ライフサイエンスコーパス: adaptor protein

1 es recruiting syntenin-1, a CD63-interacting adaptor protein.

2 ll the signaling processes that involve this adaptor protein.

3 ique mechanism that involves a discrete PilZ adaptor protein.

4 via the appropriate receptors and the MyD88 adaptor protein.

5 terleukin-1 receptor (TIR) domain-containing adaptor protein.

6 f an enzyme target indirectly through a PilZ adaptor protein.

7 by the PDZ-protease Prc bound to its cognate adaptor protein.

8 cturally conserved between COPI and clathrin/adaptor proteins.

9 s, cGAS, and IFI16 as well as their proximal adaptor proteins.

10 oplasm after recruitment to mRNA by specific adaptor proteins.

11 nvolves a variety of signaling molecules and adaptor proteins.

12 motifs could be a common mechanism for PilZ adaptor proteins.

13 ical for interaction with the mu1 subunit of adaptor protein 1 and the major histocompatibility compl

14 The adaptor protein-1 complex (AP-1), which transports cargo

15 tions create potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold p

16 luorescence complementation reveals that the adaptor protein 14-3-3, known to bind to H3S10ph, intera

17 nd its sequestration in the cytoplasm by the adaptor protein 14-3-3.

18 Interaction of T-bet with the adaptor protein 14-3-3z in the cytosol of CD8(+) T cells

19 pid down-regulation of CD4 via the endocytic adaptor protein 2 (AP-2) complex, a process linked to en

20 identified as cargo proteins of the classic adaptor protein 2 (AP2) complex of the clathrin-mediated

21 Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathr

22 f predicted to recruit the clathrin adaptor, Adaptor protein 2 (AP2).

23 requires palmitoylation for interacting with adaptor protein-2 (AP-2) and AP-3, respectively, for tra

24 al cord slices and that it is carried out by adaptor protein-2 (AP-2) via clathrin-mediated endocytos

25 ere clathrin interacts with the membrane via adaptor proteins; 2) elongation, where the membrane is t

26 n AP3D1 that leads to destabilization of the adaptor protein 3 (AP3) complex.

27 Such is the case for SH2B adaptor protein 3 (SH2B3), which is a negative regulator

28 (HPS2) is a primary immunodeficiency due to adaptor protein-3 (AP-3) complex deficiency.

29 iated by the phagosomal trafficking molecule adaptor protein-3 (AP-3).

30 HgIA also required the adaptor protein-3 complex, which transports TLRs from th

31 AZ amplification loop lies downstream of the adaptor protein 3BP2, which is mutated in the craniofaci

32 When anchorage is disrupted, both the adaptor Protein 4.1B and the cytoskeleton protein betaII

33 absence of signaling via the IL-17 receptor adaptor protein Act-1, the protective effect of IL-17A w

34 abeling with BirA-Usp12 revealed several TCR adaptor proteins acting as interactors in stimulated cel

35 of PI4KB and its interacting partner, Golgi adaptor protein acyl-coenzyme A binding domain containin

36 itis, the expression of Gal3, NLRP3, and the adaptor protein adaptor apoptosis-associated speck-like

37 Recent studies identified the adaptor protein Ajuba as a positive regulator of Yes-ass

38 The modular adaptor protein ALIX is a key player in multiple ESCRT-I

39 spanin CD63, syntenin-1 and ESCRT-associated adaptor protein ALIX.

40 F receptor-associated factor 6 (TRAF6) is an adaptor protein and an E3 ubiquitin ligase that mediates

41 sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulate

42 Cdc37 cochaperone reaches beyond that of an adaptor protein and find that it participates in the sel

43 widely expressed clathrin binding endocytic adaptor protein and known for the endocytosis of the low

44 transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of an

45 (siRNA)-mediated silencing of TGN-associated adaptor proteins and a panel of dominant negative (DN) R

46 motes recruitment of the Nck1/2 cytoskeletal adaptor proteins and downstream actin remodeling.

47 itment and stabilization of clathrin-binding adaptor proteins and the clathrin coat.

48 The aim of this study was to investigate the adaptor proteins and the signaling interactions that med

49 of Cdc48 to interact with a large number of adaptor proteins and to remodel macromolecular proteins

50 interaction of SHP2 with p85, independent of adaptor proteins and transfected FLAG-p85 provided evide

51 ification of IAP antagonists, unique caspase adaptor proteins, and mutually exclusive subcellular dom

52 molecular interactions among RNA molecules, adaptor proteins, and scaffold proteins.

