ライフサイエンスコーパス: alkylation

1 ted alkenes undergoes radical defluorinative alkylation.

2 lem, often resulting in varying amounts of N-alkylation.

3 atropisomeric biaryls by a cation-directed O-alkylation.

4 tionship was set via a Nicholas-type enolate alkylation.

5 ladium(0)-catalyzed branch-selective allylic alkylation.

6 cyclopropane are essential for efficient DNA alkylation.

7 lkylation and palladium(0)-catalyzed allylic alkylation.

8 this reaction channel compared to that of O-alkylation.

9 tive acrylate addition or asymmetric allylic alkylation.

10 activity by an episulfonium ion-mediated DNA alkylation.

11 motifs to prepare using conventional enolate alkylation.

12 sometimes showing competitive Friedel-Crafts alkylation.

13 e, becoming more unfavorable with increasing alkylation.

14 l, followed by intramolecular Friedel-Crafts alkylation.

15 iastereoselective enolate hydrogen borrowing alkylation.

16 ause environmental chemicals may trigger DNA alkylation.

17 enolates, leading to highly atropselective O-alkylation.

18 ling mechanism for sensing damage induced by alkylation.

19 is demonstrated for both linear and branched alkylations.

20 ssues associated with related Friedel-Crafts alkylations.

21 pplied to hydrodefluorinative Friedel-Crafts alkylations.

22 involved a domino process of Friedel-Crafts alkylation, 1,4-AlCl3 shift, transesterification, and pr

23 onalization of enaminone precursors, such as alkylation; 1,2- 1,3-, or 1,4-addition; and C-O bond for

24 Most crucially, we demonstrate that N-alkylation activates the otherwise unreactive amide bond

25 ivatives and evaluated their DNA binding and alkylation activity.

26 Loss of this subunit impedes alkylation adduct repair kinetics and increases sensitiv

27 Enzymatic approaches for locating alkylation adducts at single-base resolution in DNA coul

28 n at the 2-position undergo intramolecular N-alkylation after activation of the primary alcohol, and

29 duct contradicts the traditional view that S alkylation always forms the initial reaction of GSH with

30 As for the gallium-catalyzed Friedel-Crafts alkylation, an unusual concerted SEAr mechanism involvin

31 in five steps via an enantioselective ketone alkylation and a diastereoselective pinacol cyclization.

32 sulfonamides could be further elaborated by alkylation and arylation similarly to nitrobenzenesulfon

33 ough additional reactor modules performing N-alkylation and arylation, deprotection, and amidation to

34 in both copper-catalyzed asymmetric allylic alkylation and copper-catalyzed asymmetric borylation.

35 irreversibly damage proteins and DNA through alkylation and cross-linking and interfere with redox ho

36 w how RNA Pol II copes with minor-groove DNA alkylation and establishes a mechanism for drug resistan

37 uence of selective gamma-deprotonation/alpha-alkylation and palladium(0)-catalyzed allylic alkylation

38 reactive radical species that can engage in alkylations and arylations.

39 polymerization that otherwise plagues these alkylations and generates a reactive metalated nitrile f

40 After online reduction, alkylation, and digestion with trypsin, the digests were

41 he mechanisms of Ni-catalyzed C-H arylation, alkylation, and sulfenylation with N,N-bidentate directi

42 ells is largely driven by initial on-rate of alkylation; and (3) evaluating the consequences of prote

43 d from these precursors in high yields in an alkylation/annulation sequence.

44 ten being obtained, this net decarbonylative alkylation approach becomes particularly useful.

45 reliminary studies on the asymmetric allylic alkylation are promising.

46 Regioselective N1-alkylation, -arylation, and -heteroarylation of 3-substi

47 By alkylation assays, we demonstrate that VKOR is required

48 addition of Grignard reagents followed by N-alkylation at position 1 afforded the 1,7,7-trisubstitut

49 l ether does not significantly contribute to alkylation at the aromatic ring.

50 or five different photoredox reactions (beta-alkylation, beta-aminoalkylation, dehalogenation, amine

51 Protein and DNA alkylation by endogenously produced electrophiles is ass

52 The major product of DNA alkylation by NMs is a cationic NM-N7-dG adduct that can

53 stablish that photoinduced, copper-catalyzed alkylation can also be applied to C-C bond formation, sp

54 sented include, among others, Friedel-Crafts alkylation, carbonylation, polymerization, cyclization,

55 ole C3 position greatly improved the allylic alkylation chemistry and enabled a highly efficient Negi

56 ubstrates in Pd-catalyzed asymmetric allylic alkylation chemistry facilitates rapid access to multipl

57 stems were accessed using nitrile lithiation/alkylation chemistry while the methyl-substituted spirop

58 tion damage is particularly important, since alkylation chemotherapy is one of the most widely used s

59 rates, and provides multiple new targets for alkylation chemotherapy sensitization of tumors.

