ライフサイエンスコーパス: engulfment

1 macrophage filopodia in particle capture and engulfment.

2 iently Rab14 positive within 2 min following engulfment.

3 rylated, which is required for Jedi-mediated engulfment.

4 nd mediates changes of F-actin that drive AC engulfment.

5 ilencing significantly affected cryptococcal engulfment.

6 there is an optimum ligand density for quick engulfment.

7 th receptors being driven toward the site of engulfment.

8 rane-surface tension that produce successful engulfment.

9 cludes signaling and captures both stages of engulfment.

10 ype macrophages is not sufficient to enhance engulfment.

11 ce neutrophil binding, motility, and biofilm engulfment.

12 regulation of the luminal pH after particle engulfment.

13 d-absent hemisphere to complete the particle engulfment.

14 nclear whether PG surrounds prespores during engulfment.

15 ating macrophage properties during and after engulfment.

16 orespore in a phagocytic-like process called engulfment.

17 ow size and shape of targets determine their engulfment.

18 ptation to energy demand during tracking and engulfment.

19 ral cell wall around the prespore throughout engulfment.

20 ecreasing Rac1 expression prevented particle engulfment.

21 s completed shortly before the completion of engulfment.

22 hrough macropinocytosis rather than directed engulfment.

23 and replication, which are completed before engulfment.

24 olymerization process that leads to pathogen engulfment.

25 rosine kinase (MerTK) and Rho GTPases during engulfment.

26 TAM tyrosines of Jedi-1 and MEGF10 prevented engulfment.

27 hages failed to respond to C1q with enhanced engulfment.

28 ation of JNK bypasses the need for Draper in engulfment.

29 otic immunity" (IAI)) even in the absence of engulfment.

30 ) became active only after the completion of engulfment.

31 ell migration and elmo1-dependent macrophage engulfment.

32 f chromosome translocation and completion of engulfment.

33 ive Syk inhibitor (BAY 61-3606) also blocked engulfment.

34 espore in a phagocytosis-like process termed engulfment.

35 receptors to initiate signaling pathways for engulfment.

36 idespread proteolysis, nucleolysis, and cell engulfment.

37 ctor 6 (Arf6) plays a key role in fibrinogen engulfment.

38 IIQ(H120S) interact with SpoIIIAH throughout engulfment.

39 esting a phagocytic-like process for vesicle engulfment.

40 body-coated solid particles, signaling their engulfment.

41 uole maturation and nutrient recovery during engulfment.

42 xtension during cell migration and bacterial engulfment.

43 e two proteins also form a backup system for engulfment.

44 e process of Entamoeba histolytica host cell engulfment.

45 eptor MARCO, which was required for enhanced engulfment.

46 spread that specifically promotes protrusion engulfment.

47 counteract the torque caused by rapid water engulfment [6].

48 the initiation, modulation and end stages of engulfment, a paradigm that is consistent with unsteady

49 Interventions that boost glial engulfment activity, however, can substantially reverse

50 mixture with PEG, which induces cell fusion, engulfment, aggregation or lysis.

51 Both engulfment and a channel-like function may be ancestral

52 es of myofibroblasts in regulating apoptotic engulfment and a fundamental importance of these cells i

53 nvolves cell fusion, as opposed to pseudopod engulfment and bacterial escape from double-membrane vac

54 If engulfment and body acceleration are temporally distinct

55 Engulfment and cell motility 1/dedicator of cytokinesis

56 Previously we reported that engulfment and cell motility protein 1 (ELMO1) in macrop

57 have demonstrated that polymorphisms in the engulfment and cell motility protein 1 gene (ELMO1) are

58 that requires integrin-linked kinase (ILK), Engulfment and Cell Motility-2 (ELMO2), integrin beta1,

59 Nr4a1-deficient mice have impaired thymocyte engulfment and clearance.

60 e process whereby autophagosomes mediate the engulfment and delivery of cytoplasmic components into l

61 Engulfment and destruction of invading microorganisms by

62 han the opsonizing fragment that facilitates engulfment and destruction of targets by phagocytes.

