ライフサイエンスコーパス: indene

1 roton beta to the indanyl-type carbocations (indenes).

2 and this increases to 1.22 eV for 2H-benz[f]indene.

3 osition analysis for Raman spectra of liquid indene.

4 r distribution of products was afforded from indene.

5 ation and enables access to C(2)-substituted indenes.

6 and 0.82/0.74 kcal/mol for the C-2 Me (E/Z)-indenes.

7 peritoneal or oral administration of several indenes.

8 total PM index followed by naphthalenes and indenes.

9 ing either Sn-substituted naphthalenes or Sn-indenes.

10 cyclodehydrations leading to functionalized indenes.

11 e (-0.49 eV), fluorene (-0.07 eV), 1H-benz[f]indene (0.13 eV), 1,2-benzofluorene (0.25 eV), 2,3-benzo

12 predictions are cyclopentadiene (-0.63 eV), indene (-0.49 eV), fluorene (-0.07 eV), 1H-benz[f]indene

13 ransformed to 2-(1,3-dihydroxyallylidene)-1H-indene-1,3(2H)-dione or by loss of alcohol to indeno[1,2

14 ional methods, and these were condensed with indene-1,3-dicarbaldehyde, 5-formylsalicylaldehyde, or 3

15 nzyl]-1-methyl-3-[(1R,3'R)-methyl-1'H-spiro[ indene-1,4'-piperidin]-1'-yl]cyclopentanecarboxamide (16

16 1-(1H-indol-3-ylm ethyl)-2-oxoethyl]spiro[1H-indene-1,4'-piperidine]-1'-carboxamide) in DA amacrine c

17 ounds 18 and 19, and the spiro[1H-cyclobut[a]indene-1,9'-[9H]fluorene] 20 (trans/cis = 5:1).

18 The spiro[1H-cyclobut[a]indene-1,9'-[9H]fluorene] 20 apparently was produced via

19 luorenylidene 33 and the spiro[1H-cyclobut[a]indene-1,9'-[9H]fluorene] 39 (trans/cis = 3:1) were like

20 -d to provide the 2,3- and 1,2,3-substituted indenes 13b-d in good yields.

21 s, cyclobuta[de]naphthalene 6, cyclopenta[cd]indene 16, and benzofulvenallene 17, are explained in te

22 On the basis of overall profile, indene 1d and benzothiophene 2a had pharmacokinetic prop

23 is(methanylylidene))bis(3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))d imalononitrile (IDIC) is develop

24 dene)) bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile (NITI), is success

25 e corresponding expected 3'-phenyl-1'H-spiro[indene-2,2'-quinazoline]-1,3,4'(3'H)-triones were obtain

26 akis(2-ethylhexyl)-5,10-dihydroindeno[2,1-a] indene-2,7-diyl)bis(2-octylthieno[3,4-b]thiophene-6,4-di

27 diate occurred, furnishing the 1H-cyclobut[a]indene 27 exclusively.

28 ydro-7-(2-hydroxy ethyl)-3a-methyl-1H-benz[e]indene-3-carbonitrile (BI-2) using single-channel patch-

29 rahydro-7-methyl-5,5-bis(trifluoromethyl)-4H-indene-4,4-dicarb onitrile (8).

30 e donor and indene-C(60) bisadduct (ICBA) or indene-[6,6]-phenyl-C(61)-butyric acid methyl ester (IPC

31 1H-Benz[f]indene, a naphthalene-annulated cyclopentadiene, is pred

32 sition 2 with phenyl acetylene, styrene, and indene afforded polycyclic isoindolone derivatives.

33 significant amounts from an earlier reported indene/aldehyde condensation reaction.

34 yields of dicarbaporphyrinoids with adjacent indene and azulene subunits.

35 sed in light of pyrolysis experiments on CPD-indene and CPD-acenaphthylene mixtures conducted by Prof

36 readily derivatized to afford functionalized indene and dihydrobenzofuran carboxylates.

37 orobenzylidene)-2-(2,4,6-trichlorophenyl)-1H-indene and its hydrogenation product 3-(2,4,6-trichlorob

38 se of 1.13/0.69 kcal/mol for the C-2 H (E/Z)-indenes and 0.82/0.74 kcal/mol for the C-2 Me (E/Z)-inde

39 Indenes and fluorenes are obtained by intramolecular rea

40 modular procedure affords highly substituted indenes and indanones with excellent chirality transfer

41 llows the efficient synthesis of substituted indenes and inden-2-ones, in two steps, from aromatic ke

42 oxidations of toluene, ethylbenzene, cumene, indene, and cyclohexene.

