ライフサイエンスコーパス: congenic

1 ne of these have been analyzed with interval congenics.

2 hat wild-type and galanin knockout mice on a congenic 129/OlaHsd background are responsive to the loc

3 To explore genetic contributions, a pair of congenic a and alpha mating type strains was generated b

4 ed into the XL280 background to generate the congenic a and alpha pair strains.

5 fection models of murine cryptococcosis, the congenic a and alpha strains displayed comparable levels

6 ant for its morphogenesis and pathogenicity, congenic a and alpha strains for a filamentous form were

7 Wild-type (WT) C57BL/6 mice, congenic A1-AdoR knockout (A1-KO) mice, and mice that ha

8 ghly autoreactive in vitro and are lethal in congenic adoptive transfer in vivo, demonstrating a crit

9 Using congenic analysis of alleles in NOD and NOD-resistant (N

10 spare TECs from radiation-induced damage in congenic and allogeneic BMTs.

11 Using congenic and allogeneic mice as recipients and depleting

12 the subcongenic mice, along with B6.TH-tabw2 congenic and B6-homozygous control mice were fed either

13 omotor activity was exhibited in B6.TH-tabw2 congenic and subcongenic mice compared to controls when

14 lipidemia and related metabolic disorders in congenic and subcongenic rat strains.

15 cal congenic rats were generated (LEW.WCrgn1 congenic and WKY.LCrgn1 congenic), immunized with recomb

16 is a natural Rab38 knockout, supported by a congenic animal (FHH.BN-Rab38) having less proteinuria t

17 Because these congenic animals contain Brown Norway (BN) alleles for f

18 xtensive liver damage, and death, whereas WT congenic animals failed to develop disease.

19 Ly108-H1, which is absent in two lupus-prone congenic animals.

20 d for generations of backcrossing to achieve congenic animals.

21 -old wild-type (WT) and Tnfr1(-/-) mice into congenic apolipoprotein E-deficient (Apoe(-/-)) mice and

22 S3 (ApoE(-/-), HPS3(-/-)) were compared with congenic, atherosclerosis-prone mice with normal platele

23 mice were crossed with B6.129-Sle16 (Sle16)-congenic autoimmune mice to obtain Sle16.

24 econstitution of Rag1(null) mice with normal congenic B cells that have matured in vitro restores the

25 R3 and wildtype B6 mice and cotransferred to congenic B6 recipients of BALB/c heart allografts.

26 tory mouse strains are deficient in Mx1, but congenic B6-Mx1(r/r) mice that carry the wild-type Mx1 g

27 study evaluated the response of C57Bl/6 and congenic B6.129c1 mice (expressing the 129-derived Slam

28 MHC-mismatched H-2(b) C57BL/6 or MHC-matched congenic B6.H-2(g7) recipients, we demonstrate that NOD.

29 diminishes T cell-dependent autoimmunity in congenic B6.Sle1b mice.

30 pathologies of these SNV mice with those of congenic (B6.129S1-Cdh23(Ahl+) and 129S1.B6-Cdh23(ahl))

31 n the presence of endogenous self-Ag (IgH(a) congenic background), AM14 Tg Act1(-/-) B cells were spo

32 (-/-)) were generated on outbred and C57BL/6 congenic backgrounds.

33 dose of oral kanamycin, Salmonella-infected congenic BALB/c.D2(NrampG169) mice, which carry a wild-t

34 ysis of islet-infiltrating T cells in Iddm30 congenic BBDP animals revealed that overexpression of pa

35 an F2(BBDP x ACI.1u.Lyp) cohort and Iddm26.2 congenic BBDP sublines has revealed an association of Pt

36 ce and their therapeutic potential following congenic bone marrow transplantation (BMT) in a proteogl

37 We used a congenic breeding program and comparative genomics to ex

38 bronchus of TLR4-defective (both C3H/HeJ and congenic C.C3-Tlr4(Lps-d)/J) and control mice to initiat

39 use TIM-3 showing a higher capacity than the congenic C.D2 Es-Hba-allelic variant.

