ライフサイエンスコーパス: bases

1 ny complex phenotypes sharing common genetic bases.

2 nding of other nitrogen-containing acids and bases.

3 11-position and the C2-NH2 groups of guanine bases.

4 s and reveals their cognitive and anatomical bases.

5 known as chalcogen bonding (ChB), with Lewis bases.

6 ility rather than the pH itself or conjugate bases.

7 onsider the interdependencies of residues or bases.

8 eaction additives such as inorganic salts or bases.

9 the short sequence read length of 100 to 150 bases.

10 d into tetrazoles through the treatment with bases.

11 the stem, that are less tolerant of unpaired bases.

12 he free nucleoside, depending on neighboring bases.

13 ed affinity for ssNA structures with stacked bases.

14 ugh tautomerization and/or ionization of the bases.

15 s, nitrogen is usually associated with Lewis bases.

16 n ssDNA containing equal amounts of the four bases.

17 th motifs consisting of a stretch of thymine bases.

18 ey do not readily hydrolyze, nor bind to DNA bases.

19 proofreading by excision of misincorporated bases.

20 ed excision and repair of 5-carboxylcytosine bases.

21 glycosylases that recognize specific altered bases.

22 cyclic olefins (NHOs) as well as phosphazene bases.

23 upled to proton transfer to various pyridine bases.

24 ns in visual working memory and their neural bases.

25 ual numbers of correct and incorrect C and T bases.

26 ce, but rather is trimmed back three or more bases.

27 ell-characterized adducts with various Lewis bases.

28 using currently available genomic knowledge bases.

29 bulin gene mutation spectrum from G-C to A-T bases.

30 compounds (IOCs) such as weak acids and weak bases.

31 o-acid-like modifications on both pyrimidine bases.

32 s to form covalently linked adducts with DNA bases.

33 fts, while inhibitory inputs localize to the bases.

34 ics of RNA, particularly, the interaction of bases.

35 the human genome are methylated at cytosine bases.

36 olecular rotors of boron derived from Schiff bases: (2,4,8,10-tetra-tert-butyl-6-phenyldibenzo[d,h][1

37 DNA polymerase (pol) processivity, i.e., the bases a polymerase extends before falling off the DNA, a

38 Out of the five randomized bases, a 5' thymidine is present in most of the top rank

39 ed method was optimized by testing different bases, acids with varying concentrations of dinitropheny

40 matching bases, or also at directly adjacent bases, allowed 1-, 2-, or 3-bp substitutions in MMR-prof

41 engage in the C-H alkylation of heterocyclic bases and 1,4-quinones.

42 region-specific analysis determined that 81 bases and 100 drones would be required to deliver an AED

43 work across all regions required 39.5% fewer bases and 30.0% fewer drones to achieve similar AED deli

44 epair apparatus capable of repairing damaged bases and abasic sites.

45 determining the course of the reaction with bases and alkyl halides 3 are discussed.

46 llowed reactions to take place with nitrogen bases and alkyl halides 3 to give alpha-alkyl ketones 1(

47 tructure, including extrusion of consecutive bases and backbone distortions, with a sharp bending of

48 and childhood glaucomas have strong genetic bases and disease-causing mutations have been discovered

49 initiation dependent and another pool in the bases and necks of small spines that was initiation inde

50 d their upregulation in spine heads, but not bases and necks, during consolidation.

51 int mutations by mis-replication of oxidized bases and other lesions in the genome.

52 odulators (SLMs) to generate spatial optical bases and reconstruct N by N images over 16 spectral cha

53 4- and 5-arylethynyl water-soluble Mannich bases and related quaternary ammonium salts were synthes

54 scattered on sporangia that grow from their bases and release spores at their tips.

55 Interestingly, the targeting of C/G bases and the frequency of transition mutations at C/G b

56 econdary interactions between the nucleotide bases and the metal.

57 f this reaction is governed by the nature of bases and the reaction sequence.

58 Accumulation of oxidized DNA bases and their inefficient processing by base excision

59 ut they discard large amounts of uncorrected bases and thus lead to low throughput.

