ライフサイエンスコーパス: feedforward

1 This feedforward ACh-NGF axis activates the gastric cancer ni

2 Thus, a feedforward ACK1/pY88-H4/WDR5/MLL2/AR epigenetic circuit

3 and choice propagated in an S1-S2 loop along feedforward and feedback axons.

4 ing rules which lead to identical changes at feedforward and feedback connections.

5 tic plasticity and its roles in shaping both feedforward and feedback control.

6 We find that solving the task involves feedforward and feedback correlation paths linking senso

7 ensely interconnected to one another in both feedforward and feedback directions, inconsistent with a

8 classes in the barrel cortex integrate both feedforward and feedback information from throughout the

9 network and suggest that the integration of feedforward and feedback information is implemented by c

10 ronal dynamics supporting integration of the feedforward and feedback information.

11 the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber

12 d by mossy fibers (MFs) and grcs and provide feedforward and feedback inhibition to grcs.

13 ritic integration is dynamically balanced by feedforward and feedback inhibition, resulting in suppre

14 dams exhibited compromised CCK-INT-mediated feedforward and feedback inhibition.

15 s arise from network properties dependent on feedforward and feedback inputs; however, the relative c

16 elegant model demonstrates the necessity of feedforward and feedback interactions between multiple s

17 al sensory networks in immune cells, such as feedforward and feedback loops or ligand antagonism, som

18 Feedforward and feedback mechanism alterations each were

19 This effect was not specific to identified feedforward and feedback neurons.

20 imination behavior, specifically identifying feedforward and feedback neurons.

21 Feedforward and feedback pathways connecting cortical ar

22 l and parvalbumin (PV)-expressing neurons in feedforward and feedback pathways interconnecting primar

23 areas are interconnected via layer-specific feedforward and feedback projections.

24 terconnected via a reciprocal arrangement of feedforward and feedback projections.

25 Our results demonstrate that feedforward and feedback signaling use distinct frequenc

26 al layers, have also been closely related to feedforward and feedback streams of information.

27 x endowed with realistic plasticity (at both feedforward and lateral synapses) and mutual inhibition.

28 ers to the visual cortex, the system is less feedforward and more dominated by intracortical signals

29 present a supervised learning scheme for the feedforward and recurrent connections in a network of he

30 sue because the interneurons responsible for feedforward and recurrent inhibition are anatomically se

31 Throughout the brain, the recruitment of feedforward and recurrent inhibition shapes neural respo

32 , we find that the relative contributions of feedforward and recurrent pathways differ between princi

33 motor system and based on the integration of feedforward and sensory feedback signals.SIGNIFICANCE ST

34 it has been implicated in both anticipatory (feedforward) and reactive (feedback) control.

35 Results showed that a feedforward architecture from EVC to the occipital face

36 ls of sensory processing in the brain have a feedforward architecture in which each stage comprises s

37 However, neocortex is not a feedforward architecture.

38 e in temperature is well predicted through a feedforward Artificial Neural Network.

39 and A1 suggests the involvement of alpha in feedforward as well as feedback processes and is consist

40 ve feedback, mutual repression, and coherent feedforward, as well as signaling interaction circuitry.

41 ory cortex activity as well as modulation of feedforward, but not feedback, coupling within a temporo

42 opaminergic D1 receptor stimulation activate feedforward calcium-protein kinase C and cyclic AMP-prot

43 Specifically targeting the positive feedforward cAMP/Ca(2+) loop may be beneficial for the d

44 ignaling pathway whereby caspase-8 engages a feedforward cascade that leads to CAS up-regulation and

45 leads to a mature adaptive response whereby feedforward changes in motor output mirror both the ampl

46 rotein interactions, generating feedback and feedforward circuitry, are generally required for these

47 Feedforward circuits may become imbalanced at low stimul

48 It remains elusive how FSI-based feedforward circuits regulate the output of NAc MSNs.

49 intricate network of regulatory feedback and feedforward circuits that fine-tuned gene expression lev

50 periodic synaptic connectivity patterns into feedforward circuits with a broad class of experimentall

51 intricate network of regulatory feedback and feedforward circuits.

