ライフサイエンスコーパス: endocytotic

1 hanism is usually classified as fusogenic or endocytotic.

2 Epsin and AP180/CALM are endocytotic accessory proteins that have been implicated

3 orm, and phorbol ester treatment rescued the endocytotic activity blocked by agatoxin, but not the re

4 caCdc42 also increased endocytotic activity of DC, whereas dominant-negative Cd

5 e we report a simple method to visualize the endocytotic activity of LCs in living animals.

6 depolarization a basal level of constitutive endocytotic activity was observed at approximately 30% o

7 HLA-DR and CD11c, decreased CD14, increased endocytotic activity, and the ability to stimulate T cel

8 es to clathrin protein expression levels and endocytotic activity, but no detectable changes to stead

9 ther, indicating marked heterogeneity in exo-endocytotic activity.

10 esting a dynamic, light-modulated control of endocytotic activity.

11 Taken together, our results suggest that endocytotic alterations in cancer cells that affect cell

12 nesis by targeting key genes involved in the endocytotic and endosomal/lysosomal pathways, and disrup

13 ng at multiple steps, including not only the endocytotic and exocytotic rates, but also the two rate

14 rs in such a pool may contribute to receptor endocytotic and exocytotic trafficking and recycling.

15 quirement for the correct functioning of the endocytotic and secretory machinery.

16 Our work therefore demonstrates that the B12 endocytotic apparatus is not only present in this airway

17 le epithelial cells have an extensive apical endocytotic apparatus that is critical for the reabsorpt

18 ne (Ser-412) in beta-arrestin1 regulates its endocytotic but not its desensitization function.

19 nd preferentially penetrate cancer cells via endocytotic, caveosome-directed, and caveosome-independe

20 We propose that Arr1 mediates an endocytotic cell-survival activity, scavenging phosphory

21 receptor for endocytosis (HARE) mediates the endocytotic clearance of HA and other glycosaminoglycans

22 and cell biological methods to characterize endocytotic compartments that participate in trafficking

23 loop connecting PI(4,5)P2 and PA during the endocytotic cycle of synaptic vesicles and serve as a si

24 though much is understood of the transferrin endocytotic cycle, little has been uncovered of the mole

25 ortened the half-life of ERBB2 by increasing endocytotic degradation.

26 n in the "lattice network" characteristic of endocytotic domains in Drosophila presynaptic terminals.

27 Both exocytotic (NSF) and endocytotic (dynamin) ATPase/GTPase activity are require

28 uantifies the competition between fusion and endocytotic entry pathways.

29 but they did support the hypothesis that an endocytotic event(s) plays a role in the cell contact-me

30 ition by NA was due to a decreased number of endocytotic events without a change in vesicle size.

31 dependent exocytotic and Ca(+2)- independent endocytotic events.

32 ripheral ruffles by inhibiting Rab5-mediated endocytotic/exocytotic trafficking of Rac1.

33 Upon low-frequency electro-stimulation, endocytotic FM1-43 (SynaptoGreen) uptake in the presynap

34 in particular the lungs, and show decreased endocytotic function in fibroblasts.

35 e adjacent to the dense body could represent endocytotic images (newly forming vesicles) rather than

36 is, and suggest that calmodulin modulates an endocytotic intermediate process, which in turn affects

37 eceptor for 24p3 (24p3R) that is involved in endocytotic iron delivery has also been cloned.

38 ptic site, where they become available to an endocytotic machinery and are selectively internalized.

39 cts with several other key components of the endocytotic machinery in co-IP assays, including clathri

40 s are thought to organize the exocytotic and endocytotic machinery precisely at active zones.

41 in the development of the oocyte's powerful endocytotic machinery we determined the structure of the

42 in and AP180 are essential components of the endocytotic machinery, which controls internalization of

43 easome, the nucleus, the cytoskeleton or the endocytotic machinery.

44 g receptor binding to the AP2 protein of the endocytotic machinery.

45 out photoconversion (PC) of the fluorescent endocytotic marker FM 1-43 by using 3,3'-diaminobenzidin

46 ration of presynaptic function, assayed with endocytotic markers, followed accumulation of synapsin I

47 re crucial for penetration of the BBB via an endocytotic mechanism (transcytosis).

48 netics and a predominantly clathrin-mediated endocytotic mechanism, irrespective of dendrimer end-ter

49 e absence of protein degradation, through an endocytotic mechanism.

50 hrin-coated pits and are internalized via an endocytotic mechanism.

51 of mechanisms, from direct entry to various endocytotic mechanisms (both receptor independent and re

52 s an opportunity to study clathrin-dependent endocytotic mechanisms in temporal isolation from those

53 ion into mitochondria that is independent of endocytotic mechanisms.

