ライフサイエンスコーパス: endogenous inhibitor

1 nsively studied, little is known about their endogenous inhibitors.

2 made in identifying molecular substrates and endogenous inhibitors.

3 on of multiple proteolytic enzymes and their endogenous inhibitors.

4 lance between stimulatory growth factors and endogenous inhibitors.

5 ndidate-based approach to identify potential endogenous inhibitors.

6 h factors to overcome the baseline levels of endogenous inhibitors.

7 l proliferation, little is known about their endogenous inhibitors.

8 ase 2A (PP2A), which in turn is modulated by endogenous inhibitor 2 (I2 (PP2A)).

9 irst time suggest that through the action of endogenous inhibitors, alpha(v)beta(3) integrin may also

10 12, and cathepsins K and S relative to their endogenous inhibitors and increased elastolytic activity

11 l evidence adds resolvin E1 to this group of endogenous inhibitors and provides further rationale for

12 es, including extracellular matrix proteins, endogenous inhibitors, and coagulation proteins, with so

13 EL activity is regulated by two endogenous inhibitors, ANGPTL3 and ANGPTL4, and by PCs t

14 potential tumor suppressor antizyme and its endogenous inhibitor (antizyme inhibitor, AZI) have been

15 The main endogenous inhibitors are members of the IAP family and

16 angiogenesis, the activities associated with endogenous inhibitors are poorly understood.

17 cription factors, oxidants, proteinases, and endogenous inhibitors, as well as the role of leukocyte

18 ed by measuring the ratio of arginine to its endogenous inhibitors, asymmetric and symmetric dimethyl

19 t even in unstimulated brain but bound to an endogenous inhibitor, BIRC4 (xIAP), suggesting a mechani

20 reported structures of calpain bound to its endogenous inhibitor calpastatin have motivated the use

21 ent cysteine protease calpain along with its endogenous inhibitor calpastatin is widely distributed.

22 ed in the cytosolic compartment, as is their endogenous inhibitor calpastatin.

23 the activity of calpain is regulated by its endogenous inhibitor calpastatin.

24 calpain II, resulting in degradation of its endogenous inhibitor calpastatin.

25 in protein levels or decreased levels of its endogenous inhibitor calpastatin.

26 -protein interaction between calpain and its endogenous inhibitor calpastatin.

27 Their endogenous inhibitor, calpastatin, consists of four inhi

28 (2+)-dependent intracellular proteases whose endogenous inhibitor, calpastatin, is targeted by Hla-in

29 was due to TLR-induced up-regulation of the endogenous inhibitor, calpastatin.

30 clear levels of calpain and calpastatin (its endogenous inhibitor) changed in a reciprocal fashion as

31 ding of GRP78 actions, little is known about endogenous inhibitors controlling its expression.

32 PP2A (here accomplished through antagonizing endogenous inhibitors) could be a novel antitumor strate

33 een cysteinyl cathepsins and their principal endogenous inhibitor cystatin C (CystC) may favor proteo

34 of solid tumors, whereas the absence of its endogenous inhibitor cystatin C resulted in opposite phe

35 protease content and decreased levels of the endogenous inhibitor cystatin C, suggesting an imbalance

36 grading activity of CatB is inhibited by its endogenous inhibitor, cystatin C (CysC).

37 1 by inducing dissociation of SIRT1 from its endogenous inhibitor DBC1.

38 deacetylase SirT1 or loss of function of its endogenous inhibitor Deleted in breast cancer-1 (Dbc1) p

39 lex 1 (mTORC1) is regulated, in part, by the endogenous inhibitor DEPTOR.

40 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR.

41 TOPFLASH and increasing transcript levels of endogenous inhibitor, Dkk-1.

42 ew insight into how blood vessels respond to endogenous inhibitors during angiogenesis stimulated by

43 the regulation of caspase-1 activity via an endogenous inhibitor expressed by human vascular smooth

44 n that Rheb activates mTOR by binding to its endogenous inhibitor FKBP38 and preventing it from assoc

45 g TRP channels and identify RvD2 as a potent endogenous inhibitor for TRPV1/TRPA1 and inflammatory pa

46 ignals dissociated 7SK small nuclear RNA, an endogenous inhibitor, from cyclin T-Cdk9.