60 s colocalize with docked RNA granules at the bases and tips of new branches.

61 was expected for large structures (over 300 bases) and although a few strong localised restrictions

62 including a reaction intermediate, 2 Schiff bases, and 28 bis- or tris(pyrazol-3(4)-yl)methane ligan

63 tions from biological pathways and knowledge bases, and analysis of the covariance of ovary gene expr

64 rate that various solutions of copper salts, bases, and ancillary ligands can be utilized to elute [(

65 The sigma-holes are binding sites for Lewis bases, and binding energies correlate with the magnitude

66 is protocol is free from ligands, additives, bases, and cocatalysts.

67 DNA repair enzymes that displace mismatched bases, and is differentiated from other DNA-targeted che

68 gands of the type R1R2NMgX, so-called Hauser bases, and their Turbo analogue R1R2NMgX.LiCl play an ou

69 The element is 11 bp long, hundreds of bases apart from the WRE, and exhibits a suppressive eff

70 In prokaryotes, modified bases appear primarily to be part of an arms race betwee

71 Strong bases are avoided in this desaturation approach, and the

72 ng chromatin, and allow repair when oxidized bases are induced in the genome.

73 The bases are labeled crystallographic hexagons.

74 le formation on temperature for all of these bases are negative.

75 Its neurophysiological bases are not known.

76 Posttranscriptional modifications of RNA bases are not only found in many noncoding RNAs but have

77 velopment; however, the underlying molecular bases are not well understood.

78 The bases are recognized by the monofunctional thymine DNA g

79 The A1 and A2 bases are recognized specifically by zinc finger 2 (ZF2)

80 cted auditory attention, its neurobiological bases are unclear.

81 s, susceptible to isomerization by acids and bases, are suitable for the [4+2] anionic annulation to

82 ification of strong neutral nitrogen organic bases as proton sponges (kinetically inert compounds) or

83 e and isoguanine and does not accept natural bases as substrates.

84 s a clinical diagnosis with multiple genetic bases associated with an extensive variety of congenital

85 tatively map oxidized 5-methylcytosine (5mC) bases at high resolution.

86 In comparing the distributions of bases at positions with respect to an mCpG, statisticall

87 kely the open-X structure which has unpaired bases at the junction.

88 ries of polymers, including polymer Bronsted bases blended with organic acid proton donors.

89 otential to increase solubilisation of these bases by employing high temperatures or alkaline pH.

90 finger 2 (ZF2) of CPSF-30 and the A4 and A5 bases by ZF3.

91 Under conditions of excess enzyme, C/mC bases can be deaminated to completion in long DNA segmen

92 every position in the purine and pyrimidine bases can be modified; often the sugar is also modified.

93 If left unrepaired, these damaged DNA bases can disrupt cellular processes such as replication

94 'alphabet' by synthetic incorporation of new bases can introduce new functionalities and enable the f

95 orescence in filopodia and at their tips and bases concurrently with their morphological and dynamic

96 f biological pathways, and expansion of data bases containing information about interactions of biomo

97 This loss of bases could limit the completeness of downstream assembl

98 biosensor can be profitable to evaluate DNA bases damage.

99 irs and that most remaining mutations at A-T bases depend on two additional uracil glycosylases, thym

100 By adjusting the number of selective bases, different numbers of genomic sites are targeted f

101 SB1, which encodes an exporter of long chain bases dihydrosphingosine (DHS) and phytosphingosine (PHS

102 analogue tC(O) stands out among fluorescent bases due to its virtually unquenched fluorescence emiss

103 formation of cross-links (assessed as Schiff bases) during freezing and the subsequent processing may

104 In particular, the presence of bases (e.g. K2CO3) and/or phase transfer catalysts (PTC)

105 ial 2-pyridinesulfonylacetonitrile with mild bases, either K2 CO3 or DBU, and subsequent sulfone-meta

106 NAs with short homologies ( approximately 35 bases) engage in a highly efficient gene conversion mech

107 se, most of the so-called push-pull nitrogen bases exhibit a very high basicity.