52 ues for optimal control of movement in which feedforward commands can play a significant role.

53 feedback process but includes a significant feedforward component.

54 inputs converge into a perceptual outcome as feedforward computations are reinforced in a feedback lo

55 ns in the visual cortex arise through random feedforward connections between semi-regular mosaics of

56 group showed reduced connection strengths on feedforward connections carrying face information from E

57 ctor could be achieved via plasticity in the feedforward connections from external sensory cues (i.e.

58 s may have a different form from learning at feedforward connections, and our results depend critical

59 Even though models with random feedforward connectivity are capable of creating computa

60 ur irrespective of CS identity suggests that feedforward connectivity from LA to BL can be overridden

61 that is thought to rely on both predictive, feedforward control as well as reactive, feedback contro

62 Experiment 1 tested feedforward control by examining speech adaptation acros

63 We propose that modulation of feedback and feedforward control can determine repression or resistan

64 bellar degeneration are impaired in adapting feedforward control of speech but retain the ability to

65 rebellum is crucial for maintaining accurate feedforward control of speech, but relatively uninvolved

66 about past network output and contributes to feedforward control of subsequent locomotor bouts.

67 its functional contribution to feedback and feedforward control remains controversial.

68 t the cerebellum forms a crucial part of the feedforward control system for speech but is not essenti

69 The patients were impaired in adapting their feedforward control system relative to controls, exhibit

70 ch are inhibited by glucocorticoids, provide feedforward control to limit expression of the transcrip

71 Here we tested whether there is a feedforward cycle between the increased RyR calcium rele

72 each brain area depends on a combination of feedforward drive (bottom-up from the previous processin

73 tates, neural responses are dominated by the feedforward drive and the theory is identical to a conve

74 The relative contributions of feedforward drive, feedback drive, and prior drive are c

75 ed the importance of the integration between feedforward estimation and sensory feedback, and therefo

76 hich PMBS indexes the confidence in internal feedforward estimation in Bayesian sensorimotor integrat

77 l sensorimotor control, sensory feedback and feedforward estimation of a movement's sensory consequen

78 ted with the uncertainty associated with the feedforward estimation, which was recursively updated in

79 cts indexes the evaluation of uncertainty in feedforward estimation.

80 eristics, showing that in the visual system, feedforward excitation and inhibition are driven with eq

81 unctionally isolate CA1 from CA3 by reducing feedforward excitation and theta information flow.

82 ry input to mitral cells is indirect through feedforward excitation from external tufted cells.

83 direct OSN signals and capable of mediating feedforward excitation of MCs.

84 We also observed feedforward excitation of mitral cells with weak stimula

85 the olfactory bulb, are solely activated by feedforward excitation.

86 chain of cells connected by highly redundant feedforward excitation.

87 ess of sequence generation more complex than feedforward excitation.

88 Feedforward excitatory and inhibitory circuits regulate

89 s provide a mechanistic understanding of how feedforward excitatory and inhibitory circuits shape Pur

90 ensure reliable activation of the M-cell, a feedforward excitatory motif that may extend to other ne

91 feature selectivity depends, not only on the feedforward excitatory projections into the cortex, but

92 NLGN3 induced PI3K-mTOR pathway activity and feedforward expression of NLGN3 in glioma cells.

93 d reading processes occur in a hierarchical, feedforward fashion or within an interactive framework.

94 Feedforward (FF) inhibition is a common motif in many ne

95 uditory cortex (A1) of adult mice to promote feedforward (FF) processing and also strengthens intraco

96 es IGF1R(+) TSCs to express FGF4, inducing a feedforward FGFR1-ETS2 angiocrine cascade that obviates

97 xperiments have outlined a blueprint for the feedforward flow of activity in cortical circuits: signa

98 ANCE STATEMENT Visual perception relies on a feedforward flow of information from sensory regions, wh

99 le of gamma-band activity (40-100 Hz) in the feedforward flow of sensory information, whereas feedbac