47 es glucose production, and is subject to the endogenous inhibitor GK regulatory protein (GKRP).

48 rough the binding of a small molecule to its endogenous inhibitor, glucokinase regulatory protein (GK

49 ng oncogenic potential when unopposed by its endogenous inhibitor, HAI-1.

50 ogical switch that liberates P-TEFb from its endogenous inhibitors Hexim1 and 7SK snRNA, but is not r

51 CAD is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characterist

52 ort, we examine the sequences of spn and its endogenous inhibitor ifs from a worldwide collection of

53 minal phosphorylation and degradation of its endogenous inhibitor, IkappaB.

54 wnstream effects of induction of NF-kappaB's endogenous inhibitor, IkappaBalpha, a putative heat shoc

55 e expression of cysteine proteases and their endogenous inhibitor in the gonadal sheath cells surroun

56 r data demonstrate that AIP1 functions as an endogenous inhibitor in VEGFR2-mediated adaptive angioge

57 Endogenous inhibitors, including those on residual myeli

58 r angiogenesis is restrained by a variety of endogenous inhibitors, including thrombospondin 1 (TSP1)

59 However, multiple proteases and endogenous inhibitors interact to govern MP activity, of

60 Their main endogenous inhibitor is tissue inhibitor of metalloprote

61 sibility that regulation also occurs through endogenous inhibitors is still debated.

62 yzing alpha-1,6-glucosidic linkages, and its endogenous inhibitor (LDI) was solved at 2.7 A.

63 Our results suggest that the natural, endogenous inhibitor MAP-1 effectively inhibits lectin p

64 Accumulating evidence indicates that endogenous inhibitors may regulate NOS.

65 stimulus dependent and tightly regulated by endogenous inhibitors, namely, suppressor of cytokine si

66 A key endogenous inhibitor of Abeta self-association is human

67 inhibitor of metalloproteinase 3 (TIMP3), an endogenous inhibitor of ADAM17, transcripts.

68 hibitor of metalloproteinases-3 (TIMP-3), an endogenous inhibitor of ADAMTS-4 and -5.

69 )-macroglobulin (alpha(2)M) as an additional endogenous inhibitor of ADAMTS-4 and ADAMTS-5.

70 of matrix metalloproteinases-3) is the only endogenous inhibitor of ADAMTS-4/-5 that has been identi

71 s a small basic protein that functions as an endogenous inhibitor of adipose triglyceride lipase (ATG

72 DEPTOR is the only known endogenous inhibitor of all known cellular mTOR function

73 racts directly with the alphaIIb tail, is an endogenous inhibitor of alphaIIbbeta3 activation; overex

74 r the ability of tumstatin to function as an endogenous inhibitor of angiogenesis and an indirect sup

75 The mechanism of action of Endostatin, an endogenous inhibitor of angiogenesis and tumor growth, r

76 Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS

77 eaved high molecular weight kininogen) is an endogenous inhibitor of angiogenesis formed by the cleav

78 An endogenous inhibitor of angiogenesis known as tissue inh

79 Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression su

80 mstatin, previously considered to be only an endogenous inhibitor of angiogenesis, also directly inhi

81 nsistent with the hypothesis that ADMA is an endogenous inhibitor of angiogenesis.

82 essor with caspase recruitment domain) is an endogenous inhibitor of apoptosis that antagonizes both

83 essor with caspase recruitment domain) is an endogenous inhibitor of apoptosis that antagonizes both

84 In this study, we demonstrate that the endogenous inhibitor of apoptosis, hILP/XIAP, is also cl

85 redox-sensing enzyme thioredoxin (Trx) is an endogenous inhibitor of ASK1.

86 -ATF6 alpha, suggesting that ATF6 beta is an endogenous inhibitor of ATF6 alpha.

