ライフサイエンスコーパス: endocytosis

1 cifer yellow uptake (a marker of fluid phase endocytosis).

2 el closure and transitioning GJ channels for endocytosis.

3 elevated cell-surface levels due to reduced endocytosis.

4 tects the channel against ubiquitination and endocytosis.

5 ion via TORC1 is sufficient to trigger their endocytosis.

6 they must first cross the plasma membrane by endocytosis.

7 oton channel that acidifies the virion after endocytosis.

8 g of Cav1.2 channels without affecting their endocytosis.

9 interfere with iron export independently of endocytosis.

10 es, such as cell motility, cell division and endocytosis.

11 gl2 from Celsr1 is a prerequisite for Celsr1 endocytosis.

12 ontrol cell surface density of GPR15 through endocytosis.

13 aptic efficacy through AMPA receptor (AMPAR) endocytosis.

14 of an agent to these cells through Siglec-8 endocytosis.

15 gulates the trafficking of VE-cadherin after endocytosis.

16 in-synaptojanin1 interaction required for SV endocytosis.

17 membrane trafficking, vesicle secretion, and endocytosis.

18 of GluA1 subunits through dynamin-dependent endocytosis.

19 arch has focused on the stochastic nature of endocytosis.

20 protein internalization by clathrin-mediated endocytosis.

21 e, and that this stereotyped output requires endocytosis.

22 ich has a dramatic effect on proximal tubule endocytosis.

23 vity of RIN1 regulates surface GluA1 subunit endocytosis.

24 f the endocytic machinery to mediate granule endocytosis.

25 aptor protein-2 (AP-2) via clathrin-mediated endocytosis.

26 to trigger high-affinity glucose transporter endocytosis.

27 d, including direct membrane penetration and endocytosis.

28 ctin overexpression phenotypes by increasing endocytosis.

29 ired for efficient, activity-dependent AMPAR endocytosis.

30 nternalization by blocking clathrin-mediated endocytosis.

31 ion of clathrin-dependent EGFR signaling and endocytosis.

32 een previously associated with a function in endocytosis.

33 ily proteins that regulate actin binding and endocytosis.

34 phrinB1-dependent macropinocytosis and trans-endocytosis.

35 phobic channel in the receptor, or after HDL endocytosis.

36 article uptake in macrophages by suppressing endocytosis.

37 localized with the zone of clathrin-mediated endocytosis.

38 namics of phosphoinositide conversion during endocytosis.

39 gulating their ubiquitylation and subsequent endocytosis.

40 ells, motors pull tubes, particularly during endocytosis.

41 lamellipodia protrusion, cell migration and endocytosis.

42 is, but also for rapid phase of compensatory endocytosis.

43 by which nutrients modulate ART activity and endocytosis.

44 kinase responsible for regulating Gliotactin endocytosis.

45 Activated GPCRs undergo clathrin-dependent endocytosis.

46 membrane tension exerts inhibitory action on endocytosis.

47 ein involved in AMPA-type glutamate receptor endocytosis.

48 ane from biosynthetic pathways or removal by endocytosis.

49 rough mechanoregulation of clathrin-mediated endocytosis.

50 eovirus is internalized by receptor-mediated endocytosis.

51 cles from the membrane via clathrin-mediated endocytosis.

52 t GluA1-containing AMPARs resist OGD-induced endocytosis.

53 of EEA1, a protein involved in AMPA receptor endocytosis.

54 CCPs, thus modulating its own signaling and endocytosis.

55 e ventricles, it controlled inflammation and endocytosis.

56 fy Flower as a key protein mediating granule endocytosis.

57 as well as its role in mGluR-dependent AMPAR endocytosis.

58 phosphorylation of Akl1, adjusts the rate of endocytosis.

59 s are removed from the cell surface via bulk endocytosis [4].

60 ous vesicle exocytosis, followed by arrested endocytosis, accounting for the disappearance of evoked

61 ssive cells, we determined how impairment of endocytosis affects productive infection by prion strain

62 We found that modulation of autophagy or exo/endocytosis, affects alpha-syn transfer.

63 trypanosomes to AEE788 inhibited transferrin endocytosis, altered cell morphology, and decreased cell

64 monitor the acidification of vesicles during endocytosis, an essential function that aids in cargo so

65 Endocytosis analysis revealed that MOFs are internalized

66 n gene-related peptide (CGRP) stimulated CLR endocytosis and activated protein kinase C (PKC) in the

67 bitors of clathrin and dynamin prevented CLR endocytosis and activation of cytosolic PKC and nuclear

68 itin ligase Neuralized, thus fine tuning the endocytosis and activity of this apical determinant.

