ライフサイエンスコーパス: independent

1 (n = 85), tracer sensitivity was largely PSA-independent.

2 his effect was stimulus dependent and action independent.

3 mega.cm, while being essentially temperature independent.

4 DeltagpsB mutant was PgdA-dependent and OatA-independent.

5 dependent, androgen producing, and androgen independent.

6 ver domain of the histidine kinase CYTOKININ-INDEPENDENT 1 (CKI1RD) from Arabidopsis thaliana We obse

7 were assigned probabilities of achieving an independent (60 DFLYs), semidependent (30 DFLYs), or dep

8 ation with all-ion-fragmentation (AIF), data-independent-acquisition (DIA), and data-dependent-acquis

9 in hypoxic PH involves an early compartment-independent activation of lung macrophages toward a cons

10 Our findings demonstrate that Ras oncogene-independent activation of RALB signaling is a therapeuti

11 inhibited both phosphoantigen-dependent and -independent activation of Vgamma9Vdelta2 T cells and, im

12 nd in beta-arrestin 2 recruitment, no ligand-independent activity could be measured.

13 The independent addressing of many microrobots enables highe

14 ecific IgM Abs upon immunization with T cell-independent Ags, and they are more susceptible to Gram-n

15 astoma (GBM) and it remains unclear why such independent amplification events, and associated recepto

16 L and circulating progenitor cell levels are independent and additive predictors of adverse cardiovas

17 d increased lipoprotein(a) concentration are independent and causal risk factors for coronary heart d

18 phages, and revises current understanding of independent and collaborative functions of M36 and M45 i

19 t birth.The aim of this study was to examine independent and combined effects of antenatal and newbor

20 , functional and anatomical measures provide independent and converging evidence for functional organ

21 we show that elements of polygenic risk are independent and differ in their relationship with phenot

22 itical role in airway SM contraction that is independent and distinct from the function of SM myosin.

23 We aimed to quantify the independent and joint associations of two measures of ch

24 T-ALL NOTCH1 mutations result in ligand-independent and sustained NOTCH1-receptor signaling, whi

25 that hydrolyses COS, is expected to be light independent, and thus plants without stomata should cont

26 lets with an energy that is largely material independent ( approximately 30 meV).

27 ation were dependent ( approximately 30%) or independent ( approximately 70%) of Twist-mediated EMT.

28 with minimal, low-energy bioprocessing, two independent aquaculture trials were performed.

29 n patients with aortic stenosis, there is an independent association between post-TAVR blood pressure

30 is achieved by co-opting and regulating two independent biosynthetic pathways of floral volatile com

31 riptional SHAPE-Seq by developing a sequence-independent biotin-streptavidin (SAv) roadblocking strat

32 roduce cognitive decline, and drives amyloid-independent brain atrophy during the earliest stage of d

33 We also found that NBR1-independent bulk autophagy prevents premature plant deat

34 ommon endpoint of both EMT-dependent and EMT-independent cancer dissemination programs.

35 nic mechanisms of overnutrition, a confirmed independent cancer risk factor, remain poorly understood

36 used microarray data on whole blood from two independent case-control studies of MDD: the GlaxoSmithK

37 lts demonstrate a lung-intrinsic, herniation-independent cause of PH in CDH.

38 the costs of generic ZA and one of the first independent CE analyses not sponsored by either Novartis

39 Variability was added by extracting RNA from independent cell cultures and degrading particular sampl

40 were important for suppression of a caspase-independent cell death and the long-term survival of FA-

41 cycles, suppresses proliferation of androgen-independent cells and lowers cumulative drug dose.

42 haracter or minor subpopulations of androgen-independent cells that are poised for clonal selection a

43 In two independent clinical cohorts from tissue microarrays (TM

44 further studied 1536 samples obtained from 3 independent clinical trials with drisapersen, an antisen

45 we observed polyclonal seeding, in which two independent clones seeded the metastatic liver tumor aft

46 multivariable analysis, AS LGE was the best independent CMR predictor of the combined endpoint (odds

47 ion and exclusion criteria were applied by 2 independent coders with 20% overlap.

