ライフサイエンスコーパス: functional gene

1 rgence and that the overlapping ORF is not a functional gene.

2 nt HGT events and further fuse them into one functional gene.

3 in the relative abundances of representative functional genes.

4 is central to Ag binding and consists of 48 functional genes.

5 ts by inversions and permutations to produce functional genes.

6 n be mapped to two biologically relevant and functional genes.

7 nerated, heterochromatic chromosome with few functional genes.

8 idual genome contains the full complement of functional genes.

9 of recombination, and ancient Ys contain few functional genes.

10 ly inert heterochromatic DNA but contain few functional genes.

11 unusually small, containing only two to five functional genes.

12 insulin and downregulation of many beta cell functional genes.

13 e nonfunctional genomic sequences resembling functional genes.

14 f the E. chaffeensis genome were verified as functional genes.

15 is a powerful approach to discovering novel functional genes.

16 eticals (42%) with limited homology to known functional genes.

17 nstructs into Drosophila, even those lacking functional genes.

18 their impact on the experimental analysis of functional genes.

19 se divergence (HMD) or that mice gained many functional genes.

20 ains, suggesting that they all correspond to functional genes.

21 ty, and the upstream sites had more distinct functional genes.

22 ans and Europeans, and thus are likely to be functional genes.

23 he investigation of the interactions between functional genes.

24 identified 2,335 genes, including 565 within functional genes.

25 o promote positive interactions of important functional genes.

26 ucing protein Tipalpha) and hitherto unknown functional genes.

27 findings suggest that bacterial species and functional genes absent in the gut microbiome of individ

28 gnificant correlations were observed between functional gene abundance and vascular plant primary pro

29 Hence, functional gene abundance is a valuable index that integ

30 anges in microbial community composition and functional gene abundance may imply actual changes in su

31 2O production were accounted for by archaeal functional gene abundance.

32 d shifts in many microbial, phylogenetic and functional gene abundances and pathways.

33 Etheneotroph and methanotroph functional gene abundances ranged from 10(2) to 10(9) ge

34 Based on path analysis, functional gene abundances were the most important varia

35 Thus, although the resulting Y-linked functional gene acquisition rate (0.25 new genes per mil

36 We assessed abundance of functional genes affiliated with nitrification (bacteria

37 Determination of PRNP functional gene alleles from 47 CWD-positive mule deer s

38 The tropical isolates have several functional genes also present in known fluorescent Pseud

39 metabolism, as well as most of the detected functional genes also showed clear backwater and riverin

40 fate, water, carbonate, and ferrous iron and functional gene analyses of adenosine 5'-phosphosulfate

41 Functional gene analysis indicated that genes involved i

42 anscriptional profiling, bioinformatics, and functional gene analysis, we identify a new axis of mosq

43 A interference (RNAi) is a powerful tool for functional gene analysis, which has been successfully us

44 hin sample diversity analysis, enterotyping, functional gene and metagenomic species analysis have be

45 es and 414 pseudogenes, while mice have 1037 functional genes and 354 pseudogenes.

46 d be broadly applicable to understanding the functional genes and evolutionary processes important fo

47 varies significantly in the multiplicity of functional genes and in the substrate specificity of its

48 retensis is undergoing decay through loss of functional genes and insertion sequence expansion, often

49 ., Limnohabitans), and a higher abundance of functional genes and KEGG orthology (KO) groups involved

50 g, most arise from genomic regions devoid of functional genes and many are antisense to regions conta

51 The human microbiome contributes functional genes and metabolites which affect human phys

52 nly a limited number of available reports on functional genes and microbes that take part in the degr

53 ucted a detailed phylogenetic analysis using functional genes and pseudogenes.

54 processes are mediated by the expression of functional genes and their translation into enzymes that

55 etheneotroph and anaerobic VC-dechlorinator functional genes and transcripts than those with bulk VC

56 sociation studies have struggled to identify functional genes and variants underlying complex phenoty

57 impact of thaw on microbial phylogenetic and functional genes, and relate these data to measurements

58 recognition, often annotating pseudogenes as functional genes, and users then propagate these errors

59 Functional gene annotation analysis indicated predominan

60 Several functional gene annotation databases have been developed

61 as well as gain-of-function mutagenesis for functional gene annotation in vertebrate models, includi

62 lizing SARG and a previously proposed hybrid functional gene annotation pipeline, we developed an onl

63 In addition, ANISEED provides full functional gene annotation, anatomical ontologies and so

64 genome assembly and gene model set, refined functional gene annotation, and anatomical ontologies, a

65 ted gene functions is a powerful approach of functional gene annotation.