63 f the molecular mechanisms that regulate the engulfment and digestion of the efferocytic cargo.

64 mportant antimicrobial defense weapons after engulfment and exposure of pathogens to the content of p

65 that membrane topology at the final stage of engulfment and FisB-cardiolipin interactions ensure that

66 Those effects are due to defective engulfment and impaired LAP-mediated clearance of apopto

67 are impaired in the morphological process of engulfment and late forespore gene expression and freque

68 Engulfment and Motility (ELMO) proteins are involved in

69 tion during endospore maturation, exhibiting engulfment and partial cortex and spore coat formation.

70 ic bifunctional molecule able to mediate the engulfment and phagocytosis of C. albicans cells by huma

71 l environment, including ones that stimulate engulfment and proliferation.

72 Here we tested the link between engulfment and sigma(G) activation by perturbing DNA tra

73 ent with a strong link between completion of engulfment and sigma(G) activation.

74 rences between bacilli and clostridia in the engulfment and spore coat formation steps.

75 The engulfment and subsequent degradation of apoptotic cells

76 ent capacity, with lower potential enhancing engulfment and vice versa.

77 factor 8 (MFG-E8), which promotes apoptotic engulfment, and determined that serum response factor is

78 a new model for how PG synthesis might drive engulfment, and obviates the need to synthesize a PG lay

79 mutants of C. difficile result in anomalous engulfment, and that disruption of the SpoIIQ LytM domai

80 sential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein

81 l spread that involves protrusion formation, engulfment, and vacuolar escape.

82 the spoIIQ or spoIIIAH mutants that complete engulfment are impaired in post-engulfment, forespore an

83 olecular mechanisms leading to C1q-dependent engulfment are not fully understood.

84 polystyrene beads, we measure the fractional engulfment as a function of time and demonstrate that ph

85 the phagophore-assembly site, Atg24 in cargo engulfment, Atg26 in cytoplasm-to-vacuole targeting, and

86 lfment increases dramatically, with complete engulfment attained soon afterwards.

87 al mechanism for the creation of a force for engulfment based on the coordination between cell wall s

88 We find a whole range of different engulfment behaviors with some ellipsoids engulfing fast

89 CAV1(-/-) RPE in situ showed normal particle engulfment but delayed phagosome clearance and reversed

90 orespore-protein SpoIIQ leads to zipper-like engulfment, but quantitative understanding is missing.

91 tudies suggest a new role for Rac1-dependent engulfment by airway epithelial cells and in establishin

92 ilis genome had the largest effect, delaying engulfment by at least 90 min.

93 Here, we show that apoptotic corpse engulfment by Drosophila macrophages is an essential pri

94 trusion of PS on LCs, which in turn promoted engulfment by E2/ERalpha-activated macrophages that was

95 cells in a mouse model resulted in defective engulfment by epithelial cells and aberrant anti-inflamm

96 ansgene was used that highlights cell corpse engulfment by fluorescence microscopy.

97 Inactivating epn-1 or chc-1 disrupts engulfment by impairing actin polymerization.

98 oskeleton prevent phagocytosis and bacterial engulfment by macrophages, thus preventing V. cholerae c

99 IGF-1 did not alter engulfment by macrophages.

100 r leaflet of transduced cells triggers their engulfment by microglia through TAM receptor-dependent m

101 ithin the intestinal lumen, leading to their engulfment by neutrophils, while phenotypically avirulen

102 o identify mechanisms of dying cardiomyocyte engulfment by phagocytes and, for the first time, to ass

103 parasite, binds several receptors to trigger engulfment by phagocytes, leading to cutaneous or viscer

104 tosis in vivo is their rapid recognition and engulfment by phagocytic cells (a process called efferoc

105 e chordate Botryllus schlosseri, cell corpse engulfment by phagocytic cells is the recurrent mechanis

106 by which apoptotic tissue is recognized for engulfment by phagocytic cells such as macrophages.

107 lockade or removal reduces their binding and engulfment by RPE in culture.

108 In both processes, engulfment by the cell depends critically on both partic

109 rs on the developing spore just as forespore engulfment by the mother cell begins.