87 ated over-expression of N-Cadherin, ICAT (an endogenous inhibitor of beta-catenin/TCF signaling), or

88 genes, we examined the effects of noggin, an endogenous inhibitor of BMP-2 and BMP-4 on bone formatio

89 Our data suggest that activin A is an endogenous inhibitor of bud formation and that cancellat

90 ic cascade in the heart, and functions as an endogenous inhibitor of Ca-ATPase transport activity.

91 hydrolyzing pyrophosphate, but OPN is not an endogenous inhibitor of calcification in rat aorta.

92 e-activating protein domain, functions as an endogenous inhibitor of calcineurin and Ras/extracellula

93 verexpression of MCIP1, a recently described endogenous inhibitor of calcineurin, impacts the hypertr

94 Here we identify an endogenous inhibitor of calcineurin, named Carabin, whic

95 amining expression of calpastatin (CAST), an endogenous inhibitor of calpain in three liver cell divi

96 gulatory proteins, calpastatin, the specific endogenous inhibitor of calpain, and the 28-kDa regulato

97 rthermore, overexpression of calpastatin, an endogenous inhibitor of calpain, or knockdown of calpain

98 overexpression of calpastatin, the specific endogenous inhibitor of calpain, prevents 2-day post-con

99 or overexpressing calpastatin (CAST Tg), the endogenous inhibitor of calpains were fed with high (60%

100 overexpression of calpastatin, which is the endogenous inhibitor of calpains, and induced muscle atr

101 Protein kinase inhibitor (PKI) is an endogenous inhibitor of cAMP-dependent protein kinase A

102 inhibitor of apoptosis (XIAP) is the primary endogenous inhibitor of caspases, its regulation may pla

103 of diminishing expression of cystatin B, an endogenous inhibitor of cathepsins B, H and L, on the de

104 X-linked inhibitor of apoptosis (XIAP) is an endogenous inhibitor of cell death that functions by sup

105 of inducible cAMP early repressor (ICER), an endogenous inhibitor of CRE-mediated transcription, is i

106 Cystatin C (CysC, CST3) is an endogenous inhibitor of cysteine proteases, including ca

107 The endogenous inhibitor of DFF40/CAD, ICAD, is correctly pr

108 volving Smad1, 5, and 8, and it up-regulates endogenous inhibitor of differentiation (Id1) protein, a

109 els of pigment epithelium-derived factor, an endogenous inhibitor of DN.

110 erminal (BET) family member, functions as an endogenous inhibitor of DNA damage response signalling b

111 These results suggest that Adrx is an endogenous inhibitor of endothelial activation, and migh

112 s of asymmetric dimethylarginine (ADMA), the endogenous inhibitor of endothelial nitric oxide synthas

113 vitro studies showing that caveolin-1 is an endogenous inhibitor of eNOS.

114 factor beta (TGF-beta), a potent ubiquitous endogenous inhibitor of epithelial cell growth, is secre

115 These results suggest that SVIP is an endogenous inhibitor of ERAD that acts through regulatin

116 ognosis human breast cancer, functions as an endogenous inhibitor of ERalpha function.

117 Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of factor Xa and the coagulant init

118 er, these data indicate that FRNK acts as an endogenous inhibitor of FAK signaling in SMCs.

119 ase-related nonkinase (FRNK), a SMC-specific endogenous inhibitor of FAK, which subsequently suppress

120 rminal region of FGF23, and by generating an endogenous inhibitor of FGF23.

121 lasminogen activator inhibitor-1 (PAI-1), an endogenous inhibitor of fibrinolysis, increases APAP-ind

122 ose to modulate GK activity by targeting the endogenous inhibitor of GK, glucokinase regulatory prote

123 evidence that the nuclear protein DBC1 is an endogenous inhibitor of HDAC3.

124 NPM is an endogenous inhibitor of HDM2:p53 interaction and knockdo

125 chaperone properties of Hsp27, making MK2 an endogenous inhibitor of Hsp27.