60 rations including a one-pot Pomeranz-Fritsch alkylation/cyclization and an Ullmann-type lactone ring

61 s that mediate recognition and repair of DNA alkylation damage is particularly important, since alkyl

62 revealed that base excision repair (BER) of alkylation damage is significantly modulated by chromati

63 Alkylation damage resistance, which is critical in cance

64 roducts), ethyl methanesulfonate (generating alkylation damage), mitomycin C (generating interstrand

65 ndent pathway induced specifically to repair alkylation damage, shedding light on the molecular mecha

66 promotes high-fidelity bypass of MMS-induced alkylation damage, such as N3-methyladenine, as well as

67 nduces its own expression upon repairing DNA alkylation damage, we found that undamaged cells on aver

68 acts as a tumor suppressor in the setting of alkylation damage.

69 ecessary for cytotoxicity in response to DNA alkylation damage.

70 n that protects the bacterial genome against alkylation damage.

71 iety of DNA lesions, including oxidative and alkylation damage.

72 log (ALKBH) enzymes activity and induces DNA alkylation damage.

73 trand break damage resulting from oxidation, alkylation, deamination, and spontaneous hydrolysis.

74 tituent at the 6-position, an intermolecular alkylation/desilylation provides endocyclic unstabilized

75 Additionally, an intramolecular alkylation/desilylation/cycloaddition sequence provides

76 Moreover, an intramolecular alkylation/desilylation/cycloaddition sequence with the

77 reocenter was set by using direct asymmetric alkylation enabled by a C2-symmetric tetramine and lithi

78 y identified and quantified 398 aHNE protein alkylation events (386 cysteine sites and 12 histidine s

79 ation with super-resolution imaging, protein alkylation events may be registered and individually cou

80 Importantly, comparison of the alkylation fingerprint with that generated from an artem

81 racemic form via diastereoselective malonate alkylation followed by C- to N-transposition.

82 uted 1,2-dihydropyridines via protonation or alkylation followed by desilylation.

83 Furthermore, bis-alkylation has also been achieved using para-substituted

84 hesis of beta-mannopyranosides by anomeric O-alkylation has been developed.

85 g agents, the use of unactivated olefins for alkylations has become attractive from both cost and sus

86 Imine carbon alkylation identified a methyl/ethyl binding pocket that

87 Here we show how different forms of DNA alkylation impair transcription by RNA Pol II in cells a

88 n the gas phase, avoiding chemical reduction/alkylation in solution.

89 hich would otherwise have contributed to the alkylation in the kinetically relevant step.

90 ically improved by boron alkylation, whereas alkylation in the meso-methyl position has no effect.

91 ble and increase in strength with increasing alkylation, indicating favorable sp(3)C-amide sp(2)N and

92 in the presence of LDA, followed by in situ alkylation-intramolecular condensation of the resulting

93 The regioselectivity toward C-alkylation is explained by the much larger exothermicity

94 In DMF, O-alkylation is faster than retroaldol-aldol rearrangement

95 The sp(3) C-H alkylation is highly selective for the alpha-C-H of amin

96 Alkylation is predominantly observed within mitochondria

97 catalytic enantioselective formal C(sp(2))-H alkylation is reported.

98 In THF, O-alkylation is slower than rearrangement, giving selectiv

99 An especially challenging alkylation is that of unactivated esters and amides.

100 nd activated alkyl halides in basic media (O-alkylation) is superseded by a pathway leading to carbin

101 lishes the highly selective photoredox alpha-alkylation/lactonization of alcohols with methyl acrylat

102 hen paired with dT or dA and suggest that N7 alkylation may alter the base pairing patterns of guanin

103 absence, are conditions under which the same alkylation may lead to beneficial catalytic activity.

104 n with a new deborylative conjugate addition-alkylation method enables a one-pot procedure in which m

105 have been synthesized via a direct two-step alkylation method.