48 ional RNA-seq analysis was carried out in an independent cohort of 43 ER+ HER2- and ER- HER2- primary

49 dy sought to validate the RD-OGI Score in an independent cohort of patients.

50 hort and 0.82 (95% CI, 0.73 to 0.92) for the independent cohort.

51 In two independent cohorts of melanoma patients treated with an

52 ervational study following three sequential, independent cohorts, from a single U.S. health system, t

53 n (46%) of these loci could be replicated in independent cohorts, underlining the role of epigenetic

54 es are often not reproducible when tested in independent cohorts.

55 s independent components (ICs) yielded by an independent component analysis (ICA) of EEG data and mea

56 We operationalize functional modules as independent components (ICs) yielded by an independent c

57 We investigated this question by using Independent Components Analysis to obtain functional bra

58 We use a multi-echo sequence with independent components analysis, which has been shown to

59 We assessed neuronal-dependent and -independent contributions by activating or inhibiting ne

60 opril partially reduced ACR, consistent with independent contributions of these disorders to renal di

61 a intermittent slips that exhibit a material-independent critical size distribution.

62 the model prediction was validated using an independent data set from England and Wales.

63 In an independent data set, 2 of 9 (22.2%) ERBB2/HER2-negative

64 ed reasonable performance on our data and an independent data set.

65 In this study, we reanalyzed data from seven independent data sets with totally 1079 breast cancer pa

66 rs, and SSBs in Australia by using multiple, independent data sources.The study was designed to compa

67 ery, and consequently suppressing the oxygen-independent degradation of HIF-1alpha.

68 istry, and they can be the focus of multiple independent development efforts over an extended period.

69 Independent drivers of these aberrant developmental traj

70 An independent echocardiographic core laboratory evaluated

71 factors known to affect recurrence to assess independent effects of DEB-TACE response on recurrence.

72 markers of tricarboxylic acid-dependent and -independent energy biogenesis and oxygen consumption in

73 d metabolic heterogeneity in a population of independent Escherichia coli cells growing in a defined

74 s nidulans, we show that AP-2 has a clathrin-independent essential role in polarity maintenance and g

75 ples, and by benchmarking the method against independent experimental data.

76 ve graphics from data obtained with repeated independent experiments.

77 s except nitrofurantoin (NIT) were higher in independent facilities (IUs) as compared to contracted f

78 The results support the notion that CD19-independent factors drive early B cell mobilization and

79 ulsive action and choice separating into two independent factors.

80 Cell-cell fusion assays show a strain-independent failure of fusion pore enlargement among H2

81 We describe eight patients from three independent families having biallelic truncating variant

82 es ( ACACB, PTPRS, MIB1) in individuals from independent families.

83 est model was built using a set of cell type-independent features such as specific sequences recogniz

84 cell lines classified as K-Ras-dependent or -independent for co-dependency on protein kinase C delta

85 background particle concentration (B) to be independent for use in fate modeling.

86 er organisms revealed varying levels and TET-independent formation of this new RNA modification.

87 eed in addition to age, sex and hypertension independent from brain atrophy.

88 proportional to the severity of suicidality independent from depression severity.

89 in a series of steps, one of which is partly independent from syntactic hierarchy.

90 impossible to explore the possible signaling-independent functions of the receptor, which are indicat

91 Such independent genetic control suggests that breeders will

92 We then compared these culture-independent genomes to existing genomes of bacterial iso

93 agonism is sufficient to drive growth-factor-independent growth in the context of concurrent tumor su

94 Rev in a dose-dependent manner, although ATP-independent helicase activity is not.

95 more, DDX21 is both an ATP-dependent and ATP-independent helicase, and both ATPase and ATP-dependent

96 r efforts uncover replication-dependent and -independent ICL repair networks, and establish nematodes

97 esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes.

98 sed by myosin-IIA overassembly, and a myosin-independent increase in microtubule acetylation, which i

99 C-derived features that provide biologically independent information across a variety of mammalian ce

100 with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions.