69 rized, it is generally considered to involve endocytosis and an initial surface-binding event.

70 dynamin isoforms differentially regulate the endocytosis and apoptotic signaling downstream of TNF-re

71 gh these functions require receptor-mediated endocytosis and appropriate subcellular localization, th

72 factor (GEF) Brag2, which controls integrin endocytosis and cell adhesion and is impaired in cancer

73 This polarization depends on actin-mediated endocytosis and contributes to the subcellular partition

74 mRNA level and at the protein level through endocytosis and degradation triggered by tyrosine phosph

75 activity are mutually required for receptor endocytosis and degradation, triggered by Hedgehog prote

76 s, which may relate to increased VE-cadherin endocytosis and degradation.

77 omplex is internalized via clathrin-mediated endocytosis and degraded in lysosomes, leading to attenu

78 at spatiotemporally control PI conversion in endocytosis and endolysosomal membrane dynamics during e

79 (HSV) entry into a subset of cells requires endocytosis and endosomal low pH.

80 eraction with betaarr is dispensable for V2R endocytosis and ERK activation and therefore provide nov

81 tion-deficient V2R mutant exhibits efficient endocytosis and ERK activation upon agonist stimulation.

82 ctions are important for the coordination of endocytosis and exocytosis and have an impact on stomata

83 For endocytosis and exocytosis, membranes transition among p

84 ele and show that it has a decreased rate of endocytosis and growth defects that are shared with othe

85 nal injury with disrupted clathrin-dependent endocytosis and impaired receptor desensitization.

86 Myo1p concentrates at the site of endocytosis and initiates a zone of actin filaments asse

87 rgistic effects of P-gp inhibition, enhanced endocytosis and intracellular sequentially drug release.

88 Mechanistic understanding of the endocytosis and intracellular trafficking of nanoparticl

89 ent with fluid-phase than receptor-dependent endocytosis and is subject to bidirectional modulation b

90 PICK1 is required for both OGD-induced GluA2 endocytosis and lysosomal sorting.

91 Mechanistically, SRC impacts on syndecan endocytosis and on syntenin-syndecan endosomal budding,

92 hat plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by

93 an additional motif that drives VE-cadherin endocytosis and pathological junction disassembly associ

94 gy or extracellular material internalized by endocytosis and phagocytosis.

95 Thus, XLalphas restricts clathrin-mediated endocytosis and plays a critical role in iron/transferri

96 ase PIP5K6 is required for clathrin-mediated endocytosis and polar tip growth in pollen tubes.

97 ion, in association with reduced aquaporin-2 endocytosis and prolonged plasma membrane aquaporin-2 re

98 MP-3 and increased ability to inhibit TIMP-3 endocytosis and protect cartilage.

99 ng ATP hydrolysis effectively abolished slow endocytosis and rapid endocytosis but only partially inh

100 is mechanism allows constitutive VE-cadherin endocytosis and recycling to contribute to adherens junc

101 ermeant Halo dyes allows imaging of integrin endocytosis and recycling.

102 n up by astrocytes through receptor-mediated endocytosis and resulted in astroglial NF-kappaB activat

103 c, a sugar-nucleotide that inhibits receptor endocytosis and signaling by promoting N-acetylglucosami

104 ulation of CME, leading to autoregulation of endocytosis and signaling downstream of surface receptor

105 rotein modulates alpha2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3

106 vivo by disrupting receptor tyrosine kinase endocytosis and signaling.

107 ic pathway in deregulating DAergic neuron SV endocytosis and that they play additive roles in facilit

108 e repurposing existing proteins to diversify endocytosis and trafficking, as well as preferential exp

109 pecifically and synergistically regulate PTC endocytosis and transport processes.