106 Because conventional radical-based alkylation methods require the use of stoichiometric oxi

107 ttern of reactivity, including both C- and O-alkylation, Michael addition via C-5 to an acetylenic es

108 Protonation and alkylation occur either at the metal or the ligand, depe

109 , Claisen rearrangement, ene reaction, and O-alkylation occurred in high yields.

110 Protonation and alkylation of (Idipp)Si horizontal lineSi(Idipp) (1) aff

111 concise and novel method for site-selective alkylation of 1,3,6',3''-tetraazidokanamycin has been de

112 azoles analogues has been achieved involving alkylation of 2-bromo-1-(phenylsulfonylmethyl)arene/hete

113 A Rh(III)-catalyzed highly efficient C6-alkylation of 2-pyridones has been achieved successfully

114 through LiClO4-catalyzed Friedel-Crafts-type alkylation of 2-vinylindoles with activated aziridines f

115 nexpected retroaldol-aldol reaction during O-alkylation of a beta-hydroxy lactam was found to be high

116 l acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporat

117 utive coupling reactions, namely a selective alkylation of a dienolate and a Heck reaction, are the k

118 s the first example of the direct asymmetric alkylation of a nitrile anion.

119 acrynic acid inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.

120 The method features sequential reduction and alkylation of a peptide on solid phase combined with seq

121 This method allows for the alpha-C-H alkylation of a variety of substituted pyrrolidines, pip

122 The asymmetric alkylation of acyclic ketones is a longstanding challeng

123 eported enantioselective photochemical alpha-alkylation of aldehydes with electron-poor organic halid

124 ic substitution reaction, the selective mono-alkylation of aliphatic amines by unactivated, hindered

125 y enantioselective rhodium-catalyzed allylic alkylation of allyl benzoate with alpha-substituted benz

126 n we report an iron phthalocyanine-catalyzed alkylation of allylic and benzylic C(sp(3))-H bonds.

127 A catalytic, enantioselective gamma-alkylation of alpha,beta-unsaturated malonates and ketoe

128 ion, the thiourea-catalyzed enantioselective alkylation of alpha-chloroethers, is detailed.

129 o promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well

130 A convenient, practical and green N-alkylation of amines has been accomplished by applying r

131 a redox-neutral cascade for the biocatalytic alkylation of amines using primary and secondary alcohol

132 first example of the direct enantioselective alkylation of an aldehyde enolate per se.

133 formation, hydrocupration of an alkyne, and alkylation of an alkenyl copper intermediate.

134 entiating step involves a diastereoselective alkylation of an alpha-monosubstituted malonate-imidazol

135 Regioselective O-alkylation of an amide to form the corresponding imidate

136 Although the alkylation of an amine by an alkyl halide serves as a "t

137 and enantioselective iridium-catalyzed alpha-alkylation of an extended enolate, and a subsequent tran

138 ndoles that usually require preformation and alkylation of an indole precursor.

139 The para-selective C-H alkylation of aniline derivatives furnished with a pyrim

140 A phase transfer catalyzed asymmetric alkylation of anthrones with cyclic allylic bromides usi

141 a variety of catalytic processes, including alkylation of aromatics, catalytic cracking, methanol-to

142 o be applicable to the C2-selective branched alkylation of azabenzimidazoles.

143 arbonyl auxiliaries for Ir(I) -catalyzed C-H alkylation of azacycles is described.

144 UII((4-11)) analogs 6-11 by routes featuring alkylation of azasulfuryl-glycine tripeptide precursors

145 catalytic system for the ortho-selective C-H alkylation of azines by acrylates and acrylamides is rep

146 or the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors.

147 Pd(II)-catalyzed ortho-alkylation of benzoic acids with both terminal and inter

148 talyzed azidation or amination and reductive alkylation of benzylazide by a helicenyl dichloroborane.

149 lladium(II)-catalyzed meta-C-H arylation and alkylation of benzylsulfonamide using 2-carbomethoxynorb

150 Direct nickel-catalyzed alkylation of chiral N-acyl-4-isopropyl-1,3-thiazolidine

151 he procedure suitable for the late-stage C-H alkylation of complex molecules.

152 and LDA allows a general deconjugative alpha-alkylation of cyclic alkenenitriles.

153 and nano-LC-MS/MS analysis, we confirmed the alkylation of Cys797.

154 Alkylation of cysteine residues in TG2 or inhibition of

155 ides and proteins through site-selective bis-alkylation of cysteine residues present as disulfides un

156 de bonds to enable tryptic digestion without alkylation of cysteine residues.