100 Second, feedforward functional connectivity between S1 and S2 wa

101 SGCs directly, as well as indirectly through feedforward GABAergic/cholinergic signals mediated by st

102 ponse correlations or covariance, as well as feedforward gain-control models with multiple layers, an

103 We also compared speed of feedback to feedforward glutamate release measured at the same cone/

104 experimental evidence, that SM results from feedforward, horizontal, and feedback interactions with

105 IL-4 receptor on microglia, facilitating a "feedforward" increase in (1) their expression of trophic

106 PC mutations is sustained by ZBP-89-mediated feedforward induction of CTNNB1 mRNA.

107 ss talk permits amplification of maladaptive feedforward inflammatory loops that contribute to the de

108 revealed that in the primate visual system, feedforward influences are carried by theta-band ( appro

109 While feedforward influences convey sensory signals, feedback

110 e dopaminergic system affects the passage of feedforward information through the BG by modulating inp

111 A1 ITDP results from long-term depression of feedforward inhibition (iLTD) as a result of activation

112 lar cells, which drive direct excitation and feedforward inhibition (through SACs) to DSGCs, thus mai

113 Synaptic delays in feedforward inhibition allow transmission of temporally

114 This enables SynCAM 1 to regulate feedforward inhibition and set network excitability.

115 CA3 glutamatergic synaptic transmission and feedforward inhibition are significantly attenuated in c

116 ry and establish asynchronous excitation and feedforward inhibition as critical regulators of granule

117 connections excite LGN, rather than driving feedforward inhibition as observed in the adult.

118 Feedforward inhibition attenuates local depolarization w

119 demonstrate that abnormally strong striatal feedforward inhibition can promote synchronous oscillato

120 Here, we characterized a feedforward inhibition circuit, through which BLA-evoked

121 ted, at least in part, via modulation of the feedforward inhibition circuitry in the auditory cortex.

122 Feedforward inhibition circuitry, in which a common exci

123 This reduction of feedforward inhibition coincides with a complimentary in

124 ich is counterbalanced by variable levels of feedforward inhibition from local interneurons.

125 In vivo whole cell recordings suggest that feedforward inhibition from olfactory bulb periglomerula

126 This is likely to affect feedforward inhibition from the perirhinal to the entorh

127 ystem and found evidence for a dual role for feedforward inhibition in seizures: while inhibition at

128 This feedforward inhibition in the dACC limits the time windo

129 ice that inputs from the MD drive disynaptic feedforward inhibition in the dorsal anterior cingulate

130 CA3 disinhibition, in agreement with reduced feedforward inhibition in this network in the absence of

131 Simulations showed that feedforward inhibition interacts with asynchronous excit

132 to CA3 pyramidal cells combines with robust feedforward inhibition mediated by both GABAA and GABAB

133 essential for the establishment of thalamic feedforward inhibition mediated by parvalbumin interneur

134 rough a D4 receptor-dependent enhancement of feedforward inhibition mediated by parvalbumin-expressin

135 e rostromedial tegmentum in habenula-induced feedforward inhibition of dopamine neurons.

136 that BLA inputs elicit direct excitation and feedforward inhibition of layer 2 projection neurons in

137 SI synapses, entailing enhanced FSI-mediated feedforward inhibition of MSNs upon BLA activation.

138 al approaches, we characterized and compared feedforward inhibition of NAc MSNs from CB1(+) FSIs and

139 ns directly innervate the brainstem to drive feedforward inhibition of nociceptive neurons.

140 g TIDA neurons, and that this may serve as a feedforward inhibition of prolactin release.

141 excite PV interneurons that in turn mediate feedforward inhibition of pyramidal neurons in layer 3 o

142 Overall, this resulted in a robust and slow feedforward inhibition of spike transfer at mf-CA3 pyram

143 le cells and receptor activation reduces the feedforward inhibition of spontaneous and odor-driven mi

144 As a consequence, feedforward inhibition of spontaneous and odor-evoked ac

145 vefront fails, allowing seizure propagation, feedforward inhibition of the surrounding centimeter-sca

146 l and electrical synapses and exert a potent feedforward inhibition on Purkinje cells.