40 on on Ed MeV brain infection was tested with congenic C57BL/10 H-2(d) neonatal mice.

41 cause of Fanconi syndrome, is reproduced in congenic C57BL/6 cystinosin knockout (KO) mice.

42 abrogates neurovirulence in neonatal H-2(d) congenic C57BL/6 mice.

43 ere we report that a commonly used CD45.1(+) congenic C57BL/6 mouse substrain is characterized by sel

44 one susceptibility in Apobec-1(-/-) mice and congenic C57BL/6 wild type controls.

45 press high levels of Pbx1-d as compared with congenic C57BL/6J (B6) MSCs.

46 Congenic C57BL/6J (B6-Mx1(r/r)) mice expressing a wild-t

47 ld be rescued by moving the transgene onto a congenic C57BL/6J background and recurred on reintroduct

48 nder- and genetic background-dependent, with congenic C57BL/6J male mice exhibiting the most aggressi

49 of NZB and 129S6 mtDNAs in the presence of a congenic C57BL/6J nuclear background.

50 evels of the genes of interest were noted in congenic C57BL/6J-Ah(d) allele mice, when compared to th

51 anel of intra-H2(k) recombinant strains from congenic C57L.M-H2(k/b) (MCMV resistant) mice for precis

52 on when the IL-10 concentration is high into congenic CD45.2 recipients develop into the MHC II(lo) m

53 In this study, comparisons of congenic cells with and without functional molecules reg

54 Using CD45 congenic cells, we show that induction of niT cells and

55 vels as a function of CGG-repeat length in a congenic (CGG-repeat knock-in) mouse model using 57 wild

56 tally to TCDD were mixed 1:1 with cells from congenic controls and used to reconstitute lethally irra

57 Here, we show that, very unexpectedly, congenic D2-Mx1(r/r) mice carrying the wild-type Mx1 gen

58 Most remarkably, congenic D2-Mx1(r/r) mice expressing a functional Mx1 wi

59 In this study, we used NZB.NZW-Lbw2 congenic (designated Lbw2 congenic) mice containing an i

60 background, we created and phenotyped DBA/2J-congenic Dmdmdx mice (D2-mdx) and compared them with the

61 g beta(2)-microglobulin-deficient (beta(2)m) congenic donor bone marrow cells.

62 )lineage(-) hemopoietic stem cells (HSC) and congenic donor T cells led to increased donor CD4(+) and

63 We report that DBA/1 mice as well as congenic FcgammaRIII(-/-) and FcRgamma(-/-) mice immuniz

64 ammatory effect was similar in wild-type and congenic females.

65 Further analysis using mice congenic for chromosome 7 confirmed Pdcc1, demonstrating

66 e to MCMV infection in novel BALB substrains congenic for different MHC (or H-2 in mice) haplotypes,

67 DBA/2J mice, doubly congenic for the Bax mutant allele and the ganglion cell

68 thritis development was confirmed in B6 mice congenic for the C3H allele of Bbaa1 (B6.C3-Bbaa1), whic

69 C57BL/6 mice congenic for the C3H Gusb allele were prone to increased

70 Muscle cells from BALB/c mice congenic for the C57BL/6 Lsq-1 quantitative trait locus

71 utants in different strains of mice that are congenic for the H-2 locus indicates that CD4 T-cell rec

72 Compared with C57BL/6 mice congenic for the H2 gene complex from NOD mice (B6.g7),

73 Examination of BBDP sublines congenic for the Iddm26.2 locus that includes Ptpn22 has

74 megalovirus (MCMV) infection, using NOD mice congenic for the protective NK gene complex from C57BL/6

75 protection from tissue necrosis in a shorter congenic fragment of Lsq-1 (C.B6-Lsq1-3).

