ライフサイエンスコーパス: hydroxylase

1 cells as a result of CYP27A1, a cholesterol hydroxylase.

2 Ns) using the intracellular marker, tyrosine hydroxylase.

3 .g., flagella, prophages, and salicylic acid hydroxylase.

4 in the gene CYP7B1 encoding oxysterol-7alpha-hydroxylase.

5 sgenic line expressing the castor fatty acid hydroxylase.

6 e stained immunohistochemically for tyrosine hydroxylase.

7 hibitor, and a flavonol synthase/flavanone 3-hydroxylase.

8 as both an arginine demethylase and a lysyl-hydroxylase.

9 pamine antibodies but not with anti-tyrosine hydroxylase.

10 ncluding the TET family of 5'-methylcytosine hydroxylases.

11 cytochrome P450s related to known fatty acid hydroxylases.

12 due to parasite-encoded aromatic amino acid hydroxylases.

13 in part through the regulation of bacterial hydroxylases.

14 o counteract any residual activity of prolyl hydroxylases.

15 h mammary-specific disruptions of tryptophan hydroxylase 1 (Tph1) or low-density lipoprotein receptor

16 oxm1, both G1/S and G2/M cyclins, tryptophan hydroxylase 1 (Tph1), and islet serotonin production, fo

17 icity protein 2 (Sp2, rs3708840), tryptophan hydroxylase 1 (Tph1, rs262731280) and serotonin receptor

18 bone tissue, consistent with decreased lysyl hydroxylase 1 in proband osteoblasts.

19 IL-33 enhanced the expression of tryptophan hydroxylase 1, serotonin synthesis, and storage, as well

20 er potent and specific inhibitors of 17alpha-hydroxylase/17,20-lyase (CYP17), the key enzyme which ca

21 Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysin

22 ociated with inactivating mutations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein 65 (F

23 Overexpression of prolyl-hydroxylase 2 (PHD2) transgene, a predominant isoform of

24 usly generates neurons that express tyrosine hydroxylase 2 (th2).

25 mice carrying a loxP-conditional tryptophan hydroxylase 2 (Tph2) allele.

26 of medullary raphe serotonergic, tryptophan hydroxylase 2 (Tph2)(+) neurons by postnatal day (P) 5 t

27 iated disruption of Egln1 (encoding prolyl-4 hydroxylase 2 [PHD2]; Egln1(Tie2)) in endothelial cells

28 rotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiological prop

29 the brain 5-HT synthesis enzyme, tryptophan hydroxylase 2.

30 fects during acute colitis via a NTR1-prolyl hydroxylase 2/HIF-1alpha-miR-210 signaling pathway.

31 tions in LEPREL1, the gene encoding prolyl 3-hydroxylase-2 (P3H2), have recently been identified in i

32 Specific knockout of prolyl hydroxylase-2 (PHD2) increased HIF-2alpha/Notch3 express

33 HL-60 cell differentiation and vitamin D-24-hydroxylase (24-OHase) transcription as compared to 1alp

34 ule responsible for the recruitment is lysyl hydroxylase 3 (LH3).

35 partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly iden

36 AKG also inhibited the expression of proline hydroxylase 3 (PHD3), one of the important oxidoreductas

37 HIF-1alpha degradation by suppressing prolyl hydroxylase 3 expression.

38 droxylated on proline 419 and 426 via prolyl hydroxylase 3.

39 e discovery and characterization of vinorine hydroxylase, a cytochrome P450 enzyme that hydroxylates

40 ngly, these cells immunolabeled for tyrosine hydroxylase, a key component in dopamine synthesis.

41 racterized as a new inhibitor of CINNAMATE 4-HYDROXYLASE, a key enzyme of the phenylpropanoid pathway

42 The absence of coexpression of tyrosine hydroxylase, a marker for dopamine production, in GABAer

43 Low oxygen inhibits Ofd1 hydroxylase activity and stabilizes the Ofd1-Rps23-Nro1

44 Based on the evidenced hydroxylase activity and the interactions of specific re

45 rate (isoliquiritigenin), revealing that the hydroxylase activity is not correlated with the acceptan

46 However, AUS1 showed hydroxylase activity toward its natural substrate (isoli

47 ownregulation was suppressed when HIF-prolyl hydroxylase activity was pharmacologically inhibited usi

48 eversed albumin-induced inhibition of prolyl-hydroxylase activity.