157 high optical purity (up to 98% ee) by alpha-alkylation of deprotonated alpha-aminonitriles derived b

158 The alpha-alkylation of deprotonated Strecker products derived fro

159 palladium-catalyzed decarboxylative allylic alkylation of differentially N-protected piperazin-2-one

160 a mode of RNA Pol II stalling that is due to alkylation of DNA in the minor groove.

161 ism and cancer chemotherapy can give rise to alkylation of DNA, and the resulting alkylated thymidine

162 lable menthol-derived sulfinate or the alpha-alkylation of enantiopure S-chiral alpha-sulfinyl benzoa

163 perhaps the most widely used reagent for the alkylation of free sulfhydryls in proteomic experiments.

164 oacetamide or disulfides, enabling selective alkylation of free thiols and site-specific analysis of

165 ethods exploit transition metals to catalyze alkylation of heterocycles with olefins via a C-H activa

166 -centered radical that can engage in the C-H alkylation of heterocyclic bases and 1,4-quinones.

167 The enantioselective N-alkylation of indole and its derivatives with aldimines

168 enzaldehydes, followed by iodine-catalyzed C-alkylation of indole with the Baylis-Hillman adducts.

169 The selective C3-alkylation of indoles with N-protected ethanolamines inv

170 I) catalyzed enantioselective Friedel-Crafts alkylation of indoles.

171 Moreover, selective tandem double alkylation of isopropanol is achieved by sequential addi

172 Although the alpha-alkylation of ketones has already been established, the

173 The alkylation of ketones is taught at basic undergraduate l

174 t a general method for the direct asymmetric alkylation of ketones remains an unmet target.

175 for intermolecular branched-selective alpha-alkylation of ketones using simple alkenes as the alkyla

176 ly applicable methodology for the asymmetric alkylation of ketones.

177 This anomeric O-alkylation of mannopyranose-derived lactols is proposed

178 e highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with anth

179 This compound was found to catalyze the alkylation of N-(diphenylmethylene)glycine cumyl ester i

180 Synthesis involved N(4)-alkylation of N-aryl-5-methylfuro[2,3-d]pyrimidin-4-amin

181 s, a mild and general catalytic method for C-alkylation of nitroalkanes with unactivated alkyl iodide

182 We report a method for the monoselective alkylation of ortho-C-H bonds of N-quinolyl benzamides w

183 Alkylation of P88H/Q152HMb with HNE accelerated metMb fo

184 An efficient Rh(III)-catalyzed ortho-alkylation of phenoxy substrates with diazo compounds ha

185 orane amino acid derivatives was achieved by alkylation of phenylphosphine borane with gamma-iodo-alp

186 y enantioselective rhodium-catalyzed allylic alkylation of prochiral alpha,alpha-disubstituted aldehy

187 ant permits extensive denaturation/reduction/alkylation of proteins and inactivation of endogenous pr

188 Reduction and alkylation of proteins either prior to or post subcritic

189 The intermolecular alkylation of pyridine units with simple alkenes has bee

190 x catalysis enables direct gamma- C(sp(3))-H alkylation of saturated aliphatic carbonyl compounds.

191 ysts; highly enantioselective phase transfer alkylation of several types of substrates including dihy

192 An intermolecular alkylation of sulfonamides with trichloroacetimidates is

193 and stereospecific rhodium-catalyzed allylic alkylation of tertiary allylic carbonates with alkenyl c

194 O-Alkylation of the C3 hydroxyl group generated novel 3-O-

195 ylated twisted amides prepared directly by N-alkylation of the corresponding non-planar lactams.

196 We have compared the graphene arylation and alkylation of the GIC using 4-tert-butylphenyldiazonium

197 e intermediates, but they could be caught by alkylation of the isomerization active thiol.

198 zation with excellent selectivity, through O-alkylation of the keto-enolate.

199 h the largely ignored experimental fact that alkylation of the N-H functionality within M/NH bifuncti

200 cupration of an alkyne by NHCCuH followed by alkylation of the resulting alkenylcopper intermediate b

201 -azide-omega-alkyne monomer and simultaneous alkylation of the resulting poly(1,2,3-triazole)s with a

202 Alkylation of this cysteine with a thioreactive reagent

203 K11007 stabilized p53 in vitro via selective alkylation of two surface-exposed cysteines without comp

204 port on the first base metal-catalyzed alpha-alkylation of unactivated amides and esters by alcohols.