147 Collectively, our results thus identify feedforward inhibition onto granule cells as a core feat

148 Feedforward inhibition onto granule cells originated fro

149 ry cortex that produce direct excitation and feedforward inhibition onto mitral and tufted cells, the

150 receive potent excitatory drive, and mediate feedforward inhibition onto principal neurons.

151 demonstrates that abnormally strong striatal feedforward inhibition promotes synchronous oscillatory

152 Together these data suggest that feedforward inhibition provides a parsimonious explanati

153 epileptic oscillations whereas the striatal feedforward inhibition suppresses the positive feedback

154 Interestingly, this led to a feedforward inhibition that depressed LS firing by a rob

155 Interneurons provide feedforward inhibition that transiently hyperpolarizes p

156 xcite nuclear neurons and drive polysynaptic feedforward inhibition via Purkinje neurons, setting up

157 quently, BLA inputs are able to drive robust feedforward inhibition via two parallel interneuron path

158 Furthermore, CB1(+) FSI-mediated feedforward inhibition was preferentially suppressed by

159 We conclude that compromised feedforward inhibition within the local circuit generate

160 g interneurons, a reduction in the amount of feedforward inhibition, and a change in CA2 pyramidal-ne

161 early or linearly at low firing rates due to feedforward inhibition, but sum supralinearly at high fi

162 Feedforward inhibition, in concert with recurrent intrac

163 Hence, feedforward inhibition, known to enforce temporal fideli

164 This difference is dictated by feedforward inhibition, which restricts mature GC activa

165 ocampal CA1 pyramidal neurons by suppressing feedforward inhibition.

166 o-subthalamo-nigral pathway and the striatal feedforward inhibition.

167 a complex interplay of direct excitation and feedforward inhibition.

168 each granule cell also received synchronous feedforward inhibition.

169 tic tree of each ganglion cell and relies on feedforward inhibition.

170 trengthening as well as a transient surge in feedforward inhibition.

171 hibition onto granule cells via a disynaptic feedforward inhibitory circuit involving deep short-axon

172 trol of MSNs and a critical component of the feedforward inhibitory circuits regulating the output of

173 istributed throughout the NAc, forming local feedforward inhibitory circuits.

174 nsory processing, (1) reciprocally connected feedforward inhibitory interneurons implement behavioral

175 Using a realistic model of a feedforward inhibitory microcircuit in the hippocampal C

176 Nonetheless, feedforward inhibitory strength covaries with the amount

177 mulation in BA suppresses plastic changes of feedforward inhibitory transmission onto CeM neurons as

178 al, depending on the ongoing activity state, feedforward input could either increase or decrease nois

179 ore, as V4 noise correlations remain without feedforward input from V1, these results suggest instead

180 vestigated how statistical properties of the feedforward input shape the statistics of the evoked act

181 We masked feedforward input to a region of V1 cortex and studied t

182 ersibly inactivated V2 and V3, which provide feedforward input to MT that conveys more information ab

183 eedback crucially ignore the contribution of feedforward input to the statistics of the evoked activi

184 s-an inversion of the canonical push-pull of feedforward input.

185 a sensory thalamic relay area that receives feedforward inputs from retinal ganglion cells (RGCs) in

186 ated by a model wherein cells receive random feedforward inputs.

187 of early visual cortex selectively increased feedforward interactions with FEF and extrastriate visua

188 is intrinsically non-linear, while cortical feedforward is generally linear relative to the stimulus

189 The incoherent feedforward is implemented by the opposing effects of th

190 However, the integration of feedforward, lateral, and feedback inputs within each co

191 Neuronal cortical circuitry comprises feedforward, lateral, and feedback projections, each of

192 er stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch to separate stem

193 built around a common motif, the incoherent feedforward loop (IFFL), where an input simultaneously a

194 The incoherent feedforward loop and the essential role of p53 activatio

195 ghlight the existence of a positively acting feedforward loop between ATAF1 expression, which is indu

196 biphasic control results from an incoherent feedforward loop between miR-337-3p and hepatocyte nucle

197 demonstrate that a highly amplified positive feedforward loop between the cAMP and Ca(2+) pathways is