66 Large-scale expression data, functional gene annotations, experimental protein-protei

67 The available data consist of structural and functional gene annotations, homologous gene families, m

68 ging from building phylogenies to predicting functional gene annotations.

69 and seven monitor wells were analysed with a functional gene array (GeoChip 3.0), and functional mole

70 Functional gene array (GeoChip 5.0) analysis showed the

71 Here, 16S rRNA Illumina sequencing and functional gene array (GeoChip 5.0) were used to assess

72 In this study, a functional gene array (i.e., geochip 4.2) was used to an

73 Functional gene array (i.e., GeoChip) analysis of Arctic

74 oups in a forest soil, using a comprehensive functional gene array with >24,000 probes.

75 NA sequencing, qPCR of mcrA transcripts, and functional gene array-based analysis of arsM expression,

76 atasets of 12-day time-series generated by a functional gene array-GeoChip 4.2.

77 ) experimental sites using a high-throughput functional gene array.

78 Functional gene arrays (FGAs) are a special type of micr

79 Functional gene arrays (FGAs) have been considered as a

80 Comprehensive functional gene arrays covering a wide range of ecologic

81 ng a metagenomic approach with GeoChip-based functional gene arrays to establish metabolic capabiliti

82 gies, such as high throughout sequencing and functional gene arrays, provide revolutionary tools for

83 ; however, a plasmid knockout identified the functional gene as being present on the chromosome.

84 Second, the usefulness of functional genes as indicators of stress response was ex

85 In particular, functional gene assessment showed ribosomal protein prob

86 Putative functional gene assignments included small and large ter

87 The relative abundance of functional genes associated with assimilatory sulfate re

88 trogen metabolism, the relative abundance of functional genes associated with dissimilatory pathways

89 e sequence data using PICRUSt and identified functional genes associated with nitrogen and sulfur met

90 yrosequencing to identify microorganisms and functional genes associated with PCE degradation to ethe

91 potential) analysis identifies a core set of functional genes associated with root colonization in bo

92 et the transcriptome changes, we constructed functional gene association networks of differentially e

93 es, the resulting interactome captured 17226 functional gene associations and displayed characteristi

94 estries may facilitate the identification of functional genes at associated loci.

95 Here, we present a functional gene-based framework for describing microbial

96 from engineered and natural environments, a functional gene-based microarray, termed StressChip, has

97 transcription factors for the expression of functional genes being differentially expressed.

98 decreased by 25% and 5%, while the community functional gene beta-diversity increased by 34% and 45%,

99 measurements of pmoA, which is a widely used functional gene biomarker for methanotrophs.

100 two smaller chromosomes are devoid of known functional genes but nonetheless contain diagnostic mito

101 evolving features associated with different functional gene categories and particular aspects of imm

102 , at 95.25% coverage, representing all broad functional gene categories in the genome.

103 Among the differentially expressed functional gene categories was the ubiquitin-proteasome

104 clear receptors and distinct enrichments for functional gene categories.

105 mosomal clustering of expression changes and functional gene categories.

106 process was the most significantly affected functional gene category.

107 f TCRalpha and TCRbeta genes, and amplifying functional genes characteristic of different T cell subs

108 sed to identify novel expression patterns of functional gene classes, including aromatic and branched

109 Thus, the Solanum functional gene cluster evolved by duplication and diver

110 esis, nonparalogous genes were arranged to a functional gene cluster with shared regulatory elements.

111 cDNA microarray analysis and functional gene clustering identified groups of TGFbeta-

112 ession profiles revealed temporally distinct functional gene clusters for apoptosis, chemotaxis, and

113 First, we identified functional gene clusters from these data.

114 ments were predicted from a diverse range of functional gene clusters supports the hypothesis that ci

115 ing to identify gene orthologs and potential functional gene clusters, and detecting genome modificat

116 Functional gene clusters, containing two or more genes e

117 ction and glucose uptake, many of which form functional gene clusters.

118 e how the similarities of both taxonomic and functional genes co-vary over geographic distance within

119 he differences in coral-associated microbial functional gene composition and metabolic potential amon

120 n some permafrost soils and a rapid shift in functional gene composition during short-term thaw exper

121 es have recently revealed the identities and functional gene composition of microorganisms in some pe

122 We investigated phylogenetic turnover and functional gene composition of saprotrophic fungi along

123 r-year field experiment, we investigated the functional gene composition of three types of soils (Pha

124 eviously unappreciated level of variation in functional gene content between humans.

125 s of diversity both in terms of sequence and functional gene content.