49 PA, CYP76AD6 uniquely exhibits only tyrosine hydroxylase activity.

50 ficiency as a result of reduced renal 1alpha-hydroxylase activity.

51 we checked for immunolabeling of tryptophan hydroxylase, an enzyme associated with the synthesis of

52 pounds selectively inhibited CYP17A1 17alpha-hydroxylase and 17,20-lyase activities with IC50 values

53 ing reductions in the expression of tyrosine hydroxylase and catechol-O-methyltransferase (COMT).

54 were decreased in the NAc, whereas tyrosine hydroxylase and dopamine transporter mRNA levels and tis

55 as indicated by abundant levels of tyrosine hydroxylase and neuropeptide Y.

56 ed to overexpress 25-hydroxyvitamin D 1alpha-hydroxylase and pulsed with a myelin antigen, provide my

57 ation and induced hepatic cholesterol 7alpha-hydroxylase and sterol 12alpha-hydroxylase expression.

58 ochemical biosensor consisting of salicylate hydroxylase and tyrosinase enzymes immobilized on carbon

59 For tuber flesh colour beta-carotene hydroxylase and zeaxanthin epoxidase were ranked first a

60 to the up-regulation of both flavonoid 3',5'-hydroxylases and cytochrome b5 Overall, this work provid

61 ent oxygenases in Arabidopsis thaliana as JA hydroxylases and show that they down-regulate JA-depende

62 nduction of catabolism (CsCYP707A, an ABA 8'-hydroxylase) and buildup of dehydrophaseic acid (DPA).

63 tained in the fah1 (deficient for ferulate 5-hydroxylase) and ccr1g (deficient for cinnamoyl-coenzyme

64 A expression of dopamine receptors, tyrosine hydroxylase, and dopamine transporter genes in the zebra

65 mes deoxyhypusine synthase and deoxyhypusine hydroxylase as well as for the cancer-related isoform eI

66 Aspartate beta-hydroxylase (ASPH) is an enzyme overexpressed in human h

67 ylation of a specific set of genes, tyrosine hydroxylase, brain-derived neurotrophic factor and FK506

68 chemically characterized F3'Hs (flavonoid 3' hydroxylase) but without F3'H activity.

69 Collagen prolyl 4-hydroxylases (C-P4H-I, C-P4H-II, and C-P4H-III) catalyze

70 Collagen prolyl 4-hydroxylases (C-P4Hs) play a central role in the formati

71 nylic acid (PA), an inhibitor of CINNAMATE-4-HYDROXYLASE (C4H), the enzyme directly upstream of 4CL.

72 , as well as other retinal markers (tyrosine hydroxylase, calbindin, PKCalpha and Brna3), in R6/2 and

73 with phenylalanine, tyrosine, and tryptophan hydroxylases catalyzing the BH4-activated conversion of

74 e associated with a greater loss of tyrosine hydroxylase cell content and intense neuroinflammation.

75 nes, phospholipase A2 group VI, fatty acid 2-hydroxylase, ceruloplasmin, chromosome 19 open reading f

76 n macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription f

77 Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in response to ZIKV infe

78 rol pathway, particularly the cholesterol-25 hydroxylase (CH25H).

79 simultaneous detection of NOS with tyrosine hydroxylase, choline acetyltransferase, calbindin, calre

80 tidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid

81 tidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) KO, and GGTA1/ CMAH /b1,4 N-acetylgal

82 CMP-N-acetylneuraminic acid hydroxylase (CMAH) loss occurred approximately 2-3 milli

83 dentified as DA neurons (defined by tyrosine hydroxylase colocalization).

84 In mice expressing ChR2 in tyrosine hydroxylase-containing neurons, optical activation of SA

85 450 (P450, CYP) 21A2 is the major steroid 21-hydroxylase, converting progesterone to 11-deoxycorticos

86 through the expression of the beta-carotene hydroxylase (CrtZ) and oxyxgenase (CrtW) from Brevundimo

87 lemia, the role of DNA methylation of 11beta-hydroxylase (CYP11B1), which catalyzes cortisol biosynth

88 s, can be controlled by inhibition of 11beta-hydroxylase (CYP11B1).

