ライフサイエンスコーパス: cholesterol 7alpha-hydroxylase

1 of dysfunctional LDL receptors and inhibited cholesterol 7alpha-hydroxylase.

2 etion or the activity of, or mRNA level for, cholesterol 7alpha-hydroxylase.

3 acid pool is the most powerful inhibitor of cholesterol 7alpha-hydroxylase.

4 yl reducing agents activate transcription of cholesterol 7alpha-hydroxylase.

5 th the activity of the liver-specific enzyme cholesterol-7alpha-hydroxylase.

6 xpression of the liver-specific gene product cholesterol 7alpha-hydroxylase (7alpha-hydroxylase) was

7 point of this regulation is at the level of cholesterol 7alpha-hydroxylase (7alpha-hydroxylase), whi

8 is initiated in the endoplasmic reticulum by cholesterol 7alpha-hydroxylase, a well studied cytochrom

9 ne day increased hepatic cholesterol 75% and cholesterol 7alpha-hydroxylase activity 1.6 times withou

10 times in NZW rabbits and decreased enhanced cholesterol 7alpha-hydroxylase activity 54%, mRNA levels

11 w studies indicate that genetic variation in cholesterol 7alpha-hydroxylase activity accounts for a s

12 receptor-mediated binding was 26% less, and cholesterol 7alpha-hydroxylase activity and mRNA levels

13 Cholesterol 7alpha-hydroxylase activity and mRNA levels

14 bile acid pool and stimulated downregulated cholesterol 7alpha-hydroxylase activity but did not affe

15 feeding produced 10%-20% increments, whereas cholesterol 7alpha-hydroxylase activity declined progres

16 In Cyp27(-/-) mice, cholesterol 7alpha-hydroxylase activity is increased 5-f

17 lglutaryl CoA reductase activity, stimulated cholesterol 7alpha-hydroxylase activity, and enhanced fe

18 ce 7-oxocholesterol is a potent inhibitor of cholesterol 7alpha-hydroxylase, alternative mechanisms f

19 epatic cholesterol does not directly inhibit cholesterol 7alpha-hydroxylase and initially favors enzy

20 macrophage polarization and induced hepatic cholesterol 7alpha-hydroxylase and sterol 12alpha-hydrox

21 key bile acid synthesis proteins, including cholesterol 7alpha-hydroxylase and sterol-27-hydroxylase

22 Bile acid repression and induction of cholesterol 7alpha-hydroxylase and the ileal bile acid b

23 o bile acid synthetic pathways (classic, via cholesterol 7alpha-hydroxylase, and alternative, via ste

24 and UDCA effectively repressed expression of cholesterol 7alpha-hydroxylase, another FXR target.

25 f this family, to regulate the expression of cholesterol 7alpha-hydroxylase by means of binding to th

26 he phenotype of the cell (e.g. expression of cholesterol 7alpha-hydroxylase by the liver) may profoun

27 Purified cholesterol 7alpha-hydroxylases (C7alphaH) from human an

28 xycholic acid replacement inhibited elevated cholesterol 7alpha-hydroxylase, cholic acid synthesis, a

29 as expression of other FXR targets including cholesterol 7alpha-hydroxylase (Cyp 7a1), sterol 12alpha

30 eceptor (LDLR), apolipoprotein B (APOB), and cholesterol 7alpha-hydroxylase (CYP7).

31 he accompanying paper that mice deficient in cholesterol 7alpha-hydroxylase (Cyp7-/- mice) exhibit a

32 to induce transcription of the gene encoding cholesterol 7alpha-hydroxylase (Cyp7a), the rate-limitin

33 The gene encoding cholesterol 7alpha-hydroxylase, CYP7A, is expressed excl

34 Cholesterol 7alpha-hydroxylase Cyp7a1 expression was str

35 genes, including the key biosynthetic enzyme cholesterol 7alpha hydroxylase (Cyp7A1) and the bile sal

36 ivated FXR indirectly inhibits expression of cholesterol 7alpha hydroxylase (CYP7A1), a key enzyme in