108 d roles of Runx1, TCF-1, and Hes1, providing bases for a comprehensively updated model of the T-cell

109 offer important insights into the structural bases for allosteric site-to-active site communication a

110 ory functions, but the receptor and cellular bases for cholinergic actions are just beginning to be u

111 ature provides the mechanistic and empirical bases for considering obstructive sleep apnea and centra

112 These results provide genomic bases for improving cotton production and for further ev

113 ory functions, but the receptor and cellular bases for its beneficial effects are poorly understood i

114 ase, but little is known about the molecular bases for its unique clinical presentation.

115 urvival, jeopardizing cellular and molecular bases for neural repair in vivo.

116 eans for examining the genetic and molecular bases for neurodevelopmental impairment in model mice in

117 y from desensitization and reveal structural bases for regulation of synaptic transmission by auxilia

118 However, the underlying bases for S-H/pi interactions are not well understood.

119 lar modeling studies disclosed the molecular bases for the binding of 19 to CXCR4 and for its improve

120 Herein, we report on some of the molecular bases for the cellular toxicity of homocysteine and demo

121 s single channel current measurements reveal bases for the distinct functional and pharmacological pr

122 The involvement of two bases for the repair points to a long-living charge tran

123 ause of the lack of appropriate chiral Lewis bases for their generation.

124 The neuromolecular bases for these delays are unknown.

125 To examine the morphological bases for these differences, we performed quantitative u

126 The bases for these various classifications are defined.

127 In order to identify cellular and molecular bases for this difference, we performed comparative tran

128 We review the current mechanistic bases for this dual signaling mode of D2Rs and how these

129 andidate gene approach to identify molecular bases for two historic axolotl pigment phenotypes: white

130 erplays between the mechanical and molecular bases for vein graft restenosis.

131 Interestingly, the U3 and A6 bases form an intramolecular Hoogsteen base pair and dir

132 sociate through a path in which the terminal bases fray, without any significant contribution from lo

133 The present study sought to develop lipid bases from blends between patawa oil and palm stearin.

134 estriction glycosylase) excises unmethylated bases from its recognition sequence.

135 ffers by only two nucleotides (12th and 16th bases from the 5' end).

136 -fidelity annealing by constraining specific bases from unauthorized association and only releases an

137 Exogenous phosphine Lewis bases further modify the catalyst speciation and attenua

138 These modified pyrimidine bases, fused to a pyrrole ring, and their corresponding

139 tes (5'-NMPs) using low water-soluble purine bases has been described as less efficient due to their

140 N- and O-protected 3-deoxy-3-aminosphingoid bases have been achieved using two complementary approac

141 e biochemical pathways that involve modified bases have been identified, research into the world of R

142 cases, however, compounds other than Schiff bases have been reported to result from such reactions.

143 These unique Lewis bases have been used to generate acyl anions, enolates,

144 hat the principle of hard and soft acids and bases (HSAB) and the related Klopman-Salem concept of ch

145 hree characteristics of communication-module bases: hydrogen bonding, base stacking, and distance to

146 ly applied is trimming, in which low quality bases, identified by the probability that they are calle

147 Through randomizing bases in anticodon stem-loop followed by a functional se

148 asing amount of Semantic Web based knowledge bases in biology to use in machine learning and data ana

149 The main pathway for correcting oxidized bases in DNA is base excision repair (BER), and in verte

150 Herein, we show that 5fC bases in DNA readily form Schiff-base conjugates with Ly

151 repair, where it acts on naturally modified bases in DNA.

152 tion of strong bonds between Lewis acids and bases in frustrated Lewis pairs (FLPs), where latent rea

153 gle or mutiple genes, (ii) altering specific bases in genes of interest, and (iii) engineering genes

154 NA repair and reduced the levels of oxidized bases in genomic DNA.

155 el functional groups at just one of the four bases in modified aptamers has recently led to dramatic

156 Internal bases in mRNA can be subjected to modifications that inf

157 es sequester the repair complex for oxidized bases in non-replicating chromatin, and allow repair whe

158 ly, from 250 bases in viroids to 670 billion bases in some amoebas.