89 catabolizing enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead to increa

90 hydroxylase (CYP2R1) with 3-epi-25(OH)D3; 24-hydroxylase (CYP24A1) with 25(OH)D3, 3-epi-25(OH)D3, and

91 essential enzyme 25-hydroxyvitamin D3-1alpha-hydroxylase (CYP27B1), which can be expressed by activat

92 , rs11568820) and 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1: rs4646536) (adjusted hazard ratio

93 ihydroxyvitamin D3 [1,25(OH)2D3]; and 1alpha-hydroxylase [(CYP27B1) with 3-epi-25(OH)D3 and 1,25(OH)2

94 -25(OH)D3]; cubilin (CUBN) with 25(OH)D3; 25-hydroxylase (CYP2R1) with 3-epi-25(OH)D3; 24-hydroxylase

95 nthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene.

96 nvestigated the expression of cholesterol 24-hydroxylase (CYP46A1), the neuronal-specific and rate-li

97 Cholesterol 7alpha-hydroxylase Cyp7a1 expression was strongly down-regulate

98 markedly inhibits hepatic cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp

99 ynthesis genes, including cholesterol 7alpha-hydroxylase (Cyp7a1).

100 lpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) partly through inducing small heter

101 son of the average structures of the camphor hydroxylase cytochrome P450(cam) (CYP101) obtained from

102 the vitamin D responsive genes, 25(OH)D3-24-hydroxylase (cytochrome P450 family 24 subfamily A membe

103 Cs express very low level of 25(OH)D3-1alpha-hydroxylase (cytochrome P450 family 27 subfamily B membe

104 d tyrosine hydroxylase (TH) or dopamine beta-hydroxylase (DbetaH), respectively.

105 tor population specifically in dopamine beta-hydroxylase (DBH)-expressing cells is both necessary and

106 kinin (CCK) and noradrenergic, dopamine beta-hydroxylase (DBH)-expressing NTS neurons as two separate

107 lacking NE due to mutation of dopamine beta-hydroxylase (dbh).

108 n between SLC34A1 (NaPi-IIa) and CYP24A1 (24-hydroxylase) defects appears critical for targeted thera

109 l cohort of 108 patients with steroid 11beta-hydroxylase deficiency CAH.

110 ut on plasma samples from 117 adults with 21-hydroxylase deficiency receiving their usual glucocortic

111 Phenylketonuria (PKU, phenylalanine hydroxylase deficiency), an inborn error of metabolism,

112 Unlike CAH caused by 21-hydroxylase deficiency, the disease is far more common i

113 erone concentrations for classic (severe) 21-hydroxylase deficiency, the most common type of congenit

114 ust biochemical marker for diagnosing 11beta-hydroxylase deficiency.

115 xyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).

116 idney and liver and is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PH

117 The prolyl-4-hydroxylase domain (PHD) enzymes are regarded as the mol

118 h as iron chelators and inhibitors of prolyl hydroxylase domain (PHD) enzymes, have broad-spectrum ac

119 response to oxygen availability by prolyl-4-hydroxylase domain (PHD) proteins, with PHD2 being the m

120 ng to examine the von Hippel-Lindau/prolyl-4-hydroxylase domain (PHD)/HIF axis in cell-expressing neu

121 Cofactors involved in prolyl hydroxylase domain activity were increased in PAH smooth

122 h its interaction with the O2-sensing prolyl hydroxylase domain containing protein EGLN3 (or PHD3), w

123 Prolyl hydroxylase domain protein 2 (PHD2) (also known as EGLN1

124 Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolut

125 bition of a class of enzymes known as prolyl hydroxylase domain proteins (PHDs) has neuroprotective e

126 Prolyl hydroxylase domain proteins hydroxylate substrate prolin

127 Pharmacological inhibitors of prolyl hydroxylase domain-containing enzymes (PHDs), which resu

128 We recently demonstrated that Prolyl Hydroxylase Domain-containing Protein 2 (Phd2) is a key

129 as aeruginosa lacking the Pseudomonas prolyl-hydroxylase domain-containing protein, which has been im

130 ng the hypoxia response component and prolyl hydroxylase egl-9, with impaired subcellular localizatio

131 prolyl-hydroxylated by the oxygen-dependent hydroxylase EglN1.