54 croscopy to localize major components of the endocytotic membrane retrieval machinery in the photorec

55 We found that, in sea urchin eggs, endocytotic membrane retrieval required extracellular ca

56 Cells use endocytotic membrane retrieval to compensate for excess

57 during synaptic transmission is balanced by endocytotic membrane retrieval.

58 e channels plays a key role in signaling for endocytotic membrane retrieval.

59 In addition, characterization of Drosophila endocytotic mutants provides in vivo evidence for the pr

60 ynaptic boutons, similar to known Drosophila endocytotic mutants.

61 hilin A1 is a protein involved in generating endocytotic necks and vesicles during synaptic endocytos

62 PS-ASOs are released from membrane-enclosed endocytotic organelles to reach target RNAs remain large

63 ways and are released from membrane-enclosed endocytotic organelles, mainly late endosomes (LEs).

64 dynamin-dependent clathrin-coated vesicular endocytotic pathway although other dynamin-independent p

65 hat is localized to endosomes throughout the endocytotic pathway and functions in constitutive exocyt

66 reatment rapidly activates an actin-mediated endocytotic pathway and targets the enzyme to the endoso

67 endosomes of the apical membrane fluid-phase endocytotic pathway and to the Golgi complex.

68 The presence of a Ca2+-dependent endocytotic pathway at the active zone opens up the foll

69 ight cross the plasma membrane also by a non-endocytotic pathway gaining direct access to the cytopla

70 C virus and found that the clathrin-mediated endocytotic pathway is essential for both infection and

71 It is envisioned that the endocytotic pathway of ligand-receptor complexes of ANP-

72 lathrin-, caveolin-, and dynamin-independent endocytotic pathway similar to the one recently describe

73 provide evidence that LCMV entry involves an endocytotic pathway that is independent of clathrin and

74 ts biological activity and is mediated by an endocytotic pathway that is independent of the microtubu

75 n of cytosol, which selectively inhibits the endocytotic pathway via coated pits, inhibited TFPI.Xa-m

76 eased Abeta42 secretion originating from the endocytotic pathway, likely with cell-line restriction.

77 s, all of which block the clathrin-dependent endocytotic pathway, significantly blocked constitutive

78 s is the transferrin receptor (TfR) mediated endocytotic pathway, which provides cellular entry to th

79 e drug carriers into cytoplasm bypassing the endocytotic pathway.

80 a-2 ligands are internalized, in part, by an endocytotic pathway.

81 it is through the synthetic rather than the endocytotic pathway.

82 4 could lead to significant changes in their endocytotic pathways and action mechanisms via distinct

83 are known to be internalized via a number of endocytotic pathways and are released from membrane-encl

84 vivo evidence for the presence of different endocytotic pathways at a single synapse.

85 ) pharmacological drugs inhibiting different endocytotic pathways have either only minor or no negati

86 ry to defective endocytosis, suggesting that endocytotic pathways may be generally more sensitive to

87 nctional components of the receptor-mediated endocytotic pathways to allow virus to transverse the gu

88 osphorothioate (PS) linkages enter cells via endocytotic pathways.

89 Slc4a4, and a number of miRNAs implicated in endocytotic pathways.

90 e accumulation of both newly synthesized and endocytotic PIN2 pools in Brefeldin A compartments (BFAC

91 rs that interfere with discrete steps of the endocytotic process and antibodies for caveolae and Golg

92 ptic AMPARs turn over through a constitutive endocytotic process and that glutamate application great

93 ibuted to cancer specific differences in the endocytotic process of receptor recycling/degradation an

94 We demonstrate that calcineurin mediates an endocytotic process that is responsible for the rapid in

95 l of receptors by means of an exocytotic and endocytotic process, respectively.

96 temperature-, and peptide sequence-dependent endocytotic process.

97 y a novel clathrin- and caveolin-independent endocytotic process.

98 nt isoforms of dynamin may regulate distinct endocytotic processes and that the PH domain contributes

99 Active endocytotic processes are required for the normal distri

100 , their sensitivities to known inhibitors of endocytotic processes, and their route of uptake via con

101 observable when we blocked dynamin-mediated endocytotic processes, suggesting that PACSIN 3 specific

102 afficking and regulation of dynamin-mediated endocytotic processes.

103 ome common features with transferrin uptake (endocytotic) processes, the two systems also exhibit dis

104 ella organisms attached to M cells use their endocytotic properties to enter the cell.