53 ANK3, encoding the adaptor protein Ankyrin-G (AnkG), has been implicated in

54 that are important for binding the clathrin adaptor proteins AP-1 and AP-2in vitro Surprisingly, mut

55 taining phagosomes via interactions with the adaptor proteins AP-1 and GGAs.

56 AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family involved in protein

57 eracts with clathrin and clathrin associated adaptor protein (AP) complexes as loss of either protein

58 in platelets from mouse HPS models that lack adaptor protein (AP)-3 or biogenesis of lysosome-related

59 GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in the endocyt

60 AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatiti

61 rotein 3 (NLRP3) inflammasome to recruit the adaptor protein apoptosis-associated speck-like protein

62 ral cages during endocytosis is regulated by adaptor proteins (APs).

63 Adaptor proteins are a class of cytoplasmic proteins tha

64 Adaptor proteins are found to regulate the formation of

65 Transmembrane adaptor proteins are molecules specialized in recruiting

66 CD2AP in inflamed vessels, identifying this adaptor protein as a potential therapeutic target.

67 ulation of caspase-1 activation requires the adaptor protein ASC (apoptosis-associated speck-like pro

68 can assemble inflammasome complexes with the adaptor protein ASC and caspase-1 that result in the act

69 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to th

70 cted macrophages was dependent on NLRP3, its adaptor protein ASC, or caspase 1, the cleavage of intra

71 s found to occur independently of NLRP3, its adaptor protein ASC, or caspase 1.

72 ivated caspase-1 by recruiting NLRP3 and its adaptor protein ASC.

73 es and forms inflammasome complexes with the adaptor proteins Asc and caspase-1 to promote the matura

74 The inflammasome adaptor protein, ASC, contributes to both innate immune

75 catalytic subunit of the DUB module, but two adaptor proteins, ATXN7L3 and ENY2, are necessary for DU

76 During TCR signaling, the adaptor protein Bcl10 is inducibly recruited to the CARD

77 and by association with the multifunctional adaptor protein beta-arrestin2.

78 ces for binding other regulators, either the adaptor protein Bicaudal-D2 (BicD2) or the multifunction

79 During CME, endocytic adaptor proteins bind cargoes at the cell surface and li

80 Second, fusion kinase inhibition shifted adaptor protein binding from the fusion oncoprotein to E

81 cts constitutive phosphorylation of BCAP, an adaptor protein bridging PI3K and TLR pathways.

82 riers by interaction of sorting signals with adaptor proteins, but proteins in the other domain exit

83 entially associates with GluN2B and with the adaptor protein Ca(2+)/calmodulin-dependent serine prote

84 Here the authors show that unique caspase adaptor proteins can regulate caspase activity within mu

85 We show that p62, an autophagic adaptor protein, captures A20 to sequester it in the aut

86 ing through these receptors converged on the adaptor protein CARD9, a component of the CARD9-Bcl10-MA

87 rdiomyocytes, where it is sequestered by the adaptor protein CARP in a multiprotein complex together

88 Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous

89 model of collateral sprouting identified the adaptor protein CD2-associated protein (CD2AP; human CMS

90 The adaptor protein CD2AP-mediated internalization following

91 e of the Zc3h12a mRNA via interaction of the adaptor protein CIKS with the DEAD box protein DDX3X.

92 ied a novel interaction between PP2Ac and an adaptor protein CIN85 (Cbl-interacting protein of 85 kDa

93 betaRI interacts with the SH3 domains of the adaptor protein CIN85 in response to TGFbeta stimulation

94 The adaptor protein CIN85 is a partner of Cbl that augments

95 iated with phosphorylation of the checkpoint adaptor protein Claspin and activation of the Chk1 effec

96 We also demonstrated that the adaptor protein ClpS, an essential regulator of ATP-depe

97 P-dependent chaperones ClpC and ClpD, and an adaptor protein, ClpS1.

98 toward the subendothelial matrix, using the adaptor protein complex 1 (AP-1), where it may provide t

99 we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippo

100 Here, we find that the adaptor protein complex-1 (AP-1) mediates trafficking of

101 lar loop of PAR4 and found that the clathrin adaptor protein complex-2 (AP-2) is important for intern

102 stitutive internalization is mediated by the adaptor protein complex-2 (AP-2), whereas AP-2 and epsin

103 ct interactions with the clathrin-associated adaptor protein complexes (APs) in C. elegans.