126 probably little difference in the isolates' functional gene content.

127 on event was followed by several losses of a functional gene copy attributable to gene loss or pseudo

128 A new functional gene database, FOAM (Functional Ontology Assi

129 strains, representing the core complement of functional genes defining C. difficile.

130 The expression profiles of twelve functional genes detected via RNA-Seq were corroborated

131 this region of the human genome and describe functional gene discovery in mammals not recognized in h

132 pplication of this RNAi library approach for functional gene discovery within a predefined protein fa

133 , an important vertebrate model organism for functional gene discovery.

134 nities was significantly correlated with the functional gene dissimilarity, and the upstream sites ha

135 However, the observed decrease in functional gene diversity was more attributable to a los

136 onomic diversity, but were found to decrease functional gene diversity.

137 rary sequences and archetype analysis from a functional gene DNA microarray, detected broad phylogene

138 by combining inverse modeling and microbial functional genes during decomposition with a metagenomic

139 nal potential and are integral components of functional gene dynamics in aquatic bacterial metacommun

140 Mice without a functional gene encoding MGAT2 (Mogat2(-/-)) are protect

141 Functional gene enrichment analysis was used to find 56

142 Etheneotroph functional genes (etnC and etnE) and VC reductive dehalo

143 ize an evolutionary model according to which functional genes evolve de novo through transitory proto

144 s a homeodomain and activates structural and functional genes expressed in both classes.

145 quence itself, are significant when studying functional gene expression regulatory elements.

146 gations have revealed interesting aspects of functional gene expression within microbial habitats tha

147 beta-cell replication rate, better beta-cell functional gene expression, and higher vascular density

148 uated for beta-cell proliferation, beta-cell functional gene expression, and revascularization.

149 In conclusion, ECM could rescue the functional genes expression after cell detached from cul

150 Our findings demonstrate that -2 PRF is a functional gene-expression mechanism in eukaryotes and a

151 Despite the presence in nature of many functional gene families that contain several to many hi

152 The reaction requires functional genes for trytophanase (tnaA), a tryptophan p

153 al underpinnings of horizontal transfer of a functional gene from prokaryotes to vertebrates.

154 We evaluated FunFrame on functional genes from four PCR-amplified clones with seq

155 Ciliate development requires assembly of functional genes from segments separated by intervening

156 Functional genes from the three major VC-degrading bacte

157 rs, with EGFR-SEPT14 being the most frequent functional gene fusion in human glioblastoma.

158 ghput methodology to comprehensively catalog functional gene fusions in cancer by evaluating a paired

159 three loci identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functio

160 cts meta-analyses by genotype and predefined functional gene group (thrombophilic, vasoactive, metabo

161 s suggest that NPCs regulate the activity of functional gene groups by acting as scaffolds that promo

162 ad and long-lasting gene suppression in most functional gene groups, including housekeeping, energy m

163 eparation of expression profiles among major functional gene groups, with carbohydrate, lipid, and xe

164 Detailed analysis of 500-bp upstream of all functional genes has revealed several conserved binding

165 ain JNA for subsequent genome sequencing and functional gene identification.

166 we conducted a phylogenetic analysis of all functional genes identified from the genome sequences of

167 bacteria to humans, including some important functional genes, illustrates the significance of viral

168 modules arising from an uninterrupted, fully functional gene in the entomopathogenic bacterium Photor

169 In contrast to the presence of 13-20 functional genes in mammals, chicken has only 3 RNase ge

170 d ANGPTL3 and HLC ASE gene ACAA2 to be lipid-functional genes in mouse models.

171 uplication in some genomes, with loss of all functional genes in other species.

172 ever, pseudogenes are often mis-annotated as functional genes in sequence databases.

173 titative polymerase chain reaction (qPCR) of functional genes in the denitrification pathway.

174 superfamily contains 187 and 102 putatively functional genes in the mouse and rat, respectively.

175 Despite the high number of functional genes in the mouse Cyp2c cluster and the repo

176 oles in the regulation of expression of many functional genes in the prenatal and postnatal hearts.

177 l recessive cause of Dravet syndrome through functional gene inactivation.

178 ed by expression quantitative trait loci, or functional genes indicates that most cancer susceptibili

179 Depth horizons with functional genes indicative of methane-cycling and sulfa

180 However, its genomic and functional gene information remain unknown due to extrem

181 should instead be on higher-level taxa or on functional genes instead.