159 detect and distinguish between ten modified bases in synthetic RNAs.

160 and 5-carboxy-dC (cadC) are newly discovered bases in the mammalian genome that are supposed to be su

161 ons (indels), and truncations, to unmodified bases in the same contexts.

162 sizes have evolved to vary widely, from 250 bases in viroids to 670 billion bases in some amoebas.

163 re ultradeep sequencing patterns of modified bases, including miscoding, insertions and deletions (in

164 Biological data and knowledge bases increasingly rely on Semantic Web technologies and

165 5-carboxylcytosine (5caC), two oxidized 5mC bases indicative of active DNA demethylation events.

166 by which one can determine these biological bases individually or simultaneously.

167 iophysics is how the primary sequence of DNA bases influences the global properties of very-long-chai

168 on of the BER pathway for mutagenic oxidized bases, initiated by NEIL1 and other DNA glycosylases at

169 umber of proteins, carbohydrates, nucleotide bases, inorganic salts and other compounds.

170 f short-chain fatty acids and dihydroxylated bases into inositol phosphorylceramides and GIPCs.

171 on of epigenetic information and/or modified bases into large constructs is not feasible.

172 Its positive-sense ssRNA genome of 3,569 bases is enclosed in a capsid with one maturation protei

173 One of the most prevalent modified bases is found at the 5' end of mRNA, at the first encod

174 ramatically altered when one of the cytosine bases is replaced with methyl-, hydroxymethyl-, formyl-,

175 facets of behavior with discrete biological bases is unclear.

176 ated process to learn high quality knowledge bases linking diseases and symptoms directly from electr

177 Existing platforms rely on knowledge bases manually compiled through a labor-intensive proces

178 l in comparison to non-complementary and two bases mismatched sequences.

179 Oxidative DNA bases modified by reactive oxygen species (ROS), primari

180 ty wherein gRNA-DNA mismatches at PAM-distal bases modulate different biophysical parameters that det

181 d (H-bond) contacts with up to four adjacent bases, most of which are purines of the complementary DN

182 f reactive nitrogen species and prevents DNA bases nitration, what makes beech seeds oil interesting

183 of various subfamilies of push-pull nitrogen bases: nitriles, azoles, azines, amidines, guanidines, v

184 Open-data global data bases now exist on animal migration, species distributio

185 al neuroimaging study, we explore the neural bases of active retrieval for auditory nonverbal informa

186 iphosphates (tNTPs) bearing the four genetic bases of adenine (A), cytosine (C), thymine (T), and gua

187 Determining the genetic bases of age-related disease remains a major challenge r

188 utralization by investigating the structural bases of antibody binding and avoidance.

189 congenital visual deprivation on the neural bases of auditory processing in humans.

190 The neuroanatomical bases of autism spectrum disorder remain largely unknown

191 d insights into the molecular and structural bases of AVR-Pia-RGA5 interaction and the role of the RA

192 FICANCE STATEMENT To understand the neuronal bases of behavior, it is important to identify the under

193 is a fundamental step to uncover the neural bases of behavior.

194 This study investigates the neural bases of capacity limitations in visual working memory b

195 nt in our understanding of the physiological bases of communication disorders.

196 motion, enabling further inquiry into neural bases of communication.

197 es performed to characterize the etiological bases of CRC incidence and mortality in African American

198 to investigate the neural and neurochemical bases of different types of cost/benefit decisions.

199 ortant step toward understanding the circuit bases of drug addiction and other psychiatric disorders.

200 The genetic bases of enhanced PD-1 signaling in cHL make these tumor

201 ined test that allows the pathophysiological bases of exercise limitation to be translated, quite eas

202 s, both as perceptions of groups, and as the bases of expectations regarding individuals.

203 To clarify the molecular bases of flowering time evolution in crop domestication,

204 Understanding the genetic and molecular bases of gene function is of increasing importance to ha

205 enesis, we gained insight into the molecular bases of glycolipid recognition by Mincle.