110 2749R causes dysfunction of Vps13 protein in endocytosis and vacuolar transport, although the level o

111 bicin (a toxic compound whose entry requires endocytosis), and impedes Lucifer yellow uptake (a marke

112 d homophilic adhesion is necessary for trans-endocytosis, and adhesive junctional PCP complexes appea

113 luding maintenance of stereocilia structure, endocytosis, and autophagosome maturation.

114 size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded with

115 protein that functions in clathrin-dependent endocytosis, and beta-1,3-glucoronyltransferase 2 (B3GAT

116 ce of cholesterol, LDLR-mediated cholesterol endocytosis, and cholesterol efflux are all essential to

117 TDP-43 inhibits endocytosis, and co-localizes strongly with endocytic pr

118 was only modestly affected by inhibition of endocytosis, and could be blocked with an anti-TLR3 anti

119 st cells, identify mechanisms underlying its endocytosis, and demonstrate whether a toxin can be targ

120 n regulators of Rho-type GTPases, E-cadherin endocytosis, and epithelial junctional remodeling, as bo

121 phorylation and activation of Dyn1, TRAIL-DR endocytosis, and increased resistance to TRAIL-induced a

122 n filament arrays that drive cell migration, endocytosis, and other processes.

123 naling or an inhibition of clathrin-mediated endocytosis, and PKD inhibitors do not need to be presen

124 ys and warrant that cargo ubiquitylation and endocytosis appropriately respond to nutritional inputs.

125 Using RNAi and tracer endocytosis as a functional read-out, we screened Drosop

126 ently-tagged MkMPs inside HSPCs demonstrates endocytosis as one mechanism of cargo delivery.

127 ynamins, key components of clathrin-mediated endocytosis, as binding partners of XLalphas.

128 is a Ca(2+)-dependent negative regulator of endocytosis, as NCALD knockdown improves endocytosis in

129 Using micropatterning with a receptor trans-endocytosis assay, we show that signaling between pairs

130 uorescence recovery after photobleaching and endocytosis assays, integrin recycling between both site

131 h Ubp2 and Ubp15 results in a defect in Hxt6 endocytosis associated with Art4 instability.

132 ed ATP requirement in three typical forms of endocytosis at rat calyx of Held terminals by whole-cell

133 entous fungi concentrate both exocytosis and endocytosis at the apex.

134 aid in investigations of pH dynamics during endocytosis at the nanoscale, we have specifically desig

135 We show that secretion and endocytosis at the plasma membrane are sensitive to CHC1

136 s ATP-independent mechanism(s) to accelerate endocytosis at the same time as preserving ATP availabil

137 ATP-independent endocytosis became more significant at 34-35 degrees C,

138 ediated negative regulation of Akl1 enhances endocytosis, because an Akl1 mutant immune to Fpk1 phosp

139 amin, which mediates membrane fission during endocytosis, binds endophilin and other members of the B

140 +/-) and LRRK2 G2019S does not exacerbate SV endocytosis but impairs sustained exocytosis in MB neuro

141 ctively abolished slow endocytosis and rapid endocytosis but only partially inhibited excess endocyto

142 erminals, ATP was required not only for slow endocytosis, but also for rapid phase of compensatory en

143 context-dependent signals drive VE-cadherin endocytosis, but p120 binding to the cadherin juxtamembr

144 ce that isolated mitochondria enter cells by endocytosis, but the mechanism has not been fully charac

145 to monitor acidification of vesicles during endocytosis, but the size of vesicles is below the diffr

146 rge onto Csr2 to regulate hexose transporter endocytosis by glucose availability.

147 Tracer endocytosis by nephrocytes required Cubilin and reflecte

148 The GIPC family adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI

149 cell surface receptors via clathrin-mediated endocytosis, cells assemble at least 50 proteins, includ

150 bustness of processes like clathrin-mediated endocytosis (CME) across a diverse range of organisms an

151 Clathrin-mediated endocytosis (CME) constitutes the major pathway for upta

152 itical initiation phase of clathrin-mediated endocytosis (CME) determines where and when endocytosis

153 Clathrin-mediated endocytosis (CME) is a major internalization route for P

154 Clathrin-mediated endocytosis (CME) is used to internalize a diverse range

155 During clathrin-mediated endocytosis (CME), endocytic-site maturation can be divi

156 ernalized and regulated by clathrin-mediated endocytosis (CME).

157 es membrane fission during clathrin-mediated endocytosis (CME).