110 ssary to coordinate germline cell death with engulfment by the somatic epithelium.

111 Internalization was marked by a process of engulfment by thin membrane extensions from the endothel

112 tic targets, thus preventing recognition and engulfment by tissue-resident phagocytes.

113 cavenging of extracellular macromolecules by engulfment can sustain cell growth in a nutrient-deplete

114 cy of foraging is driven both by the whale's engulfment capacity and the comparative locomotor capabi

115 tential of the phagocyte critically controls engulfment capacity, with lower potential enhancing engu

116 nd the intracellular signaling intermediates engulfment cell motility 1 (ELMO1) and Rac1, as ABCA1 in

117 ver the surface of targeted particles during engulfment, cells must change shape through extensive me

118 During engulfment, CHC is tyrosine phosphorylated, which is req

119 In these whales, engulfment coincided largely with body deceleration; how

120 function of the complex, required following engulfment completion.

121 d ttr-52 mutants and partially rescues their engulfment defects.

122 ngle amino acid substitution (H120S) impairs engulfment differently.

123 tionary innovation, allowing fast and robust engulfment even for large particles.

124 hat complete engulfment are impaired in post-engulfment, forespore and mother cell-specific gene expr

125 anisms, including complement-mediated lysis, engulfment, formation of neutrophil extracellular traps,

126 The engulfment function of macrophages relies on complex mol

127 tive splice variant, potently inhibits glial engulfment function.

128 I-Csw signaling prolongs expression of glial engulfment genes after axotomy and reduces the ability o

129 Both approaches decreased binding and engulfment >40%.

130 ntly contribute, which can even lead to fast engulfment in [Formula: see text] 60 [Formula: see text]

131 e to investigate the origin of fast bistable engulfment in absence of the cell wall.

132 ic cells, ced-8 is important for cell corpse engulfment in C. elegans.

133 he medium osmolarity in experiments prevents engulfment in line with our predictions.

134 physical principles are likely applicable to engulfment in other cell types, e.g. during phagocytosis

135 erestingly, BAI1 also mediates Rac-dependent engulfment in professional phagocytes through its intera

136 Possibly, SpoIIQ(H120S) supports normal engulfment in some cells but not a second function of th

137 leading to the notion that the capacity for engulfment in vivo is vast.

138 We propose a simple model for engulfment in which the junction between the septum and

139 t approximately half-engulfment, the rate of engulfment increases dramatically, with complete engulfm

140 resulted in cycloheximide-sensitive enhanced engulfment, indicating a requirement for de novo protein

141 ic ligands are the key to cargo recognition, engulfment initiation, and activity regulation.

142 cts with cell surface gangliosides, allowing engulfment into a membrane vesicle by a clathrin-indepen

143 cell cannibalism by entosis, a form of cell engulfment involving live cells, also leads to polyploid

144 limited accessibility to circulating cells, engulfment is carried out by neighboring non-professiona

145 uring peak retinogeniculate pruning and that engulfment is dependent upon neural activity and the mic

146 Efficient pathogen engulfment is mediated by cargo-selecting autophagy adap

147 How GULP promotes engulfment is not known.

148 In elmo1-deficient macrophages, engulfment is rare and may occur through macropinocytosi

149 During the first 2 days of development, engulfment is rare, and most apoptotic cells lyse at the

150 During the first stage, engulfment is relatively slow and progressively slows do

151 osome marker, suggesting that ABCF1-mediated engulfment is through a phagocytic pathway.

152 obacterium tuberculosis (Mtb) infection, the engulfment ligand annexin1 is an important mediator in D

153 DD1alpha appears to function as an engulfment ligand or receptor that engages in homophilic

154 Although some of the engulfment ligands involved in efferocytosis have been i

155 work identifies new components of the glial engulfment machinery and shows that glial activation, ph

156 er receptor Draper and downstream phagocytic engulfment machinery.

157 depletion of Mg(2+) observed upon phagosomal engulfment may act to trigger isoTb biosynthesis.

158 Forespore engulfment may thus not only be an ideal model system to

159 racterized by acceleration to high speed and engulfment of a large volume of prey-laden water [1-4].