132 ve identified a critical role for the prolyl hydroxylase enzyme Phd2 in maintaining the balance betwe

133 -inducible transcription factor (HIF)-prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) is a suitable

134 -inducible transcription factor (HIF)-prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) is a suitable

135 Prolyl hydroxylase enzymes (PHD1-3) are molecular oxygen sensor

136 Prolyl hydroxylase enzymes (PHDs) sense cellular oxygen upstrea

137 The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIF

138 ting an inhibition of the activity of prolyl-hydroxylases, enzymes promoting the degradation of HIF-1

139 t to originate exclusively from the tyrosine-hydroxylase-expressing (TH(+)) neurons in the ventral te

140 he E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non

141 xpression analysis revealed reduced tyrosine hydroxylase expression and the regulation of genes invol

142 owed that daf-7 TGFbeta and tph-1 tryptophan hydroxylase expression in specific neurons encode food a

143 ells (brain nitric oxide synthetase/tyrosine hydroxylase expression) and ganglion cell axons via a Tr

144 oid hormone levels, and higher renal 1-alpha-hydroxylase expression, serum 1,25-dihydroxyvitamin D, a

145 sterol 7alpha-hydroxylase and sterol 12alpha-hydroxylase expression.

146 QTL) mapping and identified a FLAVONOID 3'5' HYDROXYLASE (F3'5'H) gene therein.

147 t, 4-coumarate-CoA ligase (4CL2), ferulate-5-hydroxylase (F5H), and caffeoyl shikimate esterase (CSE)

148 d SbCYP82D2, which function as the flavone 6-hydroxylase (F6H) and flavone 8-hydroxylase (F8H), respe

149 he flavone 6-hydroxylase (F6H) and flavone 8-hydroxylase (F8H), respectively, in S. baicalensis.

150 lyl hydroxylases (PHD1-3) and an asparaginyl hydroxylase (factor-inhibiting HIF (FIH)).

151 The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen

152 ed to overexpress 25-hydroxyvitamin D 1alpha-hydroxylase for de novo synthesis of a focally high 1,25

153 poxic stress and the potential for targeting hydroxylases for therapeutic benefit.

154 Recently, mutations in the prolyl hydroxylase gene (PHD) 1 and 2 and in the hypoxia-induci

155 ere it significantly reduced feruloyl CoA 6'-hydroxylase gene expression, scopoletin accumulation and

156 tionally characterised a putative ferulate 5-hydroxylase gene through overexpression of it in Brachyp

157 s a seven membered family of feruloyl CoA 6'-hydroxylase genes, four of which are expressed in the st

158 C) domain-containing protein demethylase and hydroxylase, has been implicated in an array of biologic

159 d in the endoplasmic reticulum, where ABA 8'-hydroxylases have been shown to be localized, and that i

160 protease (Clp-1) and an isotrichodermin C-15 hydroxylase (HiC-15), and targeted by miR166 and miR159,

161 t alter Fos-immunoreactivity within tyrosine hydroxylase-immunolabeled neurons of VTA, but did attenu

162 Dopamine- and tyrosine hydroxylase-immunopositive cells (TH cells) modulate vis

163 ility, we quantified the density of tyrosine hydroxylase-immunoreactive axons as a measure of dopamin

164 ervation patterns of both 5-HT- and tyrosine hydroxylase-immunoreactive processes relative to each ot

165 Another finding was a loss of tyrosine hydroxylase immunoreactivity in gut neurons with aggrega

166 he sympathetic ganglia, increase in tyrosine hydroxylase in both nerve terminals in the SAT and sympa

167 The absence of tyrosine hydroxylase in GABAergic nerve terminals in the median e

168 these data identify Phd2 as the dominant HIF-hydroxylase in neutrophils under normoxic conditions and

169 rocytes and decreased expression of tyrosine hydroxylase in periglomerular cells, vesicular glutamate

170 Expression of liver oxysterol 7alpha-hydroxylase in the alternative bile acid synthesis pathw

171 zed by CYP46A1, the principal cholesterol 24-hydroxylase in the brain.