76 y, against a high degree of homogeneity in a congenic genetic background, selectively impaired active

77 7BL/6J (B6), DBA2/J (D2)] and two reciprocal congenic genotypes (B6D2, D2B6) with the proximal region

78 Conversely, a second fully congenic group (F > 10) had less variable features patho

79 An MKS-like incipient congenic group (F6 to F10) manifested very variable neur

80 Furthermore, Lbw2 congenics had greater numbers of marginal zone B cells a

81 loci that had high (14%-32%) whereas 2 other congenics had low (4%) TGCT incidences.

82 .5 and surviving pups were transplanted with congenic hematopoietic cells on day of life 1.

83 Canonical B cells from congenic HKIR.Sle1 mice gave rise to elevated short and

84 bred (C57BL/6, BALB/c, and A/J) strains, one congenic (HLA-A2 on the C57BL/6 background) strain, and

85 Early after congenic HSCT, we found that Ly49G2(high) single-positiv

86 the virulence function of YopM, C57BL/6J or congenic IL-10(-)/(-) mice were infected intravenously w

87 enerated (LEW.WCrgn1 congenic and WKY.LCrgn1 congenic), immunized with recombinant rat alpha3(IV)NC1,

88 retaining the distal region of the TH donor congenic interval exhibited significantly larger fat mas

89 Genotypic analysis revealed a 42.1-mbp congenic interval in B6.SJL including 306 genes, and at

90 en the B6 and SJL genotype within the B6.SJL congenic interval influence HSC engraftment and result i

91 L6 (B6) strain with the exception of a small congenic interval on chromosome 1 harboring an alternati

92 The 1.7-Mb congenic interval on chromosome 3, containing eight gene

93 ice bearing the Sle2(z) lupus-susceptibility congenic interval on chromosome 4 display high titers of

94 chow feeding map to the distal region of the congenic interval, whereas the diet-induced obesity medi

95 Congenic introduction of the susceptible Cdcs1 interval

96 The eyes of congenic IRBP knockout (KO) and C57BL/6J wild-type (WT)

97 Congenic knockout mice and mice overexpressing Sept5 in

98 Here, we generated a minimal congenic line (Rf-1a+4_a) to identify a 4.1-Mb region of

99 ility to renal disease, suggesting that this congenic line is an important model for studying pathway

100 ed a unique multimodal imaging strategy in a congenic line of DYT1 mutant mice that contain the Delta

101 ockout of the Rab38 gene on the FHH.BN-Rab38 congenic line recapitulated a proteinuric phenotype indi

102 assessment of a novel inbred BBDP.ACI-Iddm30 congenic line.

103 g B6.D2(Csnk1e) and D2.B6(Csnk1e) reciprocal congenic lines (78-86.8 and 78.7-81.6 Mb, respectively).

104 Reciprocal interval-specific congenic lines (ISCL) that encompass Bbaa1, Bbaa2-Bbaa3,

105 In GHS chromosome 1 congenic lines bred onto a WKY genomic background, we fo

106 We generated congenic lines carrying smaller intervals (subcongenics)

107 Five WF.COP congenic lines containing COP RN02 segments were compare

108 from advanced interval-specific recombinant congenic lines identified myostatin as uniquely upregula

109 By using congenic lines on the BN genomic background, we show tha

110 All other congenic lines tested were susceptible.

111 Advanced congenic lines were developed to reduce the physical siz

112 uing finding that metanephric allografts and congenic, major histocompatibility complex-mismatched gr

113 onto a WKY genomic background, we found that congenic males had significantly (P < 0.0001) higher CVs

114 In Pgia8-congenic males, arthritis severity was 30% less (P < 0.0

115 Congenic mapping and sequence analysis in rats suggested

116 We used congenic mapping to refine Candq1 and its candidate gene

117 Then, by combining congenic mapping, in silico haplotype analyses, and comp

118 etected in progeny from a-alpha opposite-sex congenic mating; thus, both homothallic and heterothalli

119 total) to detect underlying genetic loci; 2) congenic mice (n = 23) to replicate the identified locus

120 Using B6.129c1 congenic mice and adoptive transfer, we found that diver

121 were compared between cohorts of B6.Sle2.lpr congenic mice and B6.lpr mice of ages up to 6 months.