101 capture the different sources of common and independent input, by quantifying the coherence of MU di

102 Moreover, LIF-independent iOCT4 ES cells retain the capacity to differ

103 to facilitate both recycling-dependent and -independent iron uptake.

104 -) definitive hematopoietic mesoderm and WNT-independent KDR(+)CD235a(+) primitive hematopoietic meso

105 eding full assistance (KPS 10%-40%) vs being independent (KPS 80%-100%) were more likely to be discha

106 uding susceptibility, were replicated by two independent laboratories.

107 Typically, stem cells of independent lineages work coordinately within mature org

108 Remarkably, within and across independent loci, T2D risk alleles that overlap with RFX

109 In an independent London-based cohort of 37 participants (23 H

110 ered five novel heart rate loci, and one new independent low-frequency non-synonymous variant in an e

111 ource.Some aerobic bacteria contain a biotin-independent malonate decarboxylase (MDC), which allows t

112 ble Cre-ER(T2), our system enables parallel, independent manipulation of alleles targeted by Cas9 and

113 Hsp20 binds AC9 in a Yotiao-independent manner and deletion of AC9 decreases Hsp20-a

114 ecific binding site can take place in a path-independent manner given reasonable values of the free e

115 ) serum enhanced HAdV-5 transduction in a FX-independent manner in CHO-CAR and SKOV3-CAR cells (CHO o

116 ient to sustain intrinsic signaling in a LIF-independent manner to promote ES cell pluripotency and s

117 P12 increase hepcidin expression in a ligand-independent manner, through BMP-SMAD signaling.

118 NO also appears to function in a cGMP-independent manner, via S-nitrosation (SNO), a redox-bas

119 lamellipodium buckles upward in a myosin II-independent manner.

120 e damaged DNA after UV irradiation in a DDB2-independent manner.

121 bilization of Ctn RNA occurred in an editing-independent manner.

122 somes to increase protein synthesis in a CAP-independent manner.

123 R/AR-V7 target genes in ligand dependent and independent manners respectively.

124 f the GABRA6 rs3219151 T allele with several independent markers and predictors of suicidal behaviour

125 urements of membrane coverage with multiple, independent measurements of membrane vesiculation reveal

126 Using three independent measures-calibrated imaging, FRAP, and photo

127 strate that the former loading leads to size-independent mechanical properties while the latter resul

128 the PDF receptor, the former through a cAMP-independent mechanism and the latter through a cAMP-PKA

129 ical approaches, we found that an interferon-independent mechanism involving Toll-IL-1-receptor domai

130 he biological processes controlled by a GPCR-independent mechanism of G protein activation mediated b

131 ort a physiologically relevant NMDA-receptor-independent mechanism that drives increased AMPA recepto

132 its T cell expansion via a regulatory T cell-independent mechanism that involves caspase-dependent T

133 12-fold, showing the two effects are due to independent mechanisms that tune the surface properties.

134 ogenic diet on IRS-1 are mediated by miR-126 independent mechanisms, including increased IRS-1 protei

135 myelopoiesis through Tet2-dependent and Tet2-independent mechanisms.

136 ity likely underlie this form of translation-independent memory.

137 Overall, we found evidence for at least 13 independent mesopolyploidies followed by different degre

138 mutation- and single nucleotide polymorphism-independent method could be crucial in dominant diseases

139 mouse brain with RNA-Seq and validation with independent methods.

140 The outcomes suggest that use of an independent modular filter may be associated with a lowe

141 ning through Ragulator-dependent, but mTORC1-independent, modulation of BORC.

142 We summarize reasons for mandating independent monitoring of greenhouse gas emission reduct

143 This suggested a NEXT-independent Mtr4 function, and, consistent with this, we

144 Erk suppression is relieved through independent mutagenesis of the PTB domain and the CH1 ty

145 o systematically characterize the common and independent neural input, originated from different leve

146 ic cause of juvenile or late-onset and cilia-independent NPH.

147 osolic metabolic roles and a distinct biotin-independent nuclear coregulatory function.