172 challenges of therapeutic modulation of HIF hydroxylases in the therapy of cardiovascular disease.

173 fferentiation, but the potential role of TET hydroxylases in these processes has not yet been examine

174 volves oxygen-dependent catalysis by the HIF hydroxylases; in humans there are three HIF prolyl hydro

175 tarate, which interferes with iron-dependent hydroxylases, including the TET family of 5'-methylcytos

176 triol bioavailability due to ITZ-mediated 24-hydroxylase inhibition but rather from a direct interact

177 Furthermore, pharmacological hydroxylase inhibition reduces virulence factor expressi

178 le factor (HIF) stabilization via HIF prolyl hydroxylase inhibition using the isoquinolone Roxadustat

179 We used the prolyl hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate (DHB)

180 dose of the hypoxia-inducible factor-prolyl hydroxylase inhibitor GSK1278863 and hemoglobin response

181 Systemic administration of a HIF-prolyl hydroxylase inhibitor replicated the Phd2-deficient phen

182 ilable hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that promotes coordinated erythrop

183 HIF) pathway under normoxia using a prolyl-4-hydroxylase inhibitor, dimethyloxalylglycine (DMOG) and

184 dy, we report the discovery of an HIF prolyl-hydroxylase inhibitor, DMOG [N-(2-Methoxy-2-oxoacetyl) g

185 ggested that telotristat ethyl, a tryptophan hydroxylase inhibitor, reduces bowel movement (BM) frequ

186 Hypoxia-inducible factor prolyl hydroxylase inhibitors stabilize levels of hypoxia-induc

187 We report studies using small molecule HIF hydroxylase inhibitors that investigate the extent to wh

188 sensory (CGRP) but not sympathetic (tyrosine hydroxylase) innervation for Old versus Young MAs.

189 Here we show the structure of a diiron hydroxylase intermediate formed during a reaction with t

190 on thalamic activation of striatal tyrosine hydroxylase interneurons (THINs).

191 Feruloyl CoA 6'-hydroxylase is a controlling enzyme in the biosynthesis

192 ydroxylase related to animal HIFalpha prolyl hydroxylases is required for optimal parasite proliferat

193 Cytochrome P450 27A1 (CYP27A1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional enzyme cat

194 ytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority

195 e kinase 1 and Glucokinase but not of prolyl hydroxylase isoforms.

196 Here, we exposed dopamine beta-hydroxylase knock-out (Dbh(-/-)) mice, which lack NE com

197 in D3-deficient 25-hydroxy-vitamin-D3-1alpha-hydroxylase knockout mice and 1,25-vitamin D3-deficient

198 ssed secondary hyperparathyroidism in 1alpha-hydroxylase knockout mice.

199 tidine monophosphate-N-acetylneuraminic acid hydroxylase KO mice and exhibited in vitro normal insuli

200 from mutations in the genes coding for lysyl hydroxylase (LH) 2 or peptidyl-prolyl cis-trans isomeras

201 l heterodimer partner and cholesterol-7alpha-hydroxylase mRNA expression, implicates bile salt hydrol

202 Geraniol-10 hydroxylase (NnCYP76B6) an important enzyme in CPT biosy

203 ttenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression.

204 or substrate-binding (W116C) site of 11beta-hydroxylase, or alterations in its stability (L299P and

205 tion or pharmacological inhibition of prolyl hydroxylase oxygen sensors, indicating the molecular com

206 cities of individual members of the prolyl 3-hydroxylase (P3H) gene family.

207 anics (QM/MM) calculations of the fatty acid hydroxylase P450 BM3 predict the binding mechanism of th

208 Prolyl-4-hydroxylase (P4H) is a non-heme iron hydroxylase that re

209 Prolyl 4-hydroxylases (P4Hs) are mononuclear non-heme iron alpha-

210 s, and function for the enzyme phenylalanine hydroxylase (PAH) can lead to needed new therapies for p

211 The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary

212 mutations in the gene encoding phenylalanine hydroxylase (PAH), and a small proportion (2%) exhibit t

213 ed by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFalph

214 Inhibition of prolyl hydroxylase (PHD) is known to activate the transcription

215 nsic expression of the oxygen-sensing prolyl-hydroxylase (PHD) proteins is required to maintain local

216 trates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible facto

217 The role of prolyl hydroxylase (PHD)-3 as a hypoxia inducible factor (HIF)-

218 of HIFalpha isoforms, as catalysed by prolyl hydroxylases (PHD 1-3).