122 to nearly those of wild-type B6 in the B6/B6 congenic mice as follows: 83% rescue of low pial collate

123 In an earlier study, we used Ly5.1 congenic mice as transplant recipients to investigate th

124 DCC-susceptible C3H/He and B6.C3H(Dyscalc1) congenic mice at day 3 after injury.

125 Congenic mice bearing the disease loci Sle1 or Sle1 and

126 moter and inhibits its expression in NOD.C3H congenic mice carrying C3H alleles at Idd6.3.

127 Congenic mice carrying the impulsivity locus (Impu1) con

128 ne phenotypes can be isolated in recombinant congenic mice containing both genes.

129 on and IL-17 production in interval-specific congenic mice demonstrated that the two identified genet

130 The B6.TH-tabw2 congenic mice developed increased adiposity that became

131 ntrol, and the bacteria were inoculated into congenic mice differing only at Nramp1.

132 Lbw2 congenic mice exhibited marked reductions in AEAs and sp

133 ogenitor responded equally to DMBA and BP in congenic mice expressing the PAH-resistant AhR (AhR(d)).

134 ich Nba2 genes accomplish this, we generated congenic mice expressing various Nba2 intervals where ge

135 Analyses of lupus-prone congenic mice have pointed to an important role for the

136 s (Tregs), and we found that B10.S-Eae5(SJL) congenic mice have significantly greater numbers of lymp

137 C57BL/6-congenic mice heterozygous for the F508del CFTR mutation

138 Bone marrow-derived macrophages from Bbaa1 congenic mice implicated this locus as a regulator of ty

139 trains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked by E

140 ated effector CD4(+) T cells into tumor-free congenic mice mediates rejection of tumor challenge 9 mo

141 Crry derived from B6.Sle1c congenic mice migrated at a higher m.w. by SDS-PAGE comp

142 dependency, we used genetically modified and congenic mice on the C57BL/10 background and in vitro T-

143 gene (designated Tnfrsf9) in NOD.B10 Idd9.3 congenic mice protected from type 1 diabetes (T1D).

144 Transplantation of Vk*MYC tumor cells into congenic mice selected for a more aggressive disease tha

145 As previously reported, B6.TH-tabw2 congenic mice showed a significantly larger fat mass tha

146 Analysis of a panel of subinterval congenic mice showed that the full effect of Lbw2 on AEA

147 have developed novel NOD.B10-Idd9 (line 905) congenic mice that predominantly harbor islet-reactive C

148 tations to the reported genetically modified congenic mice that were generated using 129-strain ESCs

149 esis of EAE, we generated phenotype-selected congenic mice using EAE-resistant B10.S and EAE-suscepti

150 erived LSK(-) cells upon transfer into naive congenic mice were found to differentiate predominantly

151 We showed previously that C57BL/6 congenic mice with an introgressed homozygous 70 cM (125

152 lated from the paws of male and female Pgia8-congenic mice with collagen antibody-induced arthritis.

153 However, the use of congenic mice with limited phenotypes in this study has

154 producing the phenotype observed for DC from congenic mice with the NZB c1 70-100 cM interval.

155 in genetically resistant BALB/c.D2(Slc11a1) congenic mice with the wild-type Nramp1 locus.

156 Using congenic mice with varying levels of extracellular super

157 9S-Cdh23(c.753A) SNV and 129S1.B6-Cdh23(ahl) congenic mice, and a linkage backcross involving these s

158 B6.TH-tabw2 congenic mice, but not subcongenic mice, also had signif

159 rom T1D to the same extent as NOD.B10 Idd5.1-congenic mice, demonstrating that increased liCTLA-4 exp

160 Lyme arthritis in the reduced interval Bbaa1 congenic mice, formally implicating myostatin as a novel

161 NOD.B10 Idd9 congenic mice, in which the NOD Idd9 chromosomal region

162 In reciprocal chromosome 5 congenic mice, introgressed D2 alleles increased HSC num

163 However, unlike NOD.B6 Idd3 congenic mice, the knockin mice were not protected from

164 strain mapping using autoimmune NOD.C57BL/6J congenic mice, we demonstrated previously that the type