126 catalytic polypeptide-like 3G; APOBEC3G), an endogenous inhibitor of human immunodeficiency virus typ

127 14-prostaglandin J2 (15d-PGJ2) formation, an endogenous inhibitor of IKKbeta activity.

128 inducing the expression of IL-18BP, a potent endogenous inhibitor of IL-18.

129 els of IL-1 receptor antagonist (IL-1RA), an endogenous inhibitor of IL-1beta, has been suggested to

130 Arginase is the endogenous inhibitor of inducible NO synthase (iNOS), be

131 Here, we show that MFGE8 is an endogenous inhibitor of inflammasome-induced IL-1beta pr

132 A2A adenosine receptors (A2ARs) are endogenous inhibitor of inflammation.

133 Thus, Del-1 is an endogenous inhibitor of inflammatory cell recruitment an

134 echanistically, we identify annexin A1 as an endogenous inhibitor of integrin activation evoked by th

135 is a Csk-binding protein and functions as an endogenous inhibitor of integrin signaling.

136 Interleukin-10, a dominant endogenous inhibitor of interleukin-12, is largely prote

137 2-AG, acting through the CB1 receptor, is an endogenous inhibitor of invasive prostate cancer cells.

138 t the time- and stage-specific inhibition of endogenous inhibitor of kappaB kinase (IKK)--nuclear fac

139 It is known as an endogenous inhibitor of lipoprotein lipase (LPL), and it

140 r recombinant Dickkopf-related protein-1, an endogenous inhibitor of LRP6, effectively inhibited infl

141 eported previously that cystatin M, a potent endogenous inhibitor of lysosomal cysteine proteases, si

142 mice by genetically deleting cystatin B, an endogenous inhibitor of lysosomal cysteine proteases.

143 Calpastatin (CS) is a specific, endogenous inhibitor of m- and micro -calpains that does

144 Altogether, our results identify GILZ as an endogenous inhibitor of macropinocytosis in DCs, the act

145 protease inhibitor (TAPI), as well as by an endogenous inhibitor of matrix metalloproteases, tissue

146 etalloproteinases (TIMP)-2 gene, which is an endogenous inhibitor of matrix metalloproteinases involv

147 Latexin, an endogenous inhibitor of metallocarboxypeptidases, locali

148 used by a reduction in the expression of the endogenous inhibitor of metalloproteases tissue inhibito

149 r PKC-mediated phosphorylation of CPI-17, an endogenous inhibitor of MLC phosphatase.

150 inhibitor of metalloproteinases (TIMP)-3, an endogenous inhibitor of MMP-2, which cleaves Fas-L and a

151 Our findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity

152 We hypothesized that Rtp801, an endogenous inhibitor of mTORC1, which is predominantly e

153 Our study identifies XPLN as an endogenous inhibitor of mTORC2 and delineates a noncanon

154 Myostatin is an endogenous inhibitor of muscle conserved across diverse

155 cle wasting such as DMD and since it uses an endogenous inhibitor of myostatin should help circumvent

156 accompanied by lower expression of Del-1, an endogenous inhibitor of neutrophil adhesion dependent on

157 Elafin, an endogenous inhibitor of neutrophil elastase, is expresse

158 Thus, HNE is an endogenous inhibitor of NF-kappaB activation that acts b

159 These results indicate that FoxO4 is an endogenous inhibitor of NF-kappaB and identify a novel f

160 r findings reveal that ANXA1 is an inducible endogenous inhibitor of NF-kappaB in human cancer cells

161 apidly up-regulated IkappaBalpha, a specific endogenous inhibitor of NF-kappaB.

162 Therefore, caspase 2 functions as an endogenous inhibitor of NFkappaB-dependent cell survival

163 Lynx1, an endogenous inhibitor of nicotinic acetylcholine receptor

164 catestatin fragment of chromogranin A is an endogenous inhibitor of nicotinic cholinergic transmissi

165 Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS).

166 ed on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a pote

167 An endogenous inhibitor of nitric oxide synthase, asymmetri

168 Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is increa

169 gh levels of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase.