104 These findings show that 14-3-3 adaptor protein complexes are druggable targets and iden

105 Heterotetrameric adaptor protein complexes are important mediators of car

106 owed by recruitment of SH2 domain-containing adaptor proteins constitutes a central mechanism of intr

107 Here, we show that the rab5 effector APPL1 (adaptor protein containing pleckstrin homology domain, p

108 ent with the role of Xrs2 as a chaperone and adaptor protein coordinating interactions between the MR

109 Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10 regulator of kinase II (CrkII), r

110 Unexpectedly, the periplasmic adaptor protein CusB is a key metal-sensing element that

111 Loss of the adaptor protein cyclin-dependent kinase regulatory subun

112 d abundance of megalin and its intracellular adaptor protein Dab2 by immunofluorescence microscopy in

113 CSF1R, we found that the microglial membrane adaptor protein DAP12 was required for both nerve injury

114 moving processively towards minus ends in an adaptor protein-dependent manner.

115 Here, we have identified the adaptor protein disabled homolog 2 (DAB2) as a regulator

116 this network in Drosophila We find that the adaptor protein Disabled stimulates Abl kinase activity.

117 Mechanistically, Siglec-1 associates with adaptor protein DNAX-activation protein of 12 kDa (DAP12

118 in-1, transportin-3, importin-13) or through adaptor proteins (e.g., importin-alpha, snurportin-1, sy

119 f its enzymatic activity, MICAL3 targets the adaptor protein ELKS and Rab8A-positive vesicles to the

120 e endocytosed in signal-sending cells by the adaptor protein Epsin.

121 kinase RIPK1, the pseudokinase MLKL, and the adaptor protein FADD, and forms independently of signali

122 C4 and its H443P mutant are dependent on the adaptor protein FADD.

123 The FE65 adaptor proteins (FE65, FE65L1 and FE65L2) bind proteins

124 a yeast two-hybrid screen and identified the adaptor protein, FHL2, as a novel binding partner that i

125 Arrestin2 (Arr2) is a ubiquitous scaffolding/adaptor protein first characterized as a regulator of G

126 Cingulin is an adaptor protein first discovered in epithelium and is in

127 KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase.

128 We propose that Pet309 acts as an adaptor protein for Mss116 action on the COX1 mRNA 5-UTR

129 rial antiviral-signaling protein (MAVS), the adaptor protein for RIG-I like receptor in regulating ho

130 rial antiviral signaling protein (MAVS), the adaptor protein for RIG-I-like receptor in regulating ho

131 HO-2 was also found to bind TRAM, an adaptor protein for Toll-like receptor 4 (TLR4), and the

132 that skin hyperplasia requires FGF receptor adaptor protein Frs2alpha and tyrosine phosphatase Shp2,

133 In non-neuronal cells, CD2AP, like other adaptor proteins, functions to selectively control the s

134 pproach identified the SH2 domain-containing adaptor protein GADS as the dominant interaction partner

135 This may occur due to interference with the adaptor protein GGA1-mediated trans Golgi network-to-end

136 ains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycli

137 receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to sti

138 rt the high-resolution structure of the tail adaptor protein gp7 from phage Sf6.

139 nce that Drk, the Drosophila ortholog of the adaptor protein Grb2, is essential for ARM within adult

140 Themis2 constitutively bound the adaptor protein Grb2, src-kinase Lyn and signal transduc

141 CABIT domain of Themis and indirectly to the adaptor protein Grb2, with the latter interaction enabli

142 Near the cell membrane, an adaptor protein GRIP1, which can associate with EFNB2, w

143 the absence of extracellular stimulation the adaptor protein growth factor receptor-bound protein (Gr

144 The small adaptor protein growth factor receptor-bound protein 2 (

145 h factor receptor (EGFR) and the cytoplasmic adaptor protein growth factor receptor-bound protein 2 (

146 rom decreased postsynaptic expression of the adaptor protein Homer1, which is necessary for coupling

147 Imd is a receptor-proximal adaptor protein homologous to mammalian RIP1 that is reg

148 is negatively regulated by an actin-binding adaptor protein, i.e., CD2AP, to allow a balanced and sp

149 ntrinsic dual activity of MDA-5 required the adaptor protein IFNbeta promoter stimulator 1 (IPS-1, MA

150 PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-kappaB

151 s, including CRKLCRKL encodes a src-homology adaptor protein implicated in mediating tyrosine kinase

152 ide insight into the mechanistic role of the adaptor protein in mediating the sequential assembly of