158 drug release behavior, and promoted cellular endocytosis compared with free ICG or EPI.

159 could show that Ca(2+)-dependent adiponectin endocytosis contributes to the measured capacitance sign

160 ls and ameliorates pharmacologically induced endocytosis defects in zebrafish.

161 genic RAS specifically triggers constitutive endocytosis-dependent movement of effector kinases to a

162 annels, rather than ZO-1 interfering with GJ endocytosis directly.

163 tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and

164 Thus, endocytosis dysfunction may be an underlying cause of AL

165 ne of mammalian cells undergoes constitutive endocytosis, endocytic sorting, and recycling, which del

166 further report that transcripts involved in endocytosis, extracellular exosomes, and metal ion bindi

167 cilitates endocytosis remains debated in the endocytosis field, and has been rarely studied for vesic

168 ocytosis but only partially inhibited excess endocytosis following intense stimulation.

169 suggest that lipid stress disrupts steps of endocytosis following MC4R localization to clathrin-coat

170 cGAMP-PC7A NP requires endocytosis for intracellular delivery and immune signal

171 ss cytokine signalling, although the role of endocytosis for prolactin signalling is not known.

172 In the early stages of endocytosis, fPlas-gold nanoparticles appear mostly as s

173 Endocytosis has been generally recognized as a major ATP

174 r, few cargoes exhibiting muniscin-dependent endocytosis have been identified, and the sorting sequen

175 er, no specific molecular mechanisms of TIE2 endocytosis have been reported.

176 -phase CME proteins and supported productive endocytosis, identifying it as an Ede1 functional homolo

177 clathrin does not play an important role in endocytosis in A. nidulans.

178 try of several viruses; however, the role of endocytosis in cellular trafficking of viruses beyond vi

179 OGD does not cause GluA2 endocytosis in cortical neurons, and we show that PICK1

180 asts, in order to study a post-entry role of endocytosis in HCMV life cycle.

181 ossible role of the CUBAM complex in albumin endocytosis in human podocytes.

182 tional use of actin during clathrin-mediated endocytosis in mammalian cells suggests that the cell co

183 th factor receptor-beta (PDGFRbeta)-mediated endocytosis in mouse striatum.

184 ovide evidence for an important role of FZD4 endocytosis in NDP/FZD4 signalling and in CNS vascular b

185 rment of clathrin-dependent and -independent endocytosis in proximal tubules, phenocopying what has b

186 pool (RRP) in many synapses, but the role of endocytosis in PTP is unknown.

187 d, and has been rarely studied for vesicular endocytosis in secretory cells.

188 Maximal endocytosis in Siglec-8-transduced HEK293T cells require

189 of endocytosis, as NCALD knockdown improves endocytosis in SMA models and ameliorates pharmacologica

190 We show that GPR15 undergoes a constitutive endocytosis in the absence of ligand.

191 and motif of aquaporin-2 and accelerates its endocytosis in the absence of vasopressin.

192 hese data reveal a novel role for ECM-driven endocytosis in the positive regulation of cytokine signa

193 nfirmed by direct measurement of fluid-phase endocytosis in the presence of these compounds.

194 n polymerization and force generation during endocytosis in yeast, using a model in which NPFs form a

195 Impairing endocytosis increases TDP-43 toxicity, aggregation, and

196 ocytic adaptor AP-2 proteins fails to rescue endocytosis, indicating that Flower interacts with prote

197 ographs (TEM) of infected cells treated with endocytosis inhibitors showed intact nuclear stages of n

198 Using endocytosis inhibitors, bacterial isogenic mutants, and

199 lting in single molecule binding to CD22 and endocytosis into cells.

200 ptic vesicles undergo multiple rounds of exo-endocytosis, involving recycling and/or degradation of s

201 Substrate-transport-elicited endocytosis is a common control mechanism of membrane tr

202 Endocytosis is a crucial cellular process in eukaryotic

203 Clathrin-mediated endocytosis is a major regulator of cell-surface protein

204 However, K5-induced VE-cadherin endocytosis is associated with displacement of p120 from

205 The coupling of exocytosis and endocytosis is assumed to be Ca(2+) dependent, but the e

206 The albumin endocytosis is Ca(2+)-dependent and accompanied by ORAI1

207 R-mediated ryanodine receptor activation and endocytosis is dependent on early caspase-8 activation.

208 that perforation-dependent L. monocytogenes endocytosis is distinct from the resealing machinery.