160 be recognized by Toll-like receptors (TLRs), engulfment of ACs does not initiate inflammation in heal

161 s rapidly underwent apoptosis in response to engulfment of an extrusion, while uptake of an equivalen

162 ewires the tumor microenvironment to inhibit engulfment of antibody-targeted tumor cells.

163 nsducer of so-called "eat-me" signals during engulfment of apoptotic cells and microorganisms, is exp

164 issue resident macrophages could inhibit the engulfment of apoptotic cells by inflammatory monocytes.

165 n of TLR3 or TLR9, but not of TLR2, enhances engulfment of apoptotic cells by macrophages.

166 The engulfment of apoptotic cells by phagocytes, a process r

167 ment component C1q is required for efficient engulfment of apoptotic cells in mice and humans; howeve

168 ndicate that stimulation of LXR enhances the engulfment of apoptotic cells via regulating directly an

169 phages can also be induced by the successful engulfment of apoptotic cells, highlighting the importan

170 er-Fc fusion protein inhibited C1q-dependent engulfment of apoptotic cells, indicating a requirement

171 Following MFG-E8-mediated engulfment of apoptotic cells, myofibroblasts acquired a

172 hanism for macrophage-mediated C1q-dependent engulfment of apoptotic cells.

173 sulting in increased amounts of F-actin upon engulfment of apoptotic cells.

174 brain angiogenesis inhibitor 1 (BAI1) in the engulfment of apoptotic GECs using human tissue and cell

175 d knockdown in glial precursors prevents the engulfment of apoptotic neurons.

176 This review will highlight how the engulfment of apoptotic neutrophils by human phagocytes

177 The engulfment of apoptotic polymorphonuclear cells (PMN) du

178 After engulfment of apoptotic tumor plasma cells via CD91, bon

179 gulatory function of macrophage TIM-4 in the engulfment of apoptotic/necrotic bodies in innate immuni

180 lial proliferation, phagocytic activity, and engulfment of approximately 30% of neurons within 3 d.

181 Draper-I promotes engulfment of axonal debris through an immunoreceptor ty

182 Cs) mediate the abrupt arrest and subsequent engulfment of B cells circulating in the liver sinusoids

183 ation of macrophage phagosomes following the engulfment of C. albicans cells.

184 r Jedi-1 or MEGF10 in HeLa cells facilitated engulfment of carboxylated microspheres to a similar ext

185 ssociated with loss of Cdkn2b and normalized engulfment of Cdkn2b-deficient cells.

186 ive cell processes and lysosomes, suggesting engulfment of complement-tagged synapses by microglia.

187 s of cells and molecules responsible for the engulfment of dead cells in the infarcted area remain la

188 D300a-negative cell lines also decreased the engulfment of dead cells.

189 studied primarily as receptors necessary for engulfment of debris following apoptosis or axonal injur

190 Nevertheless, DCs were activated upon engulfment of dying cancer cells.

191 As such, annexin A1 promotes the engulfment of dying cells and dampens the postphagocytic

192 e dampening of pro-inflammatory signals upon engulfment of dying cells and prevention of autoantigen

193 Mitophagy, the selective engulfment of dysfunctional mitochondria by autophagasom

194 The ex vivo or in vivo engulfment of EMPs or cMPs by peripheral blood monocytes

195 xt, we identified the mechanism by which the engulfment of erythrocytes with exposed phosphatidylseri

196 o allow for efficient membrane expansion and engulfment of extracellular material.

197 ogenesis, host genes involved in the initial engulfment of fungi and subsequent stages of infection a

198 , during hepatocyte regeneration, macrophage engulfment of hepatocyte debris induced Wnt3a expression

199 Phagosomes form during engulfment of large particles and become increasingly ac

200 We further confirmed E2-dependant engulfment of LCs by real-time 3D imaging.

201 Ex vivo engulfment of lyso-PS(high) neutrophils (95% viable) by

202 quired FIP200 and TBK1, both involved in the engulfment of microbes by xenophagy.