170 ls of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase.

171 a asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase.

172 Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthesis and a ris

173 or levels of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide.

174 ns of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric-oxide (NO) synthase, are

175 Both asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO production, and endothelin-1

176 se of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase.

177 e due to elevated concentrations of ADMA, an endogenous inhibitor of NO synthase.

178 Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthesis, and elevated plasm

179 we speculate that such accumulation of this endogenous inhibitor of NOS, by virtue of its pressor or

180 ough Abeta(1-42) increases expression of the endogenous inhibitor of Notch-1, numb (Nb), this can be

181 udies demonstrate that caveolin-1 acts as an endogenous inhibitor of Nrf2, as shown by the enhanced u

182 hese results define Iduna as the first known endogenous inhibitor of parthanatos.

183 t JAM-A in resting platelets functions as an endogenous inhibitor of platelet function.

184 increased the active form of inhibitor-1, an endogenous inhibitor of PP1.

185 Finally, ECE-2 processes PEN-LEN, an endogenous inhibitor of prohormone convertase 1, into pr

186 Taken together, proSAAS may represent an endogenous inhibitor of prohormone convertase 1.

187 (AnxA2) was reported to be an extracellular endogenous inhibitor of proprotein convertase subtilisin

188 Inhibitor-1, the first identified endogenous inhibitor of protein phosphatase 1 (PP-1), wa

189 Here we analyzed an endogenous inhibitor of protein phosphatase 2A (PP2A) ac

190 level of I (1)(PP2A), a 249-amino acid long endogenous inhibitor of protein phosphatase 2A (PP2A), i

191 tifies intracellular mature IL-37 as a novel endogenous inhibitor of Rac1.

192 We identified an endogenous inhibitor of remyelination, Endothelin-1 (ET-

193 tes that its biosynthetic intermediate is an endogenous inhibitor of respiration, and provides key me

194 rial inner membrane protein identified as an endogenous inhibitor of respiratory chain complex I.

195 eceded by the induced expression of Rnd3, an endogenous inhibitor of Rho protein function.

196 Cdelta-/- SMCs overexpressed RhoGDIalpha, an endogenous inhibitor of Rho signaling pathways.

197 Here we show that G-substrate, an endogenous inhibitor of Ser/Thr protein phosphatases, ex

198 overed by addition of alpha1-antitrypsin, an endogenous inhibitor of serine proteases.

199 with His-105 of the beta subunit acts as an endogenous inhibitor of sGC.

200 ight of the critical function of Smad7 as an endogenous inhibitor of Smad signaling that restricts th

201 Furthermore, the endogenous inhibitor of STAT3, protein inhibitor of acti

202 cturnal airway cell expression of GRbeta, an endogenous inhibitor of steroid action.

203 leotide uridine diphosphate, is an important endogenous inhibitor of T cell function in allergic pulm

204 MCs, suggesting that PEDF may function as an endogenous inhibitor of TGF-beta expression and fibronec

205 ent and pathophysiology by functioning as an endogenous inhibitor of TGF-beta signaling.

206 thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of the antioxidant thioredoxin and

207 xcess regulator of calcineurin 1 (RCAN1), an endogenous inhibitor of the calcineurin phosphatase that

208 re whether C1 esterase inhibitor (C1INH), an endogenous inhibitor of the contact phase, may protect f

209 s, indicating that the Drosophila TIMP is an endogenous inhibitor of the Drosophila MMPs.

210 argets astrocytes in vivo to overexpress the endogenous inhibitor of the JAK/STAT3 pathway [suppresso

211 mTOR interacting protein and functions as an endogenous inhibitor of the kinase activity for both TOR

212 ratio of the expression of ATPase to IF1, an endogenous inhibitor of the mitochondrial ATPase, was lo

213 Each elastase inactivated the endogenous inhibitor of the other, with neutrophil elast

214 ning inositol-5'-phosphatase 1 (SHIP1) is an endogenous inhibitor of the phosphoinositide-3-kinase pa

215 inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular sign

216 ole in respiratory influenza of serpinB1, an endogenous inhibitor of the serine proteases elastase, c

217 Thus, RACK1 functions as an endogenous inhibitor of the Src kinase in diverse signal

218 cycle control in late G(1) that works via an endogenous inhibitor of the Src kinase.