206 an opportunity for understanding the neural bases of how changing internal states alter reward proce

207 opment of the human fundus and the molecular bases of human gastric physiology and pathophysiology, a

208 ovel point of comparison on the evolutionary bases of important agronomic traits among different crop

209 However, the neurobiological bases of impulsivity and their relation to antisocial be

210 Based on 1.92 x 10(12) bases of leaf mRNAseq data, functional genotypes, compri

211 ential to provide novel insights into neural bases of literacy, numeracy, and impairments in these co

212 loids are needed to understand the molecular bases of metal-amyloid interactions.

213 iments were performed to study the molecular bases of NAC thrombolytic effect, including platelet agg

214 al information for understanding the genetic bases of ornamental traits and the determinants and evol

215 A more detailed understanding of the neural bases of rehabilitation efficacy is needed to inform the

216 pt that the anatomic and genetic etiological bases of RLS are diverse.

217 re commonly found at sites encoding unpaired bases of RNA stem-loop structures.

218 h phalloidin) was observed at the apices and bases of RPE cells.

219 tic, biochemical structural, and serological bases of serotypes 35C and 42.

220 fer some examples from research on the brain bases of sign language perception.

221 as observed in the two species, the cellular bases of some auditory working memory processes in human

222 ask can be voluntarily regulated, the neural bases of such faculty and its behavioural effects are ye

223 recruited domain-general networks, the brain bases of switching during comprehension seemed language

224 s elaborate dendritic arbors innervating the bases of taste hairs.

225 ontacts, each finger of ZF3-7 contacts three bases of the 15-bp consensus sequence.

226 ence-recognition helix made contact with the bases of the 7-bp motif in the major groove, and the win

227 hydrogen bonds mostly involving the adenine bases of the G.A and A.G pairs.

228 ates in pi-pi interactions with the unpaired bases of the immobilized aptamer (Apt-GMNPs-GO-L-AgNPs).

229 body by a looming stimulus, i.e., the neural bases of the interaction between a dynamic visual stimul

230 nonhuman primate, to investigate the neural bases of the prediction of an impact to the body by a lo

231 The neural bases of these modulations are unknown.

232 The molecular bases of these sensory processes are largely unknown.

233 The neurobiological bases of this association include the induction of alter

234 Little is known about the molecular bases of this calcium-independent activation.

235 complex ability, to uncover the fundamental bases of this impairment.

236 The neurobiological bases of this time interval learning are unknown.

237 Bronsted bases of widely varying strength are shown to decompose

238 lications for understanding the neurogenetic bases of WS as well as social anxiety.

239 otides that specifically pair with alkylated bases offer a possible strategy for recognition and ampl

240 ions of both nucleobases and weak acids/weak bases on these gradient stationary phases have been comp

241 ploited for over 150 years to produce Schiff bases, one of the most popular classes of compounds in b

242 mperature and in the absence of neutralizing bases or illumination.

243 D source, without the addition of any extra bases or metal.

244 Biological entities, such as DNA bases or proteins, possess numerous tautomers and isomer

245 ic acids (LNAs) in the ssODNs at mismatching bases, or also at directly adjacent bases, allowed 1-, 2

246 her 5-methylcytosine (mC) or TET-oxidized mC bases (ox-mCs), which include 5-hydroxymethylcytosine, 5

247 is virtually unaffected by the neighbouring bases (PhiF = 0.20-0.25), resulting in an average bright

248 and polar compounds and seven weak acids and bases (pKa = 3-5.2) selected from among industrial chemi

249 to remove the methyl group on these modified bases prior to cDNA synthesis using enzymes.

250 g head-related transfer function (HRTF) data bases provide descriptions of reception of the resultant

251 transitioning into SPEM cells only in gland bases, rather than the proliferative stem cell zone.

252 istening in natural environments, its neural bases remain obscure.

253 nital heart defects, their precise molecular bases remain unknown in the majority of patients.

254 the simultaneous measurement of the four DNA bases remains a challenge.

255 The number of bases removed by this proofreading mechanism is much lar

256 r de novo synthesis of purine and pyrimidine bases required for DNA and RNA biosynthesis.