182 from Arabidopsis thaliana seeds to compute a functional gene interaction network, termed Seed Co-Pred

183 og this heterogeneity and use it to identify functional gene interactions and genotype-dependent liab

184 stance of purposeful integration of multiple functional genes into a clostridial chromosome--here, th

185 Correspondently, key functional genes involved in metal homeostasis (e.g., ch

186 First, 46 functional genes involved in microbial responses to envi

187 Fungal beta-diversity and composition of functional genes involved in plant litter decay were unr

188 s facilitating lactate utilization, and that functional genes involved in plant polysaccharide metabo

189 that the unique ORFX in the WIV1 strain is a functional gene involving modulation of the host immune

190 tion of a genotyping method specific for the functional gene is critical for large-scale studies to i

191 Efficient integration of functional genes is an essential prerequisite for succes

192 The increase of the functional genes led to an increase in both soil respira

193 ersity and composition at both taxonomic and functional gene levels, and microbial association networ

194 ompare phylogenetic approaches for inferring functional gene links.

195 inkage map, using both anonymous markers and functional gene loci, that will enable the localization

196 pping was performed using probes to the four functional gene loci.

197 ces in disease outcome, we found evidence of functional gene loss and identified regions of heightene

198 The impact of functional gene loss was predicted based upon position w

199 flect a balance between gene acquisition and functional gene loss.

200 ts photosynthetic sister groups to correlate functional gene losses with the evolution of a achloroph

201 suggest that variations in transcription of functional genes may supplement sOUR based assays as ear

202 genes were identified using high-throughput functional gene microarray (GeoChip 3.0), and functional

203 sequencing of 16S rRNA gene amplicons and a functional gene microarray.

204 Methanotroph functional genes (mmoX and pmoA) were not related to VC

205 ks, provides a powerful approach to identify functional gene modules.

206 Here, we present an updated co-functional gene network for A. thaliana, AraNet v2, whic

207 ly published a description of a genome-scale functional gene network for A. thaliana, AraNet, which w

208 er's yeast, exists in two distinct states: a functional gene network in Portuguese strains and, in Ja

209 uese strains and, in Japanese strains, a non-functional gene network of allelic pseudogenes.

210 1 week and yielded over 60% of cells with a functional gene network.

211 Functional gene networks and crucial molecules associate

212 vered by the API include 144 tissue-specific functional gene networks in human, global functional net

213 pression and promote selective deployment of functional gene networks in response to complex profiles

214 omatin bound transcription factors regulates functional gene networks in response to GPCR activation

215 h was constructed by integrating multiple co-functional gene networks inferred from diverse data type

216 ntation donor organ samples, but most of the functional gene networks overlapped.

217 Bioinformatics analysis identified functional gene networks, including members of the compl

218 nvolved in both mutation-specific and shared functional gene networks.

219 matics analysis identified multiple affected functional gene networks.

220 the dorsal flap tissue thereby bringing new functional gene networks; these presumably enabled the T

221 to survey the diversity of a denitrification functional gene, nirS (encoding cytchrome-cd1 nitrite re

222 on of heterocyst regulatory, structural, and functional genes occurred over the 24 h required to form

223 tion were successfully complemented with the functional genes of C. jejuni 11168.

224 because it identifies the abundances of the functional genes of the organisms present in the origina

225 to their corresponding structural (SCOP) or functional (Gene Ontology) annotation.

226 Pathway and functional gene ontology analysis showed that these gene

227 acterizing composition and protein homology, functional Gene Ontology annotations presented via the A

228 ange of biochemical properties and span most functional gene ontology categories.

229 could be potentially treated by supplying a functional gene or changing the expression levels of spe

230 important information for screening the key functional genes or molecular markers of estrus expressi

231 t, in addition, the chimpanzee has a seventh functional gene, Patr-AL, which is not polymorphic but c

232 rmal vent sites and symbiont evolution using functional gene phylogenies.

233 inimally thawed site, the number of detected functional gene probes across the 15-65 cm depth profile

234 n noncatarrhine mammals, indicating that the functional gene product is subjected to considerable phy

235 from the definition and arguing that final, functional gene products (rather than intermediate trans

236 on, particularly for efficient expression of functional gene products.

237 retrotransposition or genomic duplication of functional genes, pseudogenes are "genomic fossils" valu

238 es recently described algorithms to de-noise functional gene pyrosequences and performs ecological an

239 Normal liver stiffness maintained functional gene regulation by hepatocyte nuclear factor

240 However, identifying functional gene regulatory elements has been challenging

241 Functional genes related to key biogeochemical cycles in

242 decrease in both the abundance and number of functional genes related to methanogenesis.