219 Siah1, and Siah2, and suppressed the prolyl hydroxylases (PHD) 2 and PHD3.

220 ors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described.

221 ted in normoxia by the oxygen-sensing prolyl hydroxylase PHD1 (also known as EGLN2).

222 ylases; in humans there are three HIF prolyl hydroxylases (PHD1-3) and an asparaginyl hydroxylase (fa

223 o did not inhibit the activity of the prolyl-hydroxylase PHD2, experiments with mouse liver showed th

224 re heterozygous for the principal HIF prolyl hydroxylase, PHD2, show enhanced ventilatory sensitivity

225 on involves succinate, which inhibits prolyl hydroxylases (PHDs).

226 Mammalian phenylalanine hydroxylase (PheH) is an allosteric enzyme that catalyze

227 Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that requires

228 not D2L prevents the inhibition of tyrosine hydroxylase phosphorylation and, thereby, of dopamine sy

229 expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a circadian

230 is hydroxylated by an O2-dependent prolyl-4-hydroxylase (PhyA), and the resulting hydroxyproline can

231 nzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple).

232 Mice lacking ErbB4 in tyrosine hydroxylase-positive (TH+) neurons, but not in PV+ GABAe

233 Sympathetic innervation (tyrosine hydroxylase-positive axon density) and endothelium-depen

234 ACh transporter immunoreactivity in tyrosine hydroxylase-positive cardiac sympathetic fibers.

235 uroprotective effects by preserving tyrosine hydroxylase-positive neurons in the substantia nigra of

236 or function, diminished the loss of tyrosine hydroxylase-positive neurons in the substantia nigra, an

237 RDN reduced tyrosine hydroxylase-positive sympathetic nerve staining and resu

238 led axons (135 of 136 sampled) were tyrosine hydroxylase-positive.

239 nd WD-40 domain protein (Fbxw7) and Prolyl 4-hydroxylase possessing a transmembrane domain (P4HTM) re

240 P450 family 4 fatty acid omega-hydroxylases preferentially oxygenate primary C-H bonds

241 r the control of the Arabidopsis cinnamate-4-hydroxylase promoter boosted the p-coumaroylation of mat

242 ABA homeostasis through regulation of ABA 8'-hydroxylase protein stability, representing a novel cont

243 n of this intermediate, normally fleeting in hydroxylases, provides a rationale for the carbon-carbon

244 led to decreases in phosphorylated tyrosine hydroxylase (pTH-Ser40) levels in the VTA and dopamine t

245 Therefore, we propose that the hydroxylase reaction is a general functionality of PPOs.

246 The hypoxia-inducible factor (HIF) hydroxylases regulate hypoxia sensing in animals.

247 Previous studies showed that a prolyl 4-hydroxylase related to animal HIFalpha prolyl hydroxylas

248 mutations in CYP11B1, a gene encoding 11beta-hydroxylase, represents a rare autosomal recessive Mende

249 ocytosis assessed by measuring dopamine-beta-hydroxylase (secretory granule membrane) internalization

250 s accompanied by a higher number of tyrosine hydroxylase(+) SN neurons (increase of approximately 29%

251 se additional fibers also expressed tyrosine hydroxylase, suggesting a sympathetic origin.

252 al microRNA (aMIR) of NnCYP76B6 (geraniol 10-hydroxylase) suggests its role in CPT biosynthesis.

253 tudies of the hypoxia-inducible factor (HIF) hydroxylase system.