165 Using H2-congenic mice, we show that the observed difference in f

166 Using NOD congenic mice, we validate that both the MHC and the chr

167 In this study, we used C57BL/6.S (B6.S) congenic mice, which carry H-2(s) MHC genes instead of H

168 nificantly increased in the B6.C3H(Dyscalc1) congenic mice, which carry only the Dyscalc1 locus with

169 neration compared with T cells from NOD.Idd3 congenic mice, which carry the protective Idd3 allele fr

170 leads to autoimmune cholangitis in NOD.Abd3 congenic mice.

171 on intratracheal adoptive cell transfer into congenic mice.

172 g the systemic administered MDSC from CD45.1 congenic mice.

173 f them had fat mass as large as the original congenic mice.

174 controls, and comparable that to B6.TH-tabw2 congenic mice.

175 optively transferred into Rag1((-)/(-))Ly5.1 congenic mice.

176 ne marrow-derived dendritic cells from Cdcs1 congenic mice.

177 e measured in aging female gld and wild-type congenic mice.

178 ficantly dysregulated in arthritic joints of congenic mice; expression of these genes was also sex sp

179 used NZB.NZW-Lbw2 congenic (designated Lbw2 congenic) mice containing an introgressed fragment of Ne

180 Here, we used congenic models and comparative genomics to refine the R

181 By combining congenic models and cross-species studies, we narrowed t

182 stem to track haematopoietic cells following congenic mouse bone marrow transplants.

183 A novel NOD congenic mouse expressing aberrant Pkhd1, but lacking th

184 In this study, we generated a congenic mouse model carrying a mutated Nnt(C57BL/6J) al

185 and mucin (TIM) proteins, identified using a congenic mouse model of asthma, critically regulate inna

186 Here, we used the NOD.NK1.1 congenic mouse model to examine the role of NK cells in

187 Here we use an MHC congenic mouse model to test the hypothesis that genetic

188 nal role of IRAK1 was next examined by using congenic mouse models bearing the disease loci: Sle1 or

189 We used two congenic mouse models that differ at the Ahr gene and en

190 Here, we generated the corresponding congenic mouse strain by introgression of a segment of C

191 For this, we generated a congenic mouse strain carrying the A2G wild-type Mx1 res

192 8Mit293-D8Mit137)/Mx (NOD-Idd22) recombinant congenic mouse strain was generated in which NOD mice ca

193 We previously established a congenic mouse strain with TALLYHO/Jng (TH) donor segmen

194 The B6.SJL-Ptprc(d)Pep3(b)/BoyJ (B6.SJL) congenic mouse strain, a valuable and widely used tool i

195 We generate two NOD.H2(k).B10-Chr9 congenic mouse strains and validate the role of this gen

196 c lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment

197 ploited the genetic structure of recombinant congenic mouse strains by performing a reciprocal interc

198 The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms

199 between diabetes-susceptible and -resistant congenic mouse strains.

200 ne target and/or insulitis trigger in NOD or congenic mouse strains.

201 the same collection of mutants was tested in congenic mouse-derived primary macrophages, a major Nram

202 tudies demonstrate the inimitable benefit of congenic MSC therapy in reversing experimental type 1 di

203 mine this question by testing the ability of congenic MSCs, obtained from the NOR mouse strain, to re

204 ell-free filtrate of their blood to immunize congenic naive mice.

205 d3/Il2 or Idd5 are able to partially protect congenic NOD mice from insulitis and diabetes, and to pa

206 Congenic normal mdr2 (+/+) hepatocytes were isolated by

207 II (as revealed in immunized intra-H-2(d/b) congenic or CD154(-/-) H-2(d) strains, and by selective

208 detection of these cells through the use of congenic or clonotypic markers.