148 Three independent observers (A, B, C) measured PVRs at two dif

149 Two independent observers performed all measurements.

150 ents, bona fide viruses evolved on multiple, independent occasions throughout the course of evolution

151 "analytical zones" in a manner which is then independent of absolute exosome concentration and sample

152 A newer approach independent of additional information is to directly com

153 ecline in SI and a lower SI at age 18 years, independent of adiposity.

154 confidence interval: 0.478-0.677, P < 0.001) independent of age (P < 0.001), T stage (P < 0.001), N s

155 e with altered lung lining fluid composition independent of age or genotype.

156 n might be a general coping strategy that is independent of age, task content and brain region.

157 Changes in Nab3 binding are largely independent of alterations in transcription rate during

158 thermogenesis of brown adipose tissue (BAT) independent of ambient temperature conditions.

159 In stratified analyses, these findings were independent of any individual causative risk factor such

160 n also be due to decisional criterion shifts independent of any sensory changes.

161 es, leading to a xylose catabolic activation independent of catabolite repression control.

162 care early, and this outcome appeared to be independent of CD4+ count or WHO stage.

163 cfDNA-triggered NETosis is independent of classical TLR9 signaling.

164 n addition, susceptibility to IAV segregates independent of copy number variation in multicopy ChrY g

165 .4 mm/year, P=0.0424), although this was not independent of current smoking habit (P=0.1993).

166 ping strategies that work through mechanisms independent of current treatment options.

167 tool for data pre-processing that could run independent of existing high-performance computing (HPC)

168 enesis of these quiescence-induced miRNAs is independent of Exportin-5 and depends instead on Exporti

169 ernal nutrient concentrations are completely independent of external nutrient concentrations for all

170 ity contributes in part to readmission rates independent of factors involving patients.

171 es conventional autophagy components, but is independent of FAM134B.

172 a characteristic time tauc, and then becomes independent of filament lifetime and sharply dependent o

173 orneum lipid architecture in AD and IV HEEs, independent of FLG genotype.

174 plays specific roles in platelet activation independent of formation of the terminal complement comp

175 Gbetagamma, indicating that this effect was independent of Gbetagamma.

176 abnormalities related to DN involvement were independent of global and regional brain atrophy.

177 c outflow and reduced cBRS in RA that can be independent of hypertension.

178 Inhibition was independent of IFNalpha, IFNbeta, IFNL1, IFNL2, or Janus

179 This antimicrobial activity was independent of IL-26, because both natural IL-26 release

180 function, Pck2 remained partially functional independent of its catalytic activity.

181 omain that promotes transport of the protein independent of its interaction partners.

182 d VEGFR1-STAT3 binding and STAT3 activation, independent of Janus-activated kinase-1)/Janus-activated

183 Whereas PIF3 binds EBFs independent of light, the recruitment of PIF3-EBFs to th

184 and cognitive deterioration (all p < 0.001), independent of mutant HTT CAG repeat size.

185 d contributor to Alzheimer's disease that is independent of neuronal hypometabolism, predates changes

186 th production pathways stimulated by low O2, independent of NO2(-) concentrations.

187 These results seem independent of ordering.

188 predicted mechanical response of the myosin independent of other factors present in a sarcomere, suc

189 duction in per-protocol analysis (P = 0.043).Independent of other lifestyle changes, prebiotic supple

190 The effect was independent of potential confounding variables, includin

191 This need associated with serum levels of IS independent of renal function.

192 usions are associated with shorter survival, independent of sepsis, after colon cancer resection.

193 -8-mediated cell death dependent on FADD but independent of Ser(533) phosphorylation.

194 hat differences in sterics and connectivity, independent of stacking, significantly affect tertiary f

195 mulus-responsive enhancers for a target gene independent of stimulus exposure.

196 SE (P < .001-.017) and cylinder (P < .001), independent of surgical indication, compared to PK over

197 text] The coefficient [Formula: see text] is independent of temperature and inhomogeneity lengthscale

198 ion was found to be intrinsically disordered independent of the activation state of caspase-6; howeve

199 tories and is often assumed to be static and independent of the actual evolutionary process.

