cause of thyroid agenesis is unknown.

29 internalization in thyroid cells, endogenous TSH receptors traffic retrogradely to the trans-Golgi ne

30 The gene for the TSH receptor (TSH-R) was expressed in intestinal T cells

31 ghput screening to identify a small-molecule TSH receptor (TSHR) agonist that was modified to produce

32 eam of thyroid-stimulating hormone (TSH) and TSH receptor (TSHR) and is indispensable for TSH/TSHR-me

33 TSH receptor (TSHR) engagement stimulates the production

34 teoclastic bone resorption, mediated via the TSH receptor (TSHR) found on osteoblast and osteoclast p

35 stem, the expression and distribution of the TSH receptor (TSHr) has been studied by immunoprecipitat

36 ch requires TSH binding to both sites of the TSH receptor (TSHR) homodimer, and TSH-stimulated IP1 pr

37 g affinity (negative cooperativity) requires TSH receptor (TSHR) homodimerization, the latter involvi

38 tested whether persistent cAMP signaling by TSH receptor (TSHR) is dependent on internalization.

39 Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein alpha subunit (GNA

40 responsive BM cells defined by expression of TSH receptor (TSHR) using flow cytometry were selectivel

41 Thyrotropin (TSH) activation of the TSH receptor (TSHR), a 7-transmembrane-spanning receptor

42 the constitutively active ligand-independent TSH receptor (TSHR).

43 Thyrotropin (TSH) receptor (TSHR) A and B subunits are formed by intr

44 o gain insight into the thyrotropin hormone (TSH) receptor (TSHR) cleavage, we sought to convert the

45 The thyrotropin (TSH) receptor (TSHR) is a member of the heterotrimeric G

46 ent bind to the thyroid stimulating hormone (TSH) receptor (TSHR) with high affinity, inhibit labelle

47 athogenic autoantibodies to the thyrotropin (TSH) receptor (TSHR), can be treated but not cured.

48 y acting on the thyroid-stimulating hormone (TSH) receptor (TSHR), TSH negatively regulates osteoclas

49 he thyrotropin [thyroid-stimulating hormone (TSH)] receptor (TSHR) is known to acutely and persistent