209 ), hESC line expressing no MECP2 (MECP2-KO), congenic pair of wild-type and mutant RTT patient-specif

210 The congenic pair was used to investigate three traits: mito

211 60, the incompatibility depended on breeding congenic pairs or the introduction of H60 by transgenic

212 Compared with the congenic parental strain (Ahr(Fx/Fx)), non-fasted Cre(Al

213 vation in vitro was assessed in parental and congenic rat bone marrow-derived macrophages (BMDMs).

214 ction of nephrotoxic nephritis in the double-congenic rats (WKY.LCrgn1,2) produced markedly fewer glo

215 ole of this QTL in EAG induction, reciprocal congenic rats were generated (LEW.WCrgn1 congenic and WK

216 reserved in DA.F344(Cia3) and DA.F344(Cia3d) congenic rats with PIA, while DA rats had pronounced syn

217 , a Vdr expression signature was detected in congenic rats, along with up-regulation of mediators of

218 significantly lower levels in DA.ACI(Cia25) congenic rats.

219 nor B cells were adoptively transferred into congenic recipients and allowed to remain for 1 mo in th

220 ls with germline VRC01 B cell receptors into congenic recipients to elucidate the roles of precursor

221 hich were confirmed, were located within the congenic region and contained several sequence variants.

222 and to exclude other genes within the 1.5 Mb congenic region from involvement in causing the FHH phen

223 Because the original Rf-4 congenic region is 61.9 Mbp, it is necessary to reduce t

224 T1D as the result of a NOR-derived 44.31-Mb congenic region on distal Chr.

225 the large effects that strain background and congenic regions have on the hearing loss associated wit

226 mory impairment, memories in GluA3-deficient congenics remained unaffected.

227 on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb.

228 measurements were made in C57BL6/J mice and congenic Sftpd-/- mice at 8, 27 and 80 weeks of age (n =

229 ncidences were combined, males of the double congenic showed lower than expected TGCT incidence (nega

230 rate the matted and Flg mutations to produce congenic single-mutant strains for genetic and immunolog

231 ially controls lupus-related autoimmunity in congenic Sle1b mice; for instance, the presence of the p

232 Developmental processes were investigated in congenic Sox10(Dom) mice, an established Hirschsprung di

233 ensitive hypertension, and salt-insensitive, congenic SS.13(BN26) rats fed a high-salt diet.

234 lla of SS rats, but not the salt-insensitive congenic SS.13(BN26) rats, was significantly increased w

235 lity complex-matched C57BL/6 (B6) background congenic stock differed in capacity to inhibit type 1 di

236 Our study demonstrates that the MAIThi congenic strain allows phenotypic and functional charact

237 ts of Crgn1 and Crgn2, we generated a double-congenic strain by introgressing these loci from glomeru

238 asured in B6-Ldlr(-/-)Cdkn2a(+/-) mice and a congenic strain carrying the region of homology with the

239 ) integrins (SAMP1/YitFc Itgb7(-/-)) using a congenic strain developed via marker-assisted selection.

240 We generated an A/J congenic strain lacking c-Kit by introgression of the Wv

241 By congenic strain mapping using autoimmune NOD.C57BL/6J co

242 Interestingly, in a congenic strain of mice carrying low-affinity, ligand-bi

243 Using a newly discovered congenic strain of mice, we show a previously unrecogniz

244 ificantly to TGCT, when combined in a double congenic strain resulted in greater than expected TGCT i

245 s in ischemic tissue injury, and generated a congenic strain set with wide allele dose-dependent vari

246 We generated a MAIThi congenic strain that was then crossed to a transgenic Ro

247 For the triple congenic strain, depending on the analysis, the overall

248 imilar results were observed in an SS.5(Lew)-congenic strain, in which a smaller region of chromosome

249 s test focused on the obesity-resistant 6C2d congenic strain, which carries the Obrq2a(A/J) allele on

250 Through the use of a series of novel congenic strains containing the Idd3/Il2 region and diff

251 Analysis of congenic strains demonstrated that the FcgammaR and SLAM

252 t harbor susceptibility genes and a panel of congenic strains derived from a selected CSS to determin

253 The congenic strains each with their characteristic TGCT inc

254 Mice from recombinant congenic strains expressing Sle1c2 exhibited increased C

255 Immunized H-2(d)-congenic strains had more rapid, sustained, and elevated

256 ify and map tumor loci from M19 we generated congenic strains harboring MOLF chromosome 19 segments o

257 rmal placental development, we characterized congenic strains homozygous for the hypomorphic Egfr(wa2

258 significant muscle inflammation in multiple congenic strains of C57BL/6 and NOD mice.