43 1-Indanones, indeno indenes, and indeno furanones were accessed through casc

44 to 11H-benzo[b]fluoren-11-ols, 1H-cyclobut[a]indenes, and related compounds via biradicals generated

45 richlorobenzyl)-2-(2,4,6-trichlorophenyl)-1H-indene], and even for the parent hydrocarbon 1,2-bis(phe

46 haracterized by X-ray diffraction, and a bis-indene-annulated porphyrin.

47 We found that the planar trans-trans benz[f]indenes are active, but less active than the steroids th

48 cis-trans, either planar or nonplanar benz[f]indenes are obtained.

49 The product indenes are synthesized having N-heterocyclic substituen

50 Benz[e]indenes are tricyclic analogs of neuroactive steroids an

51 Benz[f]indenes are tricyclic compounds with a linear 6-6-5 fuse

52 ts support the previously established use of indenes as rigid analogues of the AAIs.

53 he porphyrin framework with cyclopentadiene, indene, azulene, cycloheptatriene, or benzene, new famil

54 of an indenyl cyclobutanol to a spirocyclic indene bearing a quaternary carbon.

55 t has been used for the investigation of the indene bioconversion network expressed in Rhodococcus sp

56 We demonstrate this method in the indene bioconversion network of Rhodococcus modified for

57 Two pairs of (E)- and (Z)-naphthylidene indenes (C-2 H and C-2 Me) were considered.

58 ly(3-hexylthiophene) (P3HT) as the donor and indene-C(60) bisadduct (ICBA) or indene-[6,6]-phenyl-C(6

59 61)-butyric acid methyl ester (PC(61)BM) and indene-C(60) bisadduct (ICBA), was examined.

60 A fullerene variant, Indene-C60 bis-adduct, is used to achieve optimized inte

61 Using indene-C60 bisadduct (IC60BA) in place of PC60BM, we obs

62 Indene-C60 bisadduct (ICBA) with higher-lying lowest-uno

63 When properly substituted, benz[f]indenes can satisfy the pharmacophore requirements of th

64 tonation involves addition onto the internal indene carbon and proton NMR spectroscopy for the sample

65 protonation readily occurred at the interior indene carbon, but deuterium exchange also occurred at t

66 data for indene oxide monomer as well as cis-indene carbonate display near planarity of the fused cyc

67 Poly(indene carbonate) is thermally stable up to 249 degrees

68 The produced poly(indene carbonate) samples have molecular weights of up t

69 doses that relieve neuropathy symptoms, the indenes completely lacked, while the brain-permeant CB1R

70 mined the mechanisms of action of the benz[e]indene compound [3S-(3alpha,3aalpha,5abeta,7beta,9aalpha

71 Indole and indene compounds were engineered for high hCB1R affinity

72 oducts containing a chlorinated cyclopenta[a]indene core of suspected enediyne polyketide biosyntheti

73 f heteropolycyclic structures containing the indene core.

74 QMT) for 2,2a,5,7b-tetrahydro-1H-cyclobuta[e]indene derivatives (2a-2j) in governing their product se

75 quinone as a diene system toward a number of indene derivatives as dienophiles, first in intermolecul

76 e 4a-substituted 2a,2a(1)-diazacyclopenta[cd]indene derivatives as the first representatives of a nov

77 e triflates are transformed into indanone or indene derivatives depending on which substituents on th

78 igratory ring expansion for the synthesis of indene derivatives possessing a stereogenic spirocyclic

79 sis, affords substituted polycyclic aromatic indene derivatives through a domino reaction involving t

80 by the synthesis of several polysubstituted indene derivatives through conventional palladium-cataly

81 osperms have been structurally identified as indene derivatives.

82 od for the construction of functionalized 1H-indene derivatives.

83 he controlled construction of functionalized indene derivatives.

84 oped for the synthesis of highly substituted indene derivatives.

85 ing furan or thiophene carbaldehydes with an indene-derived enamine in the presence of di-n-butylboro

86 lvene aldehydes were prepared by reacting an indene-derived enamine with azulene aldehydes in the pre

87 ne ortho-quinone methide with benzofuran and indene, each generating 12 new stereogenic centers.

88 s and allows the synthesis of both 3-iodo-1H-indenes (from beta-alkyl-beta-alkyl/aryl-o-(alkynyl)styr

89 The synthesis of highly substituted indenes has been achieved by three different transition

90 ompetitive conversion of 1-QM to an inactive indene in protic medium.

91 d range of substrates, producing substituted indenes in excellent yields.

92 to a broad range of substrates, producing 1H-indenes in good to excellent yields.

93 namaldehydes cyclize to 1-methoxy-2-alkyl-1H-indenes in good-to-high yields.