200 influences on the present genomic diversity, independent of the admixture, showing that a few centuri

201 flecting absorbers.Reflectionless absorption independent of the angle of incidence usually requires t

202 e performance and clinical outcome measures, independent of the associated antecedent increased annua

203 lective off-on fluorescence response that is independent of the enantiomeric sample composition and r

204 es have an intrinsic circadian clock that is independent of the host, and which regulates parasite bi

205 tion of LjIpt2 and LjLog4 transcripts occurs independent of the LjLhk1 receptor during nodulation.

206 nd the diastolic depolarization rate that is independent of the maximum upstroke velocity, a paramete

207 demonstrated a novel role of Pik3r1 that was independent of the regulatory function of phosphoinositi

208 pression collapse onto a single master curve independent of the strength and number of competitor sit

209 activation of IRF3, a substrate of TBK1, was independent of the TBD.

210 The strong association was independent of the use of modern systemic chemotherapy a

211 ed form, and the extent of fractionation was independent of the Zn:ligand ratio used, indicating isot

212 velopment and regulation of allergic disease independent of their antibody reactivity, is still lacki

213 cell death and PAMP-triggered immunity (PTI) independent of their enzymatic activity in Nicotiana ben

214 risk-taking by the entire group, for reasons independent of their physiological oxygen requirements.

215 pools and rates of soil N cycling that were independent of those of species richness.

216 ediated increases in P-glycoprotein activity independent of transporter protein expression.

217 termining drought tolerance, and are largely independent of wood density-a trait commonly associated

218 e to which geographic variability in ADHD is independent of, or explained by, risk factors may provid

219 ecord wet year of 2013/2014, however, Rs was independent on N supply because of the inhibition effect

220 il moisture is remarkably consistent between independent, overlapping SAR tracks covering a region 1

221 intenance of genomic stability through a DDR-independent pathway.

222 PDF in enhancing PER/TIM stability occur via independent pathways downstream of the PDF receptor, the

223 persisted across age, as observed within two independent PGC-SCZ2 subsamples, and showed an increase

224 otential leading to the activation of Ca(2+)-independent phospholipase A2gamma (iPLA2gamma) and the p

225 These results offer a general, system/model-independent, physical/observable-based approach to ident

226 seven of these proteins were validated in an independent planned myocardial injury cohort (n=15; P<1.

227 Their sheet-like structure derives from two independent polymeric networks - one of laminin and one

228 Results were validated in an independent population of asthmatic children (n = 30) by

229 ealthy control population (n = 36) and in an independent population of white adult atopic asthmatic p

230 the Detroit and St. Clair represent two semi-independent populations that could require separate mana

231 Organization-level Independent Practice and Support subscale, an NP-PCOCQ s

232 econd-year fellows felt "fully prepared" for independent practice.

233 ensure readiness for the entire spectrum of independent practice.

234 liver fat (OR 2.17; 95%CI: 1.05-4.46) was an independent predictor of increased liver stiffness.

235 calcitonin by more than 80% is a significant independent predictor of mortality and may aid in sepsis

236 exponential regression model coefficients of independent predictors at the last step after checking f

237 f maximal SB dilatation remained significant independent predictors for weaning off PN.

238 clooxygenase-2 (COX2) have been described as independent predictors of disease outcome.

239 othelial-enriched PCs (CD34(+)/VEGF(+)) were independent predictors of mortality in patients with HF

240 Independent predictors of mortality included cardiac var

241 and time with oxygen saturation of <90% were independent predictors of outcome.

242 ents in the dissection group, were a strong, independent prognostic factor for recurrence (hazard rat

243 Stage Liver Disease (P < 0.0001) scores were independent prognostic factors.

244 gression analysis revealed the two strongest independent radiological predictors for IPA to be the VO

245 Furthermore, RYBP is required for PRC1-independent recruitment of OCT4 to the promoter of Kdm2b

246 fs plants, suggesting that additional, auxin-independent regulation is needed.