37 repressed CYP8b1 in the face of induction of cholesterol 7alpha-hydroxylase (CYP7a1 by the new nomenc

38 receptor (VDR) on hepatic activity of human cholesterol 7alpha-hydroxylase (CYP7A1) and cholesterol

39 OCA markedly inhibits hepatic cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alp

40 Cholesterol 7alpha-hydroxylase (Cyp7a1) and the bile aci

41 port, and metabolism of bile acids including cholesterol 7alpha-hydroxylase (Cyp7a1) and the Na(+)-in

42 Inhibition of cholesterol 7alpha-hydroxylase (CYP7A1) by bile acids an

43 Cholesterol 7alpha-hydroxylase (CYP7A1) catalyzes the ra

44 Cholesterol 7alpha-hydroxylase (CYP7A1) catalyzes the ra

45 hepatic-specific transcription of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene are poorly

46 fetoprotein transcription factor and repress cholesterol 7alpha-hydroxylase (CYP7A1) gene transcripti

47 We recently reported that overexpression of cholesterol 7alpha-hydroxylase (CYP7A1) in the liver res

48 ion of the rate-limiting biosynthetic enzyme cholesterol 7alpha-hydroxylase (CYP7A1) is lost in Cyp8b

49 Cholesterol 7alpha-hydroxylase (CYP7A1) is the initial a

50 Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limi

51 The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regul

52 After bile fistula drainage, cholesterol 7alpha-hydroxylase (CYP7A1) mRNA and activit

53 concentrations of insulin rapidly stimulated cholesterol 7alpha-hydroxylase (CYP7A1) mRNA expression

54 n of sterol 12alpha-hydroxylase (CYP8b1) and cholesterol 7alpha-hydroxylase (CYP7a1) on rates of CA b

55 bit expression of the known SHP target genes cholesterol 7alpha-hydroxylase (CYP7A1) or sterol 12alph

56 Transgenic expression of cholesterol 7alpha-hydroxylase (CYP7A1) prevented high f

57 The finding that expression of a cholesterol 7alpha-hydroxylase (CYP7A1) transgene in cul

58 liver through transcriptional repression of cholesterol 7alpha-hydroxylase (CYP7A1) via a mechanism

59 ntributes to repression of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), a key enzyme fo

60 e "classic" pathway, initiated by microsomal cholesterol 7alpha-hydroxylase (CYP7A1), and an "alterna

61 in a feedback mechanism, repressing hepatic cholesterol 7alpha-hydroxylase (Cyp7a1), the rate-limiti

62 t repress transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiti

63 Dietary cholesterol regulation of cholesterol 7alpha-hydroxylase (Cyp7a1), the rate-limiti

64 n activate the JNK pathway and down-regulate cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiti

65 Cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiti

66 vels of bile acid synthesis genes, including cholesterol 7alpha-hydroxylase (Cyp7a1).

67 ver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1).

68 other bile acid biosynthetic enzymes such as cholesterol 7alpha-hydroxylase (CYP7A1).

69 iption of the pathway's rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1).

70 ay bile acid negative feedback repression of cholesterol 7alpha-hydroxylase (CYP7A1).

71 which acts through hepatic FGFR4 to suppress cholesterol-7alpha hydroxylase (CYP7A1) and limit bile a

72 so displayed decreased expression of hepatic cholesterol-7alpha-hydroxylase (CYP7A1) and sterol 12alp

73 tore the fibroblast growth factor 15 (FGF15)/cholesterol-7alpha-hydroxylase (Cyp7a1) enterohepatic ax

74 ed in the 3'-untranslated region (3'-UTR) of cholesterol-7alpha-hydroxylase (CYP7A1) mRNAs from sever

75 es in the bile acid biosynthesis pathway are cholesterol 7alpha-hydroxylase/CYP7A1 (7alpha-hydroxylas

76 y rat hepatocytes, through inhibition of the cholesterol 7alpha-hydroxylase/CYP7A1 (7alpha-hydroxylas

77 es in the bile acid biosynthetic pathways is cholesterol 7alpha-hydroxylase/cytochrome P450 7alpha-hy