209 Endocytosis is entirely blocked at an early stage in Flo

210 Clathrin- and actin-mediated endocytosis is essential in eukaryotic cells.

211 Our data suggest that clathrin-mediated endocytosis is increased in PAPC-expressing cells, subse

212 ctor synaptotagmin-1 (syt1) in regulation of endocytosis is poorly understood.

213 Here we show that clathrin-mediated endocytosis is required for ECM-dependent STAT5 activati

214 biquitously expressed Dyn2, TRAIL-induced DR endocytosis is selectively regulated by activation of Dy

215 , such as cytosolic compartmentalization and endocytosis-like macromolecule uptake.

216 ugh a multistep process of receptor binding, endocytosis, low pH-induced pore formation, and the tran

217 We show here that OGD causes endocytosis, lysosomal targeting and consequent degradat

218 n-dependent reserve pool and the presynaptic endocytosis machinery.

219 To test whether reduced endocytosis mediated by p120 is required for VE-Cad form

220 ectly penetrating the plasma membrane or via endocytosis-mediated endo-lysosome rupture, leading to f

221 Lewy body disease (DLBD) preferentially show endocytosis-mediated seeding associated with endo-lysoso

222 nhibitory activity and specificity of BTZ by endocytosis-mediated uptake of CD38 representing a promi

223 The ATP-independent endocytosis occurred at calyces from postnatal days 8-15

224 endocytosis (CME) determines where and when endocytosis occurs.

225 abody, it robustly inhibited agonist-induced endocytosis of a broad set of GPCRs without affecting ER

226 N1 signals through Rab5 GTPases that control endocytosis of cell-surface receptors and Abl nonrecepto

227 We further show that Neur promotes the endocytosis of Crb via the NBM-containing isoforms of Sd

228 Bim accumulation was caused by marked endocytosis of EGF receptors with concomitant ERK attenu

229 the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive mol

230 luorescence and plasmonic imaging shows that endocytosis of fPlas-gold follows multiple pathways.

231 onal changes required for ubiquitination and endocytosis of Fpn.

232 In neurons, the rapid endocytosis of GluA2-containing AMPA receptors (AMPARs)

233 We propose that endocytosis of GluA2/3, caused by a hippocampal-specific

234 n critically controls the ligand-independent endocytosis of GPR15.

235 evidence that blocking the clathrin-mediated endocytosis of LGR5 could be used to pharmacologically c

236 teracts with Jagged, impedes basal recycling endocytosis of ligands, but is required for efficient re

237 To kill multiple target cells, CTLs use endocytosis of membrane components of cytotoxic granules

238 e evidence that substrate-transport elicited endocytosis of other amino acid permeases similarly invo

239 oinflammatory stimuli but were proficient at endocytosis of particulate and soluble material.

240 vity and temperature recruit ATP-independent endocytosis of pre-existing membrane (in addition to ATP

241 enters mammalian cells by receptor-mediated endocytosis of protein-bound Cbl followed by lysosomal e

242 lished by EGTA, which preferentially blocked endocytosis of retrievable membrane pre-existing at the

243 on the surface of most body cells, and after endocytosis of the complex, iron enters the cytoplasm vi

244 sion by increasing the lateral diffusion and endocytosis of the transporter.

245 e by restricting the scission and subsequent endocytosis of these membrane pits.

246 fer cells, generate ROS via dynamin-mediated endocytosis of TLR4 and NOX2, independently from MyD88 a

247 translocation domain after receptor-mediated endocytosis of toxins from the cell surface.

248 was without effect on the clathrin-mediated endocytosis of transferrin receptor (TfR).

249 In yeast, endocytosis of transporters is triggered by their ubiqui

250 transients in terminals deficient in either endocytosis or exocytosis revealed an acid efflux mechan

251 entry, fusion, and viral uncoating, but not endocytosis or HIV life cycle stages after uncoating.

252 urnover and toxicity depend in part upon the endocytosis pathway.

253 The endocytosis pathways and biological activities of PEGyla

254 nisms of cellular internalization by various endocytosis pathways and subsequent endocytic vesicle tr

255 mediates the last step of the autophagy and endocytosis pathways and supports organelle remodeling a

256 impairments of either the Gi or betaarrestin/endocytosis pathways with no effect on Gs activation.