259 to appropriate control proteins) in various congenic strains of mice.

260 Six congenic strains possessing portions of Candq1 introgres

261 In summary, the congenic strains provide a new resource for the explorat

262 The C. gattii congenic strains represent a new resource for exploring

263 The two congenic strains show the same virulence in different mo

264 fluence on selection of KLRH1(+) NK cells in congenic strains suggested that KLRH1 may have an MHC li

265 analysis and the generation of novel Idd5.1-congenic strains that differ at the disease-associated C

266 We found 3 congenic strains that each harbored tumor promoting loci

267 esponses to the HIV-1 Envelope, we have used congenic strains to identify a critical role for MHC cla

268 The resulting congenic strains were then used to test the impact of ma

269 and protein, and decreased TCR signaling in congenic strains with B6-derived Idd18.2 susceptibility

270 mouse strains (AcB/BcA panel of recombinant congenic strains) created from influenza-susceptible A/J

271 candidate gene-methods used include creating congenic strains, comparative genomics and gene expressi

272 n and virulence gene regulation by utilizing congenic strains, each harboring a unique S. aureus agr

273 nterval within the MHC-II locus of three MHC-congenic strains, of which two were protected from sever

274 dominant when 2 loci were combined in double congenic strains.

275 ntervals that have been isolated in separate congenic strains.

276 CT development, we created double and triple congenic strains.

277 owed with genetic and phenotypic analysis of congenic, subcongenic, and subsubcongenic strains, we id

278 Protective alleles in the Idd9.2 congenic subregion are required for the maximal reductio

279 c inherited glaucoma, using as a control the congenic substrain DBA/2J Gpnmb(+/SjJ) (D2G), which is n

280 ng factors, this original demonstration used congenic/syngeneic dam and foster pup pairs.

281 ight on the limitations of the CD45.1/CD45.2 congenic system for tracking lymphocyte development.

282 ve smaller lesions, and adoptive transfer of congenic T cells into athymic nude mice prior to infecti

283 Congenic Tbx1 heterozygous (HT) mice were impaired in so

284 RESEARCH DESIGN AND After congenic transfer of the NOD H2(g7) haplotype onto 129S1

285 verall repopulation of primary and secondary congenic transplantation recipients.

286 durable donor-derived HSC engraftment after congenic transplantation.

287 Using fetal liver and BM congenic transplantations and deleting IKKalpha from ear

288 Congenic transplants into T(FH)-deficient CD4(-/-) mice

289 anting lethally irradiated C57BL/6 mice with congenic VDR or wild type BM.

290 Female KO and congenic wild type (WT) mice were treated with racemic P

291 RR Z/DeltaLRR Z) mice, Cryo(-Z/-Z) mice, and congenic wild-type (WT) mice were challenged with endoto

292 on, mice were simultaneously inoculated with congenic wild-type and luxS strains, and bacterial numbe

293 Compared to congenic wild-type animals, Irf5-/- and CMV-Cre Irf5fl/f

294 Compared to congenic wild-type controls, Ifit2(-/-) mice showed enha

295 ary changes, Lck(-/-) mice and corresponding congenic wild-type mice were chronically exposed to ciga

296 e and following ozone exposure compared with congenic wild-type mice.

297 2/TLR-4-double-knockout, MyD88-knockout, and congenic wild-type mice.

298 as the sequenced reference (CC-503) are not congenic with respect to sta6 (CC-4348), underscoring th

299 However, when congenic with the C57Bl/6 strain, 80% of ADAMTS9+/- mice

300 tive strategies, such as the construction of congenics with very small donor regions.