198 This feedforward loop can be effectively blocked by C3aR inhi

199 Thus, USP10 and AMPK form a key feedforward loop ensuring amplification of AMPK activati

200 Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kina

201 Disruption of this feedforward loop leads to improper AMPK activation and m

202 or NLRC5 shapes NF-kappaB activity through a feedforward loop of NLRC5 ubiquitination and deubiquitin

203 A model based on a putative feedforward loop orchestrated by Akt consistently predic

204 study reports the first small RNA-controlled feedforward loop relying on posttranscriptional activati

205 embryonic stem cells, and find an incoherent feedforward loop structure involving Stat3, Tfcp2l1, Esr

206 l cytoskeleton dynamics and thus establish a feedforward loop that ensures a proper angiogenic respon

207 S-dependent NO production was required for a feedforward loop that maintains CYGB expression.

208 Taken together, E2 generates a feedforward loop via GPER/GPR30, which enhances Ca(2+)/C

209 er, RprA and sigma(S) orchestrate a coherent feedforward loop with AND-gate logic to tightly control

210 vity, doing so in part by forming a positive feedforward loop with Stat1/2 and a negative feedback lo

211 Through an incoherent feedforward loop, chemotherapy drugs not only activate p

212 strate that Nodal functions in an incoherent feedforward loop, together with Fgf, to determine the pa

213 findings suggest that catecholamines drive a feedforward loop, whereby upregulation of neurotrophins

214 bacterial clearance in an NF-kappaB-mediated feedforward loop, which is required for sustained pathog

215 an integral feedback loop and an incoherent feedforward loop.

216 AMP-activated protein kinase (AMPK)-mediated feedforward loop.

217 (i) the role of miRNA-mediated feedback and feedforward loops in fine-tuning of gene expression; (ii

218 nctional microcircuit evidence that intra-LH feedforward loops may facilitate appropriate switching b

219 , sensory pathways develop sequentially in a feedforward manner, whereby each local microcircuit refi

220 er RyR-mediated Ca(2+) release, suggesting a feedforward mechanism between NOX and RyR.

221 y GABAergic and reveal a glutamate-mediated, feedforward mechanism that inhibits LS cells.

222 Collectively, these data suggest a feedforward mechanism that integrates both NOX activity

223 PI3K/Akt/mTOR signaling might function as a feedforward mechanism to produce the large amounts of my

224 responses in LOC, which is consistent with a feedforward mechanism.

225 are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and

226 grip force contractions to determine whether feedforward mechanisms supporting initial motor output b

227 e results support the rapid integration of a feedforward model during perception and provide a neurop

228 been hard to account for by the traditional feedforward model of sensory processing, including the t

229 Neurophysiological evidence of a feedforward model of the action and its outcome has been

230 Here we describe a feedforward model of the olfactory system that achieves

231 nd the theory is identical to a conventional feedforward model, thereby preserving all of the desirab

232 presented our stimuli to four well developed feedforward models and found that none of them were able

233 ternal models of object dynamics to generate feedforward motor commands.

234 ate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circu

235 measure the temporal characteristics of the feedforward motor output during the decay of learning.

236 RNs are frequently observed in a cell as the feedforward network is one of fundamental motifs of gene

237 By fitting a nonlinear feedforward network model (a network receptive field) to

238 t into these findings, we developed a simple feedforward network model.

239 ting auditory cortical neural responses with feedforward network models expands on simple linear rece

240 fically, if fast species constitute either a feedforward network or a complex balanced network, the r

241 al circuit motifs employed by the brain is a feedforward network where parallel signals converge, div

242 has been known that synchronous activity in feedforward networks asymptotically either approaches an

243 rate-a relationship previously explained in feedforward networks driven by correlated input-emerges

244 The divergent feedforward networks thought to underlie this computatio

245 tions indicate that if the components of the feedforward neural network are non-negative, the output

246 the presence of a strong linear component, a feedforward neural network model with entirely random co

247 Consequently, the feedforward neural network with function of logarithmic

248 often considered the product of a multistage feedforward neural processing between visual cortical ar

249 ons and external inputs, rather than through feedforward or asymmetric connections.