205 rone by a process combining 1,4-addition and alkylation of vinylogous enolate to stereoselectively re

206 -tolerant catalyst for direct Friedel-Crafts alkylations of a variety of slightly activated and neutr

207 Enantioselective Pd-catalyzed allylic alkylations of dihydropyrido[1,2-a]indolone (DHPI) subst

208 ond formation, contrary to the already known alkylations of such ambident nucleophiles, is mostly tri

209 mical catalytic processes for Friedel-Crafts alkylations of unactivated arenes is an important object

210 Review summarizes transition-metal-catalyzed alkylations of various carbon-hydrogen bonds (addition o

211 However, the effect of the N7 alkylation on the hydrogen-bonding patterns of the guani

212 pidly assembles quaternary nitriles by three alkylations, only one of which requires an organometalli

213 nd mild one-pot protocols involving either O-alkylation or acidic microwave activation were developed

214 ogate, which can be synthesized using robust alkylation or alkenylation reactions, and thus obviates

215 ium PEG polyelectrolytes can be obtained via alkylation or alkoxylation of MTEGE, providing access to

216 ncipal type of transformation addressed: (1) alkylation or arylation, (2) core heteroatom replacement

217 pon hydrogenation or hydration, various beta-alkylation or beta-aldol products of the ketones are obt

218 on FGF2 surface cysteines as either chemical alkylation or substitution with alanines impairs these p

219 By combining an initial acylation, alkylation, or glycosylation step with an amine-mediated

220 The sulfonamide alkylation partner appears to be only limited by sterics

221 y is assigned on the basis of the determined alkylation pattern.

222 ochemical induction for the enantioselective alkylation process.

223 vinyl phenyl sulfones, whereas the saturated alkylation products were obtained in good yield with alp

224 The surprising stability of the chiral N-alkylation products will open new windows for asymmetric

225 and carbazole, to afford the corresponding N-alkylation products.

226 ABPP equivalent confirms a highly conserved alkylation profile, with both endoperoxide classes targe

227 oteins and subjected to automated reduction, alkylation, protein digestion, tandem mass tag (TMT) 6-p

228 strongly to plasma proteins, but a reduction/alkylation (R/A) procedure breaks this bond, enabling am

229 U, and subsequent sulfone-metal exchange and alkylation rapidly assembles quaternary nitriles by thre

230 egioselectivity of the anchimerically driven alkylation reaction depends on the nucleophiles.

231 ped this concept by performing the reductive alkylation reaction in monolayer CVD graphene films.

232 synthetic strategy based on a Friedel-Crafts alkylation reaction is developed for the textural engine

233 and regioselective iridium-catalyzed allylic alkylation reaction of prochiral enolates to form an all

234 ithiane-2,5-diol, and a domino Michael/alpha-alkylation reaction of the derived chiral dihydrothiophe

235 rations and geometries of two Frater-Seebach alkylation reaction products with long hydrocarbon chain

236 s-enables an enantioselective alpha-aldehyde alkylation reaction that employs simple olefins as coupl

237 ramolecular 1,4-addition-type Friedel-Crafts alkylation reaction to afford interesting complex molecu

238 enabling the development of a practical C-H alkylation reaction using 0.5 mol % Pd catalyst.

239 palladium-catalyzed decarboxylative allylic alkylation reaction using a novel bisphosphine ligand.

240 then is subjected to a sequential, one-pot N-alkylation reaction with N-allyl-N-(p-tosyl)amine and a

241 all known metallocorrole types and for the N-alkylation reactions are presented.

242 t) in palladium-catalysed asymmetric allylic alkylation reactions has proved to be extremely versatil

243 Transition-metal-catalyzed alkylation reactions of arenes have become a central tra

244 is Co catalyst class is also able to mediate alkylation reactions of both esters and amides.

245 ribe the state-of-the-art in terms of direct alkylation reactions of some carbonyl groups.

246 Alkylation reactions represent an important organic tran

247 process to accomplish mild, non-traditional alkylation reactions using alcohols as radical precursor

248 alpha-carbanions undergo diastereoselective alkylation reactions with alkyl halides to predominantly

249 P(n) and Si-OTP(n), can be used to carry out alkylation reactions with an array of different nucleoph

250 coupling, there is a growing demand for C-H alkylation reactions, wherein sp(3) C-H bonds are replac

251 We find that the alkylation repair complex ASCC (activating signal cointe

252 emotherapy, depends on the overexpression of alkylation repair proteins.