153 We further show that TRIF, an adaptor protein in Toll-like receptor signaling, activat

154 lete disruption of DNA damage response (DDR) adaptor proteins in ETI cells causes severe growth defec

155 Adaptor proteins in the insulin/insulin-like-growth fact

156 n of T cells (LAT) leading to recruitment of adaptor proteins, including Grb2, is one prototypical ex

157 NFalpha), CCL2, CXCL10, IL6R, and SQSTM1, an adaptor protein involved in nuclear factor kappa-light-c

158 MyD88 is an adaptor protein involved in proinflammatory signaling.

159 dynamics of the N-terminal domain that binds adaptor proteins involved in controlling p97 function.

160 The Grb7 adaptor protein is a therapeutic target for both TNBC an

161 Cleavage of a Rab adaptor protein is thus a mechanism by which viruses mod

162 However, since CusB is an adaptor protein, its role in operating this system is si

163 rins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the

164 r cysteine (C151) of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEA

165 nterfering with a putative synaptic tag, the adaptor protein KIBRA, which protects the atypical PKM f

166 The integrin-activating adaptor protein kindlin-2 plays a central role for cell

167 nd that CUL3 interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), t

168 , recruits a complex of SLP65/SLP76 and Grb2 adaptor proteins, known to be involved in the activation

169 nals in the cytosolic tails of the cargos by adaptor proteins, leading to cargo packaging into coated

170 erate intracellular signals, the immune cell adaptor protein linker for the activation of T cells (LA

171 aryotic cells which involves clathrin and/or adaptor proteins, lipid kinases, phosphatases and the ac

172 s-of-function mutations in the gene-encoding adaptor protein LNK (also known as SH2B3) are found in P

173 he findings in hematologic malignancies, the adaptor protein LNK acts as a positive signal transducti

174 egulate JAK2 stability and signaling via the adaptor protein LNK/SH2B3.

175 Here, we present the structure of the PilZ adaptor protein MapZ cocrystallized in complex with c-di

176 we identified the extracellular matrix (ECM) adaptor protein Matrilin-4 (Matn4) as an important negat

177 g that either other nucleocapsid proteins or adaptor proteins may be required.

178 The GIPC family adaptor proteins mediate endocytosis by tethering cargo

179 This adaptor protein-mediated dynamic pump assembly allows th

180 ), a 4.1R-ezrin-radixin-moesin (FERM) domain adaptor protein, mediates numerous cellular responses, i

181 gy, causing abnormal accumulation of p62, an adaptor protein mediating NF-kappaB activation.

182 RIG-I, as well as the adaptor protein mitochondrial antiviral signaling protei

183 ly promotes Drp1 binding to the MOM resident adaptor protein mitochondrial fission factor (Mff).

184 and identified the Toll-like receptor (TLR) adaptor protein MYD88 as a key regulator of the antiprol

185 and the recruitment of the death domain (DD) adaptor protein MyD88 into an oligomeric post receptor c

186 The adaptor protein MYD88 is critical for relaying activatio

187 Most of the TLRs exploit the universal adaptor protein MyD88 to activate NF-kappaB.

188 TLR2 and its downstream adaptor protein MyD88 were required for IAPP-induced cyt

189 oll-interleukin 1 receptor domain containing adaptor protein)-MyD88-IRAK (interleukin-1 receptor-asso

190 mplexes consisting of a class VII myosin and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and

191 The adaptor proteins Nck1 and 2 are known regulators of cyto

192 events, including recruitment of cytoplasmic adaptor proteins Nck1 and Nck2 that regulate actin cytos

193 that Rai/ShcC, a member of the Shc family of adaptor proteins, negatively regulates Th17 cell differe

194 olated the G-protein-coupled receptor (GPCR)-adaptor protein Norbin (Neurochondrin, NCDN) from mouse

195 hanism of P-Rex1 regulation through the GPCR-adaptor protein Norbin, a direct P-Rex1 interacting prot

196 One autophagic adaptor protein not previously identified in sIBM was FY

197 nd requires the CUL3-based E3 ligase and its adaptor proteins, NPR3 and NPR4, which are receptors for

198 We find that the endosomal adaptor protein Numb regulates levels of Notch receptor

199 ly down-regulated protein 4) and endocytosis adaptor proteins Numb and epidermal growth factor recept

200 Here, we have found that the endocytic adaptor proteins NUMB and NUMBL were required for downre

201 mal protein 68 (Cep68), and the cytoskeletal adaptor protein obscurin-like 1 protein (OBSL1) as putat