203 f CHC in HeLa cells prevents Jedi-1-mediated engulfment of microspheres, and knockdown in glial precu

204 f larger apoptotic cells was reduced whereas engulfment of microvesicles was increased.

205 le for autophagosome formation and selective engulfment of mitochondria, but essential for autophagos

206 In vitro, AIM enhanced the engulfment of necrotic debris by macrophages derived fro

207 n, are responsible for the receptor-mediated engulfment of Neisseria gonorrheae or Neisseria meningit

208 ith increased caspase-3 cleavage and reduced engulfment of neurons expressing cleaved caspase-3 by ac

209 ir phenotype, and increase of the phagocytic engulfment of neutrophils by macrophages.

210 Of note, membrane engulfment of P. aeruginosa occurred independently of ac

211 the early stages of phagocytosis enables the engulfment of particles or pathogens and receptor signal

212 In addition, macrophage engulfment of persister cells was significantly lower th

213 pportunities to enhance or retard macrophage engulfment of phagocytic targets such as zymosan.

214 s characterized at the cellular level by the engulfment of portions of the cytoplasm in double-membra

215 help of Vps4, ESCRT-III/Snf7 promotes direct engulfment of preexisting Grh1 containing vesicles and t

216 nals, and murine studies revealed microglial engulfment of presynaptic terminals during acute infecti

217 We find that engulfment of protein-free model lipid vesicles is promo

218 293 cells, which rendered them competent for engulfment of PtdSer-bearing targets.

219 uced eye-specific segregation and microglial engulfment of RGC inputs.

220 s accumulation of the protein LC3B following engulfment of Salmonella or treatment with autophagy-ind

221 tion, autophagosomal membrane formation, and engulfment of Salmonella.

222 Engulfment of synapses and neural progenitor cells (NPCs

223 Microglia can mediate synapse loss by engulfment of synapses, likely via a complement-dependen

224 C4, recently implicated in schizophrenia, in engulfment of synaptic structures by human microglia.

225 not into the cytoplasmic interior formed by engulfment of the autophagic membrane.

226 r the bending of the plasma membrane and the engulfment of the bacterium--a key process in bacterial

227 was sufficient to achieve complete membrane engulfment of the bacterium.

228 on cargos, thus facilitating the autophagic engulfment of the cargo.

229 Engulfment of the colloidosomes enables selective delive

230 Engulfment of the forespore by the mother cell is a univ

231 toxic oxygen metabolites and opsonization or engulfment of the microbes, but depended on beta(2) inte

232 was attributed to (i) cation exclusion, (ii) engulfment of the nascent chain by the hydrophobic pore

233 Following completion of engulfment of the prespore by the mother cell, sigma(G)

234 The engulfment of these targets occurred gradually and along

235 persister cells was significantly lower than engulfment of total population, both before and followin

236 urthermore, blocking CD47 signaling promotes engulfment of tumor cells by macrophages in vitro and in

237 phagocytes, including chemotaxis toward and engulfment of unicellular organisms or cell debris.

238 developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neu

239 rotein around neurons caused by insufficient engulfment of VEGF by VEGFR2-deficient neurons.

240 ges coordinate the recognition, capture, and engulfment of zymosan bioparticles.

241 ing and impairs their migration to, and thus engulfment of, dying cells.

242 lthough their timely clearance by macrophage engulfment, or efferocytosis, is critical for efficient

243 tica correlates with the degree of host cell engulfment, or phagocytosis, and E. histolytica phagocyt

244 aces epn-1 and chc-1 in the same cell-corpse engulfment pathway as ced-1, ced-6 and dyn-1.

245 Our findings reveal a novel function of the engulfment pathways and provide a better understanding o

246 Therefore, we propose that components of the engulfment pathways promote programmed cell death by enh

247 Components of the conserved engulfment pathways promote programmed cell death in Cae

248 hibited temporally distinct acceleration and engulfment phases, with humpback whales reaching maximum

249 ngs were recapitulated in vivo; the enhanced engulfment phenotype resulted in increased bacterial cle

250 prespore and increase in size and number as engulfment proceeds.

251 whereas on macrophages no enhancement of the engulfment process was observed.