94 es of BrettPhosAuNTf(2), affording tricyclic indenes in mostly good yields.

95 the efficient synthesis of phosphorus-based indenes, indenones, benzofurans, and isochromenes via in

96 While indene is 21 kcal mol(-1) more stable than isoindene, th

97 -diketopiperazines oxytocin antagonists from indene is described.

98 strategy for the synthesis of functionalized indenes is presented.

99 and straightforward synthesis of 1-amino-1H-indenes is reported from 1,2-bis(boronates) via a sequen

100 hore, based on a gem-dichlorocyclopropanated indene, is synthesized and used as a cross-linker in pol

101 ation that the C-2 H (E/Z)- and C-2 Me (E/Z)-indene isomers can mimic the positions of the aromatic s

102 ne-3,5-dione (MeTAD) with acenaphthylene and indene leads not only to the formation of the expected [

103 ses with the size of the system, the regular indenes, like PAHs in general, suffer from the loss of a

104 Substituted indenes may be prepared from 2-indanones in high yields

105 For cis-cyclooctene, indene, methyl acrylate, methyl methacrylate, vinyl meth

106 interior chlorine atom was found to tilt the indene moiety by 29.59(4) degrees relative to the [18]an

107 H=CMe unit on the pyrrolic ring opposite the indene moiety, gave a long-range coupling constant of 4J

108 The requisite indene o-quinone precursor 75 was synthesized through a

109 This cage bound C60-indene or C60-anthracene bisadducts selectively, whereas

110 oscopic metabolite balancing and showed that indene oxidation in steady state chemostat cultures proc

111 X-ray structural data for indene oxide monomer as well as cis-indene carbonate dis

112 he catalytic coupling of carbon dioxide with indene oxide utilizing (salen)Co(III)-2,4-dinitrophenoxi

113 ate from the coupling reactions of CO(2) and indene oxide.

114 can oxidize such compounds as indole, indan, indene, phenetole, and acenaphthene.

115 furan, thiophene, selenophene, tellurophene, indene, phosphole, and silole are highly promising macro

116 Subsequent indene product elimination involving a 1,2-hydrogen tran

117 ability of the naphthalene-derived 1H-benz[f]indene radical anion significantly.

118 arbon bonds of the pyrrole units next to the indene ring are part of a fully delocalized 18pi electro

119 s led to an improved synthesis of the benz[f]indene ring system and the first enantiospecific total s

120 orted 1,6-difunctionalized dodecahydrobenz[f]indene ring system is described.

121 Thus, the benz[f]indene ring system provides an opportunity to extend the

122 modified and cyclized to produce the benz[f]indene ring system.

123 ores, yields two isomeric dihydrocyclopent[a]indene ring systems, spiro-fused to the 9-position of a

124 l angles of the component pyrrole, furan and indene rings relative to the mean [18]annulene plane wer

125 were overlayed at their corresponding indole/indene rings, the (E)- and (Z)-indenes were able to over

126 ers suggested mainly CB1R contribution to an indene's antiallodynic effects.

127 two series of ER ligands, based on a common indene scaffold, in an attempt to develop compounds that

128 A variety of fused beta-naphthol and indene scaffolds were obtained in good yields with high

129 so utilized for the synthesis of substituted indenes selectively deuterated in position 3, which are

130 A five-membered ring indene skeleton is also prepared via olefin isomerizatio

131 macrocycle is reasonably planar although the indene subunit is tilted out of the mean macrocyclic pla

132 i-conjugated system containing phthalide and indene subunits.

133 The metallo-radical catalyzed indene synthesis in this paper represents a unique examp

134 cycloaddition reaction to highly substituted indene systems possessing a chlorine residue on the arom

135 m sequence circumvents the predisposition of indene to undergo C(1)-alkylation and enables access to

136 en combined with the faster rate of HAT from indene versus cyclohexadiene, this trend is consistent w

137 or the catalytic synthesis of substituted 1H-indenes via metalloradical activation of o-cinnamyl N-to

138 A synthesis of the naphthylidene indenes was developed using Horner-Wittig chemistry that

139 y calculations revealed that when 1 and each indene were overlayed at their corresponding indole/inde

140 oline (2) and WIN-55, 212-2 (1), and of each indene were performed using the semiempirical method AM1

141 nuclear Pd(II)-C(0) complexes of 2-methyl-1H-indene were synthesized and structurally characterized b

142 onding indole/indene rings, the (E)- and (Z)-indenes were able to overlay naphthyl rings with the cor

143 A variety of fused tetracyclic dihydroindeno-indenes were accomplished.

144 nes, since fluorene, the isomer of 1H-benz[f]indene, with separated six-membered rings, has an electr