78 , targeted inactivation of the gene encoding cholesterol 7alpha-hydroxylase does not lead to increase

79 Cyp 7-/- mice lack a functional cholesterol 7alpha-hydroxylase enzyme and develop choles

80 se in LXR expression, and a 90% reduction in cholesterol 7alpha-hydroxylase expression in comparison

81 SHP is central to feedback repression of cholesterol 7alpha hydroxylase gene (CYP7A1) expression

82 hat mediate bile acid feedback inhibition of cholesterol 7alpha-hydroxylase gene (C YP7A1) transcript

83 The cholesterol 7alpha-hydroxylase gene (CYP7A) is transcrip

84 The cholesterol 7alpha-hydroxylase gene (CYP7A1) plays an im

85 Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcripti

86 idate the mechanism of insulin regulation of cholesterol 7alpha-hydroxylase gene expression in human

87 se element in the promoter region of the rat cholesterol 7alpha-hydroxylase gene.

88 displayed a significant enhancement of human cholesterol 7alpha-hydroxylase (human [h]CYP7A1; median

89 We conclude that cholesterol 7alpha-hydroxylase is an essential enzyme fo

90 Cholesterol 7alpha-hydroxylase is the first and rate-lim

91 Cholesterol 7alpha-hydroxylase is the rate-limiting enzy

92 nd mice indicate that direct manipulation of cholesterol 7alpha-hydroxylase leads to changes in plasm

93 The reduced expression of cholesterol 7alpha-hydroxylase most likely resulted from

94 Cholesterol 7alpha-hydroxylase mRNA is reduced to undete

95 se, dietary cholesterol or colestipol induce cholesterol 7alpha-hydroxylase mRNA levels but do not af

96 ion of hepatic small heterodimer partner and cholesterol-7alpha-hydroxylase mRNA expression, implicat

97 erol metabolism altered by the expression of cholesterol-7alpha-hydroxylase NADPH:oxygen oxidoreducta

98 ffect of transient overexpression of hepatic cholesterol 7alpha-hydroxylase on low density lipoprotei

99 ductase, but it did not change activities of cholesterol 7alpha-hydroxylase or acyl-CoA:cholesterol a

100 igms of cholesterol homeostasis suggest that cholesterol 7alpha-hydroxylase plays a crucial role in s

101 ed human CYP8B1 promoter activities, whereas cholesterol 7alpha-hydroxylase promoter factor (CPF), an

102 ar receptor fetoprotein transcription factor/cholesterol-7alpha-hydroxylase promoter factor (CPF/FTF/

103 ochrome P450 (P450) 7A1 is well known as the cholesterol 7alpha-hydroxylase, the first enzyme involve

104 Cholesterol- and bile acid-controlled liver cholesterol 7alpha-hydroxylase, the limiting enzyme for

105 Mice deficient in cholesterol 7alpha-hydroxylase, the rate-limiting enzyme

106 ts was associated with reduced expression of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme

107 LPS down-regulates hepatic cholesterol 7alpha-hydroxylase, the rate-limiting enzyme

108 Coupled with our earlier studies on cholesterol 7alpha-hydroxylase, these data indicate that

109 lated cholic acid synthesis by up-regulating cholesterol 7alpha-hydroxylase to use cholesterol and re

110 cholesterol- and bile acid-controlled liver cholesterol 7alpha-hydroxylase transcription by FGFR4 an

111 lglutaryl coenzyme A (HMG-CoA) reductase and cholesterol 7alpha-hydroxylase was investigated in 19 Ne

112 ncentrations were reduced significantly when cholesterol 7alpha-hydroxylase was stimulated even in th

113 Studies in which cholesterol 7alpha-hydroxylase was transiently overexpre

114 The CYP7A1 gene encodes the enzyme cholesterol 7alpha-hydroxylase, which catalyzes the init

115 repressed transcription of the gene encoding cholesterol 7alpha-hydroxylase, which is the rate-limiti

116 nthesis and cellular uptake and induction of cholesterol 7alpha-hydroxylase, which leads to the remov

117 xpression of the liver-specific gene product cholesterol 7alpha-hydroxylase with MTP resulted in leve