257 ones, showed involvement of skin barrier and endocytosis/phagocytosis/autophagy, in addition to known

258 ta suggest that internalization of Notch via endocytosis plays a role in this process.

259 ATP-independent endocytosis primarily involved retrieval of pre-existing

260 that occur after receptor internalization by endocytosis provide a critical level of control of cellu

261 This reciprocal regulation of signaling and endocytosis provides opportunities for the establishment

262 s a key player in postsynaptic AMPA receptor endocytosis, providing multiple ways of negatively regul

263 e obtained estimates of adiponectin exo- and endocytosis rates, and we have predicted adiponectin sec

264 her membrane tension inhibits or facilitates endocytosis remains debated in the endocytosis field, an

265 This less understood endocytosis represents a non-canonical mechanism regulat

266 ATP-independent endocytosis represents a non-canonical mechanism that ca

267 However, AQP4 endocytosis requires an activating FcgammaR's gamma subu

268 ation, and protein levels, whereas enhancing endocytosis reverses these phenotypes.

269 s a monomeric TLR4-MD2 complex that triggers endocytosis, ROS generation and increases pro-interleuki

270 that the DeltaMoglo3 mutant is defective in endocytosis, scavenging of the reactive oxygen species,

271 how that platelets are capable of a range of endocytosis steps, with VAMP-3 being pivotal in these pr

272 escribe a new role for SLAMF1 to mediate MeV endocytosis that is in contrast with the alternative, an

273 This spatial reorganization requires endocytosis, the kinase activities of MEK-ERK and CK2, a

274 ce GLP-1R activation with clathrin-dependent endocytosis, the SNXs were found to control the balance

275 Apart from a role in endocytosis, they are known for global effects on mRNA r

276 defense responsive pathways include effector endocytosis through clathrin-coated vesicle trafficking,

277 an essential determinant of synaptic vesicle endocytosis time course by delaying the kinetics of vesi

278 er, it is not known whether GFR modulates PT endocytosis to enable maximally efficient uptake of filt

279 nown to use cell membrane fusion rather than endocytosis to enter fibroblasts, in order to study a po

280 STRACT: Neurotransmission relies on membrane endocytosis to maintain vesicle supply and membrane stab

281 Endodermal cells utilize proteins linked to endocytosis to perform this unique 'cannibalistic' proce

282 ic phosphatase that couples synaptic vesicle endocytosis to the dephosphorylation of PI(4,5)P2, a rea

283 we were able to predict the contribution of endocytosis to the measured exocytotic rate under differ

284 sting membrane (in addition to ATP-dependent endocytosis) to efficiently retrieve membrane at nerve t

285 the beta-arrestin engagement and subsequent endocytosis toward the oxytocin receptor (OXTR).

286 nal excitability, the AP-2 clathrin-mediated endocytosis trafficking mechanism may enable targeting o

287 After endocytosis, transmembrane cargo reaches endosomes, wher

288 human podocytes are committed to performing endocytosis via a receptor-mediated mechanism even in th

289 R4) on RAW264.7 macrophages, followed by its endocytosis via TLR4.

290 The endocytosis was clathrin dependent and partially depende

291 of low ligand concentrations in tumors, EGFR endocytosis was kinase-dependent and blocked by inhibito

292 This endocytosis was not affected by a reduction of exocytosi

293 An ATP-independent form of endocytosis was recruited to accelerate membrane retriev

294 rface lifetimes by pharmacologically slowing endocytosis was sufficient to increase arrestin-mediated

295 for basophilic kinases, markedly reduced the endocytosis, whereas phosphomimetic mutation of Ser-357

296 ered to be an important factor in regulating endocytosis, whether membrane tension inhibits or facili

297 by a dynamic balance between exocytosis and endocytosis, which can often be regulated by physiologic

298 n humans and showed that SMN deficit impairs endocytosis, which is rescued by elevated PLS3 levels.

299 a process that depends on clathrin-mediated endocytosis, while its ablation by CRISPR/Cas9 in an ost

300 rescent PtdIns(4,5)P2 reporter and decreased endocytosis without impairing membrane association of PI