252 During the engulfment process, an essential channel, the so-called

253 ecA-Gb3 interaction is adequate to drive the engulfment process.

254 gh efferocytosis, a dedicated apoptotic cell engulfment process.

255 ize particles via a chemoattractant-mediated engulfment process.

256 les formed by phagocytosis, or the live-cell engulfment program entosis, undergo sequential steps of

257 IIQ assembles foci along the path defined by engulfment proteins degrading peptidoglycan.

258 SpoIIQ interacts with both SpoIIIAH and the engulfment proteins or their peptidoglycan cleavage prod

259 r increased by the additional absence of the engulfment proteins.

260 ays: SpoIIIAH and the SpoIID, SpoIIM, SpoIIP engulfment proteins.

261 ring and solid-state (2)H NMR correlate with engulfment rates measured by flow cytometry.

262 ed for phagocytosis mediated by the nematode engulfment receptor CED-1.

263 Here we show that the glial engulfment receptor Draper is protective in a Drosophila

264 ction of MMP-1 requires the highly conserved engulfment receptor Draper, as well as AP-1 and STAT92E.

265 ique isoforms of the Drosophila melanogaster engulfment receptor Draper.

266 ere, we show that the highly conserved glial engulfment receptor Draper/MEGF10 provides neuroprotecti

267 n transcriptional up-regulation of the glial engulfment receptor Draper; there is extension of glial

268 Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.

269 is mediated, in part, through the mammalian engulfment receptor Jedi-1.

270 this study, we report that the absence of an engulfment receptor leads to a pronounced accumulation o

271 Draper/Ced-1/MEGF-10 is an engulfment receptor that promotes clearance of cellular

272 equal, and that compensation among specific engulfment receptors is context and tissue dependent.

273 ticulin, a ligand required for activation of engulfment receptors on phagocytic cells.

274 e kinematics of lunge feeding, the timing of engulfment relative to body acceleration has been modele

275 owever, the mechanisms by which they promote engulfment remained unknown.

276 This engulfment requires the guanine nucleotide exchange fact

277 ith experimental time-lapse microscopy, with engulfment sensitive to the number of SpoIIQ-SpoIIIAH bo

278 s downstream of the Draper/Src42a/Shark/Rac1 engulfment signaling pathway.

279 pruning and reveals, unexpectedly, that the engulfment signaling pathways engaged by glia depend on

280 hat glia promote neurite destruction through engulfment signaling.

281 Upon completion of engulfment, SpoIIQ and SpoIIIAH are integral components

282 The presence of PG throughout engulfment suggests new roles for PG in sporulation, inc

283 Mecp2(LSL/y)) had little effect on excessive engulfment, synapse loss, or phenotypic abnormalities.

284 However, during engulfment, the lipid content of the apoptotic cells tri

285 phages toward C. albicans cells, the rate of engulfment, the overall uptake of fungal cells, or early

286 However, at approximately half-engulfment, the rate of engulfment increases dramaticall

287 During engulfment, the whale accelerates, opens its jaw until i

288 of these foci before completion of forespore engulfment then sets up the scaffold to which coat prote

289 melanogaster receptor Draper, which mediates engulfment through activation of the tyrosine kinase Sha

290 I thrombospondin repeats and triggers their engulfment through an ELMO1/Dock/Rac1 signaling module.

291 drive cytoskeletal rearrangements and target engulfment through Rac1.

292 via ubiquitin binding and mediate autophagic engulfment through their association with microtubule-as

293 The data shows an increase in the average engulfment time for increased target size, for spherical

294 We measure single-event engulfment time from a large number of phagocytosis even

295 odulate the coordination of acceleration and engulfment to optimize foraging efficiency by minimizing

296 enotypic conversion, directly linking debris engulfment to tissue repair.

297 Dendritic cells (DCs) are specialized in Ag engulfment via a wide variety of uptake receptors on the

298 of SpoIIQ-SpoIIIAH while the requirement for engulfment was alleviated through the emergence of redun

299 e space allows the refinement of a model for engulfment, which has been known to include peptidoglyca

300 intercellular tension to promote protrusion engulfment, which represents a distinctive strategy for