202 Dab2, an adaptor protein of clathrin-mediated endocytosis, is not

203 E Bet1 but increases its binding to p47, the adaptor protein of p97.

204 EEVD(Hsp70) binds adaptor proteins of the Hsp90 chaperone system and mitoc

205 the regulatory dominance of the melanophilin adaptor protein over its associated motor and offer an u

206 Subchronic L-DOPA increases levels of adaptor protein p11 (S100A10) in dopaminoceptive neurons

207 It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of E

208 tigated whether epigenetic regulation of the adaptor protein p66(Shc), a key driver of mitochondrial

209 ere, we assessed the contribution of the SH2 adaptor protein p66Shc (encoded by Shc1) in regulating r

210 These results establish the adaptor protein p66Shc as a regulator of renal vascular

211 Adaptor proteins participate in selective autophagy, whi

212 cal adhesion kinase (FAK) and the downstream adaptor protein paxillin (PXN), resulting in enhanced ce

213 via its receptor roundabout4 (Robo4) and the adaptor protein, Paxillin were involved in reducing BBB

214 MYO6 is present on peripheral adaptor protein, phosphotyrosine interacting with PH dom

215 d c.280G>A [p.Asp94Asn]) in the gene for the Adaptor Protein, Phosphotyrosine Interaction, PH domain,

216 ouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysf

217 Recent work has suggested that adaptor proteins provide a mechanism for cargo-specific

218 Mutations in the adaptor protein PSTPIP2 are the cause of the autoinflamm

219 the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation a

220 ssays showed that suppression of AP2M1 (AP-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting

221 ranches of the pathway, in that mTORC1 (with adaptor protein Raptor) is the main complex mediating th

222 Spata2 (spermatogenesis-associated 2) is an adaptor protein recruited into the TNF-RSC to modulate t

223 The Nck adaptor protein recruits cytosolic effectors such as N-W

224 The 14-3-3 family of adaptor proteins regulate diverse cellular functions inc

225 lar targets other than TIR domain-containing adaptor protein remain unclear.

226 and function of islets, whereas mTORC2 (with adaptor protein Rictor) impacts islet mass and architect

227 viral infection causes cleavage of the Rab7 adaptor protein RILP (Rab interacting lysosomal protein)

228 kinase MLKL, and apoptosis, dependent on the adaptor proteins RIPK1 and FADD.

229 at SLE T cells display reduced levels of the adaptor protein SAP, probably as a result of continuous

230 nks the two ATPase heads, and the Scc1-bound adaptor protein Scc3.

231 dies have shown that increased levels of the adaptor protein Sequestosome 1/p62 are observed in human

232 t 4E-BP2 deletion induces translation of the adaptor protein SH2B1 and promotes the formation of a co

233 ted the possibility that the phosphotyrosine adaptor protein ShcA regulates nephrin turnover.

234 The adaptor protein SLP-76 is recruited to the phosphorylate

235 rylation on Y783 by a specific region of the adaptor protein, SLP-76.

236 l the molecular basis for how dynein and its adaptor protein Spindly are recruited to the ROD-Zw10-Zw

237 w that increased expression of the autophagy adaptor protein, SQSTM1/p62, is associated with poor res

238 The adaptor protein Src homology 2 domain-containing leukocy

239 ne monophosphate synthase and the downstream adaptor protein stimulator of IFN genes (STING).

240 cyclic dinucleotide 2',3'-cGAMP can bind the adaptor protein STING (stimulator of interferon [IFN] ge

241 pathway upon binding to the homodimer of the adaptor protein STING on the surface of endoplasmic reti

242 econd messenger that binds and activates the adaptor protein STING to induce type I interferons (IFNs

243 The adaptor proteins STING (stimulator of IFN genes), MAVS (

244 Adaptor proteins such as receptor-interacting serine/thr

245 Upon ligand binding, TLRs and IL-1Rs recruit adaptor proteins, such as myeloid differentiation primar

246 Here, we show that the adaptor protein TAX1BP1 functions as a negative regulato

247 lex virus 1 (HSV-1) interacts with CIN85, an adaptor protein that augments Cbl functions.