219 thioredoxin-interacting protein (TxNIP), an endogenous inhibitor of the thiol oxidoreductase thiored

220 nterleukin-22 binding protein (IL-22BP), the endogenous inhibitor of the tissue-protective cytokine I

221 cally unstructured protein that serves as an endogenous inhibitor of the yeast aspartic proteinase A

222 Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of tissue factor associated coagula

223 Expression of Smad7, the endogenous inhibitor of transforming growth factor-beta/

224 ata suggest that adenosine could serve as an endogenous inhibitor of TRPV1 activity by directly inter

225 se collagen XVIII is a recently demonstrated endogenous inhibitor of tumor angiogenesis and endotheli

226 roteolytic fragment of collagen XVIII, is an endogenous inhibitor of tumor angiogenesis that also inh

227 uction of thrombospondin-2 (TSP-2), a potent endogenous inhibitor of tumor growth and angiogenesis.

228 sm in which U33 mimicked the function of the endogenous inhibitor of uPA to gain entry into the cance

229 role for local vascular Klotho, first, as an endogenous inhibitor of vascular calcification and, seco

230 nly in the absence of pyrophosphate, another endogenous inhibitor of vascular calcification.

231 These data suggest that endostatin may be an endogenous inhibitor of vasopermeability as well as neov

232 IA(3), the endogenous inhibitor of yeast aspartic proteinase A (YPr

233 s a highly specific and potent 68-amino acid endogenous inhibitor of yeast proteinase A (YprA), and X

234 nhibitor of apoptosis proteins (IAPs) act as endogenous inhibitors of active caspases.

235 elated protein and agouti signaling protein, endogenous inhibitors of alphaMSH.

236 ur data suggest that physiological levels of endogenous inhibitors of angiogenesis can serve as endot

237 angiogenesis array kit and detected several endogenous inhibitors of angiogenesis exclusively presen

238 ted in inflamed tissue, the biologic role of endogenous inhibitors of angiogenesis in inflammation ha

239 The biologic relevance of endogenous inhibitors of angiogenesis in the control of

240 these results argue for a protective role of endogenous inhibitors of angiogenesis in tumor growth an

241 or TSP-1 to assess the contribution of these endogenous inhibitors of angiogenesis on LDC-mediated tu

242 otential role of the physiological levels of endogenous inhibitors of angiogenesis on tumor growth is

243 , the identities and mechanisms of action of endogenous inhibitors of angiogenesis remain unclear.

244 ication and characterization of 27 different endogenous inhibitors of angiogenesis.

245 actors at a delicate "activity" balance with endogenous inhibitors of angiogenesis.

246 C is mediated by the pro-apoptotic action of endogenous inhibitors of angiogenesis.

247 hypothesized that cardiac allografts contain endogenous inhibitors of angiogenesis.

248 The endogenous inhibitors of APC are members of the serpin f

249 ependent pathway appears to be suppressed by endogenous inhibitors of apoptosis proteins (IAPs).

250 Our results demonstrate that LXRs are endogenous inhibitors of atherogenesis.

251 thought to be due partly to the presence of endogenous inhibitors of axon regeneration.

252 Although several endogenous inhibitors of calcineurin have been reported,

253 CaMK2N1 and CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent pr

254 Serum levels of endogenous inhibitors of coagulation (e.g., antithrombin

255 P/p300 to stimulate transcription, bona fide endogenous inhibitors of CREB-coactivator or CREB-DNA in

256 esult from an imbalance between elastase and endogenous inhibitors of elastase, leading to tissue des

257 that naturally bind such coreceptors act as endogenous inhibitors of HIV-1.