254 cade of the nuclear receptor TLX and the DNA hydroxylase Ten eleven translocation 3 (TET3) as a targe

255 with the dopamine synthesis enzymes tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase,

256 In this work, we evaluated whether tyrosine hydroxylase (TH) and cytochrome P450s (CYPs) catalyzed t

257 zymes of DA and 5-HT, respectively, tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), and d

258 Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine

259 There was a reduction in tyrosine hydroxylase (TH) density in the striatum in these cases

260 ly targets and negatively regulates tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of

261 were dopaminergic (DA), revealed by tyrosine hydroxylase (TH) immunoreactivity.

262 e reporter gene into the endogenous tyrosine hydroxylase (TH) locus enables rapid and easy quantifica

263 introduce an unexpected neuron, the tyrosine hydroxylase (TH) neuron of the arcuate nucleus (ARC), th

264 nergic fibers with somatostatin and tyrosine hydroxylase (TH) or dopamine beta-hydroxylase (DbetaH),

265 er 25 days of differentiation ( 40% tyrosine hydroxylase (TH) positive, maturing into 25% cells exhib

266 expresses eGFP under control of the tyrosine hydroxylase (TH) promoter, we found that mu opioid recep

267 imulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synt

268 rosine by the rate-limiting enzyme, tyrosine hydroxylase (TH), and tyrosine is catabolized by tyrosin

269 europrotection, BRF110 up-regulates tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase (A

270 alysis to compare protein levels of tyrosine hydroxylase (TH), glutamate decarboxylase (GAD67), and v

271 ons labeled with antibodies against tyrosine hydroxylase (TH), melanin-concentrating hormone (MCH), a

272 Immunostaining for tyrosine hydroxylase (TH), sodium channels (Nav ) and ankyrin-G (

273 cific to pain-sensing C-fibers, and tyrosine hydroxylase (Th), specific to low-threshold mechanorecep

274 (MTA1) is an upstream modulator of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine s

275 gic, as judged by the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine b

276 ression of DA neuron-enriched genes tyrosine hydroxylase (TH), vesicular monoamine transporter 2, dop

277 sis of PD and demonstrated >300,000 tyrosine hydroxylase (TH)-positive grafted cells per side with no

278 cant protection against the loss of tyrosine hydroxylase (TH)-positive neurons of substantia nigra.

279 aneous detection of VGluT2 mRNA and tyrosine hydroxylase (TH; for identification of dopamine neurons)

280 rvival of grafted dopamine neurons (tyrosine hydroxylase: TH+).

281 ion of the two non-allelic forms of tyrosine hydroxylase (th1 and th2) in zebrafish larvae.

282 1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from t

283 rolyl-4-hydroxylase (P4H) is a non-heme iron hydroxylase that regio- and stereospecifically hydroxyla

284 xygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.

285 tabotropic glutamate receptors and CYP omega-hydroxylase, the enzyme regulating 20-hydroxyeicosatetra

286 unusual dual catalytic activity of vinorine hydroxylase thereby provides a control mechanism for the

287 ety behaviors, the mRNA levels of tryptophan hydroxylase (TPH) 1, TPH2 (both are involved in serotoni

288 increases in substrate availability and TRP hydroxylase (TPH) enzymatic activity, leading to accumul

289 ly, tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), and draw an evolutionary scenario for

290 n from wild-type and mice lacking tryptophan hydroxylase (TPH1KO).

291 hila melanogaster, and identified tryptophan hydroxylase (Trh), serotonin receptor 2a (5HT2a), and th

292 EglN1, the main HIFalpha prolyl-hydroxylase, undergoes oxidative self-inactivation in th

293 the ferryl intermediate in the l-arginine 3-hydroxylase, VioC, reveals coordinated motions of active

294 and 2-HG is a known inhibitor of HIF prolyl hydroxylases, we hypothesized that 2-HG may be required

295 expressing a castor bean (Ricinus communis) hydroxylase were analyzed.

296 ponsible for the interaction with HIF-prolyl hydroxylase, were deleted.

297 b1 gene encoding 25-hydroxyvitamin D 1-alpha-hydroxylase, which produces 1,25-hydroxyvitamin D.

298 The ten-eleven translocation (TET) hydroxylases, which oxidize methylated cytosines to 5-hy

299 ee-component protein complex consisting of a hydroxylase with a nonheme diiron catalytic site; pMMO i

300 rally targeted expression of mutant tyrosine hydroxylase with enhanced catalytic activity increased d