248 malian actin-binding protein-1 (mAbp1) is an adaptor protein that binds actin and modulates scission

249 of multiple proteins, among which is a tail adaptor protein that connects the portal protein to the

250 CusB is an adaptor protein that connects the two membrane proteins

251 n receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 recep

252 p66shc is a growth factor adaptor protein that contributes to mitochondrial ROS pr

253 SQSTM1 is an adaptor protein that integrates multiple cellular signal

254 receptor substrate-1 (IRS-1) is a signaling adaptor protein that interfaces with many pathways activ

255 f wild-type two-pronged binding of the UBXD1 adaptor protein that is impaired in disease; this underl

256 microtubules with the aid of dynactin and an adaptor protein that joins dynein and dynactin into a st

257 ation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and in

258 known as RAIDD) is a death-domain-containing adaptor protein that oligomerizes with PIDD and caspase-

259 uitment domain family member 10 (Card10), an adaptor protein that participates in activation of the I

260 iated factor 2 (TRAF2) is a second messenger adaptor protein that plays an essential role in propagat

261 Vinculin (Vn) is a major adaptor protein that regulates focal adhesions in conjun

262 demonstrated that expression of Talin-1, an adaptor protein that regulates LFA-1 affinity, dictated

263 r-binding protein 3), a multidomain clathrin adaptor protein that sorts cargo proteins at the trans-G

264 We show that NSD3-short is an adaptor protein that sustains leukemia by linking BRD4 t

265 ase (ILK) is a multifunctional intracellular adaptor protein that transmits extracellular signals to

266 ent specificity of the proteases and through adaptor proteins that alter the spectrum of substrates.

267 FE65 and FE65L1 are cytoplasmic adaptor proteins that bind a variety of proteins, includ

268 llular proteins are dimeric, multifunctional adaptor proteins that bind to and regulate the activitie

269 llin and Hic-5 are homologous focal adhesion adaptor proteins that coordinate cytoskeletal rearrangem

270 hat CLIP170 interacts with the TLR2 and TLR4 adaptor protein TIRAP.

271 oll interleukin 1 receptor domain-containing adaptor protein (TIRAP) were genotyped in 139 patients w

272 TLRs interact with the TIR domain-containing adaptor protein (TIRAP), triggering a signaling cascade

273 The adaptor protein TNF receptor associated factor (TRAF) 3

274 The adaptor protein TNF receptor-associated factor 3 (TRAF3)

275 The adaptor protein TNF receptor-associated factor 3 (TRAF3)

276 hosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex.

277 r the tail nozzle only after the assembly of adaptor protein to the portal.

278 and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordina

279 ytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of

280 IL-17R (SEFIR) domain of IL-17RD targets TIR adaptor proteins to inhibit TLR downstream signalling th

281 facilitating the recruitment of cytoskeleton adaptor proteins to mediate pathogen uptake.

282 n 2) and the isolated PTB domain of Shc (SHC adaptor protein) to the EGF receptor.

283 erentiation primary response protein 88, and adaptor protein Toll/IL-1 receptor domain-containing ada

284 We further identified that muXg elevated the adaptor protein TRAF-6 and fusion genes OC-STAMP and DC-

285 The adaptor protein TRAF6 has a central function in Toll-lik

286 Moreover, the toll-like receptor signaling adaptor protein TRIF (TIR-domain-containing adapter-indu

287 nt cytokine production by promoting the TLR3 adaptor protein TRIF-assembled signalling complex.

288 caspase-8, which are engaged by TLR4 and the adaptor protein TRIF.

289 screenings, we report that the mitochondrial adaptor protein tripartite motif (TRIM)14 provides a doc

290 -like protein necroptotic signaling with the adaptor protein tumor necrosis factor receptor-associate

291 ion and phagocytosis through coupling to the adaptor protein TYRO protein-tyrosine kinase-binding pro

292 ne exchange factors, kinases, scaffolding or adaptor proteins, ubiquitin ligases, phosphatases and pa

293 homology to mammalian macromolecular complex adaptor proteins was identified.

294 rowth-factor-receptor-bound protein 2 (GRB2) adaptor protein, which drives IL-17 expression by activa

295 , a Cullin-3/Rbx1 ubiquitin ligase substrate adaptor protein, which mediates the ubiquitination and p

296 Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions.

297 riasis susceptibility gene encoding Act1, an adaptor protein with ubiquitin ligase activity that coup

298 ce of an association of native neuronal AP-2 adaptor proteins with Slack channels, facilitated by a d

299 kinase cascade through association with the adaptor protein WTIP.

300 (RHIM) in RIPK1 prevents the RHIM-containing adaptor protein ZBP1 (Z-DNA binding protein 1; also know