253 This C-H alkylation represents a catalytic variant of the Hofmann

254 tivated asymmetric alpha-amination and alpha-alkylation, respectively, of 2-acyl imidazoles catalyzed

255 vides the first experimental evidence that N-alkylation results in a dramatic increase of non-planari

256 ilic fatty acid nitroalkenes react with more alkylation-sensitive targets in TNBC cells to inhibit gr

257 tep 1,3-dipolar cycloaddition/intramolecular alkylation sequence.

258 (2) decarboxylative enantioselective allylic alkylation serves as a novel strategy to in effect acces

259 The alkylation signatures of the two chemotypes show signifi

260 The inversion of stereochemistry in the C-H alkylation step is consistent with a redox-neutral SN2 n

261 ious conclusions that the diastereoselective alkylation step proceeds via an alpha-substituted malona

262 Reduction and alkylation steps were not required.

263 omote subsequent C-H abstraction and radical alkylation steps.

264 otein quality control (PQC) aggregates under alkylation stress.

265 y enantioselective iridium-catalyzed allylic alkylation that provides access to products bearing an a

266 oach featuring a key decarboxylative allylic alkylation to access a crucial and highly congested 3,3-

267 tions with arenes proceeds as Friedel-Crafts alkylation to afford 1,1-diaryl-2-halo-3,3,3-trifluoropr

268 The first conjugate addition/alkylation to alkenyl isocyanides is described, which ad

269 actol donors is required for this anomeric O-alkylation to be efficient, probably because of its chel

270 Jung Diels-Alder reaction, an intramolecular alkylation to complete the 6-5-6-6 ring system, and a co

271 strategy incorporates an asymmetric allylic alkylation to construct the tert-alkyl aryl ether linkag

272 However, nucleobase modifications such as alkylation to the N2 position of guanine significantly i

273 uperseded by a pathway leading to carbinol C-alkylation under the conditions of rhodium-catalyzed tra

274 A catalytic C-H alkylation using unactivated alkyl halides and a variety

275 ng the door for an array of functional group alkylations using benign and readily available graphene

276 on, the Review is divided into two sections: alkylation via C-H activation and alkylation via olefin

277 The enzyme efficiently catalyzes its alkylation via either an allylic cation or a cationic tr

278 sections: alkylation via C-H activation and alkylation via olefin activation.

279 e a polarity-match-based selective sp(3) C-H alkylation via the combination of photoredox, nickel and

280 gh-valent iron oxos and nitrenes, C(sp(3))-H alkylations via isoelectronic iron carbene intermediates

281 um yields are dramatically improved by boron alkylation, whereas alkylation in the meso-methyl positi

282 -aminoethyl)-4,4'-bipyridinium bromine and N-alkylation with 2-bromoethylamine.

283 ridines, and tetrahydroisoquinolines through alkylation with alkenes.

284 y through catalytic asymmetric fluoroenolate alkylation with allylic acetates.

285 the arylation of heteroatom nucleophiles, O-alkylation with boronic acids is rare.

286 A simple and reliable protocol for amide O-alkylation with complete regioselectivity has been desig

287 ion mechanism of solid-acid-catalyzed phenol alkylation with cyclohexanol and cyclohexene in the apol

288 Phenol alkylation with cyclohexanol sets in only after a majori

289 n alkylating agent leads to atropselective O-alkylation with e.r.

290 ustrations of photoinduced, copper-catalyzed alkylation with either a carbon nucleophile or a seconda

291 ction of a quaternary carbon was achieved by alkylation with ethyl methacrylate.

292 automeric mixture, however, their subsequent alkylation with methyl iodide in the presence of potassi

293 Branched alkylation with N,N-dimethyl acrylamide was successfully

294 reactive carboxylic acid derivatives, toward alkylation with organomagnesium reagents.

295 reactant releases the product of carbinol C-alkylation with regeneration of the ketone.

296 d generates a reactive metalated nitrile for alkylations with a range of carbon and heteroatom electr

297 enantioselective palladium-catalyzed allylic alkylations with benzylic nucleophiles, activated with C

298 ared to the use of classical metal-catalyzed alkylations with toxic benzylic halides, this methodolog

299 380 enhanced only ACh potency after receptor alkylation, with no effect on maximal response, consiste

300 The use of phosphate notably improves the alkylation yield, although it may not be directly involv