1 as a regulatory mechanism for cullin and non-cullin proteins.

2 w that SAP130 can interact with a variety of cullin proteins.

3 N protein through interactions with both the cullin protein and an E2 enzyme such as UBC12.

4 g enzymes, thereby preventing neddylation of Cullin proteins and preventing the degradation of CRL ta

5                        Cdc34, Rad6B, and the Cullin proteins are expressed in a developmentally regul

6            We also show that the majority of cullin proteins are progressively neddylated during the

7                                              Cullin proteins assemble a large number of RING E3 ubiqu

8 ee subunits are the Skp1 protein; one of the cullin proteins (Cul1 in metazoans and Cdc53 or Cul A in

9 forms of RUB1 and RUB2 conjugate to the same cullin protein, CUL1, and produce the same conjugation p

10 rt of an E3 ligase complex that includes the cullin proteins Cul4A and Cul4B.

11                                              Cullin proteins form a scaffold for two functional modul

12 d by conjugation of a Nedd8 polypeptide onto Cullin proteins in a process called neddylation.

13                       Nedd8 is conjugated to cullin proteins in a process that alters SCF E3 ubiquiti

14 tinctly different patterns for Cdc34 and the Cullin proteins in germ cells.

15 lation (the conjugation of a Nedd8-moiety to Cullin proteins) in the fine tuning of the NF-kappaB res

16         Hence, combinations of ROC/APC11 and cullin proteins proteins potentially constitute a wide v

17                    Conjugation of Nedd8 to a cullin protein, termed neddylation, is an evolutionarily

18  Other F-box proteins interact with SKP1 and cullin proteins to form SCF complexes that selectively r

19                Cul3 belongs to the family of cullin proteins, which function as scaffold proteins of