258 Endogenous inhibitors of human neutrophil serine proteas

259 e been characterized, functionally important endogenous inhibitors of leukocyte adhesion have not bee

260 d modulators has emerged into a new field of endogenous inhibitors of leukocyte extravasation.

261 s, suggesting why this region is targeted by endogenous inhibitors of MACPF function.

262 nhibitors of metalloproteinases (TIMPs), the endogenous inhibitors of matrix metalloproteinases, have

263 e results suggest that SAX-1/Ndr kinases are endogenous inhibitors of neurite initiation and cell spr

264 The extended list of these endogenous inhibitors of NF-kappaB may provide new oppor

265 olites that themselves represent a family of endogenous inhibitors of nitric oxide synthase (NOS).

266 (DDAH) regulates the concentrations of human endogenous inhibitors of nitric oxide synthase, N(omega)

267 inine, arginase expression and activity, and endogenous inhibitors of NOS in patients with PAH and he

268 Two endogenous inhibitors of PP2A, I2PP2A, Inhibitor-2 of PP

269 dicate that the 6P/6D isoforms are potential endogenous inhibitors of tau filament formation and sugg

270 hways, probably related to overexpression of endogenous inhibitors of the effector-caspases, rather t

271 ibitor of metalloproteinases (TIMPs) are the endogenous inhibitors of the zinc-dependent endopeptidas

272 ein-tyrosine phosphatase 1B (PTP-1B) are two endogenous inhibitors of tyrosine kinase signaling pathw

273 lesions, we assessed whether Wnt ligands and endogenous inhibitors of Wnt signaling modulate autophag

274 tein levels of tetranectin, and t-PA and its endogenous inhibitor PAI-1, were subsequently shown to c

275 MMP activity, probably due to imbalance with endogenous inhibitors, promotes complications of atheros

276 anti-inflammation enzymes that binds to its endogenous inhibitor protein, Kelch-like ECH (erythroid

277 Phosphatase-1 is restrained by its endogenous inhibitor, protein phosphatase inhibitor-1 (P

278 However, the molecular identity of this endogenous inhibitor remained undefined.

279 on of GLI1 via RNAi or via overexpression of endogenous inhibitors results in a reduction of EWS/FLI1

280 heir intracellular expression of GrB and its endogenous inhibitor, serine protease inhibitor 6 (Spi6)

281 These enzymes are strictly regulated by endogenous inhibitors such as tissue inhibitors of MMPs

282 ation at Ser84, which releases Gli1 from its endogenous inhibitor, SuFu.

283 VLDLR is a potent endogenous inhibitor that negatively regulates the angio

284 ion between neutrophil-derived elastases and endogenous inhibitors that determines elastase-mediated

285 inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors that regulate the activity of matr

286 Its endogenous inhibitor, the proform of eosinophil major ba

287 Despite abundant endogenous inhibitors, these proteinases are protected f

288 ated with enhanced expression of Trx and its endogenous inhibitor thioredoxin interacting protein.

289 erved thiol reductase that interacts with an endogenous inhibitor, thioredoxin-interacting protein (T

290 y enhancing MMP activity and suppressing the endogenous inhibitor TIMP-1.

291 C-terminus and inhibition of activity by the endogenous inhibitor TIMP-3.

292 metalloprotease ADAM17 by competing with its endogenous inhibitor, TIMP3.

293 e matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) have also been shown to co

294 inases 1 and 3 and increases levels of their endogenous inhibitor, tissue inhibitor of metalloprotein

295 activity and a significant reduction of its endogenous inhibitor, tissue inhibitor of metalloprotein

296 aphy was unchanged between groups, while its endogenous inhibitor, tissue inhibitors of matrix metall

297 ar whether MMP activity and binding to their endogenous inhibitors, tissue inhibitors of metalloprote

298 on and an increased Akt association with its endogenous inhibitor tribbles homolog 3.

299 investigated the interaction of TRX with its endogenous inhibitor, vitamin D3-upregulated protein (VD

300 tic activity of selected elastases and their endogenous inhibitors were assessed.