243 sis of the metagenomes showed that microbial functional genes relating to energy production and conve

244 This process of functional gene relocation, now rare in eukaryotes, cont

245 ons and the identification of the implicated functional genes remain largely undefined.

246 ced differences in bacterial assemblages and functional gene repertoires were noted between US reside

247 ected vertical zonation of taxonomic groups, functional gene repertoires, and metabolic potential.

248 Based on functional gene representation, transcriptome samples cl

249 orious polychlorinated biphenyls (PCBs), and functional genes responsible for PCB detoxification rema

250 Complementation of the wcaM mutant with the functional gene restored the biofilm phenotype observed

251 n of the glycoside hydrolase and cellulosome functional genes revealed that in the rumen microbiome,

252 % and 45%, respectively, revealing decreased functional gene richness but increased community heterog

253 ection of more resistant AOB and NOB sharing functional gene sequences close to those of, respectivel

254 Microarray and functional gene set enrichment analysis revealed a strik

255 In sum, our results define the first functional gene set for habituation learning in a verteb

256 troduced an adjustable "soft threshold" to a functional gene-set algorithm and found that two differe

257 thway is an R/Python wrapper for pathway (or functional gene-set) analysis of genomic loci, adapted f

258 xisting data collections to directly extract functional gene sets from big data.

259 ved in microarray data analysis and discover functional gene sets linked to patient survival.

260 sponse target gene set with GO Slim and KEGG functional gene sets, and also by inspecting association

261 annotation, gene expression data, and known functional gene sets, we showed that the functionality o

262 spread resting enrichment of proinflammatory functional gene sets, while upstream regulator analysis

263 biology-to-clinic" framework to uncover core functional gene-sets signatures.

264 perform gene set analysis using data-defined functional gene signatures.

265 injection to the intracellular setting where functional gene silencing occurs.

266 LPS by both APC and thrombin was analyzed by functional, gene silencing, and signaling assays.

267 We sought to dissect functional genes/SNPs for asthma by combining expression

268 Two functional genes, SP-A1 (SFTPA1) and SP-A2 (SFTPA2), are

269 Two functional genes, SP-A1 and SP-A2, encode human SP-A.

270 We previously discovered that a bi-functional gene, Spag16, is essential for spermatogenesi

271 ared genes (87.2%) but had different overall functional gene structures as revealed by two datasets o

272 and DO were shown to be effective in shaping functional gene structures of the systems by statistical

273 erived Cre recombinase is widely applied for functional gene studies in mice.

274 Furthermore, we identified Sparc as a novel functional gene target of Etv1 by luciferase assays, and

275 erformed kinase inhibitor screens to predict functional gene targets in primary specimens from patien

276 community composition, biodiversity and two functional genes tested.

277 Here we revealed that the unique ORFX is a functional gene that is involved in the modulation of th

278 response should be especially pronounced for functional genes that are important for survival in a pa

279 casional transcripts from several apparently functional genes that carry aberrant recombination signa

280 are ecotype-specific signals of selection in functional genes that correspond to cultural foraging be

281 However, the Xi is a reservoir of >1,000 functional genes that could be potentially tapped to tre

282 studies that identify putative ecotypes and functional genes that determine the ecotypes' ecological

283 Pseudogenes are defined as fragments of once-functional genes that have been silenced by one or more

284 genomes affords the opportunity to mine for functional genes that may lead to new generation drugs r

285 re fueled by early reports of delivering new functional genes to dystrophic muscle in mouse models us

286 cleotide polymorphisms genotyped across 3059 functional genes to study patterns of population structu

287 specially sequences of 16S ribosomal RNA and functional genes) to biodegradation reactions in natural

288 We find that functional gene transfer is more common in selfing or cl

289 We have applied a functional gene transfer strategy to show the importance

290 uencing identified other risk alleles but no functional gene variants.

291 ericans and examined the role of whole-exome functional gene variations in the patients' antidepressa

292 Results showed that the distribution of functional genes was mainly associated with glacier area

293 determine if these coding sORFs are parts of functional genes, we evaluated each coding sORF for evid

294 ion profiles revealed that the most affected functional genes were related to angiogenesis, inflammat

295 ferentiation, some heterocyst structural and functional genes were upregulated, while the heterocyst

296 N subtypes maintain the characteristics of a functional gene while ifs becomes a pseudogene.

297 f previously unidentified bacterial taxa and functional genes with high biomedical importance.

298 observed in humans, identifying TM6SF2 as a functional gene within a locus previously known as NCAN-

299 ds have been designed to select for specific functional genes within metagenomic libraries.

300 he Y chromosome will be completely bereft of functional genes within ten million years.