250 visual areas with anatomical metrics of the feedforward or feedback character of the respective inte

251 Current debate is centered over whether feedforward or intracortical circuits generate SM, and w

252 Yet, the largely feedforward organization of the olfactory system preclud

253 k but not the motion task, indicating that a feedforward pathway that gives rise to tuning preference

254 We first examine these mechanisms in feedforward pathways and then show how the same approach

255 Although much is known about how feedforward pathways shape receptive field properties of

256 piking of NPY+ cells, suppresses both of the feedforward pathways to CA1.

257 We determined the role of feedforward pathways to decision signals in MT by record

258 This signal propagation is dominated by a feedforward process, but we also found weaker effective

259 ory experience, rather than through a simple feedforward process.

260 has been suggested that gamma power reflects feedforward processing and alpha oscillations feedback c

261 roles of gamma oscillations in the pulvinar: feedforward processing for images of snakes and cortico-

262 In sensory systems, feedforward processing transmits signals from the extern

263 ngs suggest a novel view on the relevance of feedforward projection from EVC to posterior occipitotem

264 old, and precision in timing is achieved via feedforward rather than feedback control.

265 ack enables gradient detection, and coherent feedforward regulation underlies cellular memory.

266 ncreases expression of negative feedback and feedforward regulators, including the phosphatase, DUSP1

267 y slower than either measurement kinetics or feedforward release.

268 rcepts are impaired in tandem, while leaving feedforward representations intact.

269 ex cellular phase consisting of feedback and feedforward responses of astrocytes, microglia, and vasc

270 formation-processing hierarchies beyond pure feedforward schemes.

271 ual action by beta-catenin as a signal and a feedforward sensor.

272 are not solely based on the accumulation of feedforward sensory evidence.

273 rifugal cholinergic input with broadly tuned feedforward sensory input to modulate principal cell act

274 structure, abundance, intrinsic physiology, feedforward sensory input, neuromodulation, synaptic out

275 gal cholinergic input with highly convergent feedforward sensory input.

276 ensory signals, feedback influences modulate feedforward signaling according to the current behaviora

277 w that an intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/N

278 Threat-induced anxiety produced unbalanced feedforward signaling in response to deviations in predi

279 f Cancer Cell, Hayakawa et al. demonstrate a feedforward signaling loop in which tumor-derived nerve

280 ving both negative and positive feedback and feedforward signals likely contribute to robust tissue m

281 n of bipolar cells by providing feedback and feedforward signals to photoreceptors and bipolar cells,

282 ing evidence shows that stem cells also send feedforward signals to their progeny.

283 itself, and makes use of feedback as well as feedforward signals.

284 p-down beta-band influences directly enhance feedforward stimulus-induced gamma-band processing, lead

285 er subthreshold stimulation the (excitatory) feedforward sweep of bottom-up processing terminates in

286 visual object understanding involves a rapid feedforward sweep, after which subsequent recurrent inte

287 of abstraction than what is afforded by the feedforward sweep.

288 Inflammatory signals induce feedback and feedforward systems that provide temporal control.

289 ical axons provide an activity that promotes feedforward targeting of RGC axons to the dLGN.

290 he inhibition/excitation ratio from the most feedforward to the most feedback pathway.

291 transcriptional modules that converge with a feedforward transcriptional logic.

292 ormation is traditionally viewed as having a feedforward, unidirectional circuit organization that pr

293 fically, we propose that plasticity rules at feedforward versus feedback connections are temporally o

294 lowed us to resolve both the directionality (feedforward versus feedback) and spatial scale (local or

295 ndings thus challenge strictly hierarchical, feedforward views of word reading and suggest that ortho

296 80 Hz) have been suggested to be involved in feedforward visual information processing, and might pla

297 work motifs distinguished by transcriptional feedforward vs feedback interactions.

298 e propose a single-layer neural network with feedforward weights connecting place-like input cells to

299 Random feedforward wiring within the retino-cortical pathway re

300 which cannot be explained by generic random feedforward-wiring models.