247 Perfusion-independent regulation of epithelial pattern formation b

248 er phenomenon is an emergent property of the independent regulation of pre- and post-Start cell-cycle

249 Three independent researchers performed the study selection ba

250 Independent reviewers extracted the data and assessed th

251 ction, and psoriasis is now recognized as an independent risk factor for coronary heart disease and c

252 Exposure to TDF, but not other ARVs, was an independent risk factor for fractures.

253 Interpretation: Neonatal AKI is a common and independent risk factor for mortality and longer hospita

254 periodontal destruction and diabetes may be independent risk factors for all-cause and CVD mortality

255 eal bleeding, and nosocomial infections were independent risk factors for inpatient mortality in pati

256 Thirteen independent risk factors were identified in the derivati

257 1 and ETR2 have both ethylene-dependent and -independent roles in plant cells that affect responses t

258 ssorium repolarization involves a novel, DDR-independent S-phase checkpoint, triggered by appressoriu

259 re evaluated in the 100 subjects and another independent sample of 1,627 Han Chinese subjects.

260 h microbiome diversity and replicated in the independent sample.

261 confirm and extend this finding in a larger independent sample.

262 arger dimensional ACQ sample (N=2547) and in independent samples with a dichotomous AG phenotype base

263 cattering resulting in a "universal" density-independent (scaled) conductivity at high densities.

264 ed nucleotide-specific classification of two independent secondary structure motifs.

265 ssion of OCT4 (iOCT4) supports long-term LIF-independent self-renewal of ES cells cultured in media c

266 e homologous chromosome pairs allows for the independent sequencing of each of the complementary and

267 alidation of simulated tissue outcomes on an independent set of human colorectal cancer specimens (n

268 ress on the roles of NFIC-dependent and NFIC-independent signaling pathways in tooth root formation.

269 ction through a non-canonical, transcription-independent signalling mechanism that drives assembly of

270 Thus, cAMP-independent signals contribute to the induction of hypha

271 The effective number of independent SNPs was calculated to correct for multiple

272 nd medium size (15 in each group) for either independent, somewhat correlated, or highly correlated t

273 Thus sortilin-dependent as well as sortilin-independent sorting mechanisms target aggregated Golgi m

274 However predictive biases co-exist with an independent source of bias that depends only on recent m

275 aken together, the results suggest that FtsZ-independent structures of ZapA-ZapB provide additional p

276 perceptual features of odors are encoded in independent subnetworks of neurons in the olfactory cort

277 Disassembly of anillin patches was myosin independent, suggesting that CSNK-1 prevents expulsion o

278 Here we use two independent systems to impair hepatocyte proliferation d

279 cells or a unique subset of innate-like CD1d-independent T cells.

280 between the cohorts were measured using the independent t test, Wald chi(2), and binomial regression

281 reveal that mature domains harbor their own independent targeting signals (mature domain targeting s

282 ty in Therapeutics (ASRS ReST) Committee, an independent task force formed to monitor device-related

283 ngthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs i

284 mance was evaluated retrospectively using an independent testing set.

285 based on both five-fold cross-validation and independent tests indicated that the performance of Phos

286 ethod using both 5-fold cross-validation and independent tests.

287 rns of selection operating on IGRs using two independent the proportion of singleton mutations and th

288 endrites and spines through a specialized GA-independent trafficking network.

289 ted from all participants and evaluated by 2 independent, trained research assistants who were blinde

290 nerate confident copy number measurements in independent transgenic lines in these crop species.

291 new role for the helicase complex in 3' cap-independent translation element-mediated translation and

292 ic proteome and revealing novel modes of cap-independent translation.

293 induced changes were TCF dependent, but TCF-independent TSSs exhibited the same hierarchy, indicatin

294 ted during the NCT00632476 trial followed by independent validation of selected cord blood differenti

295 Independent validation of the prediction and prognostic

296 ight-circular polarizations into states with independent values of OAM and designed another device th

297 es of lycopene with selected combinations of independent variables were 8.20-59.17mg/100g on fresh we

298 el loci associated with BP regulation, and 1 independent variant at an established BP locus.

299 In particular, we found that partially independent variation in stomatal and mesophyll conducta

300 that the 1st Hit is largely telomere length-independent, while the 2nd Hit is largely TL-dependent,