105 STNB contains a domain with homology to the endocytotic protein AP50.

106 th Stoned proteins colocalize precisely with endocytotic proteins including the AP2 complex and Dynam

107 Changes in endocytotic proteins, signal transduction kinases, and c

108 in the rat adipocyte, not only reducing the endocytotic rate constant 3-4-fold and increasing the ex

109 Endocytotic rate constants (ke) for chlorate-treated and

110 Herein, we show that SCARA5 is an endocytotic receptor whose ligand repertoire includes th

111 HBP1 and plant RPG/PMI1 proteins involved in endocytotic recycling and organellar positioning and an

112 regeneration of synaptic vesicles during exo/endocytotic recycling at nerve terminals but do not prec

113 The kinetics of exo-endocytotic recycling could restrict information transfe

114 entified vesicles capable of engaging in exo-endocytotic recycling following stimulated Ca(2+) entry.

115 cues stoned embryonic lethality and restores endocytotic recycling to normal levels.

116 We also identify synaptic vesicle endocytotic regions close to MACs and synapses and hypot

117 r (LAMA), the scaffold protein Paxillin, the endocytotic regulator Shibire (Dynamin), and the homeodo

118 egulated in part by exocytotic insertion and endocytotic retrieval of an H(+)-ATPase to and from the

119 The sensitivity of endocytotic routes to the spatial distribution of positi

120 ted by with-no-lysine (WNK) kinases, but the endocytotic signal and the internalization machinery hav

121 o be a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV.

122 The large endocytotic steps were associated with a conductance cha

123 ing or degradative pathways depending on the endocytotic stimulus.

124 me time, locates RRC in a common step of the endocytotic system before final receptor segregation int

125 Loading experiments with the endocytotic tracker FM4-64 showed dynamic plant membrane

126 lysis failed to uncover substantial exo- and endocytotic traffic of the channel.

127 ension in the daf-2 mutant are components of endocytotic trafficking of membrane proteins to lysosome

128 directly acts intracellularly to alter uPAS endocytotic trafficking.

129 ant for endoplasmic reticulum (ER) export or endocytotic trafficking.

130 Exo-endocytotic turnover of synaptic vesicles (SVs) at synap

131 nd low (4 degrees C) temperature, suggesting endocytotic uptake and microtubule-dependent transcytosi

132 These studies demonstrate that the endocytotic uptake of a thermally responsive ELP is sign

133 black widow spider venom (BWSV), we observed endocytotic uptake of FM1-43.

134 ArfGAP3 in photoreceptors strongly inhibited endocytotic uptake of FM1-43.

135 imulation-induced alkalinization and reduces endocytotic uptake of FM1-43.

136 multi-functional receptor which mediates the endocytotic uptake of several ligands implicated in neur

137 ) ileum anchored receptor, cubilin, mediates endocytotic uptake of the IF complex of vitamin B(12) to

138 We have used endocytotic uptake of the styryl dye FM1-43 at synaptic

139 al permeability and that the extraintestinal endocytotic uptake of transferred particles by circulati

140 st, deflection of the cell membrane inducing endocytotic uptake, and second, microbubble jetting indu

141 lls is achieved by various routes, including endocytotic uptake, membrane-fusion, and scavenger recep

142 ficking pathway of aminoglycosides following endocytotic uptake, we administered kanamycin to neonata

143 on followed by PI entrance; however, loss of endocytotic vacuolar trafficking of Hst 5 did not reduce

144 However, this same pathway may release endocytotic vesicle contents, resulting in an inflammato

145 ane, and its subsequent association with the endocytotic vesicle fraction may have a role in muscarin

146 ted kinases indicates a role for them in the endocytotic vesicle-mediated uptake and trafficking of p

147 firming their association with this class of endocytotic vesicle.

148 ndogenous GPP130 reversibly redistributed to endocytotic vesicles after chloroquine treatment.

149 ins that correspond in size and frequency to endocytotic vesicles and coated pits.

150 overexpression reduced the size of DCVs and endocytotic vesicles but not MVs.

151 The endocytotic vesicles grow in number and size and are occ

152 ize the thyroid hormone-dependent binding of endocytotic vesicles to microfilaments.

153 ces various membranous structures (including endocytotic vesicles) of glial or axonal origin to form,

154 f GPP130 led to a pronounced accumulation in endocytotic vesicles, and endogenous GPP130 reversibly r

155 perinuclear punctate staining reminiscent of endocytotic vesicles, the carboxylated polymer revealed

156 Y-1, a cargo protein of clathrin-independent endocytotic vesicles, to facilitate efficient entry into

157 fraction in cytoplasm that contains uncoated endocytotic vesicles.

158 the scission event required for formation of endocytotic vesicles.

159 rin receptors were internalized via the same endocytotic vesicles.

160 solutes via tight junctions (TJs) and scarce endocytotic vesicles.

161 ein specifically localized to a postsynaptic endocytotic zone of excitatory synapses.