257 -dA averaged 0.04 and 0.05 adducts per 10(6) bases, respectively.

258 -oxo-dA averaged 11 and 17 adducts per 10(6) bases, respectively.

259 Some approaches maximize the number of bases sequenced in the least amount of time, generating

260 ,4,6-Me3 C6 H2 )CH2 }2 ]) with Group 1 alkyl bases suggest this destructive process is triggered by l

261 rphisms (SNP) rate of approximately 1 per 50 bases suggestive of high levels of allelic diversity.

262 mposed of unusual hydroxylated C17 sphingoid bases (t17:0) were highly enriched in the infected cells

263 repair enzymes recognize and remove damaged bases that are embedded in the duplex.

264 is dramatically increased in the presence of bases that coordinate strongly to the copper center, e.g

265 uirement for at least 6-8 consecutive paired bases that has been inferred from in vitro studies.

266 f automatically annotated chemical knowledge bases that integrate chemical information and biological

267 is much larger than the number of erroneous bases that would be expected to be incorporated, ensurin

268 With suitable choices of acids and bases, the Cp*Rh(bpy) complex catalyzes facile and rever

269 initiates base excision repair of alkylated bases, the flipped-out nucleotide is stabilized by inter

270 species have access to more diverse resource bases, the resource breadth hypothesis posits that the d

271 Nitrogenous bases, thiols, and lanthanides do not interfere in the f

272 cleoside building blocks bearing non-natural bases to develop a synthetic methodology that allows for

273 g), which cleaves the glycosidic bond of the bases to give potentially harmful abasic sites (AP-sites

274 This triad allows for a continuous stack of bases to link the quadruplex motif with the duplex regio

275 me in sizes ranging from single modified DNA bases to several megabases in the case of heterochromati

276 ymes are best known for deaminating cytosine bases to uracil in single-stranded DNA, with characteris

277 the strongest adsorption affinity of guanine bases towards graphene, bisulfite-treated guanine-enrich

278 r findings provide functional and structural bases underlying S1P-mediated pathogenic metabolic repro

279 kidney disease and aging, but the molecular bases underlying the biologic outcomes on the evolution

280 Here, we attempt to determine the molecular bases underlying the wide range of binding properties of

281 americ sequence, CCCAGCAG, approximately 100 bases upstream of the CEBPA transcription start site, an

282 e Bronsted base reactions, and the inorganic bases used greatly influenced the profile of the reactio

283 2271 targets ranging in length from 192-252 bases using pairs of array-synthesized oligos.

284 rget recognition, the residues that read the bases vary.

285 -impacted groundwaters from 15 U.S. military bases was conducted to identify the remaining PFASs.

286 the frequency of transition mutations at C/G bases was higher in mice compared with humans, suggestin

287 On these bases, we suggest that the very nature of CS2 poisoning

288 and the energy costs for producing acids and bases were an order of magnitude lower than the costs fo

289 stically significant preferences for certain bases were found, although the corresponding biases in p

290 .1 binding as a monomer, additional flanking bases were required to invoke sequential dimerization of

291 Radiology and pathology data bases were searched for pathology-proven testicular tumo

292 ow capture efficiency for nucleic acids (>10 bases), which severely lowers the sensitivity of an aero

293 highlights an original mechanism of swapping bases, which could represent a possible '7SK signature'

294 the solvent accessibility of the neighboring bases while maintaining the overall hairpin structure.

295 airing leading to ejection of the central AT bases, while placing the proreactive centers of 1 in clo

296 enched combinations of bulky Lewis acids and bases whose dual reactivity can be exploited for the fac

297 rved to be similar in systems having EG vs G bases, with small perturbations to the charge transport

298 predicted to be readily deprotonated by many bases, with subsequent cyclization via nucleophilic atta

299 H2O2, an increase in OGG1-sensitive oxidized bases within genomic DNA, and a decrease in 8-oxoG cleav

300 n-specific quality score distribution of all bases within the sequencing run.

301 chemical diversity of TNA beyond the natural bases would enable the development of functional TNA mol