1 Subsequent oxidation provides the
indolequinone.
2 patible with the predicted absorption of 5,6-
indolequinone (
1Q).
3 nd to be opposite to that observed for other
indolequinones acting as substrates.
4 gn of both NQO1-inhibitory and noninhibitory
indolequinone analogues allowed us to test the hypothesi
5 sisting of four monomer units (hydroquinone,
indolequinone,
and its two tautomers), in arrangements t
6 We describe a series of
indolequinones as efficient mechanism-based inhibitors o
7 In this report, we describe a series of
indolequinones,
based on 5-methoxy-1,2-dimethyl-3-[(4-ni
8 A series of
indolequinones bearing various functional groups has bee
9 eatic tumor xenograft in nude mice, and lead
indolequinones demonstrated high efficacy and low toxici
10 of the FAD in the active site of NQO2 by an
indolequinone-
derived iminium electrophile to the wider
11 nyltetrazolium (MTT) and clonogenic assays];
indolequinones displayed potent cytotoxicity against all
12 The
indolequinone ES936 {5-methoxy-1,2-dimethyl-3-[(4-nitrop
13 growth inhibitory activity of this series of
indolequinones in human pancreatic cancer.
14 nd may provide a biomarker of effect of lead
indolequinones in this type of cancer.
15 A series of
indolequinones including derivatives of EO9 bearing vari
16 These
indolequinones induced caspase-dependent apoptosis but n
17 Indolequinones inhibited NQO2 activity in K562 cells at
18 iminium electrophile to the wider series of
indolequinone inhibitors.
19 The examination of
indolequinone interactions in complex with NQO1 from com
20 Indolequinones (
IQs) were developed as potential antitum
21 le indole derivatives to their corresponding
indolequinones is described.
22 des the key step in a short synthesis of two
indolequinone natural products.
23 specificity exists, but minor changes to the
indolequinone nucleus have a significant effect upon sub
24 A series of 2- and 3-substituted
indolequinone phosphoramidate prodrugs targeted to DT-di
25 Previously a series of 2- and 3-substituted
indolequinone phosphoramidate prodrugs was synthesized,
26 ions demonstrated favorable conformations of
indolequinones positioned directly above and in parallel
27 oles and subsequent oxidation to the desired
indolequinones,
thereby demonstrating a powerful applica
28 The ability of this series of
indolequinones to inhibit recombinant human NQO1 correla
29 The unsaturated nature of C-C bonds in
indolequinone units and the finite size of protomolecule
30 In vivo efficacy of the
indolequinones was also tested in the MIA PaCa-2 pancrea
31 A potential target of these
indolequinones was identified as thioredoxin reductase.
32 Inhibition of recombinant human NQO2 by the
indolequinones was NRH-dependent, with kinetic parameter
33 The mechanism of action of the
indolequinones was shown to involve metabolic reduction,
34 hree cell lines, and two specific classes of
indolequinone were particularly potent agents.
35 Selected
indolequinones were also screened against the NCI-60 cel
36 Indolequinones were found to be potent inhibitors of thi
37 These
indolequinones were irreversible inhibitors and were fou
38 The
indolequinones with 4-nitrophenoxy, 4-pyridinyloxy, and
39 The objective of this study was to identify
indolequinones with improved potency against pancreatic